MXPA03000046A - Interleucina-2 estabilizada. - Google Patents

Interleucina-2 estabilizada.

Info

Publication number
MXPA03000046A
MXPA03000046A MXPA03000046A MXPA03000046A MXPA03000046A MX PA03000046 A MXPA03000046 A MX PA03000046A MX PA03000046 A MXPA03000046 A MX PA03000046A MX PA03000046 A MXPA03000046 A MX PA03000046A MX PA03000046 A MXPA03000046 A MX PA03000046A
Authority
MX
Mexico
Prior art keywords
interleukin
stabilized
variant
preferred formulation
reconstitution
Prior art date
Application number
MXPA03000046A
Other languages
English (en)
Inventor
Wei Wang
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24424265&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MXPA03000046(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of MXPA03000046A publication Critical patent/MXPA03000046A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2013—IL-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Train Traffic Observation, Control, And Security (AREA)
  • Control Of Motors That Do Not Use Commutators (AREA)
  • Sub-Exchange Stations And Push- Button Telephones (AREA)

Abstract

Se presenta una preparacion farmacéutica estable que comprende interleucina-2 humana o una variante de la misma y una cantidad estabilizadora de histidina. Una formulacion preferida incluye glicina y sucrosa y una variante de IL-2 que tiene una mutacion simple, N88R. La formulacion preferida se encuentra en forma liofilizada la cual, al reconstituirse con un diluyente acuoso, resulta en una solucion que tiene un pH dentro de un rango de aproximadamente 5.0 a 6.5.
MXPA03000046A 2000-06-28 2001-06-27 Interleucina-2 estabilizada. MXPA03000046A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/605,577 US6689353B1 (en) 2000-06-28 2000-06-28 Stabilized interleukin 2
PCT/US2001/020675 WO2002000243A2 (en) 2000-06-28 2001-06-27 Stabilized interleukin 2

Publications (1)

Publication Number Publication Date
MXPA03000046A true MXPA03000046A (es) 2003-06-19

Family

ID=24424265

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA03000046A MXPA03000046A (es) 2000-06-28 2001-06-27 Interleucina-2 estabilizada.

Country Status (24)

Country Link
US (1) US6689353B1 (es)
EP (1) EP1370280B1 (es)
JP (3) JP5522878B2 (es)
KR (1) KR100799402B1 (es)
CN (1) CN1523997B (es)
AR (1) AR029139A1 (es)
AU (1) AU2001273063A1 (es)
BR (1) BR0112101B1 (es)
CA (1) CA2413334C (es)
CO (1) CO5290308A1 (es)
CU (1) CU23536A3 (es)
DE (1) DE60142412D1 (es)
DO (1) DOP2001000197A (es)
EC (1) ECSP014106A (es)
ES (1) ES2344729T3 (es)
HN (1) HN2001000139A (es)
IL (2) IL153587A0 (es)
MX (1) MXPA03000046A (es)
MY (1) MY128629A (es)
PE (1) PE20020127A1 (es)
SV (1) SV2002000512A (es)
TW (1) TWI235063B (es)
UY (1) UY26805A1 (es)
WO (1) WO2002000243A2 (es)

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EA034869B1 (ru) 2009-11-27 2020-03-31 Бёрингер Ингельхайм Интернациональ Гмбх Лечение генотипированных пациентов с диабетом ингибиторами дпп-4, такими как линаглиптин
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Also Published As

Publication number Publication date
AU2001273063A1 (en) 2002-01-08
CN1523997B (zh) 2010-09-01
ES2344729T3 (es) 2010-09-06
SV2002000512A (es) 2002-07-03
JP2015007114A (ja) 2015-01-15
JP2012211166A (ja) 2012-11-01
CO5290308A1 (es) 2003-06-27
US6689353B1 (en) 2004-02-10
BR0112101B1 (pt) 2017-11-14
CA2413334C (en) 2011-03-08
JP5522878B2 (ja) 2014-06-18
JP2004532791A (ja) 2004-10-28
KR20030016312A (ko) 2003-02-26
WO2002000243A3 (en) 2003-10-02
UY26805A1 (es) 2002-01-31
IL153587A0 (en) 2003-07-06
MY128629A (en) 2007-02-28
AR029139A1 (es) 2003-06-04
ECSP014106A (es) 2002-02-25
HN2001000139A (es) 2003-12-11
EP1370280A2 (en) 2003-12-17
JP5989728B2 (ja) 2016-09-07
TWI235063B (en) 2005-07-01
EP1370280B1 (en) 2010-06-16
CU23536A3 (es) 2010-06-17
DOP2001000197A (es) 2003-01-15
DE60142412D1 (de) 2010-07-29
CN1523997A (zh) 2004-08-25
CA2413334A1 (en) 2002-01-03
KR100799402B1 (ko) 2008-01-30
IL153587A (en) 2007-12-03
WO2002000243A2 (en) 2002-01-03
BR0112101A (pt) 2004-07-06
PE20020127A1 (es) 2002-04-27

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