HUE026646T2 - Elõnyös PKA-értékû lipideket tartalmazó liposzómák RNS bejuttatására - Google Patents

Elõnyös PKA-értékû lipideket tartalmazó liposzómák RNS bejuttatására Download PDF

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HUE026646T2
HUE026646T2 HUE11736500A HUE11736500A HUE026646T2 HU E026646 T2 HUE026646 T2 HU E026646T2 HU E11736500 A HUE11736500 A HU E11736500A HU E11736500 A HUE11736500 A HU E11736500A HU E026646 T2 HUE026646 T2 HU E026646T2
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rna
virus
liposomes
liposome
pka
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Andrew Geall
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Glaxosmithkline Biologicals Sa
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Claims (4)

  1. ELŐNYÖS FKÀ-ÉRTÊKÛ t IFI DEKLI ÏARTM.MAZÔ IJFOSZOMÁK RNS BEJUTTATÁSÁRA SzábM&ltás X. I iposMim RNS gertftosss^áisK Jiiteíásáís m mm, aha! a Fpeszbma tartalma® üpiJ kRtesrtltagsL amely vizes niagrészt fog körbe, ahol (i) s bpki fegRbssSgg; taDalmsz a leírásban a MpKa mérése” című részben ielnakxäak megfelelően mérve 5,0-6,8 pKla-értékii lipidet, és (ül a vizes, rnagrész taríatoaa iramruK^éKt kódoló RNS-t. 2 Az: 1. igénypont szerimi Itimszsoms, Jbal m 5,0-4,8 pR&tertékü lipid tartalmaz; tercier amint.
  2. 3. Az előző igénypontok bármelyike szeműi liposzoma, ahol m 5,106 J pKa-érté-i: 5,6-6.8. *L Az előző igerrypontnk bâmehùke seerirdl lipssszótaa, aböí ^ pKa~ertésc 5, í-S,v. 5* Az i, igesjfpöt: szsriM llpes#«®, «bel az 5.0-6,¾ pKa-4rtéiíö lipid képlete .a® ai&shi képietek báríBelyike-
    RVOt RVOä; RV04:
    R¥ö5: RV'07:
    RVQ8: R NW-, h:Vü;
    R VI6:
    vagy RW".
    b. Az előző igésypootok óámeiyfc szesmó %osæôœ8» atöslvaek: áteMje 20-220 mi.
    1. Az előzd igOm:pí>stők Odfraelyike izesmti liposzóasa, ahol az RNS-molekula «) az RNS-omíekoláfői RNSk áíími képes :RN:S*depersde5S-s RKS-pöRmsráa és {«) egy lammsogést kódol.
  3. 8, À é, sgésypóas msrmtí fipöszóma* afcaf az RNS-molekula isrtólmaz kél nyitó» leol vasási keMet. moelyek k&amp;íól m «ISO slfe'ims-feplsksat kódol és a .második az immusogéai kódolj a. % Az előző igénypontok bármelyike szerinti iíposzóma, ahol an íiNS-raolekuk #080-12000 mskeload iuíssaúságiL ÍÖ. Az előző igénypontok bármelyiks szerinti Hpesz-ósna, alsói m. immunogén in vivő immunválaszt vált ki baktérium., vírus, gomba vagy parazita. ellen. M. Az előző igénypontok Amelyike szerinti lipészőmá, ahol an mmmmgém in vivő hnmsmválasxt váh ki a köveiket elles;, faj resplealorikns szmcicláfs virus F glíkopröieinje. φ} halakat iöegbríősó vims, péidápi fctâzô lazac anionja virus (BAV), lazac hasayápaarigy-feetőgség virus (SPDV), fertőző hasnyálmirigy-elhalás vírus (IPNV). peityesharcsa-vints (€€V). halak Lymphoeystxs-lxîtegségét okozó vims (FLDV), fertőző vérképzőszsrvi elhalást okozó virus (SlhiVy kot hetpeszviros, lazac pkooanszerö vírusa (más néven atlanti lazac pkörttaszsru viruss}, nem vándorló lazacot fertőző víros {Jfendjfoefcoá sahaon vírus", LS¥i, tat* rotavirus (ASR), pisztráng ,,stre.v45«rry betegség" vírusa (TSD), coho lazac pxmothysiehns kísuiehj ncaiomrosa (€ST¥) és vírusos vérzéses vénnérgezést okozó vims (VHSY), (c) ottomkovirus. például indoeoza A, B és C Vírus vagy <d) herpesvirus, például: ïlerpes simplex vírusok ipSV), varicella-zoster varos (VZV), Epsteio-Barr Virus <08V), eitomegafe virus tCMV), humán herpeszvirús 6 plíVS^ humán herpeszvirmt 7 és humán herpeszvlms 8 (HHV8-. I I Gyógyászati készítmény, amely az előző igénypontok ínirmelyike szerinti Itpöszomát íartaintag,
  4. 13. Az ! ·!!. igénypont szerinti hposxőms vagy a ..1.¾ igénypont stzeríbíi gyógyászati készíónény gerincesben védő Imo-tmtváiasx. Mnzásáza szolgáló e ff áráshtm történő afabsazásra, amely elf ázás tartalmazza a következő lépést: a Hposzőma vagy a gyógyászait készítmény hatásos meortylségéaek beadása a gerincesnek.
HUE11736500A 2010-07-06 2011-07-06 Elõnyös PKA-értékû lipideket tartalmazó liposzómák RNS bejuttatására HUE026646T2 (hu)

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US (15) US20130171241A1 (hu)
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JP (5) JP2013537518A (hu)
CN (1) CN103153284B (hu)
AU (1) AU2011276234B2 (hu)
BR (1) BR112013000244A2 (hu)
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