IT1250075B - Composizioni farmaceutiche contenenti gonadotropine. - Google Patents

Composizioni farmaceutiche contenenti gonadotropine.

Info

Publication number
IT1250075B
IT1250075B ITRM910952A ITRM910952A IT1250075B IT 1250075 B IT1250075 B IT 1250075B IT RM910952 A ITRM910952 A IT RM910952A IT RM910952 A ITRM910952 A IT RM910952A IT 1250075 B IT1250075 B IT 1250075B
Authority
IT
Italy
Prior art keywords
pharmaceutical compositions
gonadotropine
compositions containing
lyophilisate
fsh
Prior art date
Application number
ITRM910952A
Other languages
English (en)
Inventor
Fabrizio Samaritani
Patrizia Natale
Original Assignee
Serono Cesare Ist Ricerca
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Serono Cesare Ist Ricerca filed Critical Serono Cesare Ist Ricerca
Publication of ITRM910952A0 publication Critical patent/ITRM910952A0/it
Priority to ITRM910952A priority Critical patent/IT1250075B/it
Priority to ES93901557T priority patent/ES2142860T3/es
Priority to JP51077493A priority patent/JP3702313B2/ja
Priority to US08/244,575 priority patent/US5650390A/en
Priority to AT93901557T priority patent/ATE189608T1/de
Priority to EP93901557A priority patent/EP0618808B1/en
Priority to CA002124801A priority patent/CA2124801C/en
Priority to AU32662/93A priority patent/AU677773B2/en
Priority to DK93901557T priority patent/DK0618808T3/da
Priority to PCT/IT1992/000165 priority patent/WO1993011788A1/en
Priority to PT93901557T priority patent/PT618808E/pt
Priority to DE69230672T priority patent/DE69230672T2/de
Publication of ITRM910952A1 publication Critical patent/ITRM910952A1/it
Application granted granted Critical
Publication of IT1250075B publication Critical patent/IT1250075B/it
Priority to GR20000400959T priority patent/GR3033276T3/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/24—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Reproductive Health (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dermatology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Composizioni farmaceutiche di FSH, LH e hCG stabilizzate con saccarosio. La formulazione è particolarmente adatta per la stabilizzazione del liofilizzato di gonadotropine ricombinanti.
ITRM910952A 1991-12-18 1991-12-18 Composizioni farmaceutiche contenenti gonadotropine. IT1250075B (it)

Priority Applications (13)

Application Number Priority Date Filing Date Title
ITRM910952A IT1250075B (it) 1991-12-18 1991-12-18 Composizioni farmaceutiche contenenti gonadotropine.
CA002124801A CA2124801C (en) 1991-12-18 1992-12-17 Gonadotropin containing pharmaceutical compositions with sucrose stabilizer
DK93901557T DK0618808T3 (da) 1991-12-18 1992-12-17 Farmaceutiske præparater der indeholder gonadotropin med saccharosestabilisator
US08/244,575 US5650390A (en) 1991-12-18 1992-12-17 Gonadotropin containing pharmaceutical compositions with sucrose stabilizer
AT93901557T ATE189608T1 (de) 1991-12-18 1992-12-17 Gonadotropin, das pharmazeutische zusammensetzungen mit sucrose stabilisator enthält
EP93901557A EP0618808B1 (en) 1991-12-18 1992-12-17 Gonadotropin containing pharmaceutical compositions with sucrose stabilizer
ES93901557T ES2142860T3 (es) 1991-12-18 1992-12-17 Composiciones farmaceuticas que contienen gonadotropina, con estabilizador de sacarosa.
AU32662/93A AU677773B2 (en) 1991-12-18 1992-12-17 Gonadotropin containing pharmaceutical compositions with sucrose stabilizer
JP51077493A JP3702313B2 (ja) 1991-12-18 1992-12-17 ゴナドトロピン含有薬剤組成物
PCT/IT1992/000165 WO1993011788A1 (en) 1991-12-18 1992-12-17 Gonadotropin containing pharmaceutical compositions with sucrose stabilizer
PT93901557T PT618808E (pt) 1991-12-18 1992-12-17 Composicoes farmaceuticas contendo gonadotrofina com estabilizador de sacarose
DE69230672T DE69230672T2 (de) 1991-12-18 1992-12-17 Gonadotropin, das pharmazeutische zusammensetzungen mit sucrose stabilisator enthält
GR20000400959T GR3033276T3 (en) 1991-12-18 2000-04-19 Gonadotropin containing pharmaceutical compositions with sucrose stabilizer.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITRM910952A IT1250075B (it) 1991-12-18 1991-12-18 Composizioni farmaceutiche contenenti gonadotropine.

Publications (3)

Publication Number Publication Date
ITRM910952A0 ITRM910952A0 (it) 1991-12-18
ITRM910952A1 ITRM910952A1 (it) 1993-06-18
IT1250075B true IT1250075B (it) 1995-03-30

Family

ID=11400511

Family Applications (1)

Application Number Title Priority Date Filing Date
ITRM910952A IT1250075B (it) 1991-12-18 1991-12-18 Composizioni farmaceutiche contenenti gonadotropine.

Country Status (13)

Country Link
US (1) US5650390A (it)
EP (1) EP0618808B1 (it)
JP (1) JP3702313B2 (it)
AT (1) ATE189608T1 (it)
AU (1) AU677773B2 (it)
CA (1) CA2124801C (it)
DE (1) DE69230672T2 (it)
DK (1) DK0618808T3 (it)
ES (1) ES2142860T3 (it)
GR (1) GR3033276T3 (it)
IT (1) IT1250075B (it)
PT (1) PT618808E (it)
WO (1) WO1993011788A1 (it)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5828979A (en) * 1994-09-01 1998-10-27 Harris Corporation Automatic train control system and method
AU707796B2 (en) * 1995-03-21 1999-07-22 Merck Serono Sa HCG liquid formulations
US6319504B1 (en) 1996-06-24 2001-11-20 University Of Maryland Biotechnology Institute Treatment and prevention of HIV infection by administration of derivatives of human chorionic gonadotropin
IT1284876B1 (it) 1996-08-07 1998-05-22 Applied Research Systems Hcg come inibitore della collagenasi
TW518235B (en) * 1997-01-15 2003-01-21 Akzo Nobel Nv A gonadotropin-containing pharmaceutical composition with improved stability on prolong storage
US20030166525A1 (en) * 1998-07-23 2003-09-04 Hoffmann James Arthur FSH Formulation
KR20010083126A (ko) * 1998-07-23 2001-08-31 피터 지. 스트링거 여포자극 호르몬 및 여포자극 호르몬 변이체 제형, 제품및 방법
JP2002541213A (ja) 1999-04-13 2002-12-03 インヘール セラピューティック システムズ， インコーポレイテッド 不妊症の処置のための乾燥粉末処方物の肺投与
IL151309A0 (en) * 2000-02-22 2003-04-10 Applied Research Systems Purification of lh and pharmaceutical compositions containing it
US7297777B2 (en) * 2000-02-22 2007-11-20 Laboratoires Serono Sa Process of purification of hCG and recombinant hCG purified by that method
GB0121709D0 (en) * 2001-09-07 2001-10-31 Imp College Innovations Ltd Food inhibition agent
SI1434600T1 (sl) * 2001-09-12 2009-06-30 Serono Lab Uporaba lh za kontrolirano hiperstimulacijo ovarijev
WO2003066585A2 (en) * 2002-02-08 2003-08-14 Alkermes Controlled Therapeutics, Inc. Polymer-based compositions for sustained release
ZA200507287B (en) * 2003-04-02 2007-03-28 Ares Trading Sa Liquid pharmaceutical formulations of FSH and LH together with a non-ionic surfactant
MXPA05010635A (es) 2003-04-02 2005-12-12 Ares Trading Sa Formulaciones farmaceuticas liquidas de hormona estimulante de foliculos y hormona luteinizante junto con un surfactante no ionico.
WO2004112826A1 (en) * 2003-06-20 2004-12-29 Ares Trading Sa Freeze-dried fsh / lh formulations
KR101105871B1 (ko) * 2005-09-27 2012-01-16 주식회사 엘지생명과학 인 난포자극호르몬의 안정한 용액 제형
NZ583991A (en) * 2007-11-01 2012-02-24 Merck Serono Sa Luteinizing hormone liquid formulations
CN101269215B (zh) * 2008-05-15 2011-03-23 上海天伟生物制药有限公司 一种糖蛋白激素组合物
CN102309747B (zh) * 2008-09-17 2013-04-17 上海天伟生物制药有限公司 高纯度绝经期促性腺素冻干针剂
CN102100908B (zh) * 2009-12-22 2013-05-08 上海天伟生物制药有限公司 一种蛋白质组合物
JP6426410B2 (ja) * 2013-09-11 2018-11-21 第一三共株式会社 室温保存用凍結乾燥製剤

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3637640A (en) * 1970-05-04 1972-01-25 Diagnostic Data Inc Orgotein stabilized with saccharide process and products
US3816617A (en) * 1972-07-25 1974-06-11 American Home Prod Method for inducing menses
DD141996A1 (de) * 1979-02-21 1980-06-04 Ingrid Wolf Verfahren zur herstellung von lyophilisierten lhrh-praeparationen
JPS59109862A (ja) * 1982-12-15 1984-06-25 Takeda Chem Ind Ltd 凍結乾燥感作血球の製造法
MX9203334A (es) * 1983-11-02 1992-09-01 Applied Research Ars Holding N Proteinas heteropolimericas.
JPS60258125A (ja) * 1984-06-06 1985-12-20 Hayashibara Biochem Lab Inc 蛋白性生理活性物質を含有する水溶性乾燥物
IT1206302B (it) * 1987-06-26 1989-04-14 Serono Cesare Ist Ricerca Ormone follicolo-stimolante urinario
US5215743A (en) * 1988-04-13 1993-06-01 Maninder Singh Tumor necrosis factor formulations
AU629549B2 (en) * 1988-04-29 1992-10-08 Genetics Institute Inc. Homogeneous dimeric m-csf and storage stable formulations thereof
JPH02121933A (ja) * 1988-10-28 1990-05-09 Kagaku Shiryo Kenkyusho:Kk 動物用油性ホルモン顆粒剤
US5087615A (en) * 1989-03-17 1992-02-11 Applied Research Systems Ars Holding N.V. Novel method of ovulation induction in humans
IE64738B1 (en) * 1990-03-20 1995-09-06 Akzo Nv Stabilized gonadotropin containing preparations

Also Published As

Publication number Publication date
EP0618808B1 (en) 2000-02-09
PT618808E (pt) 2000-07-31
WO1993011788A1 (en) 1993-06-24
US5650390A (en) 1997-07-22
JPH07507047A (ja) 1995-08-03
GR3033276T3 (en) 2000-09-29
ES2142860T3 (es) 2000-05-01
ATE189608T1 (de) 2000-02-15
ITRM910952A1 (it) 1993-06-18
AU677773B2 (en) 1997-05-08
DE69230672T2 (de) 2000-09-21
DK0618808T3 (da) 2000-05-15
ITRM910952A0 (it) 1991-12-18
CA2124801C (en) 2007-08-07
EP0618808A1 (en) 1994-10-12
AU3266293A (en) 1993-07-19
JP3702313B2 (ja) 2005-10-05
CA2124801A1 (en) 1993-06-24
DE69230672D1 (de) 2000-03-16

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Legal Events

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0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19961217