HUE042011T2 - Arilmetoxi-izoindolin-származékok, azok készítményei és alkalmazási módszereik - Google Patents

Arilmetoxi-izoindolin-származékok, azok készítményei és alkalmazási módszereik

Info

Publication number
HUE042011T2
HUE042011T2 HUE17157178A HUE17157178A HUE042011T2 HU E042011 T2 HUE042011 T2 HU E042011T2 HU E17157178 A HUE17157178 A HU E17157178A HU E17157178 A HUE17157178 A HU E17157178A HU E042011 T2 HUE042011 T2 HU E042011T2
Authority
HU
Hungary
Prior art keywords
preparations
methods
application
isoindoline derivatives
arylmethoxy isoindoline
Prior art date
Application number
HUE17157178A
Other languages
English (en)
Hungarian (hu)
Inventor
Hon-Wah Man
George W Muller
Alexander L Ruchelman
Ehab M Khalil
Roger Chen
Weihong Zhang
Original Assignee
Celgene Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celgene Corp filed Critical Celgene Corp
Publication of HUE042011T2 publication Critical patent/HUE042011T2/hu

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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
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    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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    • C07D498/08—Bridged systems

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  • Chemical & Material Sciences (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
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  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
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  • Cardiology (AREA)
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  • Diabetes (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Anesthesiology (AREA)
  • AIDS & HIV (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
HUE17157178A 2010-02-11 2011-02-10 Arilmetoxi-izoindolin-származékok, azok készítményei és alkalmazási módszereik HUE042011T2 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US30361810P 2010-02-11 2010-02-11

Publications (1)

Publication Number Publication Date
HUE042011T2 true HUE042011T2 (hu) 2019-06-28

Family

ID=43708752

Family Applications (3)

Application Number Title Priority Date Filing Date
HUE17157178A HUE042011T2 (hu) 2010-02-11 2011-02-10 Arilmetoxi-izoindolin-származékok, azok készítményei és alkalmazási módszereik
HUE17157170 HUE044652T2 (hu) 2010-02-11 2011-02-10 Arilmetoxi-izoindolin-származékok, az ezeket tartalmazó kompozíciók, és eljárások alkalmazásukra
HUE11704156A HUE033009T2 (en) 2010-02-11 2011-02-10 Arylmethoxy isoindoline derivatives and compositions comprising and methods of using the same

Family Applications After (2)

Application Number Title Priority Date Filing Date
HUE17157170 HUE044652T2 (hu) 2010-02-11 2011-02-10 Arilmetoxi-izoindolin-származékok, az ezeket tartalmazó kompozíciók, és eljárások alkalmazásukra
HUE11704156A HUE033009T2 (en) 2010-02-11 2011-02-10 Arylmethoxy isoindoline derivatives and compositions comprising and methods of using the same

Country Status (33)

Country Link
US (8) US8518972B2 (OSRAM)
EP (6) EP2536706B1 (OSRAM)
JP (5) JP2013519675A (OSRAM)
KR (2) KR101931468B1 (OSRAM)
CN (2) CN102822165B (OSRAM)
AR (1) AR081058A1 (OSRAM)
AU (1) AU2011215877C1 (OSRAM)
CA (1) CA2787823C (OSRAM)
CO (1) CO6571916A2 (OSRAM)
CR (1) CR20120414A (OSRAM)
CY (3) CY1119177T1 (OSRAM)
DK (3) DK3202461T3 (OSRAM)
EC (1) ECSP12012098A (OSRAM)
ES (5) ES2638517T3 (OSRAM)
HR (3) HRP20171078T1 (OSRAM)
HU (3) HUE042011T2 (OSRAM)
IL (2) IL220992A (OSRAM)
LT (3) LT3202460T (OSRAM)
ME (2) ME03441B (OSRAM)
MX (3) MX367522B (OSRAM)
NI (1) NI201200132A (OSRAM)
NZ (3) NZ700054A (OSRAM)
PH (2) PH12012501607A1 (OSRAM)
PL (3) PL2536706T3 (OSRAM)
PT (3) PT3202460T (OSRAM)
RS (3) RS59275B1 (OSRAM)
RU (1) RU2567753C2 (OSRAM)
SG (3) SG10202012179RA (OSRAM)
SI (3) SI3202461T1 (OSRAM)
SM (3) SMT201700360T1 (OSRAM)
TR (1) TR201903027T4 (OSRAM)
UA (2) UA114856C2 (OSRAM)
WO (1) WO2011100380A1 (OSRAM)

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LT3202460T (lt) * 2010-02-11 2019-10-10 Celgene Corporation Arilmetoksi izoindolino dariniai ir kompozicijos, apimantys ir jų panaudojimo būdus
WO2012135299A1 (en) 2011-03-28 2012-10-04 Deuteria Pharmaceuticals Inc 2',6'-dioxo-3'-deutero-piperdin-3-yl-isoindoline compounds
CN103688176A (zh) 2011-04-29 2014-03-26 细胞基因公司 利用cereblon作为预报因子治疗癌和炎性疾病的方法
CA3136093C (en) 2012-06-29 2025-07-08 Celgene Corporation METHODS FOR DETERMINING THE EFFICACY OF A DRUG USING PROTEINS ASSOCIATED WITH CEREBLON
US20150038511A1 (en) 2012-08-09 2015-02-05 Celgene Corporation Treatment of immune-related and inflammatory diseases
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HRP20200836T1 (hr) * 2012-08-09 2020-08-07 Celgene Corporation Liječenje bolesti povezanih s imunitetom i upalnih bolesti
LT2882737T (lt) * 2012-08-09 2019-04-25 Celgene Corporation (s)-3-(4-((4-morfolinometil)benzil)oksi)-1-oksoizoindolin-2-il)piperidin-2,6-diono hidrochlorido kieta forma
HK1211577A1 (en) 2012-08-09 2016-05-27 细胞基因公司 Processes for the preparation of (s)-3-4- ((4-(morpholinomethyl) benzyl)oxy)-1-oxoisoindolin-2-yl) piperidine-2,6-dione and pharmaceutically acceptable forms thereof
US20140343058A1 (en) * 2012-08-09 2014-11-20 Celgene Corporation Treatment of systemic lupus erythematosus
US9587281B2 (en) 2012-08-14 2017-03-07 Celgene Corporation Cereblon isoforms and their use as biomarkers for therapeutic treatment
KR20150054962A (ko) 2012-09-10 2015-05-20 셀진 코포레이션 국소 진행성 유방암의 치료방법
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EP2943201B2 (en) 2013-01-14 2020-07-29 Deuterx, LLC 3-(5-substituted-4-oxoquinazolin-3(4h)-yl)-3-deutero-piperidine-2,6-dione derivatives
WO2014116573A1 (en) 2013-01-22 2014-07-31 Celgene Corporation Processes for the preparation of isotopologues of 3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione and pharmaceutically acceptable salts thereof
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