IL108892A - Azacyclohexapeptide compounds and bactericidal preparations containing them - Google Patents

Azacyclohexapeptide compounds and bactericidal preparations containing them

Info

Publication number
IL108892A
IL108892A IL10889294A IL10889294A IL108892A IL 108892 A IL108892 A IL 108892A IL 10889294 A IL10889294 A IL 10889294A IL 10889294 A IL10889294 A IL 10889294A IL 108892 A IL108892 A IL 108892A
Authority
IL
Israel
Prior art keywords
compound
seq
xaa xaa
ch2ch2nh2
ch2conh2
Prior art date
Application number
IL10889294A
Other languages
English (en)
Hebrew (he)
Other versions
IL108892A0 (en
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21867140&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL108892(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of IL108892A0 publication Critical patent/IL108892A0/xx
Publication of IL108892A publication Critical patent/IL108892A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/08—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis for Pneumocystis carinii
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/27—Cyclic peptide or cyclic protein
IL10889294A 1993-03-16 1994-03-08 Azacyclohexapeptide compounds and bactericidal preparations containing them IL108892A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/032,847 US5378804A (en) 1993-03-16 1993-03-16 Aza cyclohexapeptide compounds

Publications (2)

Publication Number Publication Date
IL108892A0 IL108892A0 (en) 1994-06-24
IL108892A true IL108892A (en) 1998-07-15

Family

ID=21867140

Family Applications (1)

Application Number Title Priority Date Filing Date
IL10889294A IL108892A (en) 1993-03-16 1994-03-08 Azacyclohexapeptide compounds and bactericidal preparations containing them

Country Status (33)

Country Link
US (3) US5378804A (bg)
EP (1) EP0620232B1 (bg)
JP (1) JP2568474B2 (bg)
KR (1) KR100329693B1 (bg)
CN (1) CN1098274C (bg)
AT (1) ATE186736T1 (bg)
AU (1) AU668804B2 (bg)
BG (1) BG63047B1 (bg)
BR (2) BR9406009A (bg)
CA (1) CA2118757C (bg)
CZ (1) CZ286235B6 (bg)
DE (2) DE10299013I2 (bg)
DK (1) DK0620232T3 (bg)
ES (1) ES2139043T3 (bg)
FI (1) FI109542B (bg)
GR (1) GR3031872T3 (bg)
HK (1) HK1008674A1 (bg)
HR (1) HRP940161B1 (bg)
HU (2) HU217614B (bg)
IL (1) IL108892A (bg)
LU (1) LU90875I2 (bg)
LV (1) LV12574B (bg)
NL (1) NL300076I2 (bg)
NO (2) NO318372B1 (bg)
NZ (1) NZ263360A (bg)
PL (1) PL179261B1 (bg)
RO (1) RO113246B1 (bg)
RU (1) RU2122548C1 (bg)
SI (1) SI9420013B (bg)
SK (1) SK282527B6 (bg)
UA (1) UA59329C2 (bg)
WO (1) WO1994021677A1 (bg)
ZA (1) ZA941807B (bg)

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US5948753A (en) * 1993-05-04 1999-09-07 Merck & Co., Inc. Cyclohexapeptidyl propanolamine compounds
CA2195975C (en) * 1994-08-23 2001-05-15 James M. Balkovec An improved process for preparing side chain derivatives of cyclohexapeptidyl lipopeptides
US5516757A (en) * 1994-09-16 1996-05-14 Merck & Co., Inc. Semi-synthetic lipopeptides, compositions containing said lipopeptides, and methods of use
US5514651A (en) * 1994-09-16 1996-05-07 Merck & Co., Inc. Aza cyclohexapeptide compounds
DE69528065T2 (de) * 1994-09-16 2003-04-10 Merck & Co Inc Azazyklohexapeptid-verbindungen
US5516756A (en) * 1994-10-31 1996-05-14 Merck & Co., Inc. Aza cyclohexapeptide compounds
CA2211138A1 (en) * 1995-01-26 1996-08-01 Merck & Co., Inc. Novel antifungal cyclohexapeptides
US5552521A (en) * 1995-02-10 1996-09-03 Merck & Co., Inc. Process for preparing certain aza cyclohexapeptides
CA2235824A1 (en) * 1995-11-09 1997-05-15 Merck & Co., Inc. Cyclohexapeptidyl bisamine compound, compositions containing said compound and methods of use
US5952300A (en) * 1996-04-19 1999-09-14 Merck & Co., Inc. Antifungal compositions
PE63998A1 (es) * 1996-04-19 1998-10-30 Merck & Co Inc Composiciones anti-fungosas
HRP970318B1 (en) * 1996-06-14 2002-06-30 Merck & Co Inc A process for preparing certain aza cyclohexapeptides
EE03748B1 (et) * 1996-09-12 2002-06-17 Merck & Co., Inc. Pneumokandiinderivaat kasutamiseks seenhaiguste ravis
US6069126A (en) * 1996-09-12 2000-05-30 Merck & Co., Inc. Antifungal combination therapy
US5854212A (en) * 1996-10-23 1998-12-29 Merck & Co., Inc. Cyclohexapeptidyl bisamine compound, compositions containing said compound and methods of use
US5936062A (en) * 1997-06-12 1999-08-10 Merck & Co., Inc. Process for preparing certain aza cyclohexapeptides
ATE416189T1 (de) * 1999-07-27 2008-12-15 Aventis Pharma Gmbh Cyclohexapeptide, deren herstellung und verwendung in pharmazeutische zusammensetzungen
WO2003079972A2 (en) 2002-02-22 2003-10-02 New River Parmaceuticals Inc. Active agent delivery systems and methods for protecting and administering active agents
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US7214768B2 (en) * 2002-04-08 2007-05-08 Merck & Co., Inc. Echinocandin process
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CN1950396A (zh) * 2004-02-24 2007-04-18 联邦科学技术研究组织 抗真菌肽
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TW200826957A (en) * 2006-10-16 2008-07-01 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Purification processes for echinocandin-type compounds
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US20090075870A1 (en) * 2007-09-17 2009-03-19 Protia, Llc Deuterium-enriched caspofungin
US20090291996A1 (en) * 2008-05-21 2009-11-26 Ferenc Korodi Caspofungin free of caspofungin Co
US8048853B2 (en) * 2008-06-13 2011-11-01 Xellia Pharmaceuticals Aps Process for preparing pharmaceutical compound and intermediates thereof
EP2240507A2 (en) * 2008-06-25 2010-10-20 TEVA Gyógyszergyár Zártkörüen Müködö Részvénytársaság Processes for preparing high purity aza cyclohexapeptides
WO2009158034A1 (en) * 2008-06-25 2009-12-30 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Caspofungin free of caspofungin impurity a
WO2010064219A1 (en) 2008-12-04 2010-06-10 Ranbaxy Laboratories Limited Process for the preparation of a novel intermediate for caspofungin
TW201024322A (en) * 2008-12-31 2010-07-01 Chunghwa Chemical Synthesis & Biotech Co Ltd Preparation method for nitrogen containing heterocyclic hexapeptide with high conversion rate
WO2010108637A1 (en) 2009-03-27 2010-09-30 Axellia Pharmaceuticals Aps Crystalline compound
CN101602795B (zh) * 2009-07-20 2011-12-21 中国人民解放军第二军医大学 环六脂肽胺类抗真菌化合物及其盐类和制备方法
EP2463293A4 (en) * 2009-08-06 2013-06-05 Shanghai Techwell Biopharm Co AZACYCLOHEXAPEPTIDE BZW. ITS PHARMACEUTICAL ACCEPTABLE SALT, MANUFACTURING PROCESS AND USE
US8751760B2 (en) * 2009-10-01 2014-06-10 Dell Products L.P. Systems and methods for power state transitioning in an information handling system
CN101792486A (zh) * 2010-04-12 2010-08-04 浙江海正药业股份有限公司 一种合成醋酸卡泊芬净的方法
CN102219832B (zh) * 2010-04-15 2013-08-21 上海天伟生物制药有限公司 一种氮杂环六肽或其盐的纯化方法
KR20130136466A (ko) 2010-09-20 2013-12-12 셀리아 파마슈티칼즈 에이피에스 카스포펀진 조성물
ES2581562T3 (es) * 2010-09-29 2016-09-06 Shanghai Techwell Biopharmaceutical Co., Ltd Procedimiento para purificar compuestos lipopeptídicos cíclicos o sales de los mismos
RU2538274C2 (ru) * 2010-09-30 2015-01-10 Шанхай Техвелл Биофармасьютикал Ко., Лтд. Способ очистки циклопептидных соединений или их солей
CN102367268B (zh) 2010-11-10 2013-11-06 上海天伟生物制药有限公司 一种卡泊芬净类似物及其用途
CN102367267B (zh) 2010-11-10 2013-09-04 上海天伟生物制药有限公司 一种卡泊芬净的制备方法
CN102367269B (zh) 2010-11-10 2013-11-06 上海天伟生物制药有限公司 一种卡泊芬净类似物及其制备方法和用途
KR101331984B1 (ko) 2010-12-09 2013-11-25 종근당바이오 주식회사 카스포펀진 제조방법 및 그의 신규 중간체
WO2012093293A1 (en) * 2011-01-03 2012-07-12 Biocon Limited Process for preparation of caspofungin acetate and intermediates
CN102618606B (zh) * 2011-01-30 2014-09-10 浙江海正药业股份有限公司 一种棘白菌素生物转化方法
RS56426B1 (sr) 2011-03-03 2018-01-31 Cidara Therapeutics Inc Antigljivična sredstva i njihova upotreba
CN102746384B (zh) 2011-04-22 2016-01-20 上海天伟生物制药有限公司 一种高纯度的卡泊芬净或其盐及其制备方法和用途
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SI2922530T1 (sl) * 2012-11-20 2017-04-26 Fresenius Kabi Usa, Llc Formulacije kaspofugin acetata
CN105481952B (zh) * 2014-12-24 2020-12-29 上海天伟生物制药有限公司 一种含氮杂环六肽前体的组合物及其制备方法和用途
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WO2017185030A1 (en) * 2016-04-22 2017-10-26 Fresenius Kabi Usa, Llc Caspofungin formulation with low impurities
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Also Published As

Publication number Publication date
US5514650A (en) 1996-05-07
AU5783294A (en) 1994-09-22
HRP940161B1 (en) 2001-04-30
HU9502703D0 (en) 1995-11-28
BR9406009A (pt) 1995-12-26
UA59329C2 (uk) 2003-09-15
FI109542B (fi) 2002-08-30
CA2118757C (en) 2002-05-14
KR960701092A (ko) 1996-02-24
JP2568474B2 (ja) 1997-01-08
NL300076I1 (nl) 2002-03-01
NO953648D0 (no) 1995-09-15
EP0620232A1 (en) 1994-10-19
KR100329693B1 (ko) 2002-08-14
HK1008674A1 (en) 1999-05-14
CZ235895A3 (en) 1996-02-14
LV12574B (en) 2001-04-20
DE69421639D1 (de) 1999-12-23
BG63047B1 (bg) 2001-02-28
FI954327A (fi) 1995-09-14
FI954327A0 (fi) 1995-09-14
HRP940161A2 (en) 1996-08-31
BR1100273A (pt) 1999-10-13
LU90875I2 (en) 2002-03-04
NO2005020I1 (no) 2005-09-13
CN1098274C (zh) 2003-01-08
GR3031872T3 (en) 2000-02-29
CA2118757A1 (en) 1994-09-17
NL300076I2 (nl) 2002-04-02
NZ263360A (en) 1997-08-22
ZA941807B (en) 1994-10-13
HUT73496A (en) 1996-08-28
DE10299013I1 (de) 2003-01-23
SK282527B6 (sk) 2002-10-08
AU668804B2 (en) 1996-05-16
ATE186736T1 (de) 1999-12-15
WO1994021677A1 (en) 1994-09-29
CZ286235B6 (cs) 2000-02-16
LV12574A (en) 2000-11-20
BG99999A (bg) 1996-04-30
DE10299013I2 (de) 2009-11-19
US5378804A (en) 1995-01-03
SI9420013A (en) 1996-08-31
HU211890A9 (en) 1995-12-28
HU217614B (hu) 2000-03-28
IL108892A0 (en) 1994-06-24
US5792746A (en) 1998-08-11
DE69421639T2 (de) 2000-06-08
EP0620232B1 (en) 1999-11-17
NO953648L (no) 1995-11-15
NO2005020I2 (no) 2008-12-01
ES2139043T3 (es) 2000-02-01
CN1119441A (zh) 1996-03-27
NO318372B1 (no) 2005-03-14
SK113695A3 (en) 1996-02-07
SI9420013B (sl) 2002-12-31
RU2122548C1 (ru) 1998-11-27
DK0620232T3 (da) 2000-03-13
RO113246B1 (ro) 1998-05-29
PL179261B1 (pl) 2000-08-31
JPH06321986A (ja) 1994-11-22
PL310634A1 (en) 1995-12-27

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