HRP20020675A2 - Indazole compounds, pharmaceutical compositions and methods for mediating or inhibiting cell poliferation - Google Patents
Indazole compounds, pharmaceutical compositions and methods for mediating or inhibiting cell poliferation Download PDFInfo
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- HRP20020675A2 HRP20020675A2 HRP20020675A HRP20020675A2 HR P20020675 A2 HRP20020675 A2 HR P20020675A2 HR P20020675 A HRP20020675 A HR P20020675A HR P20020675 A2 HRP20020675 A2 HR P20020675A2
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- 238000000034 method Methods 0.000 title claims description 126
- 230000002401 inhibitory effect Effects 0.000 title claims description 11
- 239000008194 pharmaceutical composition Substances 0.000 title claims description 5
- 125000003453 indazolyl group Chemical class N1N=C(C2=C1C=CC=C2)* 0.000 title description 3
- 150000001875 compounds Chemical class 0.000 claims description 199
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- 229910052757 nitrogen Inorganic materials 0.000 claims description 160
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- 125000000217 alkyl group Chemical group 0.000 claims description 76
- 150000003839 salts Chemical class 0.000 claims description 67
- 125000000623 heterocyclic group Chemical group 0.000 claims description 56
- 125000003118 aryl group Chemical group 0.000 claims description 54
- 125000001072 heteroaryl group Chemical group 0.000 claims description 54
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- 239000002207 metabolite Substances 0.000 claims description 48
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- 125000002813 thiocarbonyl group Chemical group *C(*)=S 0.000 description 1
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- AXZWODMDQAVCJE-UHFFFAOYSA-L tin(II) chloride (anhydrous) Chemical compound [Cl-].[Cl-].[Sn+2] AXZWODMDQAVCJE-UHFFFAOYSA-L 0.000 description 1
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- 108091008023 transcriptional regulators Proteins 0.000 description 1
- 230000016596 traversing start control point of mitotic cell cycle Effects 0.000 description 1
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- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical class [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 description 1
- 229940029284 trichlorofluoromethane Drugs 0.000 description 1
- ITMCEJHCFYSIIV-UHFFFAOYSA-M triflate Chemical compound [O-]S(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-M 0.000 description 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 description 1
- WRECIMRULFAWHA-UHFFFAOYSA-N trimethyl borate Chemical compound COB(OC)OC WRECIMRULFAWHA-UHFFFAOYSA-N 0.000 description 1
- NDYFHTUEOLNWKC-UHFFFAOYSA-N trimethyl-[2-[(5-nitro-3-phenylindazol-1-yl)methoxy]ethyl]silane Chemical compound C12=CC([N+]([O-])=O)=CC=C2N(COCC[Si](C)(C)C)N=C1C1=CC=CC=C1 NDYFHTUEOLNWKC-UHFFFAOYSA-N 0.000 description 1
- IQTXHTYNFFTVSF-UHFFFAOYSA-N trimethyl-[2-[[2-(5-pyridin-4-yl-1h-indazol-3-yl)pyrrol-1-yl]methoxy]ethyl]silane Chemical compound C[Si](C)(C)CCOCN1C=CC=C1C1=NNC2=CC=C(C=3C=CN=CC=3)C=C12 IQTXHTYNFFTVSF-UHFFFAOYSA-N 0.000 description 1
- OWKRWLSTFSEYIE-FYWRMAATSA-N trimethyl-[2-[[3-[(e)-2-phenylethenyl]-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)indazol-1-yl]methoxy]ethyl]silane Chemical compound O1C(C)(C)C(C)(C)OB1C1=CC=C(N(COCC[Si](C)(C)C)N=C2\C=C\C=3C=CC=CC=3)C2=C1 OWKRWLSTFSEYIE-FYWRMAATSA-N 0.000 description 1
- YPNYJBGYSUPHPM-FYWRMAATSA-N trimethyl-[2-[[3-[(e)-2-phenylethenyl]-5-quinolin-4-ylindazol-1-yl]methoxy]ethyl]silane Chemical compound C12=CC(C=3C4=CC=CC=C4N=CC=3)=CC=C2N(COCC[Si](C)(C)C)N=C1\C=C\C1=CC=CC=C1 YPNYJBGYSUPHPM-FYWRMAATSA-N 0.000 description 1
- MRXKEDUXQQGSPV-ZRDIBKRKSA-N trimethyl-[2-[[5-(4-methylpyridin-3-yl)-3-[(e)-2-phenylethenyl]indazol-1-yl]methoxy]ethyl]silane Chemical compound CC1=CC=NC=C1C1=CC=C(N(COCC[Si](C)(C)C)N=C2\C=C\C=3C=CC=CC=3)C2=C1 MRXKEDUXQQGSPV-ZRDIBKRKSA-N 0.000 description 1
- MGGDZIIHNHXJNA-UHFFFAOYSA-N trimethyl-[2-[[5-phenyl-3-(2-phenylethenyl)indazol-1-yl]methoxy]ethyl]silane Chemical compound C12=CC(C=3C=CC=CC=3)=CC=C2N(COCC[Si](C)(C)C)N=C1C=CC1=CC=CC=C1 MGGDZIIHNHXJNA-UHFFFAOYSA-N 0.000 description 1
- 238000001665 trituration Methods 0.000 description 1
- 230000005747 tumor angiogenesis Effects 0.000 description 1
- 230000005748 tumor development Effects 0.000 description 1
- 230000005740 tumor formation Effects 0.000 description 1
- 230000005909 tumor killing Effects 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 208000019553 vascular disease Diseases 0.000 description 1
- 238000007631 vascular surgery Methods 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 238000012800 visualization Methods 0.000 description 1
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 229940100445 wheat starch Drugs 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
- GDJZZWYLFXAGFH-UHFFFAOYSA-M xylenesulfonate group Chemical group C1(C(C=CC=C1)C)(C)S(=O)(=O)[O-] GDJZZWYLFXAGFH-UHFFFAOYSA-M 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 239000011592 zinc chloride Substances 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B22—CASTING; POWDER METALLURGY
- B22D—CASTING OF METALS; CASTING OF OTHER SUBSTANCES BY THE SAME PROCESSES OR DEVICES
- B22D41/00—Casting melt-holding vessels, e.g. ladles, tundishes, cups or the like
- B22D41/50—Pouring-nozzles
- B22D41/56—Means for supporting, manipulating or changing a pouring-nozzle
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Mechanical Engineering (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
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US17648400P | 2000-01-18 | 2000-01-18 | |
PCT/US2001/001477 WO2001053268A2 (en) | 2000-01-18 | 2001-01-18 | Indazole compounds, pharmaceutical compositions, and their use for mediating or inhibiting cell proliferation |
Publications (1)
Publication Number | Publication Date |
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HRP20020675A2 true HRP20020675A2 (en) | 2004-12-31 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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HRP20020675 HRP20020675A2 (en) | 2000-01-18 | 2002-08-16 | Indazole compounds, pharmaceutical compositions and methods for mediating or inhibiting cell poliferation |
Country Status (39)
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US (4) | US6555539B2 (et) |
EP (1) | EP1250326A2 (et) |
JP (1) | JP2003520273A (et) |
KR (1) | KR20020073505A (et) |
CN (1) | CN1394205A (et) |
AP (1) | AP1609A (et) |
AR (1) | AR032438A1 (et) |
AU (1) | AU785013B2 (et) |
BG (1) | BG107011A (et) |
BR (1) | BR0107783A (et) |
CA (1) | CA2388885A1 (et) |
CO (1) | CO5280070A1 (et) |
CR (1) | CR6630A (et) |
DO (1) | DOP2001000120A (et) |
DZ (1) | DZ3301A1 (et) |
EA (1) | EA200200768A1 (et) |
EE (1) | EE200200398A (et) |
GE (1) | GEP20043363B (et) |
GT (1) | GT200100009A (et) |
HN (1) | HN2001000007A (et) |
HR (1) | HRP20020675A2 (et) |
HU (1) | HUP0203965A3 (et) |
IL (1) | IL150730A0 (et) |
IS (1) | IS6474A (et) |
MA (1) | MA27589A1 (et) |
MX (1) | MXPA02007058A (et) |
MY (1) | MY136604A (et) |
NO (1) | NO20022117L (et) |
NZ (1) | NZ518531A (et) |
OA (1) | OA12160A (et) |
PA (1) | PA8509901A1 (et) |
PE (1) | PE20011334A1 (et) |
PL (1) | PL357590A1 (et) |
SK (1) | SK10052002A3 (et) |
SV (1) | SV2002000293A (et) |
UA (1) | UA75880C2 (et) |
WO (1) | WO2001053268A2 (et) |
YU (1) | YU54202A (et) |
ZA (1) | ZA200203040B (et) |
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US20020150921A1 (en) * | 1996-02-09 | 2002-10-17 | Francis Barany | Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays |
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US20050009876A1 (en) * | 2000-07-31 | 2005-01-13 | Bhagwat Shripad S. | Indazole compounds, compositions thereof and methods of treatment therewith |
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US7211594B2 (en) | 2000-07-31 | 2007-05-01 | Signal Pharmaceuticals, Llc | Indazole compounds and compositions thereof as JNK inhibitors and for the treatment of diseases associated therewith |
WO2002016348A1 (en) * | 2000-08-09 | 2002-02-28 | Astrazeneca Ab | Antiangiogenic bicyclic derivatives |
EP1317442B1 (en) | 2000-09-11 | 2005-11-16 | Chiron Corporation | Quinolinone derivatives as tyrosine kinase inhibitors |
DE10046029A1 (de) * | 2000-09-18 | 2002-03-28 | Bayer Ag | Indazole |
JP4535680B2 (ja) * | 2001-04-16 | 2010-09-01 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 新規1h−インダゾール化合物 |
GB0115109D0 (en) | 2001-06-21 | 2001-08-15 | Aventis Pharma Ltd | Chemical compounds |
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FR2827861B1 (fr) * | 2001-07-27 | 2004-04-02 | Aventis Pharma Sa | Derives des indazoles ou des indoles, leur utilisation en medecine humaine et plus particulierement en cancerologie |
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JP4542338B2 (ja) * | 2001-09-26 | 2010-09-15 | ファイザー イタリア ソシエタ ア レスポンサビリタ リミタータ | キナーゼ阻害因子として活性なアミノインダゾール誘導体、それらの製造方法及びそれらを含有する医薬組成物 |
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