HUE033682T2 - Különbözõ daganatok elleni új immunterápia, beleértve a gasztrointesztinális és gyomorrákot - Google Patents
Különbözõ daganatok elleni új immunterápia, beleértve a gasztrointesztinális és gyomorrákot Download PDFInfo
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- HUE033682T2 HUE033682T2 HUE15154344A HUE15154344A HUE033682T2 HU E033682 T2 HUE033682 T2 HU E033682T2 HU E15154344 A HUE15154344 A HU E15154344A HU E15154344 A HUE15154344 A HU E15154344A HU E033682 T2 HUE033682 T2 HU E033682T2
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Claims (8)
- Szabadalmi igénypontok í. Egy pepiid, melynek aminosav szekvenciája a SEQ ID No. 23, 68, 69 és 70 által alkotott csoportból kerül : ki választ ásta,...........
- 2. Az í. Igénypont szerinti pepiid, amely képes az I, osztályú humán fö hísztokompatibiíitásí komplex (MkiC) egvik nutlektikyanäk megkötésére.
- 3. Az !. vagy 2. igénypont szerinti pepiid, azzal jellemezve, hogy a pepiid nem pepiid kötéseket tartalmaz.
- 4. Az. 1-3, igénypontok bármelyike szerinti pepiid, azzal jellemezve, hogy az említett pepiid egy fúziós protein, a BLA-OR antigén asszociált invariáns íátie {lij N*termíná!is amiuosavait tartalmazó fúziós protein részét képezi, ............
- 5. Az 1-4. igénypontok bármelyike szerinti pepiidet kódoló nukleinsav, feltéve, hogy az említett' pepiid nein egy teljes humán protein, azzal jellemezve, hogy az említett nukleinsav előnyőseit egy DNS, cDNS, PNS, RNS vagy ezek kombinációja vagy az említett nukleinsavat expresszáló expressziós vektor. 6. A/ I -4. igénypontok bármelyike szerinti pepiid, vagy m S. igénypont szerinti nukleinsav vágy expressziós vektor, a gyógyászatban történő alkalmazásra.
- 7. Az 5. igénypont szerinti nukteinsavat vagy expresszíós vektort làrtÂàÉI 'aü«lÿ éfôftyôàéft egy sntigénprezernáiú sejt. mint például egy dendritikus sejt. H. Az 1-4. igénypontok bármelyike szerinti pepiid előállítására szolgáló, a 7. igénypont szerinti gazdasejt tenyésztéséből, és az említett pepiidnek a gazdaseitbol vagy a tenyészközegbóltörténŐ izolálásából álló módszer,
- 9. Egy ín vitro módszer aktivált eitotoxíkus T-línrfocíták. (CTL j előállítására, melynek során a CTL-t in vit.ro egy alkalmas antigénprezentáló sejt felületén expresszáít humán !. osztályú, antigénnel feltöltött MHC molekulákkal hoznak érintkezésbe annyi ideig, amennyi elegendő az említett CTL antigén-specifikus aktivációjához, azzal jellemezve, hogy az említett antigén az I. vagy 2. igénypont szerinti pepiid, 10. A 9. igénypont szerinti módszer, azzal jellemezve, hogy az említett atitlgénprezemáló sejt az í. vagy 2. igénypont szerinti pepiidet expresszáló expressziós vektort tartalmazza, 11. A 9. vagy 1«. igénypont szerinti módszerrel előállított aktivált eitotoxíkus· T-límíbeiia '(CTL), amely szelektíven felismer egy sejtet, amely aberránsan expresszálja az i. vagy 2. igénypontban megadott aminosav szekvenciát tartalmazó polipeptidet. í 2 AH. igénypont szerinti módszerre] előállított aktivált citotoxikus T-iímföcita (C TL), amely a betegben lévő ráksejtek kezdésére alkalmazható, azzal jellemezve, hogy az emiíteit ráksejtek az. 1. vagy 2, igénypontban megadott aminosav szekvenciát tartalmazó pepiidet prezentálják, 13; Az 1-2. igénypont szerinti pepiid, az 5. igénypont szerinti nukleinsav vagy expressziós vektor, a 7. igénypont szerinti sejt vágj' a 12. igénypont szerinti aktivált eítotoxikus T-limfcicita, amely rákbetegség, mint pékiául tgyemorrák, gyomor-bélrendszeri rák, vastag- és végbéirák, hasnyálmirigyrák, tüdőrák vagy veserák kezelésére alkalmazható, 14, A 13, igénypont szerinti alkalmazásra szolgáló pepiid, nukleinsav vagy expressziós vektor, sejt vagy aktivált citotoxikus T-iimfbcita, azzal jellemezve, hogy az említett peptídek védőoltásként történő felhasználásra szolgálnak,
- 15, Az i. vagy 2. igénypont szerinti pepiid nem terápiás célú alkalmazása az említett pepiidet tartalmazó MHG'peptid komplex elleni specifikus antitestek dőáliításara és termeléséré; lő. Egy antitest, például egy mphokldnális antitest, amely specifikusan kötődik az 1. vagy 2. igénypont szerinti pepiidet tartalmazó Mf iC'peptid komplexhez.
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GBGB1004551.6A GB201004551D0 (en) | 2010-03-19 | 2010-03-19 | NOvel immunotherapy against several tumors including gastrointestinal and gastric cancer |
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HUE18156634A HUE051478T2 (hu) | 2010-03-19 | 2011-03-15 | Új immunterápia többféle tumor, köztük a gasztrointesztinális tumorok és a gyomorrák ellen |
HUE17203096A HUE050376T2 (hu) | 2010-03-19 | 2011-03-15 | Új immunterápia többféle tumor, köztük a gasztrointesztinális tumorok és a gyomorrák ellen |
HUE14184348A HUE032402T2 (hu) | 2010-03-19 | 2011-03-15 | Újszerû immunterápia többféle daganat ellen, beleértve a gyomorbélrendszeri és gyomorrákot |
HUE15154344A HUE033682T2 (hu) | 2010-03-19 | 2011-03-15 | Különbözõ daganatok elleni új immunterápia, beleértve a gasztrointesztinális és gyomorrákot |
HUE17157398A HUE045757T2 (hu) | 2010-03-19 | 2011-03-15 | Új immunterápia különféle tumorok, köztük az emésztõrendszer rákja és gyomorrák ellen |
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HUE18156634A HUE051478T2 (hu) | 2010-03-19 | 2011-03-15 | Új immunterápia többféle tumor, köztük a gasztrointesztinális tumorok és a gyomorrák ellen |
HUE17203096A HUE050376T2 (hu) | 2010-03-19 | 2011-03-15 | Új immunterápia többféle tumor, köztük a gasztrointesztinális tumorok és a gyomorrák ellen |
HUE14184348A HUE032402T2 (hu) | 2010-03-19 | 2011-03-15 | Újszerû immunterápia többféle daganat ellen, beleértve a gyomorbélrendszeri és gyomorrákot |
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