HUE026646T2 - Preferred liposomes containing lipids of PKA value for delivery of RNA - Google Patents

Info

Publication number

HUE026646T2

HUE026646T2 HUE11736500A HUE11736500A HUE026646T2 HU E026646 T2 HUE026646 T2 HU E026646T2 HU E11736500 A HUE11736500 A HU E11736500A HU E11736500 A HUE11736500 A HU E11736500A HU E026646 T2 HUE026646 T2 HU E026646T2

Authority

HU

Hungary

Prior art keywords

rna

virus

liposomes

liposome

pka

Prior art date

2010-07-06

Links

• Espacenet
• Global Dossier
• Discuss

• 239000002502 liposome Substances 0.000 title claims description 194
• 150000002632 lipids Chemical class 0.000 title claims description 96
• 108091032973 (ribonucleotides)n+m Proteins 0.000 claims description 218
• 241000700605 Viruses Species 0.000 claims description 78
• 230000002163 immunogen Effects 0.000 claims description 57
• 230000003612 virological effect Effects 0.000 claims description 28
• 238000001727 in vivo Methods 0.000 claims description 25
• 230000028993 immune response Effects 0.000 claims description 21
• 239000008194 pharmaceutical composition Substances 0.000 claims description 20
• 241000972773 Aulopiformes Species 0.000 claims description 14
• 235000019515 salmon Nutrition 0.000 claims description 14
• 102000040650 (ribonucleotides)n+m Human genes 0.000 claims description 13
• 241000282414 Homo sapiens Species 0.000 claims description 13
• 241000251539 Vertebrata <Metazoa> Species 0.000 claims description 13
• 150000003512 tertiary amines Chemical class 0.000 claims description 12
• 208000015181 infectious disease Diseases 0.000 claims description 9
• 241001529453 unidentified herpesvirus Species 0.000 claims description 9
• 244000045947 parasite Species 0.000 claims description 8
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 8
• 241000283690 Bos taurus Species 0.000 claims description 7
• 241000710921 Infectious pancreatic necrosis virus Species 0.000 claims description 7
• 241000700584 Simplexvirus Species 0.000 claims description 7
• 201000010099 disease Diseases 0.000 claims description 7
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 7
• 241000894006 Bacteria Species 0.000 claims description 6
• 108090000288 Glycoproteins Proteins 0.000 claims description 6
• 241000701041 Human betaherpesvirus 7 Species 0.000 claims description 6
• XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 claims description 6
• 241001505329 Lymphocystis disease virus 1 Species 0.000 claims description 6
• 241000702670 Rotavirus Species 0.000 claims description 6
• 230000002458 infectious effect Effects 0.000 claims description 6
• 102000003886 Glycoproteins Human genes 0.000 claims description 5
• 241000233866 Fungi Species 0.000 claims description 4
• 241000277338 Oncorhynchus kisutch Species 0.000 claims description 4
• 235000019688 fish Nutrition 0.000 claims description 4
• 241000894007 species Species 0.000 claims description 4
• 241000251468 Actinopterygii Species 0.000 claims description 3
• 241000277331 Salmonidae Species 0.000 claims description 2
• 150000001450 anions Chemical class 0.000 claims description 2
• 239000002243 precursor Substances 0.000 claims description 2
• 239000003814 drug Substances 0.000 claims 2
• ABQGFYSYSCHJNB-UHFFFAOYSA-N (2,5-dioxopyrrolidin-1-yl) 5-(pyridin-2-yldisulfanyl)pentanoate Chemical compound O=C1CCC(=O)N1OC(=O)CCCCSSC1=CC=CC=N1 ABQGFYSYSCHJNB-UHFFFAOYSA-N 0.000 claims 1
• 241001597810 Cocksfoot mild mosaic virus Species 0.000 claims 1
• 208000007514 Herpes zoster Diseases 0.000 claims 1
• 229920000715 Mucilage Polymers 0.000 claims 1
• 241000277263 Salmo Species 0.000 claims 1
• 241001660014 Salmon pancreas disease virus Species 0.000 claims 1
• 230000003187 abdominal effect Effects 0.000 claims 1
• 239000000853 adhesive Substances 0.000 claims 1
• 201000007201 aphasia Diseases 0.000 claims 1
• 150000005840 aryl radicals Chemical class 0.000 claims 1
• 230000034994 death Effects 0.000 claims 1
• 230000002500 effect on skin Effects 0.000 claims 1
• 238000011156 evaluation Methods 0.000 claims 1
• 230000003394 haemopoietic effect Effects 0.000 claims 1
• 230000002008 hemorrhagic effect Effects 0.000 claims 1
• 210000002751 lymph Anatomy 0.000 claims 1
• 230000000873 masking effect Effects 0.000 claims 1
• 208000037997 venous disease Diseases 0.000 claims 1
• 239000000203 mixture Substances 0.000 description 50
• -1 DOTAP or DC-Chol Chemical class 0.000 description 39
• HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 38
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 36
• 238000000034 method Methods 0.000 description 32
• 108090000765 processed proteins & peptides Proteins 0.000 description 30
• 102000004196 processed proteins & peptides Human genes 0.000 description 27
• 108090000623 proteins and genes Proteins 0.000 description 25
• 241000725643 Respiratory syncytial virus Species 0.000 description 23
• 229920001184 polypeptide Polymers 0.000 description 23
• 238000005538 encapsulation Methods 0.000 description 20
• 235000012000 cholesterol Nutrition 0.000 description 19
• NRJAVPSFFCBXDT-HUESYALOSA-N 1,2-distearoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCCCC NRJAVPSFFCBXDT-HUESYALOSA-N 0.000 description 18
• 241000710929 Alphavirus Species 0.000 description 17
• NFQBIAXADRDUGK-KWXKLSQISA-N n,n-dimethyl-2,3-bis[(9z,12z)-octadeca-9,12-dienoxy]propan-1-amine Chemical compound CCCCC\C=C/C\C=C/CCCCCCCCOCC(CN(C)C)OCCCCCCCC\C=C/C\C=C/CCCCC NFQBIAXADRDUGK-KWXKLSQISA-N 0.000 description 17
• 239000000427 antigen Substances 0.000 description 16
• 108091007433 antigens Proteins 0.000 description 16
• 102000036639 antigens Human genes 0.000 description 16
• 210000004027 cell Anatomy 0.000 description 16
• 108020004414 DNA Proteins 0.000 description 15
• 102000004169 proteins and genes Human genes 0.000 description 15
• 239000000243 solution Substances 0.000 description 15
• KSXTUUUQYQYKCR-LQDDAWAPSA-M 2,3-bis[[(z)-octadec-9-enoyl]oxy]propyl-trimethylazanium;chloride Chemical compound [Cl-].CCCCCCCC\C=C/CCCCCCCC(=O)OCC(C[N+](C)(C)C)OC(=O)CCCCCCC\C=C/CCCCCCCC KSXTUUUQYQYKCR-LQDDAWAPSA-M 0.000 description 14
• 241000699670 Mus sp. Species 0.000 description 14
• 239000000872 buffer Substances 0.000 description 14
• 229960005486 vaccine Drugs 0.000 description 14
• 102000006382 Ribonucleases Human genes 0.000 description 13
• 108010083644 Ribonucleases Proteins 0.000 description 13
• 125000002091 cationic group Chemical group 0.000 description 13
• 230000001965 increasing effect Effects 0.000 description 13
• 241000701022 Cytomegalovirus Species 0.000 description 12
• 239000004812 Fluorinated ethylene propylene Substances 0.000 description 12
• 229920009441 perflouroethylene propylene Polymers 0.000 description 12
• 241001465754 Metazoa Species 0.000 description 11
• 239000007979 citrate buffer Substances 0.000 description 11
• 235000018102 proteins Nutrition 0.000 description 11
• 108010068327 4-hydroxyphenylpyruvate dioxygenase Proteins 0.000 description 10
• 108090000695 Cytokines Proteins 0.000 description 10
• 102000004127 Cytokines Human genes 0.000 description 10
• 239000013566 allergen Substances 0.000 description 10
• 210000002865 immune cell Anatomy 0.000 description 10
• 239000012528 membrane Substances 0.000 description 10
• 125000003729 nucleotide group Chemical group 0.000 description 10
• 229920001223 polyethylene glycol Polymers 0.000 description 10
• 230000004044 response Effects 0.000 description 10
• 206010009944 Colon cancer Diseases 0.000 description 9
• 206010028980 Neoplasm Diseases 0.000 description 9
• HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 9
• 108010026228 mRNA guanylyltransferase Proteins 0.000 description 9
• 238000002156 mixing Methods 0.000 description 9
• 239000002773 nucleotide Substances 0.000 description 9
• 239000002953 phosphate buffered saline Substances 0.000 description 9
• ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 8
• 229960004784 allergens Drugs 0.000 description 8
• 230000000694 effects Effects 0.000 description 8
• 238000002474 experimental method Methods 0.000 description 8
• 201000001441 melanoma Diseases 0.000 description 8
• 239000002245 particle Substances 0.000 description 8
• 102000005962 receptors Human genes 0.000 description 8
• 108020003175 receptors Proteins 0.000 description 8
• 238000003756 stirring Methods 0.000 description 8
• 239000011550 stock solution Substances 0.000 description 8
• 102100037435 Antiviral innate immune response receptor RIG-I Human genes 0.000 description 7
• 108010084884 GDP-mannose transporter Proteins 0.000 description 7
• 241000701044 Human gammaherpesvirus 4 Species 0.000 description 7
• 241000710959 Venezuelan equine encephalitis virus Species 0.000 description 7
• 150000001412 amines Chemical class 0.000 description 7
• 238000004458 analytical method Methods 0.000 description 7
• 230000015572 biosynthetic process Effects 0.000 description 7
• 239000011521 glass Substances 0.000 description 7
• 238000002649 immunization Methods 0.000 description 7
• 230000005847 immunogenicity Effects 0.000 description 7
• 238000000338 in vitro Methods 0.000 description 7
• 239000013612 plasmid Substances 0.000 description 7
• 210000002966 serum Anatomy 0.000 description 7
• HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 6
• 241000588724 Escherichia coli Species 0.000 description 6
• 101000669402 Homo sapiens Toll-like receptor 7 Proteins 0.000 description 6
• 241000701085 Human alphaherpesvirus 3 Species 0.000 description 6
• 108060004795 Methyltransferase Proteins 0.000 description 6
• 241000699666 Mus <mouse, genus> Species 0.000 description 6
• 102100030090 Probable ATP-dependent RNA helicase DHX58 Human genes 0.000 description 6
• 241000277299 Salmoniformes Species 0.000 description 6
• 210000001744 T-lymphocyte Anatomy 0.000 description 6
• 102100039390 Toll-like receptor 7 Human genes 0.000 description 6
• 230000000240 adjuvant effect Effects 0.000 description 6
• 239000000556 agonist Substances 0.000 description 6
• 238000009472 formulation Methods 0.000 description 6
• 238000007918 intramuscular administration Methods 0.000 description 6
• 238000005259 measurement Methods 0.000 description 6
• 210000002845 virion Anatomy 0.000 description 6
• 241000222120 Candida <Saccharomycetales> Species 0.000 description 5
• 208000001333 Colorectal Neoplasms Diseases 0.000 description 5
• 241000709661 Enterovirus Species 0.000 description 5
• 241001502974 Human gammaherpesvirus 8 Species 0.000 description 5
• 241000701027 Human herpesvirus 6 Species 0.000 description 5
• 241000700723 Ictalurid herpesvirus 1 Species 0.000 description 5
• 241000546112 Infectious salmon anemia virus Species 0.000 description 5
• 102100027353 Interferon-induced helicase C domain-containing protein 1 Human genes 0.000 description 5
• 239000000232 Lipid Bilayer Substances 0.000 description 5
• 108700026244 Open Reading Frames Proteins 0.000 description 5
• 229910019142 PO4 Inorganic materials 0.000 description 5
• 241000710960 Sindbis virus Species 0.000 description 5
• 108091027544 Subgenomic mRNA Proteins 0.000 description 5
• 238000009295 crossflow filtration Methods 0.000 description 5
• 239000000975 dye Substances 0.000 description 5
• 238000001914 filtration Methods 0.000 description 5
• 230000004927 fusion Effects 0.000 description 5
• 239000012510 hollow fiber Substances 0.000 description 5
• 238000002347 injection Methods 0.000 description 5
• 239000007924 injection Substances 0.000 description 5
• 210000005007 innate immune system Anatomy 0.000 description 5
• 208000020816 lung neoplasm Diseases 0.000 description 5
• 230000003472 neutralizing effect Effects 0.000 description 5
• NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 5
• 239000010452 phosphate Substances 0.000 description 5
• 230000009467 reduction Effects 0.000 description 5
• 239000000523 sample Substances 0.000 description 5
• 238000013518 transcription Methods 0.000 description 5
• 230000035897 transcription Effects 0.000 description 5
• 101710127675 Antiviral innate immune response receptor RIG-I Proteins 0.000 description 4
• 238000011725 BALB/c mouse Methods 0.000 description 4
• 208000026310 Breast neoplasm Diseases 0.000 description 4
• 108090000626 DNA-directed RNA polymerases Proteins 0.000 description 4
• 102000004163 DNA-directed RNA polymerases Human genes 0.000 description 4
• 101000864662 Homo sapiens Probable ATP-dependent RNA helicase DHX58 Proteins 0.000 description 4
• 101000831496 Homo sapiens Toll-like receptor 3 Proteins 0.000 description 4
• 101000800483 Homo sapiens Toll-like receptor 8 Proteins 0.000 description 4
• 241000711804 Infectious hematopoietic necrosis virus Species 0.000 description 4
• 102100034170 Interferon-induced, double-stranded RNA-activated protein kinase Human genes 0.000 description 4
• 206010058467 Lung neoplasm malignant Diseases 0.000 description 4
• 241000277289 Salmo salar Species 0.000 description 4
• FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
• 101710172711 Structural protein Proteins 0.000 description 4
• 102100024324 Toll-like receptor 3 Human genes 0.000 description 4
• 102100033110 Toll-like receptor 8 Human genes 0.000 description 4
• 241000223238 Trichophyton Species 0.000 description 4
• 241000711825 Viral hemorrhagic septicemia virus Species 0.000 description 4
• 239000007864 aqueous solution Substances 0.000 description 4
• 210000000481 breast Anatomy 0.000 description 4
• 238000004520 electroporation Methods 0.000 description 4
• 239000000499 gel Substances 0.000 description 4
• 239000005090 green fluorescent protein Substances 0.000 description 4
• UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical class O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 description 4
• 210000004072 lung Anatomy 0.000 description 4
• 201000005202 lung cancer Diseases 0.000 description 4
• 238000004519 manufacturing process Methods 0.000 description 4
• 238000006386 neutralization reaction Methods 0.000 description 4
• 102000039446 nucleic acids Human genes 0.000 description 4
• 108020004707 nucleic acids Proteins 0.000 description 4
• 150000007523 nucleic acids Chemical class 0.000 description 4
• 238000003752 polymerase chain reaction Methods 0.000 description 4
• 239000000047 product Substances 0.000 description 4
• 230000010076 replication Effects 0.000 description 4
• 230000003362 replicative effect Effects 0.000 description 4
• 238000011282 treatment Methods 0.000 description 4
• 239000013598 vector Substances 0.000 description 4
• 239000012224 working solution Substances 0.000 description 4
• OGHAROSJZRTIOK-KQYNXXCUSA-O 7-methylguanosine Chemical compound C1=2N=C(N)NC(=O)C=2[N+](C)=CN1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OGHAROSJZRTIOK-KQYNXXCUSA-O 0.000 description 3
• 241000228212 Aspergillus Species 0.000 description 3
• 206010006187 Breast cancer Diseases 0.000 description 3
• 102000021350 Caspase recruitment domains Human genes 0.000 description 3
• 108091011189 Caspase recruitment domains Proteins 0.000 description 3
• 241001051708 Cyprinid herpesvirus 3 Species 0.000 description 3
• 102000004190 Enzymes Human genes 0.000 description 3
• 108090000790 Enzymes Proteins 0.000 description 3
• WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 3
• 108010043121 Green Fluorescent Proteins Proteins 0.000 description 3
• 102000004144 Green Fluorescent Proteins Human genes 0.000 description 3
• 101000952099 Homo sapiens Antiviral innate immune response receptor RIG-I Proteins 0.000 description 3
• 101000619564 Homo sapiens Putative testis-specific prion protein Proteins 0.000 description 3
• 241000257303 Hymenoptera Species 0.000 description 3
• 101710089751 Interferon-induced, double-stranded RNA-activated protein kinase Proteins 0.000 description 3
• 241000124008 Mammalia Species 0.000 description 3
• OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
• 241001480037 Microsporum Species 0.000 description 3
• 102100022208 Putative testis-specific prion protein Human genes 0.000 description 3
• 241000144282 Sigmodon Species 0.000 description 3
• 208000001203 Smallpox Diseases 0.000 description 3
• 208000004006 Tick-borne encephalitis Diseases 0.000 description 3
• 108010060825 Toll-Like Receptor 7 Proteins 0.000 description 3
• HIHOWBSBBDRPDW-PTHRTHQKSA-N [(3s,8s,9s,10r,13r,14s,17r)-10,13-dimethyl-17-[(2r)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1h-cyclopenta[a]phenanthren-3-yl] n-[2-(dimethylamino)ethyl]carbamate Chemical compound C1C=C2C[C@@H](OC(=O)NCCN(C)C)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HIHOWBSBBDRPDW-PTHRTHQKSA-N 0.000 description 3
• 125000000129 anionic group Chemical group 0.000 description 3
• 230000001580 bacterial effect Effects 0.000 description 3
• MVCRZALXJBDOKF-JPZHCBQBSA-N beta-hydroxywybutosine 5'-monophosphate Chemical compound C1=NC=2C(=O)N3C(CC(O)[C@H](NC(=O)OC)C(=O)OC)=C(C)N=C3N(C)C=2N1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O MVCRZALXJBDOKF-JPZHCBQBSA-N 0.000 description 3
• 230000002146 bilateral effect Effects 0.000 description 3
• 239000002738 chelating agent Substances 0.000 description 3
• 230000001419 dependent effect Effects 0.000 description 3
• 238000000605 extraction Methods 0.000 description 3
• 230000002538 fungal effect Effects 0.000 description 3
• 230000036541 health Effects 0.000 description 3
• 238000011065 in-situ storage Methods 0.000 description 3
• 239000002479 lipoplex Substances 0.000 description 3
• GLGLUQVVDHRLQK-WRBBJXAJSA-N n,n-dimethyl-2,3-bis[(z)-octadec-9-enoxy]propan-1-amine Chemical compound CCCCCCCC\C=C/CCCCCCCCOCC(CN(C)C)OCCCCCCCC\C=C/CCCCCCCC GLGLUQVVDHRLQK-WRBBJXAJSA-N 0.000 description 3
• 230000007935 neutral effect Effects 0.000 description 3
• 230000008569 process Effects 0.000 description 3
• 230000000770 proinflammatory effect Effects 0.000 description 3
• 230000000069 prophylactic effect Effects 0.000 description 3
• 210000000952 spleen Anatomy 0.000 description 3
• 239000007921 spray Substances 0.000 description 3
• 238000003786 synthesis reaction Methods 0.000 description 3
• 238000013519 translation Methods 0.000 description 3
• 238000002255 vaccination Methods 0.000 description 3
• 239000002435 venom Substances 0.000 description 3
• 231100000611 venom Toxicity 0.000 description 3
• 210000001048 venom Anatomy 0.000 description 3
• SSCDRSKJTAQNNB-DWEQTYCFSA-N 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(=O)OC[C@H](COP(O)(=O)OCCN)OC(=O)CCCCCCC\C=C/C\C=C/CCCCC SSCDRSKJTAQNNB-DWEQTYCFSA-N 0.000 description 2
• HXVKEKIORVUWDR-FDDDBJFASA-N 1-[(2r,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-(methylaminomethyl)-2-sulfanylidenepyrimidin-4-one Chemical compound S=C1NC(=O)C(CNC)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 HXVKEKIORVUWDR-FDDDBJFASA-N 0.000 description 2
• LDGWQMRUWMSZIU-LQDDAWAPSA-M 2,3-bis[(z)-octadec-9-enoxy]propyl-trimethylazanium;chloride Chemical compound [Cl-].CCCCCCCC\C=C/CCCCCCCCOCC(C[N+](C)(C)C)OCCCCCCCC\C=C/CCCCCCCC LDGWQMRUWMSZIU-LQDDAWAPSA-M 0.000 description 2
• VZQXUWKZDSEQRR-SDBHATRESA-N 2-methylthio-N(6)-(Delta(2)-isopentenyl)adenosine Chemical compound C12=NC(SC)=NC(NCC=C(C)C)=C2N=CN1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O VZQXUWKZDSEQRR-SDBHATRESA-N 0.000 description 2
• GJTBSTBJLVYKAU-XVFCMESISA-N 2-thiouridine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C(=S)NC(=O)C=C1 GJTBSTBJLVYKAU-XVFCMESISA-N 0.000 description 2
• 108020005345 3' Untranslated Regions Proteins 0.000 description 2
• OVONXEQGWXGFJD-UHFFFAOYSA-N 4-sulfanylidene-1h-pyrimidin-2-one Chemical compound SC=1C=CNC(=O)N=1 OVONXEQGWXGFJD-UHFFFAOYSA-N 0.000 description 2
• OIVLITBTBDPEFK-UHFFFAOYSA-N 5,6-dihydrouracil Chemical compound O=C1CCNC(=O)N1 OIVLITBTBDPEFK-UHFFFAOYSA-N 0.000 description 2
• 102100030310 5,6-dihydroxyindole-2-carboxylic acid oxidase Human genes 0.000 description 2
• VSCNRXVDHRNJOA-PNHWDRBUSA-N 5-(carboxymethylaminomethyl)uridine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(CNCC(O)=O)=C1 VSCNRXVDHRNJOA-PNHWDRBUSA-N 0.000 description 2
• VKLFQTYNHLDMDP-PNHWDRBUSA-N 5-carboxymethylaminomethyl-2-thiouridine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C(=S)NC(=O)C(CNCC(O)=O)=C1 VKLFQTYNHLDMDP-PNHWDRBUSA-N 0.000 description 2
• QXDXBKZJFLRLCM-UAKXSSHOSA-N 5-hydroxyuridine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(O)=C1 QXDXBKZJFLRLCM-UAKXSSHOSA-N 0.000 description 2
• HLZXTFWTDIBXDF-PNHWDRBUSA-N 5-methoxycarbonylmethyl-2-thiouridine Chemical compound S=C1NC(=O)C(CC(=O)OC)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 HLZXTFWTDIBXDF-PNHWDRBUSA-N 0.000 description 2
• YIZYCHKPHCPKHZ-PNHWDRBUSA-N 5-methoxycarbonylmethyluridine Chemical compound O=C1NC(=O)C(CC(=O)OC)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 YIZYCHKPHCPKHZ-PNHWDRBUSA-N 0.000 description 2
• SNNBPMAXGYBMHM-JXOAFFINSA-N 5-methyl-2-thiouridine Chemical compound S=C1NC(=O)C(C)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 SNNBPMAXGYBMHM-JXOAFFINSA-N 0.000 description 2
• LRSASMSXMSNRBT-UHFFFAOYSA-N 5-methylcytosine Chemical compound CC1=CNC(=O)N=C1N LRSASMSXMSNRBT-UHFFFAOYSA-N 0.000 description 2
• PNWOYKVCNDZOLS-UHFFFAOYSA-N 6-amino-5-chloro-1h-pyrimidin-2-one Chemical compound NC=1NC(=O)N=CC=1Cl PNWOYKVCNDZOLS-UHFFFAOYSA-N 0.000 description 2
• RGKBRPAAQSHTED-UHFFFAOYSA-N 8-oxoadenine Chemical compound NC1=NC=NC2=C1NC(=O)N2 RGKBRPAAQSHTED-UHFFFAOYSA-N 0.000 description 2
• IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
• 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 description 2
• 102100026189 Beta-galactosidase Human genes 0.000 description 2
• 241001674044 Blattodea Species 0.000 description 2
• 241000589567 Brucella abortus Species 0.000 description 2
• 241000222122 Candida albicans Species 0.000 description 2
• 241000726768 Carpinus Species 0.000 description 2
• 102000053642 Catalytic RNA Human genes 0.000 description 2
• 108090000994 Catalytic RNA Proteins 0.000 description 2
• 241000255930 Chironomidae Species 0.000 description 2
• 208000010833 Chronic myeloid leukaemia Diseases 0.000 description 2
• 208000001726 Classical Swine Fever Diseases 0.000 description 2
• 101710094648 Coat protein Proteins 0.000 description 2
• 241000711573 Coronaviridae Species 0.000 description 2
• MIKUYHXYGGJMLM-GIMIYPNGSA-N Crotonoside Natural products C1=NC2=C(N)NC(=O)N=C2N1[C@H]1O[C@@H](CO)[C@H](O)[C@@H]1O MIKUYHXYGGJMLM-GIMIYPNGSA-N 0.000 description 2
• 102100038132 Endogenous retrovirus group K member 6 Pro protein Human genes 0.000 description 2
• 241000991587 Enterovirus C Species 0.000 description 2
• 241000283073 Equus caballus Species 0.000 description 2
• 241000282326 Felis catus Species 0.000 description 2
• 241000711950 Filoviridae Species 0.000 description 2
• 241000710831 Flavivirus Species 0.000 description 2
• 241001295925 Gegenes Species 0.000 description 2
• 101710154606 Hemagglutinin Proteins 0.000 description 2
• 241000700721 Hepatitis B virus Species 0.000 description 2
• 241000724709 Hepatitis delta virus Species 0.000 description 2
• 241000709721 Hepatovirus A Species 0.000 description 2
• 208000009889 Herpes Simplex Diseases 0.000 description 2
• 241000238631 Hexapoda Species 0.000 description 2
• 101001082073 Homo sapiens Interferon-induced helicase C domain-containing protein 1 Proteins 0.000 description 2
• 101000926535 Homo sapiens Interferon-induced, double-stranded RNA-activated protein kinase Proteins 0.000 description 2
• 101001041393 Homo sapiens Serine protease HTRA1 Proteins 0.000 description 2
• 241000701806 Human papillomavirus Species 0.000 description 2
• 108010044240 IFIH1 Interferon-Induced Helicase Proteins 0.000 description 2
• UGQMRVRMYYASKQ-KQYNXXCUSA-N Inosine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C2=NC=NC(O)=C2N=C1 UGQMRVRMYYASKQ-KQYNXXCUSA-N 0.000 description 2
• 229930010555 Inosine Natural products 0.000 description 2
• 102000002227 Interferon Type I Human genes 0.000 description 2
• 108010014726 Interferon Type I Proteins 0.000 description 2
• 101710085994 Interferon-induced helicase C domain-containing protein 1 Proteins 0.000 description 2
• 108090001005 Interleukin-6 Proteins 0.000 description 2
• XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
• 102100031413 L-dopachrome tautomerase Human genes 0.000 description 2
• 241000701076 Macacine alphaherpesvirus 1 Species 0.000 description 2
• 241000555688 Malassezia furfur Species 0.000 description 2
• 102100034216 Melanocyte-stimulating hormone receptor Human genes 0.000 description 2
• 102100034256 Mucin-1 Human genes 0.000 description 2
• 241000711466 Murine hepatitis virus Species 0.000 description 2
• 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 description 2
• 108700019961 Neoplasm Genes Proteins 0.000 description 2
• 102000048850 Neoplasm Genes Human genes 0.000 description 2
• 241001263478 Norovirus Species 0.000 description 2
• 241000713112 Orthobunyavirus Species 0.000 description 2
• 101710093908 Outer capsid protein VP4 Proteins 0.000 description 2
• 101710135467 Outer capsid protein sigma-1 Proteins 0.000 description 2
• 101710098399 Outer membrane protein YopN Proteins 0.000 description 2
• 206010033128 Ovarian cancer Diseases 0.000 description 2
• 206010061535 Ovarian neoplasm Diseases 0.000 description 2
• 208000016222 Pancreatic disease Diseases 0.000 description 2
• 206010061902 Pancreatic neoplasm Diseases 0.000 description 2
• 241001631646 Papillomaviridae Species 0.000 description 2
• 108091005804 Peptidases Proteins 0.000 description 2
• 241000009328 Perro Species 0.000 description 2
• 241000710778 Pestivirus Species 0.000 description 2
• 241000709664 Picornaviridae Species 0.000 description 2
• 241000209504 Poaceae Species 0.000 description 2
• 239000002202 Polyethylene glycol Substances 0.000 description 2
• 108010076039 Polyproteins Proteins 0.000 description 2
• 101710144666 Probable ATP-dependent RNA helicase DHX58 Proteins 0.000 description 2
• 101710176177 Protein A56 Proteins 0.000 description 2
• KDCGOANMDULRCW-UHFFFAOYSA-N Purine Natural products N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 description 2
• 102000004409 RNA Helicases Human genes 0.000 description 2
• 108090000944 RNA Helicases Proteins 0.000 description 2
• 108010065868 RNA polymerase SP6 Proteins 0.000 description 2
• 229940022005 RNA vaccine Drugs 0.000 description 2
• 101800001758 RNA-directed RNA polymerase nsP4 Proteins 0.000 description 2
• 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 description 2
• 108091028664 Ribonucleotide Proteins 0.000 description 2
• 241000710961 Semliki Forest virus Species 0.000 description 2
• 102100021119 Serine protease HTRA1 Human genes 0.000 description 2
• 108020004459 Small interfering RNA Proteins 0.000 description 2
• 229940124614 TLR 8 agonist Drugs 0.000 description 2
• 102000008236 Toll-Like Receptor 7 Human genes 0.000 description 2
• 241000711484 Transmissible gastroenteritis virus Species 0.000 description 2
• 241000893966 Trichophyton verrucosum Species 0.000 description 2
• 239000007984 Tris EDTA buffer Substances 0.000 description 2
• 208000007097 Urinary Bladder Neoplasms Diseases 0.000 description 2
• 241000711970 Vesiculovirus Species 0.000 description 2
• YXNIEZJFCGTDKV-UHFFFAOYSA-N X-Nucleosid Natural products O=C1N(CCC(N)C(O)=O)C(=O)C=CN1C1C(O)C(O)C(CO)O1 YXNIEZJFCGTDKV-UHFFFAOYSA-N 0.000 description 2
• OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 description 2
• 238000005349 anion exchange Methods 0.000 description 2
• 230000000692 anti-sense effect Effects 0.000 description 2
• 230000005875 antibody response Effects 0.000 description 2
• 239000008346 aqueous phase Substances 0.000 description 2
• 238000003556 assay Methods 0.000 description 2
• 108010005774 beta-Galactosidase Proteins 0.000 description 2
• 230000008859 change Effects 0.000 description 2
• 239000000084 colloidal system Substances 0.000 description 2
• 208000029742 colonic neoplasm Diseases 0.000 description 2
• 239000002299 complementary DNA Substances 0.000 description 2
• 238000013270 controlled release Methods 0.000 description 2
• 230000029087 digestion Effects 0.000 description 2
• 238000010790 dilution Methods 0.000 description 2
• 239000012895 dilution Substances 0.000 description 2
• 108010051081 dopachrome isomerase Proteins 0.000 description 2
• 239000003937 drug carrier Substances 0.000 description 2
• 238000000635 electron micrograph Methods 0.000 description 2
• 238000005516 engineering process Methods 0.000 description 2
• 238000011067 equilibration Methods 0.000 description 2
• 239000012467 final product Substances 0.000 description 2
• 229920001002 functional polymer Polymers 0.000 description 2
• 238000001415 gene therapy Methods 0.000 description 2
• 239000003102 growth factor Substances 0.000 description 2
• 201000010536 head and neck cancer Diseases 0.000 description 2
• 208000014829 head and neck neoplasm Diseases 0.000 description 2
• 239000000185 hemagglutinin Substances 0.000 description 2
• 108010037896 heparin-binding hemagglutinin Proteins 0.000 description 2
• 208000029570 hepatitis D virus infection Diseases 0.000 description 2
• 235000008216 herbs Nutrition 0.000 description 2
• 239000008240 homogeneous mixture Substances 0.000 description 2
• FDGQSTZJBFJUBT-UHFFFAOYSA-N hypoxanthine Chemical compound O=C1NC=NC2=C1NC=N2 FDGQSTZJBFJUBT-UHFFFAOYSA-N 0.000 description 2
• 229960002751 imiquimod Drugs 0.000 description 2
• DOUYETYNHWVLEO-UHFFFAOYSA-N imiquimod Chemical compound C1=CC=CC2=C3N(CC(C)C)C=NC3=C(N)N=C21 DOUYETYNHWVLEO-UHFFFAOYSA-N 0.000 description 2
• 230000036039 immunity Effects 0.000 description 2
• 230000001976 improved effect Effects 0.000 description 2
• 208000037797 influenza A Diseases 0.000 description 2
• 208000037798 influenza B Diseases 0.000 description 2
• 208000037799 influenza C Diseases 0.000 description 2
• 229960003786 inosine Drugs 0.000 description 2
• PHTQWCKDNZKARW-UHFFFAOYSA-N isoamylol Chemical compound CC(C)CCO PHTQWCKDNZKARW-UHFFFAOYSA-N 0.000 description 2
• 238000011068 loading method Methods 0.000 description 2
• 108700021021 mRNA Vaccine Proteins 0.000 description 2
• 206010025482 malaise Diseases 0.000 description 2
• 208000015486 malignant pancreatic neoplasm Diseases 0.000 description 2
• 239000003094 microcapsule Substances 0.000 description 2
• 239000011859 microparticle Substances 0.000 description 2
• 238000001823 molecular biology technique Methods 0.000 description 2
• 238000010369 molecular cloning Methods 0.000 description 2
• 239000002539 nanocarrier Substances 0.000 description 2
• 239000013642 negative control Substances 0.000 description 2
• 239000002777 nucleoside Substances 0.000 description 2
• 238000004806 packaging method and process Methods 0.000 description 2
• 201000002528 pancreatic cancer Diseases 0.000 description 2
• 208000008443 pancreatic carcinoma Diseases 0.000 description 2
• WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 description 2
• 150000004713 phosphodiesters Chemical class 0.000 description 2
• 239000013573 pollen allergen Substances 0.000 description 2
• 229920002492 poly(sulfone) Polymers 0.000 description 2
• 239000011148 porous material Substances 0.000 description 2
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 2
• 230000001681 protective effect Effects 0.000 description 2
• 230000002685 pulmonary effect Effects 0.000 description 2
• 238000000746 purification Methods 0.000 description 2
• 150000003212 purines Chemical class 0.000 description 2
• 238000011160 research Methods 0.000 description 2
• 229950010550 resiquimod Drugs 0.000 description 2
• BXNMTOQRYBFHNZ-UHFFFAOYSA-N resiquimod Chemical compound C1=CC=CC2=C(N(C(COCC)=N3)CC(C)(C)O)C3=C(N)N=C21 BXNMTOQRYBFHNZ-UHFFFAOYSA-N 0.000 description 2
• 238000012552 review Methods 0.000 description 2
• 239000002336 ribonucleotide Substances 0.000 description 2
• 125000002652 ribonucleotide group Chemical group 0.000 description 2
• 108091092562 ribozyme Proteins 0.000 description 2
• RHFUOMFWUGWKKO-UHFFFAOYSA-N s2C Natural products S=C1N=C(N)C=CN1C1C(O)C(O)C(CO)O1 RHFUOMFWUGWKKO-UHFFFAOYSA-N 0.000 description 2
• 229920006395 saturated elastomer Polymers 0.000 description 2
• 239000011780 sodium chloride Substances 0.000 description 2
• 239000001509 sodium citrate Substances 0.000 description 2
• NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 2
• 238000001228 spectrum Methods 0.000 description 2
• 239000000758 substrate Substances 0.000 description 2
• 230000009885 systemic effect Effects 0.000 description 2
• 238000012360 testing method Methods 0.000 description 2
• 230000001225 therapeutic effect Effects 0.000 description 2
• RWQNBRDOKXIBIV-UHFFFAOYSA-N thymine Chemical compound CC1=CNC(=O)NC1=O RWQNBRDOKXIBIV-UHFFFAOYSA-N 0.000 description 2
• WYWHKKSPHMUBEB-UHFFFAOYSA-N tioguanine Chemical class N1C(N)=NC(=S)C2=C1N=CN2 WYWHKKSPHMUBEB-UHFFFAOYSA-N 0.000 description 2
• 210000001519 tissue Anatomy 0.000 description 2
• 229940044616 toll-like receptor 7 agonist Drugs 0.000 description 2
• 239000001226 triphosphate Substances 0.000 description 2
• 235000011178 triphosphate Nutrition 0.000 description 2
• 108010014402 tyrosinase-related protein-1 Proteins 0.000 description 2
• 241000701161 unidentified adenovirus Species 0.000 description 2
• 241001515965 unidentified phage Species 0.000 description 2
• 239000002691 unilamellar liposome Substances 0.000 description 2
• 125000004417 unsaturated alkyl group Chemical group 0.000 description 2
• 238000011144 upstream manufacturing Methods 0.000 description 2
• 239000003981 vehicle Substances 0.000 description 2
• PHFMCMDFWSZKGD-IOSLPCCCSA-N (2r,3s,4r,5r)-2-(hydroxymethyl)-5-[6-(methylamino)-2-methylsulfanylpurin-9-yl]oxolane-3,4-diol Chemical compound C1=NC=2C(NC)=NC(SC)=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O PHFMCMDFWSZKGD-IOSLPCCCSA-N 0.000 description 1
• OEDPHAKKZGDBEV-GFPBKZJXSA-N (2s)-6-amino-2-[[(2s)-6-amino-2-[[(2s)-6-amino-2-[[(2s)-6-amino-2-[[(2s)-2-[[(2r)-3-[2,3-di(hexadecanoyloxy)propylsulfanyl]-2-(hexadecanoylamino)propanoyl]amino]-3-hydroxypropanoyl]amino]hexanoyl]amino]hexanoyl]amino]hexanoyl]amino]hexanoic acid Chemical compound NCCCC[C@@H](C(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)CCCCCCCCCCCCCCC)CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC OEDPHAKKZGDBEV-GFPBKZJXSA-N 0.000 description 1
• MYUOTPIQBPUQQU-CKTDUXNWSA-N (2s,3r)-2-amino-n-[[9-[(2r,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-2-methylsulfanylpurin-6-yl]carbamoyl]-3-hydroxybutanamide Chemical compound C12=NC(SC)=NC(NC(=O)NC(=O)[C@@H](N)[C@@H](C)O)=C2N=CN1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O MYUOTPIQBPUQQU-CKTDUXNWSA-N 0.000 description 1
• JZSSTKLEXRQFEA-HEIFUQTGSA-N (2s,3r,4s,5r)-2-(6-aminopurin-9-yl)-3,4-dihydroxy-5-(hydroxymethyl)oxolane-2-carboxamide Chemical compound C1=NC2=C(N)N=CN=C2N1[C@]1(C(=O)N)O[C@H](CO)[C@@H](O)[C@H]1O JZSSTKLEXRQFEA-HEIFUQTGSA-N 0.000 description 1
• XIJAZGMFHRTBFY-FDDDBJFASA-N 1-[(2r,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-2-$l^{1}-selanyl-5-(methylaminomethyl)pyrimidin-4-one Chemical compound [Se]C1=NC(=O)C(CNC)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 XIJAZGMFHRTBFY-FDDDBJFASA-N 0.000 description 1
• UTQUILVPBZEHTK-ZOQUXTDFSA-N 1-[(2r,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-3-methylpyrimidine-2,4-dione Chemical compound O=C1N(C)C(=O)C=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 UTQUILVPBZEHTK-ZOQUXTDFSA-N 0.000 description 1
• BTFXIEGOSDSOGN-KWCDMSRLSA-N 1-[(2r,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methyl-1,3-diazinane-2,4-dione Chemical compound O=C1NC(=O)C(C)CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 BTFXIEGOSDSOGN-KWCDMSRLSA-N 0.000 description 1
• GFYLSDSUCHVORB-IOSLPCCCSA-N 1-methyladenosine Chemical compound C1=NC=2C(=N)N(C)C=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O GFYLSDSUCHVORB-IOSLPCCCSA-N 0.000 description 1
• UTAIYTHAJQNQDW-KQYNXXCUSA-N 1-methylguanosine Chemical compound C1=NC=2C(=O)N(C)C(N)=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O UTAIYTHAJQNQDW-KQYNXXCUSA-N 0.000 description 1
• WJNGQIYEQLPJMN-IOSLPCCCSA-N 1-methylinosine Chemical compound C1=NC=2C(=O)N(C)C=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O WJNGQIYEQLPJMN-IOSLPCCCSA-N 0.000 description 1
• NHBKXEKEPDILRR-UHFFFAOYSA-N 2,3-bis(butanoylsulfanyl)propyl butanoate Chemical compound CCCC(=O)OCC(SC(=O)CCC)CSC(=O)CCC NHBKXEKEPDILRR-UHFFFAOYSA-N 0.000 description 1
• IQZWKGWOBPJWMX-UHFFFAOYSA-N 2-Methyladenosine Natural products C12=NC(C)=NC(N)=C2N=CN1C1OC(CO)C(O)C1O IQZWKGWOBPJWMX-UHFFFAOYSA-N 0.000 description 1
• SOEYIPCQNRSIAV-IOSLPCCCSA-N 2-amino-5-(aminomethyl)-7-[(2r,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1h-pyrrolo[2,3-d]pyrimidin-4-one Chemical compound C1=2NC(N)=NC(=O)C=2C(CN)=CN1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O SOEYIPCQNRSIAV-IOSLPCCCSA-N 0.000 description 1
• BIRQNXWAXWLATA-IOSLPCCCSA-N 2-amino-7-[(2r,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-oxo-1h-pyrrolo[2,3-d]pyrimidine-5-carbonitrile Chemical compound C1=C(C#N)C=2C(=O)NC(N)=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O BIRQNXWAXWLATA-IOSLPCCCSA-N 0.000 description 1
• QNIZHKITBISILC-RPKMEZRRSA-N 2-amino-9-[(2r,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)-2-methyloxolan-2-yl]-3h-purin-6-one Chemical compound C1=NC(C(NC(N)=N2)=O)=C2N1[C@]1(C)O[C@H](CO)[C@@H](O)[C@H]1O QNIZHKITBISILC-RPKMEZRRSA-N 0.000 description 1
• PBFLIOAJBULBHI-JJNLEZRASA-N 2-amino-n-[[9-[(2r,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]purin-6-yl]carbamoyl]acetamide Chemical compound C1=NC=2C(NC(=O)NC(=O)CN)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O PBFLIOAJBULBHI-JJNLEZRASA-N 0.000 description 1
• MWBWWFOAEOYUST-UHFFFAOYSA-N 2-aminopurine Chemical class NC1=NC=C2N=CNC2=N1 MWBWWFOAEOYUST-UHFFFAOYSA-N 0.000 description 1
• XLPHMKQBBCKEFO-UHFFFAOYSA-N 2-azaniumylethyl 2,3-bis(3,7,11,15-tetramethylhexadecanoyloxy)propyl phosphate Chemical compound CC(C)CCCC(C)CCCC(C)CCCC(C)CC(=O)OCC(COP(O)(=O)OCCN)OC(=O)CC(C)CCCC(C)CCCC(C)CCCC(C)C XLPHMKQBBCKEFO-UHFFFAOYSA-N 0.000 description 1
• XLPHMKQBBCKEFO-DHYROEPTSA-N 2-azaniumylethyl [(2r)-2,3-bis(3,7,11,15-tetramethylhexadecanoyloxy)propyl] phosphate Chemical compound CC(C)CCCC(C)CCCC(C)CCCC(C)CC(=O)OC[C@H](COP(O)(=O)OCCN)OC(=O)CC(C)CCCC(C)CCCC(C)CCCC(C)C XLPHMKQBBCKEFO-DHYROEPTSA-N 0.000 description 1
• VWSLLSXLURJCDF-UHFFFAOYSA-N 2-methyl-4,5-dihydro-1h-imidazole Chemical compound CC1=NCCN1 VWSLLSXLURJCDF-UHFFFAOYSA-N 0.000 description 1
• IQZWKGWOBPJWMX-IOSLPCCCSA-N 2-methyladenosine Chemical compound C12=NC(C)=NC(N)=C2N=CN1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O IQZWKGWOBPJWMX-IOSLPCCCSA-N 0.000 description 1
• QEWSGVMSLPHELX-UHFFFAOYSA-N 2-methylthio-N6-(cis-hydroxyisopentenyl) adenosine Chemical compound C12=NC(SC)=NC(NCC=C(C)CO)=C2N=CN1C1OC(CO)C(O)C1O QEWSGVMSLPHELX-UHFFFAOYSA-N 0.000 description 1
• QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 description 1
• RHFUOMFWUGWKKO-XVFCMESISA-N 2-thiocytidine Chemical compound S=C1N=C(N)C=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 RHFUOMFWUGWKKO-XVFCMESISA-N 0.000 description 1
• GIIGHSIIKVOWKZ-UHFFFAOYSA-N 2h-triazolo[4,5-d]pyrimidine Chemical class N1=CN=CC2=NNN=C21 GIIGHSIIKVOWKZ-UHFFFAOYSA-N 0.000 description 1
• YXNIEZJFCGTDKV-JANFQQFMSA-N 3-(3-amino-3-carboxypropyl)uridine Chemical compound O=C1N(CCC(N)C(O)=O)C(=O)C=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 YXNIEZJFCGTDKV-JANFQQFMSA-N 0.000 description 1
• LKKMLIBUAXYLOY-UHFFFAOYSA-N 3-Amino-1-methyl-5H-pyrido[4,3-b]indole Chemical compound N1C2=CC=CC=C2C2=C1C=C(N)N=C2C LKKMLIBUAXYLOY-UHFFFAOYSA-N 0.000 description 1
• RDPUKVRQKWBSPK-UHFFFAOYSA-N 3-Methylcytidine Natural products O=C1N(C)C(=N)C=CN1C1C(O)C(O)C(CO)O1 RDPUKVRQKWBSPK-UHFFFAOYSA-N 0.000 description 1
• UTQUILVPBZEHTK-UHFFFAOYSA-N 3-Methyluridine Natural products O=C1N(C)C(=O)C=CN1C1C(O)C(O)C(CO)O1 UTQUILVPBZEHTK-UHFFFAOYSA-N 0.000 description 1
• BINGDNLMMYSZFR-QYVSTXNMSA-N 3-[(2r,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-6,7-dimethyl-5h-imidazo[1,2-a]purin-9-one Chemical compound C1=NC=2C(=O)N3C(C)=C(C)N=C3NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O BINGDNLMMYSZFR-QYVSTXNMSA-N 0.000 description 1
• WEVYNIUIFUYDGI-UHFFFAOYSA-N 3-[6-[4-(trifluoromethoxy)anilino]-4-pyrimidinyl]benzamide Chemical compound NC(=O)C1=CC=CC(C=2N=CN=C(NC=3C=CC(OC(F)(F)F)=CC=3)C=2)=C1 WEVYNIUIFUYDGI-UHFFFAOYSA-N 0.000 description 1
• RDPUKVRQKWBSPK-ZOQUXTDFSA-N 3-methylcytidine Chemical compound O=C1N(C)C(=N)C=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 RDPUKVRQKWBSPK-ZOQUXTDFSA-N 0.000 description 1
• ZLOIGESWDJYCTF-UHFFFAOYSA-N 4-Thiouridine Natural products OC1C(O)C(CO)OC1N1C(=O)NC(=S)C=C1 ZLOIGESWDJYCTF-UHFFFAOYSA-N 0.000 description 1
• QUZQVVNSDQCAOL-WOUKDFQISA-N 4-demethylwyosine Chemical compound N1C(C)=CN(C(C=2N=C3)=O)C1=NC=2N3[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O QUZQVVNSDQCAOL-WOUKDFQISA-N 0.000 description 1
• ZLOIGESWDJYCTF-XVFCMESISA-N 4-thiouridine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=S)C=C1 ZLOIGESWDJYCTF-XVFCMESISA-N 0.000 description 1
• UHPMCKVQTMMPCG-UHFFFAOYSA-N 5,8-dihydroxy-2-methoxy-6-methyl-7-(2-oxopropyl)naphthalene-1,4-dione Chemical compound CC1=C(CC(C)=O)C(O)=C2C(=O)C(OC)=CC(=O)C2=C1O UHPMCKVQTMMPCG-UHFFFAOYSA-N 0.000 description 1
• UVGCZRPOXXYZKH-QADQDURISA-N 5-(carboxyhydroxymethyl)uridine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(C(O)C(O)=O)=C1 UVGCZRPOXXYZKH-QADQDURISA-N 0.000 description 1
• FAWQJBLSWXIJLA-VPCXQMTMSA-N 5-(carboxymethyl)uridine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(CC(O)=O)=C1 FAWQJBLSWXIJLA-VPCXQMTMSA-N 0.000 description 1
• NFEXJLMYXXIWPI-JXOAFFINSA-N 5-Hydroxymethylcytidine Chemical compound C1=C(CO)C(N)=NC(=O)N1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 NFEXJLMYXXIWPI-JXOAFFINSA-N 0.000 description 1
• ZAYHVCMSTBRABG-UHFFFAOYSA-N 5-Methylcytidine Natural products O=C1N=C(N)C(C)=CN1C1C(O)C(O)C(CO)O1 ZAYHVCMSTBRABG-UHFFFAOYSA-N 0.000 description 1
• ZYEWPVTXYBLWRT-UHFFFAOYSA-N 5-Uridinacetamid Natural products O=C1NC(=O)C(CC(=O)N)=CN1C1C(O)C(O)C(CO)O1 ZYEWPVTXYBLWRT-UHFFFAOYSA-N 0.000 description 1
• BISHACNKZIBDFM-UHFFFAOYSA-N 5-amino-1h-pyrimidine-2,4-dione Chemical compound NC1=CNC(=O)NC1=O BISHACNKZIBDFM-UHFFFAOYSA-N 0.000 description 1
• LOEDKMLIGFMQKR-JXOAFFINSA-N 5-aminomethyl-2-thiouridine Chemical compound S=C1NC(=O)C(CN)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 LOEDKMLIGFMQKR-JXOAFFINSA-N 0.000 description 1
• LQLQRFGHAALLLE-UHFFFAOYSA-N 5-bromouracil Chemical compound BrC1=CNC(=O)NC1=O LQLQRFGHAALLLE-UHFFFAOYSA-N 0.000 description 1
• ZYEWPVTXYBLWRT-VPCXQMTMSA-N 5-carbamoylmethyluridine Chemical compound O=C1NC(=O)C(CC(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 ZYEWPVTXYBLWRT-VPCXQMTMSA-N 0.000 description 1
• ZFTBZKVVGZNMJR-UHFFFAOYSA-N 5-chlorouracil Chemical compound ClC1=CNC(=O)NC1=O ZFTBZKVVGZNMJR-UHFFFAOYSA-N 0.000 description 1
• 101710163573 5-hydroxyisourate hydrolase Proteins 0.000 description 1
• JDBGXEHEIRGOBU-UHFFFAOYSA-N 5-hydroxymethyluracil Chemical compound OCC1=CNC(=O)NC1=O JDBGXEHEIRGOBU-UHFFFAOYSA-N 0.000 description 1
• ZXIATBNUWJBBGT-JXOAFFINSA-N 5-methoxyuridine Chemical compound O=C1NC(=O)C(OC)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 ZXIATBNUWJBBGT-JXOAFFINSA-N 0.000 description 1
• HXVKEKIORVUWDR-UHFFFAOYSA-N 5-methylaminomethyl-2-thiouridine Natural products S=C1NC(=O)C(CNC)=CN1C1C(O)C(O)C(CO)O1 HXVKEKIORVUWDR-UHFFFAOYSA-N 0.000 description 1
• ZXQHKBUIXRFZBV-FDDDBJFASA-N 5-methylaminomethyluridine Chemical compound O=C1NC(=O)C(CNC)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 ZXQHKBUIXRFZBV-FDDDBJFASA-N 0.000 description 1
• ZAYHVCMSTBRABG-JXOAFFINSA-N 5-methylcytidine Chemical compound O=C1N=C(N)C(C)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 ZAYHVCMSTBRABG-JXOAFFINSA-N 0.000 description 1
• USVMJSALORZVDV-UHFFFAOYSA-N 6-(gamma,gamma-dimethylallylamino)purine riboside Natural products C1=NC=2C(NCC=C(C)C)=NC=NC=2N1C1OC(CO)C(O)C1O USVMJSALORZVDV-UHFFFAOYSA-N 0.000 description 1
• QFVKLKDEXOWFSL-UHFFFAOYSA-N 6-amino-5-bromo-1h-pyrimidin-2-one Chemical compound NC=1NC(=O)N=CC=1Br QFVKLKDEXOWFSL-UHFFFAOYSA-N 0.000 description 1
• NLLCDONDZDHLCI-UHFFFAOYSA-N 6-amino-5-hydroxy-1h-pyrimidin-2-one Chemical compound NC=1NC(=O)N=CC=1O NLLCDONDZDHLCI-UHFFFAOYSA-N 0.000 description 1
• RYYIULNRIVUMTQ-UHFFFAOYSA-N 6-chloroguanine Chemical class NC1=NC(Cl)=C2N=CNC2=N1 RYYIULNRIVUMTQ-UHFFFAOYSA-N 0.000 description 1
• CLGFIVUFZRGQRP-UHFFFAOYSA-N 7,8-dihydro-8-oxoguanine Chemical class O=C1NC(N)=NC2=C1NC(=O)N2 CLGFIVUFZRGQRP-UHFFFAOYSA-N 0.000 description 1
• LOSIULRWFAEMFL-UHFFFAOYSA-N 7-deazaguanine Chemical compound O=C1NC(N)=NC2=C1CC=N2 LOSIULRWFAEMFL-UHFFFAOYSA-N 0.000 description 1
• LPXQRXLUHJKZIE-UHFFFAOYSA-N 8-azaguanine Chemical compound NC1=NC(O)=C2NN=NC2=N1 LPXQRXLUHJKZIE-UHFFFAOYSA-N 0.000 description 1
• 229960005508 8-azaguanine Drugs 0.000 description 1
• UBKVUFQGVWHZIR-UHFFFAOYSA-N 8-oxoguanine Chemical class O=C1NC(N)=NC2=NC(=O)N=C21 UBKVUFQGVWHZIR-UHFFFAOYSA-N 0.000 description 1
• MSSXOMSJDRHRMC-UHFFFAOYSA-N 9H-purine-2,6-diamine Chemical class NC1=NC(N)=C2NC=NC2=N1 MSSXOMSJDRHRMC-UHFFFAOYSA-N 0.000 description 1
• 102100030840 AT-rich interactive domain-containing protein 4B Human genes 0.000 description 1
• 208000035657 Abasia Diseases 0.000 description 1
• 241000235389 Absidia Species 0.000 description 1
• 244000251953 Agaricus brunnescens Species 0.000 description 1
• 235000001674 Agaricus brunnescens Nutrition 0.000 description 1
• 102000002260 Alkaline Phosphatase Human genes 0.000 description 1
• 108020004774 Alkaline Phosphatase Proteins 0.000 description 1
• 241000219496 Alnus Species 0.000 description 1
• 241000223600 Alternaria Species 0.000 description 1
• 241000710189 Aphthovirus Species 0.000 description 1
• 241000256837 Apidae Species 0.000 description 1
• 241000239223 Arachnida Species 0.000 description 1
• PEMQXWCOMFJRLS-UHFFFAOYSA-N Archaeosine Natural products C1=2NC(N)=NC(=O)C=2C(C(=N)N)=CN1C1OC(CO)C(O)C1O PEMQXWCOMFJRLS-UHFFFAOYSA-N 0.000 description 1
• 241000228197 Aspergillus flavus Species 0.000 description 1
• 241001225321 Aspergillus fumigatus Species 0.000 description 1
• 241000132177 Aspergillus glaucus Species 0.000 description 1
• 241000351920 Aspergillus nidulans Species 0.000 description 1
• 241000228245 Aspergillus niger Species 0.000 description 1
• 241001465318 Aspergillus terreus Species 0.000 description 1
• 241000208837 Asterales Species 0.000 description 1
• 241000271566 Aves Species 0.000 description 1
• 102100035526 B melanoma antigen 1 Human genes 0.000 description 1
• 208000003950 B-cell lymphoma Diseases 0.000 description 1
• FTEDXVNDVHYDQW-UHFFFAOYSA-N BAPTA Chemical compound OC(=O)CN(CC(O)=O)C1=CC=CC=C1OCCOC1=CC=CC=C1N(CC(O)=O)CC(O)=O FTEDXVNDVHYDQW-UHFFFAOYSA-N 0.000 description 1
• 241000193738 Bacillus anthracis Species 0.000 description 1
• 101000878103 Bacillus subtilis (strain 168) Iron(3+)-hydroxamate-binding protein FhuD Proteins 0.000 description 1
• 241000235579 Basidiobolus Species 0.000 description 1
• DWRXFEITVBNRMK-UHFFFAOYSA-N Beta-D-1-Arabinofuranosylthymine Natural products O=C1NC(=O)C(C)=CN1C1C(O)C(O)C(CO)O1 DWRXFEITVBNRMK-UHFFFAOYSA-N 0.000 description 1
• 108060000903 Beta-catenin Proteins 0.000 description 1
• 102000015735 Beta-catenin Human genes 0.000 description 1
• 241000219429 Betula Species 0.000 description 1
• 235000003932 Betula Nutrition 0.000 description 1
• 235000018185 Betula X alpestris Nutrition 0.000 description 1
• 235000018212 Betula X uliginosa Nutrition 0.000 description 1
• 241000219495 Betulaceae Species 0.000 description 1
• 206010005003 Bladder cancer Diseases 0.000 description 1
• 241000335423 Blastomyces Species 0.000 description 1
• 241000238658 Blattella Species 0.000 description 1
• BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 description 1
• 241000588832 Bordetella pertussis Species 0.000 description 1
• 241000589969 Borreliella burgdorferi Species 0.000 description 1
• 241000710780 Bovine viral diarrhea virus 1 Species 0.000 description 1
• 241000614861 Brachiola Species 0.000 description 1
• 241000339490 Brachyachne Species 0.000 description 1
• 241000589562 Brucella Species 0.000 description 1
• 241001509299 Brucella canis Species 0.000 description 1
• 241001148106 Brucella melitensis Species 0.000 description 1
• 241001148112 Brucella neotomae Species 0.000 description 1
• 241000589568 Brucella ovis Species 0.000 description 1
• 241000514715 Brucella pinnipedialis Species 0.000 description 1
• 241001148111 Brucella suis Species 0.000 description 1
• 239000002126 C01EB10 - Adenosine Substances 0.000 description 1
• 238000011740 C57BL/6 mouse Methods 0.000 description 1
• QXANAUBYOYJUGF-UHFFFAOYSA-N CC1=CC=CC=C1.OS(=O)(=O)[N+]([O-])=O Chemical compound CC1=CC=CC=C1.OS(=O)(=O)[N+]([O-])=O QXANAUBYOYJUGF-UHFFFAOYSA-N 0.000 description 1
• 101100454807 Caenorhabditis elegans lgg-1 gene Proteins 0.000 description 1
• 101100438971 Caenorhabditis elegans mat-1 gene Proteins 0.000 description 1
• 241000714198 Caliciviridae Species 0.000 description 1
• 241001493160 California encephalitis virus Species 0.000 description 1
• 241001247232 Caligidae Species 0.000 description 1
• 241001611011 Caligus Species 0.000 description 1
• 241001611004 Caligus rogercresseyi Species 0.000 description 1
• 102100025570 Cancer/testis antigen 1 Human genes 0.000 description 1
• 241000222178 Candida tropicalis Species 0.000 description 1
• 241000283707 Capra Species 0.000 description 1
• 102000003846 Carbonic anhydrases Human genes 0.000 description 1
• 108090000209 Carbonic anhydrases Proteins 0.000 description 1
• 101710134395 Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 Proteins 0.000 description 1
• 102100027668 Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 Human genes 0.000 description 1
• 108010022366 Carcinoembryonic Antigen Proteins 0.000 description 1
• 102100025475 Carcinoembryonic antigen-related cell adhesion molecule 5 Human genes 0.000 description 1
• 241000710190 Cardiovirus Species 0.000 description 1
• 102100026548 Caspase-8 Human genes 0.000 description 1
• 108090000538 Caspase-8 Proteins 0.000 description 1
• 241000218645 Cedrus Species 0.000 description 1
• 241000282994 Cervidae Species 0.000 description 1
• 241000256128 Chironomus <genus> Species 0.000 description 1
• 201000005019 Chlamydia pneumonia Diseases 0.000 description 1
• 241000606153 Chlamydia trachomatis Species 0.000 description 1
• 208000017667 Chronic Disease Diseases 0.000 description 1
• 241001668502 Cladophialophora carrionii Species 0.000 description 1
• 241000222290 Cladosporium Species 0.000 description 1
• 241001508813 Clavispora lusitaniae Species 0.000 description 1
• 241000193155 Clostridium botulinum Species 0.000 description 1
• 241000193468 Clostridium perfringens Species 0.000 description 1
• 241000193449 Clostridium tetani Species 0.000 description 1
• 241000223205 Coccidioides immitis Species 0.000 description 1
• 241000702669 Coltivirus Species 0.000 description 1
• 241001480517 Conidiobolus Species 0.000 description 1
• 241000723382 Corylus Species 0.000 description 1
• 235000001543 Corylus americana Nutrition 0.000 description 1
• 240000007582 Corylus avellana Species 0.000 description 1
• 235000007466 Corylus avellana Nutrition 0.000 description 1
• 241001445332 Coxiella <snail> Species 0.000 description 1
• 241000150230 Crimean-Congo hemorrhagic fever orthonairovirus Species 0.000 description 1
• MIKUYHXYGGJMLM-UUOKFMHZSA-N Crotonoside Chemical compound C1=NC2=C(N)NC(=O)N=C2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O MIKUYHXYGGJMLM-UUOKFMHZSA-N 0.000 description 1
• 201000007336 Cryptococcosis Diseases 0.000 description 1
• 241000221204 Cryptococcus neoformans Species 0.000 description 1
• 240000005109 Cryptomeria japonica Species 0.000 description 1
• 241000223208 Curvularia Species 0.000 description 1
• 241000371644 Curvularia ravenelii Species 0.000 description 1
• 108010025464 Cyclin-Dependent Kinase 4 Proteins 0.000 description 1
• 102100036252 Cyclin-dependent kinase 4 Human genes 0.000 description 1
• 108010072210 Cyclophilin C Proteins 0.000 description 1
• NYHBQMYGNKIUIF-UHFFFAOYSA-N D-guanosine Natural products C1=2NC(N)=NC(=O)C=2N=CN1C1OC(CO)C(O)C1O NYHBQMYGNKIUIF-UHFFFAOYSA-N 0.000 description 1
• 108010060682 DEAD Box Protein 58 Proteins 0.000 description 1
• 241000209210 Dactylis Species 0.000 description 1
• 208000001840 Dandruff Diseases 0.000 description 1
• 208000001490 Dengue Diseases 0.000 description 1
• 206010012310 Dengue fever Diseases 0.000 description 1
• 102000016911 Deoxyribonucleases Human genes 0.000 description 1
• 108010053770 Deoxyribonucleases Proteins 0.000 description 1
• 241000238710 Dermatophagoides Species 0.000 description 1
• 208000002699 Digestive System Neoplasms Diseases 0.000 description 1
• KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
• 241000710945 Eastern equine encephalitis virus Species 0.000 description 1
• 241001115402 Ebolavirus Species 0.000 description 1
• 241000243234 Encephalitozoon Species 0.000 description 1
• 241000596569 Encephalitozoon intestinalis Species 0.000 description 1
• 108010067770 Endopeptidase K Proteins 0.000 description 1
• 241000701832 Enterobacteria phage T3 Species 0.000 description 1
• 241000194032 Enterococcus faecalis Species 0.000 description 1
• 241000194031 Enterococcus faecium Species 0.000 description 1
• 241001442406 Enterocytozoon bieneusi Species 0.000 description 1
• 101710121417 Envelope glycoprotein Proteins 0.000 description 1
• 241001480035 Epidermophyton Species 0.000 description 1
• 102000018651 Epithelial Cell Adhesion Molecule Human genes 0.000 description 1
• 108010066687 Epithelial Cell Adhesion Molecule Proteins 0.000 description 1
• 241000283086 Equidae Species 0.000 description 1
• 101000686777 Escherichia phage T7 T7 RNA polymerase Proteins 0.000 description 1
• 101710196290 Eukaryotic translation initiation factor 2-alpha kinase 2 Proteins 0.000 description 1
• 241000238739 Euroglyphus Species 0.000 description 1
• 241000223682 Exophiala Species 0.000 description 1
• 101710186862 Factor H binding protein Proteins 0.000 description 1
• 241000219427 Fagales Species 0.000 description 1
• 102100028073 Fibroblast growth factor 5 Human genes 0.000 description 1
• 108090000380 Fibroblast growth factor 5 Proteins 0.000 description 1
• 108090000331 Firefly luciferases Proteins 0.000 description 1
• GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 description 1
• 241000122862 Fonsecaea Species 0.000 description 1
• 241000710198 Foot-and-mouth disease virus Species 0.000 description 1
• 235000016623 Fragaria vesca Nutrition 0.000 description 1
• 240000009088 Fragaria x ananassa Species 0.000 description 1
• 235000011363 Fragaria x ananassa Nutrition 0.000 description 1
• 241000589601 Francisella Species 0.000 description 1
• 241001135321 Francisella philomiragia Species 0.000 description 1
• 241000589602 Francisella tularensis Species 0.000 description 1
• 241000589599 Francisella tularensis subsp. novicida Species 0.000 description 1
• 102000001390 Fructose-Bisphosphate Aldolase Human genes 0.000 description 1
• 108010068561 Fructose-Bisphosphate Aldolase Proteins 0.000 description 1
• 241000223218 Fusarium Species 0.000 description 1
• 102100039717 G antigen 1 Human genes 0.000 description 1
• 241000531123 GB virus C Species 0.000 description 1
• 101710113436 GTPase KRas Proteins 0.000 description 1
• 102000000805 Galectin 4 Human genes 0.000 description 1
• 108010001515 Galectin 4 Proteins 0.000 description 1
• 102100040510 Galectin-3-binding protein Human genes 0.000 description 1
• 101710197901 Galectin-3-binding protein Proteins 0.000 description 1
• 101710121810 Galectin-9 Proteins 0.000 description 1
• 102100031351 Galectin-9 Human genes 0.000 description 1
• 102400000921 Gastrin Human genes 0.000 description 1
• 108010052343 Gastrins Proteins 0.000 description 1
• 241000159512 Geotrichum Species 0.000 description 1
• 108010061711 Gliadin Proteins 0.000 description 1
• 102100041003 Glutamate carboxypeptidase 2 Human genes 0.000 description 1
• 108010068370 Glutens Proteins 0.000 description 1
• 101710114810 Glycoprotein Proteins 0.000 description 1
• 241001510533 Glycyphagus Species 0.000 description 1
• 206010018612 Gonorrhoea Diseases 0.000 description 1
• NYHBQMYGNKIUIF-UUOKFMHZSA-N Guanosine Natural products C1=NC=2C(=O)NC(N)=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O NYHBQMYGNKIUIF-UUOKFMHZSA-N 0.000 description 1
• 208000031886 HIV Infections Diseases 0.000 description 1
• 241001466963 Hawaii calicivirus Species 0.000 description 1
• 102000002812 Heat-Shock Proteins Human genes 0.000 description 1
• 108010004889 Heat-Shock Proteins Proteins 0.000 description 1
• 241000590002 Helicobacter pylori Species 0.000 description 1
• 108010006464 Hemolysin Proteins Proteins 0.000 description 1
• 241000711549 Hepacivirus C Species 0.000 description 1
• 208000005176 Hepatitis C Diseases 0.000 description 1
• 208000005331 Hepatitis D Diseases 0.000 description 1
• 241000724675 Hepatitis E virus Species 0.000 description 1
• 208000037262 Hepatitis delta Diseases 0.000 description 1
• 108091080980 Hepatitis delta virus ribozyme Proteins 0.000 description 1
• 241000228404 Histoplasma capsulatum Species 0.000 description 1
• 208000017604 Hodgkin disease Diseases 0.000 description 1
• 208000010747 Hodgkins lymphoma Diseases 0.000 description 1
• 241000744855 Holcus Species 0.000 description 1
• 101000792935 Homo sapiens AT-rich interactive domain-containing protein 4B Proteins 0.000 description 1
• 101000874316 Homo sapiens B melanoma antigen 1 Proteins 0.000 description 1
• 101000856237 Homo sapiens Cancer/testis antigen 1 Proteins 0.000 description 1
• 101000886137 Homo sapiens G antigen 1 Proteins 0.000 description 1
• 101000892862 Homo sapiens Glutamate carboxypeptidase 2 Proteins 0.000 description 1
• 101001011441 Homo sapiens Interferon regulatory factor 4 Proteins 0.000 description 1
• 101000934372 Homo sapiens Macrosialin Proteins 0.000 description 1
• 101001134060 Homo sapiens Melanocyte-stimulating hormone receptor Proteins 0.000 description 1
• 101000578784 Homo sapiens Melanoma antigen recognized by T-cells 1 Proteins 0.000 description 1
• 101001131670 Homo sapiens PWWP domain-containing DNA repair factor 3A Proteins 0.000 description 1
• 101001136592 Homo sapiens Prostate stem cell antigen Proteins 0.000 description 1
• 101000880770 Homo sapiens Protein SSX2 Proteins 0.000 description 1
• 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 description 1
• 101001062222 Homo sapiens Receptor-binding cancer antigen expressed on SiSo cells Proteins 0.000 description 1
• 101000973629 Homo sapiens Ribosome quality control complex subunit NEMF Proteins 0.000 description 1
• 101001059454 Homo sapiens Serine/threonine-protein kinase MARK2 Proteins 0.000 description 1
• 101100369861 Homo sapiens TLR3 gene Proteins 0.000 description 1
• 101000831567 Homo sapiens Toll-like receptor 2 Proteins 0.000 description 1
• 101000669447 Homo sapiens Toll-like receptor 4 Proteins 0.000 description 1
• 101000671653 Homo sapiens U3 small nucleolar RNA-associated protein 14 homolog A Proteins 0.000 description 1
• 241000598436 Human T-cell lymphotropic virus Species 0.000 description 1
• 101000926057 Human herpesvirus 2 (strain G) Envelope glycoprotein C Proteins 0.000 description 1
• 241000713772 Human immunodeficiency virus 1 Species 0.000 description 1
• 241000713340 Human immunodeficiency virus 2 Species 0.000 description 1
• 241000702617 Human parvovirus B19 Species 0.000 description 1
• 108010052919 Hydroxyethylthiazole kinase Proteins 0.000 description 1
• 108010027436 Hydroxymethylpyrimidine kinase Proteins 0.000 description 1
• UGQMRVRMYYASKQ-UHFFFAOYSA-N Hypoxanthine nucleoside Natural products OC1C(O)C(CO)OC1N1C(NC=NC2=O)=C2N=C1 UGQMRVRMYYASKQ-UHFFFAOYSA-N 0.000 description 1
• 241000252498 Ictalurus punctatus Species 0.000 description 1
• 108010043496 Immunoglobulin Idiotypes Proteins 0.000 description 1
• 101900159346 Influenza A virus Hemagglutinin Proteins 0.000 description 1
• 241001500351 Influenzavirus A Species 0.000 description 1
• 108010030506 Integrin alpha6beta4 Proteins 0.000 description 1
• 102100030126 Interferon regulatory factor 4 Human genes 0.000 description 1
• 102000014150 Interferons Human genes 0.000 description 1
• 108010050904 Interferons Proteins 0.000 description 1
• 241000710842 Japanese encephalitis virus Species 0.000 description 1
• 241000721662 Juniperus Species 0.000 description 1
• 208000008839 Kidney Neoplasms Diseases 0.000 description 1
• 241000588748 Klebsiella Species 0.000 description 1
• 201000008225 Klebsiella pneumonia Diseases 0.000 description 1
• 241000588747 Klebsiella pneumoniae Species 0.000 description 1
• 244000285963 Kluyveromyces fragilis Species 0.000 description 1
• 235000014663 Kluyveromyces fragilis Nutrition 0.000 description 1
• 241000589242 Legionella pneumophila Species 0.000 description 1
• 241000713666 Lentivirus Species 0.000 description 1
• 241001247233 Lepeophtheirus Species 0.000 description 1
• 241001247234 Lepeophtheirus salmonis Species 0.000 description 1
• 239000012097 Lipofectamine 2000 Substances 0.000 description 1
• 108090001030 Lipoproteins Proteins 0.000 description 1
• 102000004895 Lipoproteins Human genes 0.000 description 1
• 241000186779 Listeria monocytogenes Species 0.000 description 1
• 241000209082 Lolium Species 0.000 description 1
• 241000711828 Lyssavirus Species 0.000 description 1
• 108010000410 MSH receptor Proteins 0.000 description 1
• 102100025136 Macrosialin Human genes 0.000 description 1
• 241001539803 Magnusiomyces capitatus Species 0.000 description 1
• 241000555676 Malassezia Species 0.000 description 1
• 241001115401 Marburgvirus Species 0.000 description 1
• 201000005505 Measles Diseases 0.000 description 1
• 102100022430 Melanocyte protein PMEL Human genes 0.000 description 1
• 102100028389 Melanoma antigen recognized by T-cells 1 Human genes 0.000 description 1
• 108010052285 Membrane Proteins Proteins 0.000 description 1
• 201000009906 Meningitis Diseases 0.000 description 1
• 241000351643 Metapneumovirus Species 0.000 description 1
• 241000235048 Meyerozyma guilliermondii Species 0.000 description 1
• 241000243190 Microsporidia Species 0.000 description 1
• 241001295810 Microsporidium Species 0.000 description 1
• 241000893980 Microsporum canis Species 0.000 description 1
• 241001460074 Microsporum distortum Species 0.000 description 1
• 241001260008 Microsporum equinum Species 0.000 description 1
• 241000588655 Moraxella catarrhalis Species 0.000 description 1
• 241000712045 Morbillivirus Species 0.000 description 1
• 241000235575 Mortierella Species 0.000 description 1
• 108010008707 Mucin-1 Proteins 0.000 description 1
• 241000235395 Mucor Species 0.000 description 1
• 241000711386 Mumps virus Species 0.000 description 1
• 241000714177 Murine leukemia virus Species 0.000 description 1
• 101100476480 Mus musculus S100a8 gene Proteins 0.000 description 1
• 241000187479 Mycobacterium tuberculosis Species 0.000 description 1
• IYYIBFCJILKPCO-WOUKDFQISA-O N(2),N(2),N(7)-trimethylguanosine Chemical compound C1=2NC(N(C)C)=NC(=O)C=2N(C)C=[N+]1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O IYYIBFCJILKPCO-WOUKDFQISA-O 0.000 description 1
• RSPURTUNRHNVGF-IOSLPCCCSA-N N(2),N(2)-dimethylguanosine Chemical compound C1=NC=2C(=O)NC(N(C)C)=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O RSPURTUNRHNVGF-IOSLPCCCSA-N 0.000 description 1
• ZBYRSRLCXTUFLJ-IOSLPCCCSA-O N(2),N(7)-dimethylguanosine Chemical compound CNC=1NC(C=2[N+](=CN([C@H]3[C@H](O)[C@H](O)[C@@H](CO)O3)C=2N=1)C)=O ZBYRSRLCXTUFLJ-IOSLPCCCSA-O 0.000 description 1
• SLEHROROQDYRAW-KQYNXXCUSA-N N(2)-methylguanosine Chemical compound C1=NC=2C(=O)NC(NC)=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O SLEHROROQDYRAW-KQYNXXCUSA-N 0.000 description 1
• NIDVTARKFBZMOT-PEBGCTIMSA-N N(4)-acetylcytidine Chemical compound O=C1N=C(NC(=O)C)C=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 NIDVTARKFBZMOT-PEBGCTIMSA-N 0.000 description 1
• WVGPGNPCZPYCLK-WOUKDFQISA-N N(6),N(6)-dimethyladenosine Chemical compound C1=NC=2C(N(C)C)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O WVGPGNPCZPYCLK-WOUKDFQISA-N 0.000 description 1
• USVMJSALORZVDV-SDBHATRESA-N N(6)-(Delta(2)-isopentenyl)adenosine Chemical compound C1=NC=2C(NCC=C(C)C)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O USVMJSALORZVDV-SDBHATRESA-N 0.000 description 1
• VQAYFKKCNSOZKM-IOSLPCCCSA-N N(6)-methyladenosine Chemical compound C1=NC=2C(NC)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O VQAYFKKCNSOZKM-IOSLPCCCSA-N 0.000 description 1
• QPCDCPDFJACHGM-UHFFFAOYSA-N N,N-bis{2-[bis(carboxymethyl)amino]ethyl}glycine Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(=O)O)CCN(CC(O)=O)CC(O)=O QPCDCPDFJACHGM-UHFFFAOYSA-N 0.000 description 1
• WVGPGNPCZPYCLK-UHFFFAOYSA-N N-Dimethyladenosine Natural products C1=NC=2C(N(C)C)=NC=NC=2N1C1OC(CO)C(O)C1O WVGPGNPCZPYCLK-UHFFFAOYSA-N 0.000 description 1
• UNUYMBPXEFMLNW-DWVDDHQFSA-N N-[(9-beta-D-ribofuranosylpurin-6-yl)carbamoyl]threonine Chemical compound C1=NC=2C(NC(=O)N[C@@H]([C@H](O)C)C(O)=O)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O UNUYMBPXEFMLNW-DWVDDHQFSA-N 0.000 description 1
• SLLVJTURCPWLTP-UHFFFAOYSA-N N-[9-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]purin-6-yl]acetamide Chemical compound C1=NC=2C(NC(=O)C)=NC=NC=2N1C1OC(CO)C(O)C1O SLLVJTURCPWLTP-UHFFFAOYSA-N 0.000 description 1
• LZCNWAXLJWBRJE-ZOQUXTDFSA-N N4-Methylcytidine Chemical compound O=C1N=C(NC)C=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 LZCNWAXLJWBRJE-ZOQUXTDFSA-N 0.000 description 1
• GOSWTRUMMSCNCW-UHFFFAOYSA-N N6-(cis-hydroxyisopentenyl)adenosine Chemical compound C1=NC=2C(NCC=C(CO)C)=NC=NC=2N1C1OC(CO)C(O)C1O GOSWTRUMMSCNCW-UHFFFAOYSA-N 0.000 description 1
• VQAYFKKCNSOZKM-UHFFFAOYSA-N NSC 29409 Natural products C1=NC=2C(NC)=NC=NC=2N1C1OC(CO)C(O)C1O VQAYFKKCNSOZKM-UHFFFAOYSA-N 0.000 description 1
• 241000893976 Nannizzia gypsea Species 0.000 description 1
• 241000588653 Neisseria Species 0.000 description 1
• 241000588650 Neisseria meningitidis Species 0.000 description 1
• 108010006232 Neuraminidase Proteins 0.000 description 1
• 102000005348 Neuraminidase Human genes 0.000 description 1
• 101800000515 Non-structural protein 3 Proteins 0.000 description 1
• 241001126829 Nosema Species 0.000 description 1
• 108700001237 Nucleic Acid-Based Vaccines Proteins 0.000 description 1
• VZQXUWKZDSEQRR-UHFFFAOYSA-N Nucleosid Natural products C12=NC(SC)=NC(NCC=C(C)C)=C2N=CN1C1OC(CO)C(O)C1O VZQXUWKZDSEQRR-UHFFFAOYSA-N 0.000 description 1
• JXNORPPTKDEAIZ-QOCRDCMYSA-N O-4''-alpha-D-mannosylqueuosine Chemical compound NC(N1)=NC(N([C@@H]([C@@H]2O)O[C@H](CO)[C@H]2O)C=C2CN[C@H]([C@H]3O)C=C[C@@H]3O[C@H]([C@H]([C@H]3O)O)O[C@H](CO)[C@H]3O)=C2C1=O JXNORPPTKDEAIZ-QOCRDCMYSA-N 0.000 description 1
• 241000795633 Olea <sea slug> Species 0.000 description 1
• 240000007817 Olea europaea Species 0.000 description 1
• 241000702259 Orbivirus Species 0.000 description 1
• 241000150218 Orthonairovirus Species 0.000 description 1
• 241000700629 Orthopoxvirus Species 0.000 description 1
• 241000702244 Orthoreovirus Species 0.000 description 1
• 102000036673 PRAME Human genes 0.000 description 1
• 108060006580 PRAME Proteins 0.000 description 1
• 241001236817 Paecilomyces <Clavicipitaceae> Species 0.000 description 1
• 208000002193 Pain Diseases 0.000 description 1
• 108020002230 Pancreatic Ribonuclease Proteins 0.000 description 1
• 206010058096 Pancreatic necrosis Diseases 0.000 description 1
• 102000005891 Pancreatic ribonuclease Human genes 0.000 description 1
• 241000526686 Paracoccidioides brasiliensis Species 0.000 description 1
• 241000711504 Paramyxoviridae Species 0.000 description 1
• 208000002606 Paramyxoviridae Infections Diseases 0.000 description 1
• 102000035195 Peptidases Human genes 0.000 description 1
• 102100024968 Peptidyl-prolyl cis-trans isomerase C Human genes 0.000 description 1
• 241000238661 Periplaneta Species 0.000 description 1
• 201000005702 Pertussis Diseases 0.000 description 1
• 108010081690 Pertussis Toxin Proteins 0.000 description 1
• 241000745991 Phalaris Species 0.000 description 1
• 241000746981 Phleum Species 0.000 description 1
• 102000012288 Phosphopyruvate Hydratase Human genes 0.000 description 1
• 108010022181 Phosphopyruvate Hydratase Proteins 0.000 description 1
• 101710099976 Photosystem I P700 chlorophyll a apoprotein A1 Proteins 0.000 description 1
• 241001674048 Phthiraptera Species 0.000 description 1
• 240000009188 Phyllostachys vivax Species 0.000 description 1
• 241000235645 Pichia kudriavzevii Species 0.000 description 1
• 241000218633 Pinidae Species 0.000 description 1
• 241000305299 Pithomyces Species 0.000 description 1
• 206010035226 Plasma cell myeloma Diseases 0.000 description 1
• 241000224016 Plasmodium Species 0.000 description 1
• 241000223960 Plasmodium falciparum Species 0.000 description 1
• 241000223821 Plasmodium malariae Species 0.000 description 1
• 206010035501 Plasmodium malariae infection Diseases 0.000 description 1
• 206010035502 Plasmodium ovale infection Diseases 0.000 description 1
• 206010035503 Plasmodium vivax infection Diseases 0.000 description 1
• 241000209464 Platanaceae Species 0.000 description 1
• 241000209466 Platanus Species 0.000 description 1
• 244000268528 Platanus occidentalis Species 0.000 description 1
• 235000006485 Platanus occidentalis Nutrition 0.000 description 1
• 241001492488 Pleistophora Species 0.000 description 1
• 241000233872 Pneumocystis carinii Species 0.000 description 1
• 206010035717 Pneumonia klebsiella Diseases 0.000 description 1
• 241000711902 Pneumovirus Species 0.000 description 1
• 241000209048 Poa Species 0.000 description 1
• 241001536628 Poales Species 0.000 description 1
• 229920012266 Poly(ether sulfone) PES Polymers 0.000 description 1
• 108091036407 Polyadenylation Proteins 0.000 description 1
• 102000015623 Polynucleotide Adenylyltransferase Human genes 0.000 description 1
• 108010024055 Polynucleotide adenylyltransferase Proteins 0.000 description 1
• 241001505332 Polyomavirus sp. Species 0.000 description 1
• 241000605862 Porphyromonas gingivalis Species 0.000 description 1
• 201000009754 Powassan encephalitis Diseases 0.000 description 1
• 241000288906 Primates Species 0.000 description 1
• 206010060862 Prostate cancer Diseases 0.000 description 1
• 102100036735 Prostate stem cell antigen Human genes 0.000 description 1
• 208000000236 Prostatic Neoplasms Diseases 0.000 description 1
• 239000004365 Protease Substances 0.000 description 1
• 101800000980 Protease nsP2 Proteins 0.000 description 1
• 102000001253 Protein Kinase Human genes 0.000 description 1
• 102100037686 Protein SSX2 Human genes 0.000 description 1
• 229930185560 Pseudouridine Natural products 0.000 description 1
• PTJWIQPHWPFNBW-UHFFFAOYSA-N Pseudouridine C Natural products OC1C(O)C(CO)OC1C1=CNC(=O)NC1=O PTJWIQPHWPFNBW-UHFFFAOYSA-N 0.000 description 1
• 241000238711 Pyroglyphidae Species 0.000 description 1
• 108010066717 Q beta Replicase Proteins 0.000 description 1
• 239000013614 RNA sample Substances 0.000 description 1
• 241000711798 Rabies lyssavirus Species 0.000 description 1
• 241000700159 Rattus Species 0.000 description 1
• 101710100968 Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 description 1
• 102100029165 Receptor-binding cancer antigen expressed on SiSo cells Human genes 0.000 description 1
• 206010038389 Renal cancer Diseases 0.000 description 1
• 208000006265 Renal cell carcinoma Diseases 0.000 description 1
• 241000702263 Reovirus sp. Species 0.000 description 1
• 101710200092 Replicase polyprotein Proteins 0.000 description 1
• 241001115394 Reston ebolavirus Species 0.000 description 1
• 241001361634 Rhizoctonia Species 0.000 description 1
• 241000235527 Rhizopus Species 0.000 description 1
• PYMYPHUHKUWMLA-LMVFSUKVSA-N Ribose Natural products OC[C@@H](O)[C@@H](O)[C@@H](O)C=O PYMYPHUHKUWMLA-LMVFSUKVSA-N 0.000 description 1
• 102100022213 Ribosome quality control complex subunit NEMF Human genes 0.000 description 1
• 241000606701 Rickettsia Species 0.000 description 1
• 241000713124 Rift Valley fever virus Species 0.000 description 1
• 241000220221 Rosales Species 0.000 description 1
• 241000710799 Rubella virus Species 0.000 description 1
• 241000710801 Rubivirus Species 0.000 description 1
• 241001533467 Rubulavirus Species 0.000 description 1
• 241000907329 Russian Spring-Summer encephalitis virus Species 0.000 description 1
• 241000315672 SARS coronavirus Species 0.000 description 1
• 241000235070 Saccharomyces Species 0.000 description 1
• 241000293026 Saksenaea Species 0.000 description 1
• 241000293871 Salmonella enterica subsp. enterica serovar Typhi Species 0.000 description 1
• 241000132889 Scedosporium Species 0.000 description 1
• 241000209056 Secale Species 0.000 description 1
• 206010040047 Sepsis Diseases 0.000 description 1
• 102100028904 Serine/threonine-protein kinase MARK2 Human genes 0.000 description 1
• 241000872198 Serjania polyphylla Species 0.000 description 1
• 101500008203 Sindbis virus Capsid protein Proteins 0.000 description 1
• 241000258242 Siphonaptera Species 0.000 description 1
• 241000509413 Snow Mountain virus Species 0.000 description 1
• 101001039853 Sonchus yellow net virus Matrix protein Proteins 0.000 description 1
• 240000006394 Sorghum bicolor Species 0.000 description 1
• 235000011684 Sorghum saccharatum Nutrition 0.000 description 1
• 101710167605 Spike glycoprotein Proteins 0.000 description 1
• 241001149962 Sporothrix Species 0.000 description 1
• 241001149963 Sporothrix schenckii Species 0.000 description 1
• 241000713675 Spumavirus Species 0.000 description 1
• 241000710888 St. Louis encephalitis virus Species 0.000 description 1
• 241000191940 Staphylococcus Species 0.000 description 1
• 241000191967 Staphylococcus aureus Species 0.000 description 1
• 241001147691 Staphylococcus saprophyticus Species 0.000 description 1
• 240000006694 Stellaria media Species 0.000 description 1
• 208000005718 Stomach Neoplasms Diseases 0.000 description 1
• 241000193985 Streptococcus agalactiae Species 0.000 description 1
• 241000193998 Streptococcus pneumoniae Species 0.000 description 1
• 241000193996 Streptococcus pyogenes Species 0.000 description 1
• 241001115376 Sudan ebolavirus Species 0.000 description 1
• 241000282887 Suidae Species 0.000 description 1
• 102000019197 Superoxide Dismutase Human genes 0.000 description 1
• 108010012715 Superoxide dismutase Proteins 0.000 description 1
• 101800001271 Surface protein Proteins 0.000 description 1
• 230000024932 T cell mediated immunity Effects 0.000 description 1
• 230000005867 T cell response Effects 0.000 description 1
• 208000027585 T-cell non-Hodgkin lymphoma Diseases 0.000 description 1
• 101710137500 T7 RNA polymerase Proteins 0.000 description 1
• 101150031162 TM4SF1 gene Proteins 0.000 description 1
• 108010017842 Telomerase Proteins 0.000 description 1
• 108010060752 Toll-Like Receptor 8 Proteins 0.000 description 1
• 102100024333 Toll-like receptor 2 Human genes 0.000 description 1
• 102000008230 Toll-like receptor 3 Human genes 0.000 description 1
• 108010060885 Toll-like receptor 3 Proteins 0.000 description 1
• 102100039360 Toll-like receptor 4 Human genes 0.000 description 1
• 241000223997 Toxoplasma gondii Species 0.000 description 1
• 241001249162 Trachipleistophora Species 0.000 description 1
• 102100034902 Transmembrane 4 L6 family member 1 Human genes 0.000 description 1
• 241000589884 Treponema pallidum Species 0.000 description 1
• 241000893963 Trichophyton concentricum Species 0.000 description 1
• 241000893962 Trichophyton equinum Species 0.000 description 1
• 241001045770 Trichophyton mentagrophytes Species 0.000 description 1
• 241001609979 Trichophyton quinckeanum Species 0.000 description 1
• 241000223229 Trichophyton rubrum Species 0.000 description 1
• 241001480048 Trichophyton tonsurans Species 0.000 description 1
• 241001480050 Trichophyton violaceum Species 0.000 description 1
• 241000223231 Trichosporon beigelii Species 0.000 description 1
• 102000005924 Triose-Phosphate Isomerase Human genes 0.000 description 1
• 108700015934 Triose-phosphate isomerases Proteins 0.000 description 1
• 239000007983 Tris buffer Substances 0.000 description 1
• 108010073429 Type V Secretion Systems Proteins 0.000 description 1
• 241000132125 Tyrophagus Species 0.000 description 1
• 241000261594 Tyrophagus longior Species 0.000 description 1
• 102000003425 Tyrosinase Human genes 0.000 description 1
• 108060008724 Tyrosinase Proteins 0.000 description 1
• 102100040099 U3 small nucleolar RNA-associated protein 14 homolog A Human genes 0.000 description 1
• 108010046334 Urease Proteins 0.000 description 1
• 206010046865 Vaccinia virus infection Diseases 0.000 description 1
• 241000870995 Variola Species 0.000 description 1
• 241000256856 Vespidae Species 0.000 description 1
• 241000607626 Vibrio cholerae Species 0.000 description 1
• 206010051511 Viral diarrhoea Diseases 0.000 description 1
• 241000144556 Vittaforma Species 0.000 description 1
• 201000006449 West Nile encephalitis Diseases 0.000 description 1
• JCZSFCLRSONYLH-UHFFFAOYSA-N Wyosine Natural products N=1C(C)=CN(C(C=2N=C3)=O)C=1N(C)C=2N3C1OC(CO)C(O)C1O JCZSFCLRSONYLH-UHFFFAOYSA-N 0.000 description 1
• 241000710772 Yellow fever virus Species 0.000 description 1
• 241000607447 Yersinia enterocolitica Species 0.000 description 1
• 241000607479 Yersinia pestis Species 0.000 description 1
• 241001115400 Zaire ebolavirus Species 0.000 description 1
• TVGUROHJABCRTB-MHJQXXNXSA-N [(2r,3s,4r,5s)-5-[(2r,3r,4r,5r)-2-(2-amino-6-oxo-3h-purin-9-yl)-4-hydroxy-5-(hydroxymethyl)oxolan-3-yl]oxy-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate Chemical compound O([C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C=NC=2C(=O)N=C(NC=21)N)[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O TVGUROHJABCRTB-MHJQXXNXSA-N 0.000 description 1
• 241000606834 [Haemophilus] ducreyi Species 0.000 description 1
• PQIHYNWPAJABTB-QCNRFFRDSA-N [O-]S(CCNC[S+]=C(N1)N([C@@H]([C@@H]2O)O[C@H](CO)[C@H]2O)C=CC1=O)(=O)=O Chemical compound [O-]S(CCNC[S+]=C(N1)N([C@@H]([C@@H]2O)O[C@H](CO)[C@H]2O)C=CC1=O)(=O)=O PQIHYNWPAJABTB-QCNRFFRDSA-N 0.000 description 1
• 238000007259 addition reaction Methods 0.000 description 1
• 229960005305 adenosine Drugs 0.000 description 1
• 238000000246 agarose gel electrophoresis Methods 0.000 description 1
• HMFHBZSHGGEWLO-UHFFFAOYSA-N alpha-D-Furanose-Ribose Natural products OCC1OC(O)C(O)C1O HMFHBZSHGGEWLO-UHFFFAOYSA-N 0.000 description 1
• 102000013529 alpha-Fetoproteins Human genes 0.000 description 1
• 108010026331 alpha-Fetoproteins Proteins 0.000 description 1
• WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 1
• 229910021502 aluminium hydroxide Inorganic materials 0.000 description 1
• 125000003277 amino group Chemical group 0.000 description 1
• 125000004103 aminoalkyl group Chemical group 0.000 description 1
• 150000003863 ammonium salts Chemical class 0.000 description 1
• 230000003321 amplification Effects 0.000 description 1
• 238000000540 analysis of variance Methods 0.000 description 1
• 230000006907 apoptotic process Effects 0.000 description 1
• 238000013459 approach Methods 0.000 description 1
• 239000012062 aqueous buffer Substances 0.000 description 1
• PEMQXWCOMFJRLS-RPKMEZRRSA-N archaeosine Chemical compound C1=2NC(N)=NC(=O)C=2C(C(=N)N)=CN1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O PEMQXWCOMFJRLS-RPKMEZRRSA-N 0.000 description 1
• 229940091771 aspergillus fumigatus Drugs 0.000 description 1
• 230000002238 attenuated effect Effects 0.000 description 1
• 229940065181 bacillus anthracis Drugs 0.000 description 1
• 108010028263 bacteriophage T3 RNA polymerase Proteins 0.000 description 1
• 102000007478 beta-N-Acetylhexosaminidases Human genes 0.000 description 1
• 108010085377 beta-N-Acetylhexosaminidases Proteins 0.000 description 1
• WGDUUQDYDIIBKT-UHFFFAOYSA-N beta-Pseudouridine Natural products OC1OC(CN2C=CC(=O)NC2=O)C(O)C1O WGDUUQDYDIIBKT-UHFFFAOYSA-N 0.000 description 1
• 210000001185 bone marrow Anatomy 0.000 description 1
• 208000008921 border disease Diseases 0.000 description 1
• 206010006451 bronchitis Diseases 0.000 description 1
• 229940056450 brucella abortus Drugs 0.000 description 1
• 239000000337 buffer salt Substances 0.000 description 1
• 230000003139 buffering effect Effects 0.000 description 1
• PPBOKXIGFIBOGK-BDTUAEFFSA-N bvdv Chemical compound C([C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)C(C)C)[C@@H](C)CC)C1=CN=CN1 PPBOKXIGFIBOGK-BDTUAEFFSA-N 0.000 description 1
• 244000309466 calf Species 0.000 description 1
• 201000011510 cancer Diseases 0.000 description 1
• 229940095731 candida albicans Drugs 0.000 description 1
• 150000001720 carbohydrates Chemical class 0.000 description 1
• 230000003197 catalytic effect Effects 0.000 description 1
• 150000001768 cations Chemical class 0.000 description 1
• AOXOCDRNSPFDPE-UKEONUMOSA-N chembl413654 Chemical compound C([C@H](C(=O)NCC(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC=1C=CC=CC=1)C(N)=O)NC(=O)[C@@H](C)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H]1N(CCC1)C(=O)CNC(=O)[C@@H](N)CCC(O)=O)C1=CC=C(O)C=C1 AOXOCDRNSPFDPE-UKEONUMOSA-N 0.000 description 1
• 239000003153 chemical reaction reagent Substances 0.000 description 1
• 229940038705 chlamydia trachomatis Drugs 0.000 description 1
• 150000001860 citric acid derivatives Chemical class 0.000 description 1
• 238000003776 cleavage reaction Methods 0.000 description 1
• 238000011260 co-administration Methods 0.000 description 1
• 210000001072 colon Anatomy 0.000 description 1
• 238000007796 conventional method Methods 0.000 description 1
• 230000016396 cytokine production Effects 0.000 description 1
• 230000002950 deficient Effects 0.000 description 1
• 238000012217 deletion Methods 0.000 description 1
• 230000037430 deletion Effects 0.000 description 1
• 210000004443 dendritic cell Anatomy 0.000 description 1
• 208000025729 dengue disease Diseases 0.000 description 1
• 239000007933 dermal patch Substances 0.000 description 1
• 238000001514 detection method Methods 0.000 description 1
• 239000010432 diamond Substances 0.000 description 1
• 230000004069 differentiation Effects 0.000 description 1
• ZPTBLXKRQACLCR-XVFCMESISA-N dihydrouridine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)CC1 ZPTBLXKRQACLCR-XVFCMESISA-N 0.000 description 1
• 238000007865 diluting Methods 0.000 description 1
• 239000013024 dilution buffer Substances 0.000 description 1
• 206010013023 diphtheria Diseases 0.000 description 1
• 229960003983 diphtheria toxoid Drugs 0.000 description 1
• LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 1
• HJKTUGMLMSMABY-UHFFFAOYSA-L disodium 3-carboxy-3,5-dihydroxy-5-oxopentanoate acetate Chemical compound C(CC(O)(C(=O)O)CC(=O)[O-])(=O)[O-].[Na+].[Na+].C(C)(=O)O HJKTUGMLMSMABY-UHFFFAOYSA-L 0.000 description 1
• 231100000673 dose–response relationship Toxicity 0.000 description 1
• 238000002296 dynamic light scattering Methods 0.000 description 1
• 239000008393 encapsulating agent Substances 0.000 description 1
• 239000002158 endotoxin Substances 0.000 description 1
• 238000012407 engineering method Methods 0.000 description 1
• 229940032049 enterococcus faecalis Drugs 0.000 description 1
• 230000000688 enterotoxigenic effect Effects 0.000 description 1
• 210000002615 epidermis Anatomy 0.000 description 1
• 210000002919 epithelial cell Anatomy 0.000 description 1
• RRCFLRBBBFZLSB-XIFYLAFSSA-N epoxyqueuosine Chemical compound C1=C(CN[C@@H]2[C@H]([C@@H](O)[C@@H]3O[C@@H]32)O)C=2C(=O)NC(N)=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O RRCFLRBBBFZLSB-XIFYLAFSSA-N 0.000 description 1
• 101150016690 esxA gene Proteins 0.000 description 1
• 101150079015 esxB gene Proteins 0.000 description 1
• DEFVIWRASFVYLL-UHFFFAOYSA-N ethylene glycol bis(2-aminoethyl)tetraacetic acid Chemical compound OC(=O)CN(CC(O)=O)CCOCCOCCN(CC(O)=O)CC(O)=O DEFVIWRASFVYLL-UHFFFAOYSA-N 0.000 description 1
• 230000005284 excitation Effects 0.000 description 1
• 230000002349 favourable effect Effects 0.000 description 1
• XRECTZIEBJDKEO-UHFFFAOYSA-N flucytosine Chemical compound NC1=NC(=O)NC=C1F XRECTZIEBJDKEO-UHFFFAOYSA-N 0.000 description 1
• 229960004413 flucytosine Drugs 0.000 description 1
• 239000007850 fluorescent dye Substances 0.000 description 1
• 229960002949 fluorouracil Drugs 0.000 description 1
• 239000013568 food allergen Substances 0.000 description 1
• 238000013467 fragmentation Methods 0.000 description 1
• 238000006062 fragmentation reaction Methods 0.000 description 1
• 108020001507 fusion proteins Proteins 0.000 description 1
• 102000037865 fusion proteins Human genes 0.000 description 1
• 206010017758 gastric cancer Diseases 0.000 description 1
• 230000002496 gastric effect Effects 0.000 description 1
• 210000001035 gastrointestinal tract Anatomy 0.000 description 1
• 230000002068 genetic effect Effects 0.000 description 1
• 150000008271 glucosaminides Chemical class 0.000 description 1
• 235000021312 gluten Nutrition 0.000 description 1
• PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
• 239000010931 gold Substances 0.000 description 1
• 229910052737 gold Inorganic materials 0.000 description 1
• 239000013574 grass pollen allergen Substances 0.000 description 1
• 229940029575 guanosine Drugs 0.000 description 1
• 239000010440 gypsum Substances 0.000 description 1
• 229910052602 gypsum Inorganic materials 0.000 description 1
• 229940037467 helicobacter pylori Drugs 0.000 description 1
• 239000003228 hemolysin Substances 0.000 description 1
• 208000006454 hepatitis Diseases 0.000 description 1
• 231100000283 hepatitis Toxicity 0.000 description 1
• 208000002672 hepatitis B Diseases 0.000 description 1
• 206010073071 hepatocellular carcinoma Diseases 0.000 description 1
• HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
• 229940046533 house dust mites Drugs 0.000 description 1
• 230000007062 hydrolysis Effects 0.000 description 1
• 238000006460 hydrolysis reaction Methods 0.000 description 1
• 230000001900 immune effect Effects 0.000 description 1
• 210000000987 immune system Anatomy 0.000 description 1
• 230000000091 immunopotentiator Effects 0.000 description 1
• 230000001939 inductive effect Effects 0.000 description 1
• 206010022000 influenza Diseases 0.000 description 1
• 230000000977 initiatory effect Effects 0.000 description 1
• 230000017730 intein-mediated protein splicing Effects 0.000 description 1
• 229940047124 interferons Drugs 0.000 description 1
• 230000003834 intracellular effect Effects 0.000 description 1
• 150000002500 ions Chemical class 0.000 description 1
• 229910052742 iron Inorganic materials 0.000 description 1
• 201000010982 kidney cancer Diseases 0.000 description 1
• 229940115932 legionella pneumophila Drugs 0.000 description 1
• 208000032839 leukemia Diseases 0.000 description 1
• 230000021633 leukocyte mediated immunity Effects 0.000 description 1
• 239000003446 ligand Substances 0.000 description 1
• 239000007788 liquid Substances 0.000 description 1
• 201000004792 malaria Diseases 0.000 description 1
• 239000000463 material Substances 0.000 description 1
• 239000011159 matrix material Substances 0.000 description 1
• HLZXTFWTDIBXDF-UHFFFAOYSA-N mcm5sU Natural products COC(=O)Cc1cn(C2OC(CO)C(O)C2O)c(=S)[nH]c1=O HLZXTFWTDIBXDF-UHFFFAOYSA-N 0.000 description 1
• 230000010534 mechanism of action Effects 0.000 description 1
• 230000001404 mediated effect Effects 0.000 description 1
• 108020004999 messenger RNA Proteins 0.000 description 1
• 229910021645 metal ion Inorganic materials 0.000 description 1
• 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 1
• GWKIZNPISGBQGY-GNLDREGESA-N methyl (2S)-4-[4,6-dimethyl-9-oxo-3-[(2R,3R,4S,5R)-2,3,4-trihydroxy-5-(hydroxymethyl)oxolan-2-yl]imidazo[1,2-a]purin-7-yl]-2-(methoxycarbonylamino)butanoate Chemical class O[C@@]1([C@H](O)[C@H](O)[C@@H](CO)O1)N1C=NC=2C(=O)N3C(CC[C@@H](C(=O)OC)NC(=O)OC)=C(C)N=C3N(C)C21 GWKIZNPISGBQGY-GNLDREGESA-N 0.000 description 1
• XOTXNXXJZCFUOA-UGKPPGOTSA-N methyl 2-[1-[(2r,3r,4r,5r)-4-hydroxy-5-(hydroxymethyl)-3-methoxyoxolan-2-yl]-2,4-dioxopyrimidin-5-yl]acetate Chemical compound CO[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(CC(=O)OC)=C1 XOTXNXXJZCFUOA-UGKPPGOTSA-N 0.000 description 1
• JNVLKTZUCGRYNN-LQGIRWEJSA-N methyl 2-[1-[(2r,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-2,4-dioxopyrimidin-5-yl]-2-hydroxyacetate Chemical compound O=C1NC(=O)C(C(O)C(=O)OC)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 JNVLKTZUCGRYNN-LQGIRWEJSA-N 0.000 description 1
• WCNMEQDMUYVWMJ-UHFFFAOYSA-N methyl 4-[3-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4,6-dimethyl-9-oxoimidazo[1,2-a]purin-7-yl]-3-hydroperoxy-2-(methoxycarbonylamino)butanoate Chemical compound C1=NC=2C(=O)N3C(CC(C(NC(=O)OC)C(=O)OC)OO)=C(C)N=C3N(C)C=2N1C1OC(CO)C(O)C1O WCNMEQDMUYVWMJ-UHFFFAOYSA-N 0.000 description 1
• WZRYXYRWFAPPBJ-PNHWDRBUSA-N methyl uridin-5-yloxyacetate Chemical compound O=C1NC(=O)C(OCC(=O)OC)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 WZRYXYRWFAPPBJ-PNHWDRBUSA-N 0.000 description 1
• YACKEPLHDIMKIO-UHFFFAOYSA-N methylphosphonic acid Chemical compound CP(O)(O)=O YACKEPLHDIMKIO-UHFFFAOYSA-N 0.000 description 1
• 239000004005 microsphere Substances 0.000 description 1
• 101150084874 mimG gene Proteins 0.000 description 1
• 230000004048 modification Effects 0.000 description 1
• 238000012986 modification Methods 0.000 description 1
• 230000035772 mutation Effects 0.000 description 1
• 201000000050 myeloid neoplasm Diseases 0.000 description 1
• KHGRPHJXYWLEFQ-HKTUAWPASA-N n,n-dimethyl-2,3-bis[(9z,12z,15z)-octadeca-9,12,15-trienoxy]propan-1-amine Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCCOCC(CN(C)C)OCCCCCCCC\C=C/C\C=C/C\C=C/CC KHGRPHJXYWLEFQ-HKTUAWPASA-N 0.000 description 1
• PUPNJSIFIXXJCH-UHFFFAOYSA-N n-(4-hydroxyphenyl)-2-(1,1,3-trioxo-1,2-benzothiazol-2-yl)acetamide Chemical compound C1=CC(O)=CC=C1NC(=O)CN1S(=O)(=O)C2=CC=CC=C2C1=O PUPNJSIFIXXJCH-UHFFFAOYSA-N 0.000 description 1
• AEMBWNDIEFEPTH-UHFFFAOYSA-N n-tert-butyl-n-ethylnitrous amide Chemical compound CCN(N=O)C(C)(C)C AEMBWNDIEFEPTH-UHFFFAOYSA-N 0.000 description 1
• 239000007908 nanoemulsion Substances 0.000 description 1
• 229910052757 nitrogen Inorganic materials 0.000 description 1
• 208000002154 non-small cell lung carcinoma Diseases 0.000 description 1
• 238000003199 nucleic acid amplification method Methods 0.000 description 1
• 229940023146 nucleic acid vaccine Drugs 0.000 description 1
• 125000003835 nucleoside group Chemical group 0.000 description 1
• 229920002113 octoxynol Polymers 0.000 description 1
• 230000006320 pegylation Effects 0.000 description 1
• 229960003330 pentetic acid Drugs 0.000 description 1
• 108010021711 pertactin Proteins 0.000 description 1
• 229960005323 phenoxyethanol Drugs 0.000 description 1
• 239000008363 phosphate buffer Substances 0.000 description 1
• PTMHPRAIXMAOOB-UHFFFAOYSA-L phosphoramidate Chemical compound NP([O-])([O-])=O PTMHPRAIXMAOOB-UHFFFAOYSA-L 0.000 description 1
• 230000035479 physiological effects, processes and functions Effects 0.000 description 1
• 208000030773 pneumonia caused by chlamydia Diseases 0.000 description 1
• 229920001481 poly(stearyl methacrylate) Polymers 0.000 description 1
• 239000013641 positive control Substances 0.000 description 1
• 230000003389 potentiating effect Effects 0.000 description 1
• 238000002360 preparation method Methods 0.000 description 1
• 239000003755 preservative agent Substances 0.000 description 1
• 230000002265 prevention Effects 0.000 description 1
• 230000000644 propagated effect Effects 0.000 description 1
• 210000002307 prostate Anatomy 0.000 description 1
• 235000019833 protease Nutrition 0.000 description 1
• 235000019419 proteases Nutrition 0.000 description 1
• 108060006633 protein kinase Proteins 0.000 description 1
• PTJWIQPHWPFNBW-GBNDHIKLSA-N pseudouridine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1C1=CNC(=O)NC1=O PTJWIQPHWPFNBW-GBNDHIKLSA-N 0.000 description 1
• PSHHQIGKVLIVBD-UHFFFAOYSA-N purine-2,4-diamine Chemical class C1=NC(N)=NC2(N)N=CN=C21 PSHHQIGKVLIVBD-UHFFFAOYSA-N 0.000 description 1
• 150000003230 pyrimidines Chemical class 0.000 description 1
• 230000001698 pyrogenic effect Effects 0.000 description 1
• QQXQGKSPIMGUIZ-AEZJAUAXSA-N queuosine Chemical compound C1=2C(=O)NC(N)=NC=2N([C@H]2[C@@H]([C@H](O)[C@@H](CO)O2)O)C=C1CN[C@H]1C=C[C@H](O)[C@@H]1O QQXQGKSPIMGUIZ-AEZJAUAXSA-N 0.000 description 1
• 108010014186 ras Proteins Proteins 0.000 description 1
• 108091008146 restriction endonucleases Proteins 0.000 description 1
• 238000010839 reverse transcription Methods 0.000 description 1
• 108020004418 ribosomal RNA Proteins 0.000 description 1
• 210000003705 ribosome Anatomy 0.000 description 1
• 125000000548 ribosyl group Chemical group C1([C@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 1
• DWRXFEITVBNRMK-JXOAFFINSA-N ribothymidine Chemical compound O=C1NC(=O)C(C)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 DWRXFEITVBNRMK-JXOAFFINSA-N 0.000 description 1
• 229960002181 saccharomyces boulardii Drugs 0.000 description 1
• 210000003296 saliva Anatomy 0.000 description 1
• 230000007017 scission Effects 0.000 description 1
• 230000028327 secretion Effects 0.000 description 1
• 230000011664 signaling Effects 0.000 description 1
• 150000003384 small molecules Chemical class 0.000 description 1
• 239000001488 sodium phosphate Substances 0.000 description 1
• 229910000162 sodium phosphate Inorganic materials 0.000 description 1
• 159000000000 sodium salts Chemical class 0.000 description 1
• 238000001179 sorption measurement Methods 0.000 description 1
• 201000011549 stomach cancer Diseases 0.000 description 1
• 238000003860 storage Methods 0.000 description 1
• 229940031000 streptococcus pneumoniae Drugs 0.000 description 1
• 239000008362 succinate buffer Substances 0.000 description 1
• 239000000725 suspension Substances 0.000 description 1
• 101150047061 tag-72 gene Proteins 0.000 description 1
• 229960000814 tetanus toxoid Drugs 0.000 description 1
• RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
• 229960004906 thiomersal Drugs 0.000 description 1
• RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 description 1
• 210000001541 thymus gland Anatomy 0.000 description 1
• 229960003087 tioguanine Drugs 0.000 description 1
• 229940044655 toll-like receptor 9 agonist Drugs 0.000 description 1
• 230000000699 topical effect Effects 0.000 description 1
• 239000003053 toxin Substances 0.000 description 1
• 231100000765 toxin Toxicity 0.000 description 1
• 108700012359 toxins Proteins 0.000 description 1
• 238000001890 transfection Methods 0.000 description 1
• 108010020589 trehalose-6-phosphate synthase Proteins 0.000 description 1
• 229940055035 trichophyton verrucosum Drugs 0.000 description 1
• 230000001960 triggered effect Effects 0.000 description 1
• 125000002264 triphosphate group Chemical group [H]OP(=O)(O[H])OP(=O)(O[H])OP(=O)(O[H])O* 0.000 description 1
• UNXRWKVEANCORM-UHFFFAOYSA-N triphosphoric acid Chemical compound OP(O)(=O)OP(O)(=O)OP(O)(O)=O UNXRWKVEANCORM-UHFFFAOYSA-N 0.000 description 1
• LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
• RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
• 241001430294 unidentified retrovirus Species 0.000 description 1
• RVCNQQGZJWVLIP-VPCXQMTMSA-N uridin-5-yloxyacetic acid Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(OCC(O)=O)=C1 RVCNQQGZJWVLIP-VPCXQMTMSA-N 0.000 description 1
• YIZYCHKPHCPKHZ-UHFFFAOYSA-N uridine-5-acetic acid methyl ester Natural products COC(=O)Cc1cn(C2OC(CO)C(O)C2O)c(=O)[nH]c1=O YIZYCHKPHCPKHZ-UHFFFAOYSA-N 0.000 description 1
• 201000005112 urinary bladder cancer Diseases 0.000 description 1
• 208000007089 vaccinia Diseases 0.000 description 1
• 201000006266 variola major Diseases 0.000 description 1
• 201000000627 variola minor Diseases 0.000 description 1
• 208000014016 variola minor infection Diseases 0.000 description 1
• 239000013603 viral vector Substances 0.000 description 1
• 238000003260 vortexing Methods 0.000 description 1
• 238000005303 weighing Methods 0.000 description 1
• QAOHCFGKCWTBGC-QHOAOGIMSA-N wybutosine Chemical compound C1=NC=2C(=O)N3C(CC[C@H](NC(=O)OC)C(=O)OC)=C(C)N=C3N(C)C=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O QAOHCFGKCWTBGC-QHOAOGIMSA-N 0.000 description 1
• QAOHCFGKCWTBGC-UHFFFAOYSA-N wybutosine Natural products C1=NC=2C(=O)N3C(CCC(NC(=O)OC)C(=O)OC)=C(C)N=C3N(C)C=2N1C1OC(CO)C(O)C1O QAOHCFGKCWTBGC-UHFFFAOYSA-N 0.000 description 1
• JCZSFCLRSONYLH-QYVSTXNMSA-N wyosin Chemical compound N=1C(C)=CN(C(C=2N=C3)=O)C=1N(C)C=2N3[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O JCZSFCLRSONYLH-QYVSTXNMSA-N 0.000 description 1
• 229940051021 yellow-fever virus Drugs 0.000 description 1
• 229940098232 yersinia enterocolitica Drugs 0.000 description 1