DE69626846D1 - Phosphonsäurederivate mit metallopeptidase inhibierender aktivität - Google Patents

Phosphonsäurederivate mit metallopeptidase inhibierender aktivität

Info

Publication number
DE69626846D1
DE69626846D1 DE69626846T DE69626846T DE69626846D1 DE 69626846 D1 DE69626846 D1 DE 69626846D1 DE 69626846 T DE69626846 T DE 69626846T DE 69626846 T DE69626846 T DE 69626846T DE 69626846 D1 DE69626846 D1 DE 69626846D1
Authority
DE
Germany
Prior art keywords
aryl
heterocycle
opeptidase
metal
acid derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69626846T
Other languages
English (en)
Other versions
DE69626846T2 (de
Inventor
Gabriele Norcini
Daniela Botta
Francesco Santangelo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zambon SpA
Original Assignee
Zambon SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zambon SpA filed Critical Zambon SpA
Application granted granted Critical
Publication of DE69626846D1 publication Critical patent/DE69626846D1/de
Publication of DE69626846T2 publication Critical patent/DE69626846T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Detergent Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cosmetics (AREA)
DE69626846T 1995-11-23 1996-11-11 Phosphonsäurederivate mit metallopeptidase inhibierender aktivität Expired - Fee Related DE69626846T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT95MI002430A IT1276161B1 (it) 1995-11-23 1995-11-23 Derivati dell'acido fosfonico ad attivita' inibitrice delle metallopeptidasi
PCT/EP1996/004911 WO1997019102A1 (en) 1995-11-23 1996-11-11 Phosphonic acid derivatives with metallopeptidase inhibitory activity

Publications (2)

Publication Number Publication Date
DE69626846D1 true DE69626846D1 (de) 2003-04-24
DE69626846T2 DE69626846T2 (de) 2003-12-24

Family

ID=11372578

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69626846T Expired - Fee Related DE69626846T2 (de) 1995-11-23 1996-11-11 Phosphonsäurederivate mit metallopeptidase inhibierender aktivität

Country Status (23)

Country Link
US (1) US6548480B1 (de)
EP (1) EP0868428B1 (de)
JP (1) JP2000501079A (de)
KR (1) KR100458359B1 (de)
CN (1) CN1127513C (de)
AT (1) ATE234856T1 (de)
AU (1) AU707570B2 (de)
BR (1) BR9611465A (de)
CA (1) CA2249343A1 (de)
CZ (1) CZ291926B6 (de)
DE (1) DE69626846T2 (de)
DK (1) DK0868428T3 (de)
EA (1) EA000743B1 (de)
ES (1) ES2192619T3 (de)
HU (1) HUP0000080A3 (de)
IL (1) IL124021A (de)
IT (1) IT1276161B1 (de)
MX (1) MX9803760A (de)
NO (1) NO982363L (de)
PT (1) PT868428E (de)
SI (1) SI0868428T1 (de)
WO (1) WO1997019102A1 (de)
ZA (1) ZA969774B (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3973748B2 (ja) 1998-01-14 2007-09-12 花王株式会社 発毛抑制剤
JP4796296B2 (ja) * 2004-12-02 2011-10-19 インターナショナル・ビジネス・マシーンズ・コーポレーション Ｗｅｂページ・オーサリング装置、Ｗｅｂページ・オーサリング方法及びプログラム
KR101135332B1 (ko) * 2007-03-15 2012-04-17 닛코킨조쿠 가부시키가이샤 구리전해액 및 그것을 이용하여 얻어진 2층 플렉시블 기판

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4432972A (en) * 1981-08-03 1984-02-21 E. R. Squibb & Sons, Inc. Phosphonamidate compounds
ATE22692T1 (de) * 1981-08-03 1986-10-15 Squibb & Sons Inc Phosphonamidate verbindungen.
IT1274673B (it) * 1994-04-14 1997-07-24 Zambon Spa Derivati dell'acido fosfonico utili nel trattamento delle malattie car.iovascolari

Also Published As

Publication number Publication date
MX9803760A (es) 1998-09-30
EP0868428A1 (de) 1998-10-07
NO982363D0 (no) 1998-05-25
ITMI952430A1 (it) 1997-05-23
DE69626846T2 (de) 2003-12-24
AU707570B2 (en) 1999-07-15
AU7568996A (en) 1997-06-11
EA199800470A1 (ru) 1998-12-24
BR9611465A (pt) 1999-05-18
CN1127513C (zh) 2003-11-12
CZ158898A3 (cs) 1998-11-11
NO982363L (no) 1998-07-22
EA000743B1 (ru) 2000-02-28
CZ291926B6 (cs) 2003-06-18
ITMI952430A0 (de) 1995-11-23
CA2249343A1 (en) 1997-05-29
KR19990071550A (ko) 1999-09-27
HUP0000080A2 (hu) 2001-04-28
ES2192619T3 (es) 2003-10-16
PT868428E (pt) 2003-06-30
EP0868428B1 (de) 2003-03-19
US6548480B1 (en) 2003-04-15
ZA969774B (en) 1997-06-17
HUP0000080A3 (en) 2001-05-28
IT1276161B1 (it) 1997-10-27
KR100458359B1 (ko) 2005-01-15
CN1202901A (zh) 1998-12-23
WO1997019102A1 (en) 1997-05-29
SI0868428T1 (en) 2003-06-30
ATE234856T1 (de) 2003-04-15
JP2000501079A (ja) 2000-02-02
IL124021A (en) 2001-06-14
DK0868428T3 (da) 2003-07-21

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee