ES2192619T3 - Derivados del acido fosfonico con actividad inhibidora para la metalopeptidasa. - Google Patents

Derivados del acido fosfonico con actividad inhibidora para la metalopeptidasa.

Info

Publication number
ES2192619T3
ES2192619T3 ES96938164T ES96938164T ES2192619T3 ES 2192619 T3 ES2192619 T3 ES 2192619T3 ES 96938164 T ES96938164 T ES 96938164T ES 96938164 T ES96938164 T ES 96938164T ES 2192619 T3 ES2192619 T3 ES 2192619T3
Authority
ES
Spain
Prior art keywords
heterocicle
arilo
group
inhibiting activity
metalopeptidase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96938164T
Other languages
English (en)
Inventor
Gabriele Norcini
Daniela Botta
Francesco Santangelo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zambon Group SpA
Zambon SpA
Original Assignee
Zambon Group SpA
Zambon SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zambon Group SpA, Zambon SpA filed Critical Zambon Group SpA
Application granted granted Critical
Publication of ES2192619T3 publication Critical patent/ES2192619T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Detergent Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cosmetics (AREA)

Abstract

SE DESCRIBEN COMPUESTOS DE FORMULA (I) DONDE R ES UN GRUPO ALQUILO, ARILO O ARILALQUILO DONDE EL ARILO ES FENILO, NAFTILO O UN HETEROCICLO; R 1 Y R 2 , IGUALES O DIFERENTES, SON ATOMOS DE HIDROGENO O GRUPOS ALQUILO; R 3 ES UN GRUPO ARILO O ARILALQUILO DONDE EL ARILO ES COMO ANTERIORMENTE; R SUB,4 ES UN HETEROCICLO OPCIONALMENTE SUSTITUIDO CON UN HETEROCICLO O FENILO, O ES UN GRUPO FENILO SUSTITUIDO CON UN HETEROCICLO (R 4 NO ES IMIDAZOL O INDOL); X ES UN ENLACE O UN GRU PO OCONH O - CONH -, PROCESOS PARA SU PREPARACION Y COMPOSICIONES FARMACEUTICAS DE LOS MISMOS. LOS COMPUESTOS DE FORMULA (I) ESTAN DOTADOS DE UNA DOBLE ACTIVIDAD INHIBIDORA DE ACE E INHIBIDORA DE NEP Y SON UTILES EN EL TRATAMIENTO DE ENFERMEDADES CARDIOVASCULARES.
ES96938164T 1995-11-23 1996-11-11 Derivados del acido fosfonico con actividad inhibidora para la metalopeptidasa. Expired - Lifetime ES2192619T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT95MI002430A IT1276161B1 (it) 1995-11-23 1995-11-23 Derivati dell'acido fosfonico ad attivita' inibitrice delle metallopeptidasi

Publications (1)

Publication Number Publication Date
ES2192619T3 true ES2192619T3 (es) 2003-10-16

Family

ID=11372578

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96938164T Expired - Lifetime ES2192619T3 (es) 1995-11-23 1996-11-11 Derivados del acido fosfonico con actividad inhibidora para la metalopeptidasa.

Country Status (23)

Country Link
US (1) US6548480B1 (es)
EP (1) EP0868428B1 (es)
JP (1) JP2000501079A (es)
KR (1) KR100458359B1 (es)
CN (1) CN1127513C (es)
AT (1) ATE234856T1 (es)
AU (1) AU707570B2 (es)
BR (1) BR9611465A (es)
CA (1) CA2249343A1 (es)
CZ (1) CZ291926B6 (es)
DE (1) DE69626846T2 (es)
DK (1) DK0868428T3 (es)
EA (1) EA000743B1 (es)
ES (1) ES2192619T3 (es)
HU (1) HUP0000080A3 (es)
IL (1) IL124021A (es)
IT (1) IT1276161B1 (es)
MX (1) MX9803760A (es)
NO (1) NO982363L (es)
PT (1) PT868428E (es)
SI (1) SI0868428T1 (es)
WO (1) WO1997019102A1 (es)
ZA (1) ZA969774B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3973748B2 (ja) 1998-01-14 2007-09-12 花王株式会社 発毛抑制剤
JP4796296B2 (ja) * 2004-12-02 2011-10-19 インターナショナル・ビジネス・マシーンズ・コーポレーション Ｗｅｂページ・オーサリング装置、Ｗｅｂページ・オーサリング方法及びプログラム
US20100084275A1 (en) * 2007-03-15 2010-04-08 Mikio Hanafusa Copper electrolytic solution and two-layer flexible substrate obtained using the same

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4432972A (en) * 1981-08-03 1984-02-21 E. R. Squibb & Sons, Inc. Phosphonamidate compounds
EP0071544B1 (en) * 1981-08-03 1986-10-08 E.R. Squibb & Sons, Inc. Phosphonamidate compounds
IT1274673B (it) * 1994-04-14 1997-07-24 Zambon Spa Derivati dell'acido fosfonico utili nel trattamento delle malattie car.iovascolari

Also Published As

Publication number Publication date
PT868428E (pt) 2003-06-30
HUP0000080A3 (en) 2001-05-28
IT1276161B1 (it) 1997-10-27
AU7568996A (en) 1997-06-11
ITMI952430A1 (it) 1997-05-23
WO1997019102A1 (en) 1997-05-29
CZ158898A3 (cs) 1998-11-11
EA000743B1 (ru) 2000-02-28
AU707570B2 (en) 1999-07-15
MX9803760A (es) 1998-09-30
JP2000501079A (ja) 2000-02-02
NO982363L (no) 1998-07-22
US6548480B1 (en) 2003-04-15
DE69626846D1 (de) 2003-04-24
DK0868428T3 (da) 2003-07-21
SI0868428T1 (en) 2003-06-30
CN1202901A (zh) 1998-12-23
DE69626846T2 (de) 2003-12-24
KR19990071550A (ko) 1999-09-27
KR100458359B1 (ko) 2005-01-15
BR9611465A (pt) 1999-05-18
HUP0000080A2 (hu) 2001-04-28
EP0868428A1 (en) 1998-10-07
ATE234856T1 (de) 2003-04-15
ZA969774B (en) 1997-06-17
EP0868428B1 (en) 2003-03-19
EA199800470A1 (ru) 1998-12-24
CA2249343A1 (en) 1997-05-29
CN1127513C (zh) 2003-11-12
ITMI952430A0 (es) 1995-11-23
CZ291926B6 (cs) 2003-06-18
NO982363D0 (no) 1998-05-25
IL124021A (en) 2001-06-14

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