HUP0001994A2 - Eljárás eprosartan előállítására - Google Patents

Eljárás eprosartan előállítására

Info

Publication number
HUP0001994A2
HUP0001994A2 HU0001994A HUP0001994A HUP0001994A2 HU P0001994 A2 HUP0001994 A2 HU P0001994A2 HU 0001994 A HU0001994 A HU 0001994A HU P0001994 A HUP0001994 A HU P0001994A HU P0001994 A2 HUP0001994 A2 HU P0001994A2
Authority
HU
Hungary
Prior art keywords
formula
compound
pharmaceutically acceptable
propionic acid
piperidine
Prior art date
Application number
HU0001994A
Other languages
English (en)
Inventor
Joseph Robert Flisak
Clifford S. Labaw
Li Liu
Original Assignee
Smithkline Beecham Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corporation filed Critical Smithkline Beecham Corporation
Publication of HUP0001994A2 publication Critical patent/HUP0001994A2/hu
Publication of HUP0001994A3 publication Critical patent/HUP0001994A3/hu
Publication of HU228781B1 publication Critical patent/HU228781B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

A találmány tárgya új eljárás eprosartan, azaz (I) képletű (E) -2-{[2-butil-1-(4-karboxi-benzil)-1H-5-imidazolil]-metilén}-3-(2-tienil)-propionsav vagy gyógyászatilag elfogadható sói előállítására, amelyneksorán egy (II) képletű vegyületet vagy sav- vagy bázisaddíciós sójátcsökkentett nyomáson, katalizátor, például piperidin vagypiperidinium-propionát jelenlétében, propionsav feleslegében egy (III)általános képletű vegyülettel - amelynek képletében R' jelentése 1-4szénatomos alkilcsoport - reagáltatják, majd az R' észtertlehidrolizálják, és kívánt esetben gyógyászatilag elfogadható sótképeznek. Egy másik megoldás értelmében az (I) képletű vegyületet úgyállítják elő, hogy egy (IV) képletű vegyületet csökkentett nyomáson,katalizátor, például piperidin vagy piperidinium-propionátjelenlétében, propionsav feleslegében egy (III) általános képletűvegyülettel reagáltatnak, majd az R' észtert lehidrolizálják, éskívánt esetben gyógyászatilag elfogadható sót képeznek. Ó
HU0001994A 1997-02-14 1998-02-13 Process for preparing eprosartan HU228781B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3819597P 1997-02-14 1997-02-14
PCT/US1998/002412 WO1998035963A1 (en) 1997-02-14 1998-02-13 Process for preparing eprosartan

Publications (3)

Publication Number Publication Date
HUP0001994A2 true HUP0001994A2 (hu) 2001-06-28
HUP0001994A3 HUP0001994A3 (en) 2001-07-30
HU228781B1 HU228781B1 (en) 2013-05-28

Family

ID=21898583

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0001994A HU228781B1 (en) 1997-02-14 1998-02-13 Process for preparing eprosartan

Country Status (41)

Country Link
US (1) US6172237B1 (hu)
EP (1) EP0970073B1 (hu)
JP (1) JP4537499B2 (hu)
KR (1) KR100573638B1 (hu)
CN (1) CN1085208C (hu)
AP (1) AP1128A (hu)
AR (1) AR011125A1 (hu)
AT (1) ATE280765T1 (hu)
AU (1) AU730383B2 (hu)
BG (1) BG63804B1 (hu)
BR (1) BR9808664A (hu)
CA (1) CA2281708C (hu)
CO (1) CO4950550A1 (hu)
CY (1) CY2555B1 (hu)
CZ (1) CZ296349B6 (hu)
DE (1) DE69827240T2 (hu)
DK (1) DK0970073T3 (hu)
EA (1) EA001659B1 (hu)
EG (1) EG23935A (hu)
ES (1) ES2231963T3 (hu)
HU (1) HU228781B1 (hu)
ID (1) ID23181A (hu)
IL (1) IL131309A (hu)
IN (2) IN187999B (hu)
MA (1) MA24470A1 (hu)
MY (1) MY118704A (hu)
NO (1) NO317194B1 (hu)
NZ (1) NZ337180A (hu)
OA (1) OA11146A (hu)
PE (1) PE59299A1 (hu)
PL (1) PL192838B1 (hu)
PT (1) PT970073E (hu)
RO (1) RO119719B1 (hu)
SA (1) SA98190082B1 (hu)
SI (1) SI0970073T1 (hu)
SK (1) SK285036B6 (hu)
TR (1) TR199901936T2 (hu)
TW (1) TW399050B (hu)
UA (1) UA54487C2 (hu)
WO (1) WO1998035963A1 (hu)
ZA (1) ZA981207B (hu)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2097408A4 (en) * 2006-12-27 2010-08-25 Hetero Drugs Ltd IMPROVED PROCESS FOR THE PREPARATION OF EPROSARTAN
EP2295431A3 (en) * 2007-07-25 2011-08-03 Hetero Drugs Limited Substantially pure eprosartan free base
WO2009013760A2 (en) * 2007-07-25 2009-01-29 Hetero Drugs Limited Eprosartan mesylate crystalline particles and a process for preparing pure eprosartan
WO2009084028A2 (en) * 2007-12-03 2009-07-09 Neuland Laboratories Ltd Improved process for manufacturing anhydrous (e)-3-[2-butyl-1- {(4-carboxyphenyl) methyl}-1h-imidazole-5-yl]-(thiophen-2- ylmethyl)prop-2-enoic acid methane sulfonate
CN101215284B (zh) * 2007-12-31 2010-10-13 浙江华海药业股份有限公司 一种改进的依普罗沙坦的制备方法
EP2257540A2 (en) * 2008-03-31 2010-12-08 Hetero Research Foundation Improved process for eprosartan intermediate
WO2010023688A2 (en) * 2008-08-25 2010-03-04 Matrix Laboratories Limited An improved process for the preparation of eprosartan
WO2011004384A2 (en) 2009-06-05 2011-01-13 Glochem Industries Limited Process for the preparation of eprosartan
WO2011051975A1 (en) 2009-10-30 2011-05-05 Matrix Laboratories Ltd An improved process for the preparation of pure eprosartanand its pharmaceutical acceptable salts

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5185351A (en) * 1989-06-14 1993-02-09 Smithkline Beecham Corporation Imidazolyl-alkenoic acids useful as angiotensin II receptor antagonists
NZ239161A (en) * 1990-07-31 1994-01-26 Smithkline Beecham Corp Substituted [1h-imidazol-5-yl] alkanoic acid derivatives; medicaments,
AU9137791A (en) * 1990-12-14 1992-07-08 Smithkline Beecham Corporation Imidazolyl-alkenoic acids
US5395847A (en) * 1993-12-02 1995-03-07 Smithkline Beecham Corporation Imidazolyl-alkenoic acids
US5719293A (en) * 1994-05-20 1998-02-17 Smithkline Beecham Corporation Intermediate for preparing a pharmaceutically active compound

Also Published As

Publication number Publication date
KR100573638B1 (ko) 2006-04-26
AP1128A (en) 2002-12-06
ID23181A (id) 2000-03-23
DK0970073T3 (da) 2005-02-21
EG23935A (en) 2008-01-14
ZA981207B (en) 1998-11-12
HUP0001994A3 (en) 2001-07-30
CN1085208C (zh) 2002-05-22
EA001659B1 (ru) 2001-06-25
OA11146A (en) 2003-04-16
WO1998035963A1 (en) 1998-08-20
KR20000071007A (ko) 2000-11-25
ATE280765T1 (de) 2004-11-15
CA2281708A1 (en) 1998-08-20
CO4950550A1 (es) 2000-09-01
BR9808664A (pt) 2000-07-11
TW399050B (en) 2000-07-21
AU6150898A (en) 1998-09-08
PT970073E (pt) 2005-02-28
BG63804B1 (bg) 2003-01-31
PL335075A1 (en) 2000-04-10
NO993913L (no) 1999-08-13
SA98190082B1 (ar) 2006-08-20
NZ337180A (en) 2000-11-24
NO317194B1 (no) 2004-09-13
MY118704A (en) 2005-01-31
IL131309A (en) 2002-09-12
NO993913D0 (no) 1999-08-13
TR199901936T2 (xx) 2000-04-21
DE69827240D1 (de) 2004-12-02
AR011125A1 (es) 2000-08-02
SK285036B6 (sk) 2006-05-04
JP2001510466A (ja) 2001-07-31
AU730383B2 (en) 2001-03-08
MA24470A1 (fr) 1998-10-01
HU228781B1 (en) 2013-05-28
DE69827240T2 (de) 2005-10-13
CZ296349B6 (cs) 2006-02-15
SI0970073T1 (en) 2005-02-28
RO119719B1 (ro) 2005-02-28
IN187999B (hu) 2002-08-03
PL192838B1 (pl) 2006-12-29
BG103650A (en) 2000-06-30
EP0970073B1 (en) 2004-10-27
ES2231963T3 (es) 2005-05-16
IN192743B (hu) 2004-05-15
SK108799A3 (en) 2000-05-16
IL131309A0 (en) 2001-01-28
CZ285299A3 (cs) 2000-02-16
EP0970073A4 (en) 2001-01-24
CY2555B1 (en) 2008-07-02
UA54487C2 (uk) 2003-03-17
CA2281708C (en) 2007-08-14
CN1247539A (zh) 2000-03-15
PE59299A1 (es) 1999-09-09
EA199900740A1 (ru) 2000-02-28
AP9901620A0 (en) 1999-09-30
JP4537499B2 (ja) 2010-09-01
US6172237B1 (en) 2001-01-09
EP0970073A1 (en) 2000-01-12

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Legal Events

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MM4A Lapse of definitive patent protection due to non-payment of fees