AR011125A1 - Procedimiento para preparar eprosartano - Google Patents
Procedimiento para preparar eprosartanoInfo
- Publication number
- AR011125A1 AR011125A1 ARP980100585A ARP980100585A AR011125A1 AR 011125 A1 AR011125 A1 AR 011125A1 AR P980100585 A ARP980100585 A AR P980100585A AR P980100585 A ARP980100585 A AR P980100585A AR 011125 A1 AR011125 A1 AR 011125A1
- Authority
- AR
- Argentina
- Prior art keywords
- compound
- formula
- eprosartan
- preparation
- pharmaceutically acceptable
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Steroid Compounds (AREA)
Abstract
Un procedimiento para la preparacion de eprosartano, un compuesto de formula (I): o una de sus sales farmacéuticamente aceptables, que comprendehacer reaccionar un compuesto de formul (II): o una de sus sales de adicion de ácidos o bases conun compuesto de formula (III): en la que R es alquilo C1-C4a presion reducida en presencia de un catalizador y, después de esto, hidrolizar el éster R y opcionalmente formar una sal farmacéuticamenteaceptable. Este compuesto es unantagonis ta del receptor de la angiotensina II util en el tratamiento de la hipertension, insuficiencia cardíaca congestiva einsuficiencia renal. Además se describe un procedimiento alternativo para la preparacion de eprosartano.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US3819597P | 1997-02-14 | 1997-02-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR011125A1 true AR011125A1 (es) | 2000-08-02 |
Family
ID=21898583
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP980100585A AR011125A1 (es) | 1997-02-14 | 1998-02-10 | Procedimiento para preparar eprosartano |
Country Status (41)
Country | Link |
---|---|
US (1) | US6172237B1 (es) |
EP (1) | EP0970073B1 (es) |
JP (1) | JP4537499B2 (es) |
KR (1) | KR100573638B1 (es) |
CN (1) | CN1085208C (es) |
AP (1) | AP1128A (es) |
AR (1) | AR011125A1 (es) |
AT (1) | ATE280765T1 (es) |
AU (1) | AU730383B2 (es) |
BG (1) | BG63804B1 (es) |
BR (1) | BR9808664A (es) |
CA (1) | CA2281708C (es) |
CO (1) | CO4950550A1 (es) |
CY (1) | CY2555B1 (es) |
CZ (1) | CZ296349B6 (es) |
DE (1) | DE69827240T2 (es) |
DK (1) | DK0970073T3 (es) |
EA (1) | EA001659B1 (es) |
EG (1) | EG23935A (es) |
ES (1) | ES2231963T3 (es) |
HU (1) | HU228781B1 (es) |
ID (1) | ID23181A (es) |
IL (1) | IL131309A (es) |
IN (2) | IN187999B (es) |
MA (1) | MA24470A1 (es) |
MY (1) | MY118704A (es) |
NO (1) | NO317194B1 (es) |
NZ (1) | NZ337180A (es) |
OA (1) | OA11146A (es) |
PE (1) | PE59299A1 (es) |
PL (1) | PL192838B1 (es) |
PT (1) | PT970073E (es) |
RO (1) | RO119719B1 (es) |
SA (1) | SA98190082B1 (es) |
SI (1) | SI0970073T1 (es) |
SK (1) | SK285036B6 (es) |
TR (1) | TR199901936T2 (es) |
TW (1) | TW399050B (es) |
UA (1) | UA54487C2 (es) |
WO (1) | WO1998035963A1 (es) |
ZA (1) | ZA981207B (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008078330A1 (en) * | 2006-12-27 | 2008-07-03 | Hetero Drugs Limited | Improved process for eprosartan |
US8361507B2 (en) * | 2007-07-25 | 2013-01-29 | Hetero Drugs Limited | Eprosartan mesylate crystalline particles and a process for preparing pure eprosartan |
EP2295430A3 (en) * | 2007-07-25 | 2011-08-03 | Hetero Drugs Limited | Crystalline solid of eprosartan acetate |
WO2009084028A2 (en) * | 2007-12-03 | 2009-07-09 | Neuland Laboratories Ltd | Improved process for manufacturing anhydrous (e)-3-[2-butyl-1- {(4-carboxyphenyl) methyl}-1h-imidazole-5-yl]-(thiophen-2- ylmethyl)prop-2-enoic acid methane sulfonate |
CN101215284B (zh) * | 2007-12-31 | 2010-10-13 | 浙江华海药业股份有限公司 | 一种改进的依普罗沙坦的制备方法 |
EP2257540A2 (en) * | 2008-03-31 | 2010-12-08 | Hetero Research Foundation | Improved process for eprosartan intermediate |
WO2010023688A2 (en) * | 2008-08-25 | 2010-03-04 | Matrix Laboratories Limited | An improved process for the preparation of eprosartan |
WO2011004384A2 (en) | 2009-06-05 | 2011-01-13 | Glochem Industries Limited | Process for the preparation of eprosartan |
WO2011051975A1 (en) | 2009-10-30 | 2011-05-05 | Matrix Laboratories Ltd | An improved process for the preparation of pure eprosartanand its pharmaceutical acceptable salts |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5185351A (en) * | 1989-06-14 | 1993-02-09 | Smithkline Beecham Corporation | Imidazolyl-alkenoic acids useful as angiotensin II receptor antagonists |
NZ239161A (en) * | 1990-07-31 | 1994-01-26 | Smithkline Beecham Corp | Substituted [1h-imidazol-5-yl] alkanoic acid derivatives; medicaments, |
WO1992010189A1 (en) * | 1990-12-14 | 1992-06-25 | Smithkline Beecham Corporation | Imidazolyl-alkenoic acids |
US5395847A (en) * | 1993-12-02 | 1995-03-07 | Smithkline Beecham Corporation | Imidazolyl-alkenoic acids |
US5719293A (en) * | 1994-05-20 | 1998-02-17 | Smithkline Beecham Corporation | Intermediate for preparing a pharmaceutically active compound |
-
1998
- 1998-02-10 AR ARP980100585A patent/AR011125A1/es active IP Right Grant
- 1998-02-11 EG EG15598A patent/EG23935A/xx active
- 1998-02-12 IN IN360DE1998 patent/IN187999B/en unknown
- 1998-02-12 PE PE1998000101A patent/PE59299A1/es not_active Application Discontinuation
- 1998-02-12 MY MYPI98000577A patent/MY118704A/en unknown
- 1998-02-12 MA MA24961A patent/MA24470A1/fr unknown
- 1998-02-13 KR KR1019997007273A patent/KR100573638B1/ko not_active IP Right Cessation
- 1998-02-13 SK SK1087-99A patent/SK285036B6/sk not_active IP Right Cessation
- 1998-02-13 CA CA002281708A patent/CA2281708C/en not_active Expired - Fee Related
- 1998-02-13 CO CO98007700A patent/CO4950550A1/es unknown
- 1998-02-13 WO PCT/US1998/002412 patent/WO1998035963A1/en active IP Right Grant
- 1998-02-13 AT AT98906229T patent/ATE280765T1/de active
- 1998-02-13 JP JP52813798A patent/JP4537499B2/ja not_active Expired - Fee Related
- 1998-02-13 CN CN98802484A patent/CN1085208C/zh not_active Expired - Fee Related
- 1998-02-13 NZ NZ337180A patent/NZ337180A/xx unknown
- 1998-02-13 BR BR9808664-2A patent/BR9808664A/pt not_active IP Right Cessation
- 1998-02-13 AU AU61508/98A patent/AU730383B2/en not_active Ceased
- 1998-02-13 RO RO99-00885A patent/RO119719B1/ro unknown
- 1998-02-13 ES ES98906229T patent/ES2231963T3/es not_active Expired - Lifetime
- 1998-02-13 ID IDW990839A patent/ID23181A/id unknown
- 1998-02-13 UA UA99084635A patent/UA54487C2/uk unknown
- 1998-02-13 SI SI9830722T patent/SI0970073T1/xx unknown
- 1998-02-13 DE DE69827240T patent/DE69827240T2/de not_active Expired - Lifetime
- 1998-02-13 US US09/355,185 patent/US6172237B1/en not_active Expired - Lifetime
- 1998-02-13 ZA ZA981207A patent/ZA981207B/xx unknown
- 1998-02-13 CZ CZ0285299A patent/CZ296349B6/cs not_active IP Right Cessation
- 1998-02-13 AP APAP/P/1999/001620A patent/AP1128A/en active
- 1998-02-13 EA EA199900740A patent/EA001659B1/ru not_active IP Right Cessation
- 1998-02-13 PT PT98906229T patent/PT970073E/pt unknown
- 1998-02-13 PL PL335075A patent/PL192838B1/pl unknown
- 1998-02-13 HU HU0001994A patent/HU228781B1/hu not_active IP Right Cessation
- 1998-02-13 DK DK98906229T patent/DK0970073T3/da active
- 1998-02-13 IL IL13130998A patent/IL131309A/en not_active IP Right Cessation
- 1998-02-13 TR TR1999/01936T patent/TR199901936T2/xx unknown
- 1998-02-13 EP EP98906229A patent/EP0970073B1/en not_active Expired - Lifetime
- 1998-04-15 TW TW087101969A patent/TW399050B/zh not_active IP Right Cessation
- 1998-05-24 SA SA98190082A patent/SA98190082B1/ar unknown
-
1999
- 1999-08-10 BG BG103650A patent/BG63804B1/bg unknown
- 1999-08-13 NO NO19993913A patent/NO317194B1/no not_active IP Right Cessation
- 1999-08-13 OA OA9900179A patent/OA11146A/en unknown
-
2002
- 2002-01-28 IN IN58DE2002 patent/IN192743B/en unknown
-
2006
- 2006-04-07 CY CY0600011A patent/CY2555B1/xx unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
TW397823B (en) | Arylsulfonylamino hydroxamic acid derivatives | |
CY1112550T1 (el) | Παραγωγο δικυκλοεστερα | |
ATE297203T1 (de) | Antithrombotische mitteln | |
CO5720995A2 (es) | Compuesto novedoso | |
EA200500238A1 (ru) | Новый способ синтеза ивабрадина и его солей присоединения с фармацевтически приемлемой кислотой | |
RS50140B (sr) | Postupak za dobijanje perkihinina i njegova upotreba | |
AR011125A1 (es) | Procedimiento para preparar eprosartano | |
BRPI0416628A (pt) | uso de compostos orgánicos | |
CR7074A (es) | Derivados de mercaptoacetylamida y proceso para su preparacion y uso | |
HRP20020428B1 (en) | Bicyclic amino acids as pharmaceutical agents | |
IS2600B (is) | Ný tríasólpýrimídínefnasambönd | |
ECSP034460A (es) | Nuevos compuestos heterociclicos, su preparacion y su utilizacion como medicamentos, en especial como antibacterianos | |
MY127894A (en) | Renin inhibitors | |
BG66115B1 (bg) | Използване на рамиприл или негова фармацевтично приемлива сол за предотвратяване на конгестивна сърдечна недостатъчност | |
ATE312083T1 (de) | Imidazolcarbene | |
ECSP034658A (es) | Combinacion terapeutica de amlodipina y benazepril/benazeprilato | |
DE60019347D1 (de) | Inhibitoren der alpha-l beta-2 vermittelten zelladhäsion | |
TR200201168T2 (tr) | CGRP-Antagonistleri-yeni siklopropanlar içeren ilaçlar ve üretim yöntemleri. | |
GT200000197A (es) | 2-(3,5-bis-trifluorometil-fenil)-n-metil-n-(6- morfolin-4-il-4-o tolil-piridin-3-il)-isobutiramida. | |
DE60218064D1 (de) | Neues peptid mit angiotensinkonvertase hemmender wirkung | |
TWI361186B (en) | New compounds | |
RU2008148600A (ru) | Производные бензиламина в качестве ингибиторов сетр | |
NO20032261D0 (no) | Medisinske preparater | |
PE20020910A1 (es) | p-TIENILBENCIL-AMIDAS COMO AGONISTAS DE RECEPTORES DE ANGIOTENSINA-(1-7), PROCEDIMIENTO PARA SU PREPARACION Y PREPARADOS FARMACEUTICOS QUE LOS CONTIENEN | |
DK0752854T3 (da) | Pyrimidin- eller triazincarboxylsyrederivater til anvendelse som lægemiddel |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant, registration |