NZ504725A - Flavivirus expression and delivery system - Google Patents
Flavivirus expression and delivery systemInfo
- Publication number
- NZ504725A NZ504725A NZ504725A NZ50472598A NZ504725A NZ 504725 A NZ504725 A NZ 504725A NZ 504725 A NZ504725 A NZ 504725A NZ 50472598 A NZ50472598 A NZ 50472598A NZ 504725 A NZ504725 A NZ 504725A
- Authority
- NZ
- New Zealand
- Prior art keywords
- flavivirus
- vector
- self
- replicating
- utr
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
- C12N2770/24141—Use of virus, viral particle or viral elements as a vector
- C12N2770/24143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/60—Vector systems having a special element relevant for transcription from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
- C12N2830/85—Vector systems having a special element relevant for transcription from vertebrates mammalian
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
- C12N2840/203—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
A gene expression system comprising: a) a self-replicating expression vector of flavivirus origin which includes the flavivirus 5' untranslated region (UTR), at least a portion of the 5' coding region for flavivirus core protein, the nucleotide sequence coding for the flavivirus non-structural proteins, and the complete or most of the 3'-terminal sequence of the flavivirus 3'UTR, required for self-replication of flavivirus genomic material, which vector is adapted to receive at least a nucleotide sequence without disrupting its replication capabilities; and b) at least a second vector that is capable of expressing flavivirus structural protein(s) and any other proteins required for packaging of the self-replicating expression vector into flavivirus viral particles which vector is engineered to prevent recombination with the self-replicating vector when in its presence.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AUPP0627A AUPP062797A0 (en) | 1997-11-28 | 1997-11-28 | Flavivirus expression system |
AUPP6096A AUPP609698A0 (en) | 1998-09-23 | 1998-09-23 | Flavivirus expression system |
PCT/AU1998/000993 WO1999028487A1 (en) | 1997-11-28 | 1998-11-30 | Flavivirus expression and delivery system |
Publications (1)
Publication Number | Publication Date |
---|---|
NZ504725A true NZ504725A (en) | 2003-02-28 |
Family
ID=25645666
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NZ504725A NZ504725A (en) | 1997-11-28 | 1998-11-30 | Flavivirus expression and delivery system |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1034290A4 (en) |
JP (2) | JP2002500003A (en) |
CA (1) | CA2311395C (en) |
NZ (1) | NZ504725A (en) |
WO (1) | WO1999028487A1 (en) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1035205A1 (en) * | 1999-03-08 | 2000-09-13 | Stichting Dienst Landbouwkundig Onderzoek | Non-spreading pestivirus |
US6589531B1 (en) | 2000-01-21 | 2003-07-08 | The Regents Of The University Of California | Recombinant yellow fever virus and method of use thereof |
EP1195438A1 (en) * | 2000-10-06 | 2002-04-10 | Rijksuniversiteit te Groningen | Genetic immunisation against cervical carcinoma |
KR20020059856A (en) * | 2001-01-08 | 2002-07-16 | 김철중 | Preparation of hiv-like particles |
GB2372991B (en) * | 2001-03-09 | 2004-11-17 | Fiocruz Fundacao Oswaldo Cruz | Flavivirus expression vector |
WO2002072803A2 (en) | 2001-03-09 | 2002-09-19 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Subgenomic replicons of the flavivirus dengue |
FR2829149B1 (en) * | 2001-09-06 | 2004-09-24 | Pasteur Institut | NEUROVIRULENT STRAIN OF WEST NILE VIRUS AND ITS APPLICATIONS |
US7871814B2 (en) | 2001-05-10 | 2011-01-18 | The Regents Of The University Of California | Recombinant bicistronic flaviviruses and methods of use thereof |
WO2003046189A1 (en) * | 2001-11-26 | 2003-06-05 | The University Of Queensland | Flavivirus vaccine delivery system |
EP1593738A4 (en) * | 2003-01-30 | 2006-05-31 | Shanghai Tengen Biomedical Co | Virus-like particle vaccine containing dengue virus recombinant replicon as its carrier |
CN103088038B (en) * | 2004-07-12 | 2015-06-24 | 美国天甲生物医药有限公司 | Flavivirus vaccine |
BRPI0504945B8 (en) * | 2005-10-31 | 2022-08-02 | Fundacao Oswaldo Cruz | METHOD FOR PRODUCTION OF RECOMBINANT FLAVIVIRUS CONTAINING NUCLEOTIDE SEQUENCES ENCODING A HETEROLOGOUS PROTEIN, DNA CONSTRUCT, FLAVIVIRUS, AND, VACCINE COMPOSITION TO IMMUNIZE AGAINST FLAVIVIRUS AND/OR OTHER PATHOGENS. |
ZA200807544B (en) | 2006-02-27 | 2009-11-25 | Univ Texas | Pseudoinfectious flavivirus and uses thereof |
EA023888B1 (en) | 2008-03-14 | 2016-07-29 | Санофи Пастер Байолоджикс, Ллс | Replication-defective flavivirus vaccines and vaccine vectors |
ES2646669T3 (en) | 2010-07-06 | 2017-12-14 | Glaxosmithkline Biologicals Sa | Procedures for increasing an immune response by providing RNA |
EP2590626B1 (en) | 2010-07-06 | 2015-10-28 | GlaxoSmithKline Biologicals SA | Liposomes with lipids having an advantageous pka-value for rna delivery |
WO2012006369A2 (en) | 2010-07-06 | 2012-01-12 | Novartis Ag | Immunisation of large mammals with low doses of rna |
PL3981427T3 (en) | 2010-08-31 | 2022-09-19 | Glaxosmithkline Biologicals S.A. | Pegylated liposomes for delivery of immunogen-encoding rna |
TR201903651T4 (en) | 2010-10-11 | 2019-04-22 | Glaxosmithkline Biologicals Sa | Antigen application platforms. |
WO2015118146A1 (en) | 2014-02-10 | 2015-08-13 | Univercells Nv | System, apparatus and method for biomolecules production |
EP3061826A1 (en) * | 2015-02-27 | 2016-08-31 | Novartis AG | Flavivirus replicons |
-
1998
- 1998-11-30 EP EP98959672A patent/EP1034290A4/en not_active Withdrawn
- 1998-11-30 NZ NZ504725A patent/NZ504725A/en unknown
- 1998-11-30 CA CA002311395A patent/CA2311395C/en not_active Expired - Fee Related
- 1998-11-30 JP JP2000523363A patent/JP2002500003A/en active Pending
- 1998-11-30 WO PCT/AU1998/000993 patent/WO1999028487A1/en active IP Right Grant
-
2007
- 2007-12-20 JP JP2007329155A patent/JP2008113666A/en active Pending
Also Published As
Publication number | Publication date |
---|---|
WO1999028487A1 (en) | 1999-06-10 |
JP2002500003A (en) | 2002-01-08 |
EP1034290A4 (en) | 2004-09-15 |
JP2008113666A (en) | 2008-05-22 |
CA2311395A1 (en) | 1999-06-10 |
EP1034290A1 (en) | 2000-09-13 |
CA2311395C (en) | 2006-11-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PSEA | Patent sealed | ||
RENW | Renewal (renewal fees accepted) | ||
ASS | Change of ownership |
Owner name: THE COUNCIL OF THE QUEENSLAND INSTITUTE OF MED, AU Free format text: OLD OWNER(S): THE CROWN IN THE RIGHT OF THE QUEENSLAND DEPARTMENT OF HEALTH |
|
RENW | Renewal (renewal fees accepted) | ||
ASS | Change of ownership |
Owner name: REPLIKUN BIOTECH PTY LTD, AU Free format text: OLD OWNER(S): THE COUNCIL OF THE QUEENSLAND INSTITUTE OF MEDICAL RESEARCH |
|
RENW | Renewal (renewal fees accepted) |