WO1999005148A8 - Phosphonated agents and their antiangiogenic and antitumorigenic use - Google Patents

Phosphonated agents and their antiangiogenic and antitumorigenic use

Info

Publication number
WO1999005148A8
WO1999005148A8 PCT/US1998/015470 US9815470W WO9905148A8 WO 1999005148 A8 WO1999005148 A8 WO 1999005148A8 US 9815470 W US9815470 W US 9815470W WO 9905148 A8 WO9905148 A8 WO 9905148A8
Authority
WO
WIPO (PCT)
Prior art keywords
substituted
antitumorigenic
phosphonated
antiangiogenic
agents
Prior art date
Application number
PCT/US1998/015470
Other languages
French (fr)
Other versions
WO1999005148A1 (en
Inventor
Delwood C Collins
Antonio R Gagliardi
Peter Nickel
Original Assignee
Univ Kentucky Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Kentucky Res Found filed Critical Univ Kentucky Res Found
Priority to EP98937133A priority Critical patent/EP1019419A4/en
Priority to CA002297900A priority patent/CA2297900A1/en
Priority to AU85915/98A priority patent/AU739637B2/en
Publication of WO1999005148A1 publication Critical patent/WO1999005148A1/en
Publication of WO1999005148A8 publication Critical patent/WO1999005148A8/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3886—Acids containing the structure -C(=X)-P(=X)(XH)2 or NC-P(=X)(XH)2, (X = O, S, Se)
    • C07F9/3891—Acids containing the structure -C(=X)-P(=X)(XH)2, (X = O, S, Se)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3834—Aromatic acids (P-C aromatic linkage)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3882—Arylalkanephosphonic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Novel phosphonic acid agents are synthesized and characterized and their pharmaceutical compositions provided. Their method of use for the inhibition of angiogenesis and metalloproteinase and the treatment of tumors is also shown. Embodiments of the phosphonic acid agents include: (P-Yn1)m1-Q?1-K-(Q2-(Y¿n2-P)m2)j wherein P is a phosphonic group or a phosphonic salt, Y is -OCO-, -NR1CO- or CON(R?1)R2-; R1¿ is H, CH¿2?CO2H, or substituted or unsubstituted alkyl; R?2¿ is substituted alkyl, aryl or arylalkyl; Q?1 and Q2¿ are substituted or unsubstituted aryl groups; K is H, -NH-CO-NH-, -NH-CS-NH-, -NHCO-R3-CONH- or -NHCS-R3-CSNH-; provided when K is H, R3 is a substituted or unsubstituted aryl group; j is 0; j is 0,1,2; n1 and n2 are independently 0,1 or 2; and m1 and m2 are independently an integer from 1-4.
PCT/US1998/015470 1997-07-24 1998-07-24 Phosphonated agents and their antiangiogenic and antitumorigenic use WO1999005148A1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP98937133A EP1019419A4 (en) 1997-07-24 1998-07-24 Phosphonated agents and their antiangiogenic and antitumorigenic use
CA002297900A CA2297900A1 (en) 1997-07-24 1998-07-24 Phosphonic acid naphthylureas and their antiantiogenic and antitumorigenic use
AU85915/98A AU739637B2 (en) 1997-07-24 1998-07-24 Phosphonated agents and their antiangiogenic and antitumorigenic use

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US89999697A 1997-07-24 1997-07-24
US08/899,996 1997-07-24

Publications (2)

Publication Number Publication Date
WO1999005148A1 WO1999005148A1 (en) 1999-02-04
WO1999005148A8 true WO1999005148A8 (en) 1999-05-14

Family

ID=25411830

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/015470 WO1999005148A1 (en) 1997-07-24 1998-07-24 Phosphonated agents and their antiangiogenic and antitumorigenic use

Country Status (2)

Country Link
AU (1) AU739637B2 (en)
WO (1) WO1999005148A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL132315A0 (en) * 1999-10-11 2001-03-19 Yissum Res Dev Co Compositions comprising oxophosphonate-based metalloproteinase inhibitors
GB2367817A (en) * 2000-10-09 2002-04-17 Bayer Ag Cyclic carboxylic acids as integrin antagonists
DOP2002000333A (en) * 2001-02-14 2002-09-30 Warner Lambert Co DERIVATIVES OF ISOFTALIC ACID AS INHIBITORS OF METALOPROTEINASES OF THE MATRIX
CN113980048A (en) * 2021-09-16 2022-01-28 太仓市茜泾化工有限公司 Preparation method of dimethyl benzyl phosphate

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3920733A (en) * 1973-08-06 1975-11-18 Monsanto Co Ureidoalkylphosphonic acids
GB9403909D0 (en) * 1994-03-01 1994-04-20 Erba Carlo Spa Ureido derivatives of naphthalenephosphonic acids and process for their preparation
US6096730A (en) * 1997-07-24 2000-08-01 University Of Kentucky Research Foundation Phosphonated agents and their antiangiogenic and antitumorigenic use

Also Published As

Publication number Publication date
AU739637B2 (en) 2001-10-18
WO1999005148A1 (en) 1999-02-04
AU8591598A (en) 1999-02-16

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