HRP20020650B1 - PURIFIED hCG - Google Patents

PURIFIED hCG

Info

Publication number
HRP20020650B1
HRP20020650B1 HR20020650A HRP20020650A HRP20020650B1 HR P20020650 B1 HRP20020650 B1 HR P20020650B1 HR 20020650 A HR20020650 A HR 20020650A HR P20020650 A HRP20020650 A HR P20020650A HR P20020650 B1 HRP20020650 B1 HR P20020650B1
Authority
HR
Croatia
Prior art keywords
eluting
sample
chromatographic column
ion exchange
recombinant hcg
Prior art date
Application number
HR20020650A
Other languages
English (en)
Croatian (hr)
Inventor
Paradisi Gianfranco
Rossi Mara
Scaglia Laura
Original Assignee
Laboratoires Serono Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoires Serono Sa filed Critical Laboratoires Serono Sa
Publication of HRP20020650A2 publication Critical patent/HRP20020650A2/hr
Publication of HRP20020650B1 publication Critical patent/HRP20020650B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Reproductive Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Detergent Compositions (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
HR20020650A 2000-02-22 2002-08-01 PURIFIED hCG HRP20020650B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP00103690 2000-02-22
PCT/EP2001/000665 WO2001062773A1 (en) 2000-02-22 2001-01-22 PROCESS OF PURIFICATION OF hCG AND RECOMBINANT hCG PURIFIED BY THAT METHOD

Publications (2)

Publication Number Publication Date
HRP20020650A2 HRP20020650A2 (en) 2004-12-31
HRP20020650B1 true HRP20020650B1 (en) 2011-02-28

Family

ID=8167925

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20020650A HRP20020650B1 (en) 2000-02-22 2002-08-01 PURIFIED hCG

Country Status (32)

Country Link
US (2) US7297777B2 (no)
EP (2) EP1257564B1 (no)
JP (1) JP4588960B2 (no)
KR (1) KR100806911B1 (no)
CN (1) CN100482679C (no)
AT (1) ATE406378T1 (no)
AU (2) AU783320B2 (no)
BG (1) BG65807B1 (no)
BR (1) BRPI0108556B8 (no)
CA (1) CA2399020A1 (no)
CY (1) CY1108460T1 (no)
CZ (1) CZ303144B6 (no)
DE (1) DE60135541D1 (no)
DK (1) DK1257564T3 (no)
EA (1) EA006605B1 (no)
EE (1) EE05644B1 (no)
ES (1) ES2307585T3 (no)
HK (1) HK1052016A1 (no)
HR (1) HRP20020650B1 (no)
HU (2) HU228935B1 (no)
IL (2) IL151308A0 (no)
ME (1) ME00296B (no)
MX (1) MXPA02007871A (no)
NO (1) NO328694B1 (no)
PL (1) PL205149B1 (no)
PT (1) PT1257564E (no)
RS (1) RS50741B (no)
SI (1) SI1257564T1 (no)
SK (1) SK287146B6 (no)
UA (2) UA86938C2 (no)
WO (1) WO2001062773A1 (no)
ZA (1) ZA200206109B (no)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK287146B6 (sk) * 2000-02-22 2010-01-07 Laboratoires Serono Sa Spôsob prípravy rekombinantného choriogonadotropínu - hCG zo vzorky
US20060148699A1 (en) * 2004-10-04 2006-07-06 Avi Tovi Counterion exchange process for peptides
CN1958603B (zh) * 2005-11-04 2010-05-05 上海天伟生物制药有限公司 一种人绒毛膜促性腺素的纯化方法
WO2008007993A1 (fr) * 2006-07-11 2008-01-17 Koval, Anton Alexandrovich Utilisation d'une hormone chorionique ou lutéinisante destinée à la prévention ou au traitement de l'hypogonadisme lié à l'âge
CN101397339B (zh) * 2008-09-24 2012-07-25 上海天伟生物制药有限公司 糖蛋白中去除/灭活病毒的方法
TWI604850B (zh) * 2009-10-05 2017-11-11 菲瑞茵國際中心股份有限公司 藥學製劑
CN101792481B (zh) * 2010-03-12 2012-05-30 丽珠医药集团股份有限公司 一种绒毛膜促性腺激素的纯化方法
WO2012120535A2 (en) * 2011-02-03 2012-09-13 Sanzyme Limited A composition comprising highly purified chorionic gonadotropin, it's formulation and uses of the same
JP6087338B2 (ja) 2011-03-31 2017-03-01 フェリング ベスローテン フェンノートシャップ 医薬製剤
WO2013102921A2 (en) * 2011-11-17 2013-07-11 Sanzyme Limited Hcg - newer treatment modality for type 2 diabetes mellitus (t2dm)
CN103288950A (zh) * 2012-12-28 2013-09-11 青岛九龙生物医药有限公司 改进柱分离工序洗涤液和洗脱液配比去除杂质的方法
CN104101656A (zh) * 2013-04-01 2014-10-15 上海天伟生物制药有限公司 一种促性腺激素的纯度测定方法
US20150065426A1 (en) * 2013-08-27 2015-03-05 Professional Compounding Centers Of America Testosterone Booster Transdermal Compositions
CN105968185A (zh) * 2016-07-20 2016-09-28 宁波人健药业集团股份有限公司 一种绒促性素纯化方法
CN111233999B (zh) * 2020-03-21 2024-02-23 上海浦东明炎生物技术有限公司 一种从人尿中提取人绒毛膜促性腺激素的方法
CN113398251B (zh) * 2021-07-30 2022-08-05 宁波人健药业集团股份有限公司 一种重组人绒毛膜促性腺激素冻干粉针剂及其制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990009800A1 (en) * 1989-02-21 1990-09-07 Washington University Modified forms of reproductive hormones
EP0571337A2 (en) * 1992-05-22 1993-11-24 SORIN BIOMEDICA S.p.A. Process to purify proteins from cell systems
WO1998056808A1 (en) * 1997-06-13 1998-12-17 Genentech, Inc. Protein recovery by chromatography followed by filtration upon a charged layer

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1250075B (it) * 1991-12-18 1995-03-30 Serono Cesare Ist Ricerca Composizioni farmaceutiche contenenti gonadotropine.
KR100377967B1 (ko) 1995-03-21 2003-06-12 어플라이드 리서치 시스템스 에이알에스 홀딩 엔.브이. Hcg액상조성물
ATE295887T1 (de) * 1996-02-20 2005-06-15 Applied Research Systems Heterodimerebildende hybrid-proteine
IT1287138B1 (it) * 1996-11-07 1998-08-04 Ibsa Inst Biochimique Sa Procedimento per la separazione e purificazione di fsh e lh
AU8142198A (en) 1997-06-12 1998-12-30 Regents Of The University Of California, The A transcription factor coactivator protein, p/cip
US6583109B1 (en) * 1997-06-24 2003-06-24 Robert C. Gallo Therapeutic polypeptides from β-hCG and derivatives
SK287146B6 (sk) * 2000-02-22 2010-01-07 Laboratoires Serono Sa Spôsob prípravy rekombinantného choriogonadotropínu - hCG zo vzorky

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990009800A1 (en) * 1989-02-21 1990-09-07 Washington University Modified forms of reproductive hormones
EP0571337A2 (en) * 1992-05-22 1993-11-24 SORIN BIOMEDICA S.p.A. Process to purify proteins from cell systems
WO1998056808A1 (en) * 1997-06-13 1998-12-17 Genentech, Inc. Protein recovery by chromatography followed by filtration upon a charged layer

Also Published As

Publication number Publication date
HU228935B1 (en) 2013-06-28
HUP0204231A3 (en) 2005-09-28
NO20023985D0 (no) 2002-08-21
BRPI0108556B8 (pt) 2021-05-25
CZ20022855A3 (cs) 2002-11-13
PL357508A1 (en) 2004-07-26
SK287146B6 (sk) 2010-01-07
EP1752466A2 (en) 2007-02-14
CY1108460T1 (el) 2014-04-09
HUP0204231A2 (hu) 2003-03-28
EA200200892A1 (ru) 2003-02-27
AU2006200059A1 (en) 2006-02-02
MEP38908A (en) 2011-02-10
EP1257564A1 (en) 2002-11-20
US7297777B2 (en) 2007-11-20
BRPI0108556B1 (pt) 2015-04-14
EP1257564B1 (en) 2008-08-27
BR0108556A (pt) 2003-01-28
EA006605B1 (ru) 2006-02-24
SK12062002A3 (sk) 2002-12-03
US20030104553A1 (en) 2003-06-05
MXPA02007871A (es) 2003-02-10
IL151308A (en) 2009-11-18
PT1257564E (pt) 2008-09-10
YU60202A (sh) 2005-09-19
CN1404485A (zh) 2003-03-19
DK1257564T3 (da) 2008-10-06
JP2003524015A (ja) 2003-08-12
UA86938C2 (uk) 2009-06-10
NO20023985L (no) 2002-08-21
HRP20020650A2 (en) 2004-12-31
HK1052016A1 (en) 2003-08-29
UA78488C2 (en) 2007-04-10
CN100482679C (zh) 2009-04-29
KR20030001359A (ko) 2003-01-06
WO2001062773A1 (en) 2001-08-30
ME00296B (me) 2011-05-10
BG107000A (en) 2003-04-30
AU783320B2 (en) 2005-10-13
ES2307585T3 (es) 2008-12-01
BG65807B1 (bg) 2009-12-31
JP4588960B2 (ja) 2010-12-01
IL151308A0 (en) 2003-04-10
US20070299001A1 (en) 2007-12-27
SI1257564T1 (sl) 2008-12-31
ATE406378T1 (de) 2008-09-15
NO328694B1 (no) 2010-04-26
DE60135541D1 (de) 2008-10-09
AU2680401A (en) 2001-09-03
PL205149B1 (pl) 2010-03-31
EP1752466A3 (en) 2012-10-10
ZA200206109B (en) 2003-07-31
EE200200469A (et) 2004-04-15
KR100806911B1 (ko) 2008-02-22
CA2399020A1 (en) 2001-08-30
CZ303144B6 (cs) 2012-05-02
RS50741B (sr) 2010-08-31
HU1300063D0 (hu) 2003-03-28
EE05644B1 (et) 2013-04-15

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Legal Events

Date Code Title Description
A1OB Publication of a patent application
ARAI Request for the grant of a patent on the basis of the submitted results of a substantive examination of a patent application
PPPP Transfer of rights

Owner name: LABORATOIRES SERONO SA, CH

B1PR Patent granted
PNAN Change of the applicant name, address/residence

Owner name: MERCK SERONO SA, CH

ODRP Renewal fee for the maintenance of a patent

Payment date: 20181231

Year of fee payment: 19

ODRP Renewal fee for the maintenance of a patent

Payment date: 20191217

Year of fee payment: 20

PB20 Patent expired after termination of 20 years

Effective date: 20210122