HRP20100563T1 - Derivati dihidropirazolopirimidinona - Google Patents
Derivati dihidropirazolopirimidinona Download PDFInfo
- Publication number
- HRP20100563T1 HRP20100563T1 HR20100563T HRP20100563T HRP20100563T1 HR P20100563 T1 HRP20100563 T1 HR P20100563T1 HR 20100563 T HR20100563 T HR 20100563T HR P20100563 T HRP20100563 T HR P20100563T HR P20100563 T1 HRP20100563 T1 HR P20100563T1
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- Croatia
- Prior art keywords
- group
- phenyl
- dihydro
- amino
- salt
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- 150000001875 compounds Chemical class 0.000 claims abstract 25
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims abstract 20
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract 11
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract 10
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 claims abstract 8
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 claims abstract 7
- -1 vinyl-2-ylidene group Chemical group 0.000 claims abstract 7
- 125000002947 alkylene group Chemical group 0.000 claims abstract 6
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims abstract 6
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims abstract 6
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims abstract 5
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims abstract 5
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims abstract 5
- 125000001434 methanylylidene group Chemical group [H]C#[*] 0.000 claims abstract 5
- 229910052760 oxygen Inorganic materials 0.000 claims abstract 5
- 239000001301 oxygen Substances 0.000 claims abstract 5
- 125000000475 sulfinyl group Chemical group [*:2]S([*:1])=O 0.000 claims abstract 5
- 229910052717 sulfur Inorganic materials 0.000 claims abstract 5
- 239000011593 sulfur Substances 0.000 claims abstract 5
- 229910052736 halogen Inorganic materials 0.000 claims abstract 4
- 125000005843 halogen group Chemical group 0.000 claims abstract 4
- 150000002367 halogens Chemical class 0.000 claims abstract 4
- 125000004093 cyano group Chemical group *C#N 0.000 claims abstract 3
- 229910052757 nitrogen Inorganic materials 0.000 claims abstract 3
- 125000004433 nitrogen atom Chemical group N* 0.000 claims abstract 3
- 125000005678 ethenylene group Chemical group [H]C([*:1])=C([H])[*:2] 0.000 claims abstract 2
- 150000003839 salts Chemical class 0.000 claims 19
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 13
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 9
- 239000000824 cytostatic agent Substances 0.000 claims 8
- 230000001085 cytostatic effect Effects 0.000 claims 8
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims 6
- VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical class C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 claims 5
- 102000014150 Interferons Human genes 0.000 claims 4
- 108010050904 Interferons Proteins 0.000 claims 4
- 230000002152 alkylating effect Effects 0.000 claims 4
- 230000000340 anti-metabolite Effects 0.000 claims 4
- 229940100197 antimetabolite Drugs 0.000 claims 4
- 239000002256 antimetabolite Substances 0.000 claims 4
- 239000002246 antineoplastic agent Substances 0.000 claims 4
- 239000003972 antineoplastic antibiotic Substances 0.000 claims 4
- 239000003937 drug carrier Substances 0.000 claims 4
- 239000000945 filler Substances 0.000 claims 4
- 239000000367 immunologic factor Substances 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
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- 229940121358 tyrosine kinase inhibitor Drugs 0.000 claims 4
- 239000005483 tyrosine kinase inhibitor Substances 0.000 claims 4
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- 206010028980 Neoplasm Diseases 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 238000002360 preparation method Methods 0.000 claims 3
- BKWJAKQVGHWELA-UHFFFAOYSA-N 1-[6-(2-hydroxypropan-2-yl)-2-pyridinyl]-6-[4-(4-methyl-1-piperazinyl)anilino]-2-prop-2-enyl-3-pyrazolo[3,4-d]pyrimidinone Chemical compound C1CN(C)CCN1C(C=C1)=CC=C1NC1=NC=C2C(=O)N(CC=C)N(C=3N=C(C=CC=3)C(C)(C)O)C2=N1 BKWJAKQVGHWELA-UHFFFAOYSA-N 0.000 claims 2
- JMFPCAYGFUVNGO-UHFFFAOYSA-N 1-[6-(2-hydroxypropan-2-yl)pyridin-2-yl]-6-[4-(4-methylpiperazin-1-yl)anilino]-2-prop-2-ynylpyrazolo[3,4-d]pyrimidin-3-one Chemical compound C1CN(C)CCN1C(C=C1)=CC=C1NC1=NC=C2C(=O)N(CC#C)N(C=3N=C(C=CC=3)C(C)(C)O)C2=N1 JMFPCAYGFUVNGO-UHFFFAOYSA-N 0.000 claims 2
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- NWIBSHFKIJFRCO-WUDYKRTCSA-N Mytomycin Chemical compound C1N2C(C(C(C)=C(N)C3=O)=O)=C3[C@@H](COC(N)=O)[C@@]2(OC)[C@@H]2[C@H]1N2 NWIBSHFKIJFRCO-WUDYKRTCSA-N 0.000 claims 2
- GQPLMRYTRLFLPF-UHFFFAOYSA-N Nitrous Oxide Chemical compound [O-][N+]#N GQPLMRYTRLFLPF-UHFFFAOYSA-N 0.000 claims 2
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- 125000004430 oxygen atom Chemical group O* 0.000 claims 2
- 125000004076 pyridyl group Chemical group 0.000 claims 2
- 230000035945 sensitivity Effects 0.000 claims 2
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- FDKXTQMXEQVLRF-ZHACJKMWSA-N (E)-dacarbazine Chemical compound CN(C)\N=N\c1[nH]cnc1C(N)=O FDKXTQMXEQVLRF-ZHACJKMWSA-N 0.000 claims 1
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- 102100025573 1-alkyl-2-acetylglycerophosphocholine esterase Human genes 0.000 claims 1
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 claims 1
- AOJJSUZBOXZQNB-VTZDEGQISA-N 4'-epidoxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-VTZDEGQISA-N 0.000 claims 1
- CDXFYOYLEPJCGY-UHFFFAOYSA-N 6-[3-(hydroxymethyl)-4-(4-methylpiperazin-1-yl)anilino]-2-prop-2-enyl-1-pyridin-2-ylpyrazolo[3,4-d]pyrimidin-3-one Chemical compound C1CN(C)CCN1C(C(=C1)CO)=CC=C1NC1=NC=C2C(=O)N(CC=C)N(C=3N=CC=CC=3)C2=N1 CDXFYOYLEPJCGY-UHFFFAOYSA-N 0.000 claims 1
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- WLCZTRVUXYALDD-IBGZPJMESA-N 7-[[(2s)-2,6-bis(2-methoxyethoxycarbonylamino)hexanoyl]amino]heptoxy-methylphosphinic acid Chemical compound COCCOC(=O)NCCCC[C@H](NC(=O)OCCOC)C(=O)NCCCCCCCOP(C)(O)=O WLCZTRVUXYALDD-IBGZPJMESA-N 0.000 claims 1
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- GBABOYUKABKIAF-GHYRFKGUSA-N vinorelbine Chemical compound C1N(CC=2C3=CC=CC=C3NC=22)CC(CC)=C[C@H]1C[C@]2(C(=O)OC)C1=CC([C@]23[C@H]([C@]([C@H](OC(C)=O)[C@]4(CC)C=CCN([C@H]34)CC2)(O)C(=O)OC)N2C)=C2C=C1OC GBABOYUKABKIAF-GHYRFKGUSA-N 0.000 claims 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2006124208 | 2006-04-27 | ||
| PCT/JP2007/059408 WO2007126122A1 (fr) | 2006-04-27 | 2007-04-25 | Dérivés de dihydropyrazolopyrimidinones |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20100563T1 true HRP20100563T1 (hr) | 2010-11-30 |
Family
ID=38655640
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20100563T HRP20100563T1 (hr) | 2006-04-27 | 2010-10-18 | Derivati dihidropirazolopirimidinona |
| HRP20161763TT HRP20161763T1 (hr) | 2006-04-27 | 2016-12-21 | Derivati dihidropirazolopirimidinona |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20161763TT HRP20161763T1 (hr) | 2006-04-27 | 2016-12-21 | Derivati dihidropirazolopirimidinona |
Country Status (39)
| Country | Link |
|---|---|
| US (4) | US7935708B2 (fr) |
| EP (2) | EP2017278B1 (fr) |
| JP (2) | JP4513919B2 (fr) |
| KR (1) | KR101409161B1 (fr) |
| CN (1) | CN101432284B (fr) |
| AR (1) | AR060635A1 (fr) |
| AT (1) | ATE475662T1 (fr) |
| AU (1) | AU2007244185B2 (fr) |
| BR (1) | BRPI0710081A2 (fr) |
| CA (1) | CA2650119C (fr) |
| CR (1) | CR10359A (fr) |
| CY (2) | CY1111069T1 (fr) |
| DE (1) | DE602007008085D1 (fr) |
| DK (2) | DK2017278T3 (fr) |
| DO (1) | DOP2007000084A (fr) |
| EC (1) | ECSP088812A (fr) |
| ES (2) | ES2348751T3 (fr) |
| GT (1) | GT200800211A (fr) |
| HK (1) | HK1132498A1 (fr) |
| HN (1) | HN2008001532A (fr) |
| HR (2) | HRP20100563T1 (fr) |
| HU (1) | HUE032987T2 (fr) |
| IL (1) | IL194367A (fr) |
| LT (1) | LT2017278T (fr) |
| MA (1) | MA30428B1 (fr) |
| MX (1) | MX2008013063A (fr) |
| MY (1) | MY145408A (fr) |
| NO (1) | NO341617B1 (fr) |
| NZ (1) | NZ571196A (fr) |
| PE (1) | PE20080695A1 (fr) |
| PL (2) | PL2017278T3 (fr) |
| PT (2) | PT2016080E (fr) |
| RU (1) | RU2437885C2 (fr) |
| SI (2) | SI2017278T1 (fr) |
| SV (1) | SV2009003060A (fr) |
| TW (1) | TWI409262B (fr) |
| UA (1) | UA96152C2 (fr) |
| WO (2) | WO2007126128A1 (fr) |
| ZA (1) | ZA200807748B (fr) |
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2008
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2009
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