HRP20130194T1 - Imunosupresivni polipeptidi i nukleinske kiseline - Google Patents
Imunosupresivni polipeptidi i nukleinske kiseline Download PDFInfo
- Publication number
- HRP20130194T1 HRP20130194T1 HRP20130194AT HRP20130194T HRP20130194T1 HR P20130194 T1 HRP20130194 T1 HR P20130194T1 HR P20130194A T HRP20130194A T HR P20130194AT HR P20130194 T HRP20130194 T HR P20130194T HR P20130194 T1 HRP20130194 T1 HR P20130194T1
- Authority
- HR
- Croatia
- Prior art keywords
- polypeptide
- fusion protein
- dimeric
- seq
- lea29y
- Prior art date
Links
- 229920001184 polypeptide Polymers 0.000 title claims 42
- 108090000765 processed proteins & peptides Proteins 0.000 title claims 42
- 102000004196 processed proteins & peptides Human genes 0.000 title claims 42
- 102000039446 nucleic acids Human genes 0.000 title claims 7
- 108020004707 nucleic acids Proteins 0.000 title claims 7
- 150000007523 nucleic acids Chemical class 0.000 title claims 7
- 230000001506 immunosuppresive effect Effects 0.000 title 1
- 102000037865 fusion proteins Human genes 0.000 claims 32
- 108020001507 fusion proteins Proteins 0.000 claims 32
- 125000000539 amino acid group Chemical group 0.000 claims 7
- 230000028993 immune response Effects 0.000 claims 7
- 241000124008 Mammalia Species 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 239000000539 dimer Substances 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 210000000987 immune system Anatomy 0.000 claims 2
- 210000000056 organ Anatomy 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 239000000825 pharmaceutical preparation Substances 0.000 claims 2
- 102000040430 polynucleotide Human genes 0.000 claims 2
- 108091033319 polynucleotide Proteins 0.000 claims 2
- 239000002157 polynucleotide Substances 0.000 claims 2
- 230000000069 prophylactic effect Effects 0.000 claims 2
- 230000001225 therapeutic effect Effects 0.000 claims 2
- 101000914484 Homo sapiens T-lymphocyte activation antigen CD80 Proteins 0.000 claims 1
- 101000946850 Homo sapiens T-lymphocyte activation antigen CD86 Proteins 0.000 claims 1
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 claims 1
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 claims 1
- 230000000295 complement effect Effects 0.000 claims 1
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 102000054189 human CD80 Human genes 0.000 claims 1
- 102000049849 human CD86 Human genes 0.000 claims 1
- 238000002955 isolation Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70521—CD28, CD152
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Transplantation (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Claims (18)
1. Izolirani ili rekombinantni polipeptid koji sadrži polipeptidnu sekvencu koja se razlikuje od SEQ ID NO:36 u ne više od 6 aminokiselinskih ostataka i koja uključuje ostatke na položajima 24, 30, 32, 41, 50, 54, 55, 56, 64, 65, 70, 85, 104 i 106 koji su identični sa aminokiselinskim ostatcima na odgovarajućim položajima u SEQ ID NO:36, naznačen time da polipeptid veže humani CD80 ili humani CD86 ili izvanstaničnu domenu bilo kojeg od njih i ima sposobnost inhibicije imunološkog odgovora koja je veća od sposobnosti inhibicije imunološkog odgovora polipeptida LEA29Y koji sadrži polipeptidnu sekvencu koja je prikazana u SEQ ID NO:168.
2. Polipeptid prema zahtjevu 1, naznačen time da se polipeptid razlikuje od SEQ ID NO:36 u ne više od 1, 2, 3, 4, ili 5 aminokiselinskih ostataka.
3. Polipeptid prema zahtjevu 1, naznačen time da polipeptid sadrži polipeptidnu sekvencu koja je prikazana u SEQ ID NO:36.
4. Izolirani ili rekombinantni dimerni polipeptid koji sadrži dva polipeptida prema bilo kojem od zahtjeva 1-3, naznačen time da dimer ima veću sposobnost za suzbijanje imunološkog odgovora nego dimer koji sadrži dva polipeptida LEA29Y, pri čemu svaki polipeptid LEA29Y sadrži polipeptidnu sekvencu koja je prikazana u SEQ ID NO:168.
5. Polipeptid prema zahtjevu 1, koji je izolirani ili rekombinantni fuzijski protein naznačen time da sadrži (a) polipeptid koji sadrži polipeptidnu sekvencu koja se razlikuje od SEQ ID NO:36 u ne više od 6 aminokiselinskih ostataka i sadrži ostatke na položajima 24, 30, 32, 41, 50, 54, 55, 56, 64, 65, 70, 85, 104 i 106 koji su identični aminokiselinskim ostatcima na odgovarajućim položajima u SEQ ID NO:36 i (b) drugi polipeptid, pri čemu je drugi polipeptid Ig Fc polipeptid, te pri čemu fuzijski protein ima veću sposobnost za suzbijanje imunološkog odgovora nego LEA29Y-Ig fuzijski protein, pri čemu LEA29Y-Ig fuzijski protein sadrži polipeptidnu sekvencu prema SEQ ID NO:166.
6. Fuzijski protein prema zahtjevu 5, naznačen time da fuzijski protein sadrži polipeptidnu sekvencu koja je prikazana u SEQ ID NO:197 ili 211.
7. Dimerni polipeptid prema zahtjevu 4, koji je izolirani ili rekombinantni dimerni fuzijski protein koji sadrži dva monomerna fuzijska proteina povezana preko barem jedne disulfidne veze koja je formirana između dva cisteinska ostatka koji se nalaze u svakom monomernom mutiranom fuzijskom proteinu, naznačen time da svaki monomerni fuzijski protein sadrži (a) polipeptid sa polipeptidnom sekvencom koja se razlikuje od SEQ ID NO:36 u ne više od 6 aminokiselinskih ostataka i koja sadrži ostatke na položajima 24, 30, 32, 41, 50, 54, 55, 56, 64, 65, 70, 85, 104 i 106 koji su identični aminokiselinskim ostatcima na odgovarajućim položajima u SEQ ID NO:36 i (b) Ig Fc polipeptid, pri čemu dimerni fuzijski protein ima veću sposobnost za suzbijanje imunološkog odgovora nego dimerni fuzijski protein LEA29Y-Ig, pri čemu dimerni fuzijski protein LEA29Y-Ig sadrži dva monomerna fuzijska proteina LEA29Y-Ig koji svaki sadrži polipeptidnu sekvencu prema SEQ ID NO:166.
8. Dimerni fuzijski protein prema zahtjevu 7, naznačen time da svaki monomerni fuzijski protein sadrži polipeptidnu sekvencu koja je prikazana u SEQ ID NO:197 ili 211.
9. Izolirana ili rekombinantna nukleinska kiselina naznačena time da sadrži polinukleotidnu sekvencu koja kodira polipeptid prema bilo kojem od zahtjeva 1-3, dimerni polipeptid prema zahtjevu 4, fuzijski protein prema zahtjevu 5 ili zahtjevu 6, ili dimerni fuzijski protein prema zahtjevu 7 ili zahtjevu 8, ili njihovu komplementarnu polinukleotidnu sekvencu.
10. Vektor naznačen time da sadrži nukleinsku kiselinu prema zahtjevu 9.
11. Izolirana ili rekombinantna stanica domaćin naznačena time da sadrži:
(a) polipeptid prema bilo kojem od zahtjeva 1-3;
(b) dimerni polipeptid prema zahtjevu 4;
(c) fuzijski protein prema zahtjevu 5 ili zahtjevu 6;
(d) dimerni fuzijski protein prema zahtjevu 7 ili zahtjevu 8;
(e) nukleinsku kiselinu prema zahtjevu 9; i/ili
(f) vektor prema zahtjevu 10.
12. Farmaceutski pripravak naznačen time da sadrži farmaceutski prihvatljivu pomoćnu tvar ili farmaceutski prihvatljiv nosač i jedno ili više od slijedećeg:
(a) polipeptid prema bilo kojem od zahtjeva 1-3;
(b) dimerni polipeptid prema zahtjevu 4;
(c) fuzijski protein prema zahtjevu 5 ili zahtjevu 6;
(d) dimerni fuzijski protein prema zahtjevu 7 ili zahtjevu 8;
(e) nukleinsku kiselinu prema zahtjevu 9;
(f) vektor prema zahtjevu 10; i/ili
(g) stanicu domaćina prema zahtjevu 11.
13. Farmaceutski pripravak prema zahtjevu 12, naznačen time da sadrži farmaceutski prihvatljivu pomoćnu tvar ili farmaceutski prihvatljiv nosač i dimerni fuzijski protein prema zahtjevu 8.
14. Polipeptid prema bilo kojem od zahtjeva 1-3, dimerni polipeptid prema zahtjevu 4, fuzijski protein prema zahtjevu 5 ili zahtjevu 6, dimerni fuzijski protein prema zahtjevu 7 ili zahtjevu 8, nukleinska kiselina prema zahtjevu 9, vektor prema zahtjevu 10, ili stanica prema zahtjevu 11, naznačeni time da su za uporabu za:
(i) profilaktičko ili terapijsko liječenje za sprečavanje ili suzbijanje imunološkog odgovora kod sisavca;
(ii) liječenje bolesti ili poremećaja imunološkog sustava; ili
(iii) sprječavanje odbacivanja transplantiranog tkiva ili organa kod sisavca.
15. Dimerni fuzijski protein za uporabu prema zahtjevu 14, naznačen time da dimerni fuzijski protein je dimerni fuzijski protein prema zahtjevu 8.
16. Uporaba polipeptida prema bilo kojem od zahtjeva 1-3, dimernog polipeptida prema zahtjevu 4, fuzijskog proteina prema zahtjevu 5 ili zahtjevu 6, dimernog fuzijskog proteina prema zahtjevu 7 ili zahtjevu 8, nukleinske kiseline prema zahtjevu 9, vektora prema zahtjevu 10, ili stanice prema zahtjevu 11 naznačena time da se koristi za proizvodnju lijeka za:
(i) profilaktičko ili terapijsko liječenje za sprečavanje ili suzbijanje imunološkog odgovora kod sisavca;
(ii) liječenje bolesti ili poremećaja imunološkog sustava; ili
(iii) sprječavanje odbacivanja transplantiranog tkiva ili organa kod sisavca.
17. Uporaba dimernog fuzijskog proteina prema zahtjevu 16, naznačena time da dimerni fuzijski protein je dimerni fuzijski protein prema zahtjevu 8.
18. Postupak za dobivanje polipeptida naznačen time da sadrži kultiviranje stanice domaćina prema zahtjevu 11 u kultivacijskom mediju i izolacije polipeptida koji je stanica eksprimirala.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US98463107P | 2007-11-01 | 2007-11-01 | |
| US5121508P | 2008-05-07 | 2008-05-07 | |
| PCT/US2008/079981 WO2009058564A2 (en) | 2007-11-01 | 2008-10-15 | Immunosuppressive polypeptides and nucleic acids |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20130194T1 true HRP20130194T1 (hr) | 2013-04-30 |
Family
ID=40124836
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20130194AT HRP20130194T1 (hr) | 2007-11-01 | 2013-03-05 | Imunosupresivni polipeptidi i nukleinske kiseline |
Country Status (20)
| Country | Link |
|---|---|
| US (8) | US7794718B2 (hr) |
| EP (4) | EP2385065A1 (hr) |
| JP (1) | JP5298134B2 (hr) |
| KR (1) | KR101383476B1 (hr) |
| CN (2) | CN101998965B (hr) |
| AU (1) | AU2008319053B2 (hr) |
| CA (1) | CA2703263C (hr) |
| CY (1) | CY1113713T1 (hr) |
| DK (1) | DK2222697T3 (hr) |
| ES (2) | ES2399088T3 (hr) |
| HR (1) | HRP20130194T1 (hr) |
| IL (1) | IL205036A (hr) |
| MX (1) | MX2010004883A (hr) |
| PH (1) | PH12013501101A1 (hr) |
| PL (2) | PL2612868T3 (hr) |
| PT (2) | PT2612868T (hr) |
| RU (1) | RU2506275C2 (hr) |
| TW (1) | TWI448473B (hr) |
| WO (1) | WO2009058564A2 (hr) |
| ZA (1) | ZA201002872B (hr) |
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| US20150010550A1 (en) | 2004-07-15 | 2015-01-08 | Xencor, Inc. | OPTIMIZED Fc VARIANTS |
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