ES2142860T3 - Composiciones farmaceuticas que contienen gonadotropina, con estabilizador de sacarosa. - Google Patents

Composiciones farmaceuticas que contienen gonadotropina, con estabilizador de sacarosa.

Info

Publication number
ES2142860T3
ES2142860T3 ES93901557T ES93901557T ES2142860T3 ES 2142860 T3 ES2142860 T3 ES 2142860T3 ES 93901557 T ES93901557 T ES 93901557T ES 93901557 T ES93901557 T ES 93901557T ES 2142860 T3 ES2142860 T3 ES 2142860T3
Authority
ES
Spain
Prior art keywords
sacarosa
stabilizer
pharmaceutical compositions
compositions containing
gonadotropin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93901557T
Other languages
English (en)
Inventor
Fabrizio Samaritani
Patrizia Natale
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Applied Research Systems ARS Holding NV
Original Assignee
Applied Research Systems ARS Holding NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applied Research Systems ARS Holding NV filed Critical Applied Research Systems ARS Holding NV
Application granted granted Critical
Publication of ES2142860T3 publication Critical patent/ES2142860T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/24—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Reproductive Health (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dermatology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

COMPUESTOS FARMACEUTICOS QUE CONTIENEN FSH, LH O HCG ESTABILIZADOS POR MEDIOS DE SACAROSA. LA FORMULA ES PARTICULARMENTE CONVENIENTE PARA ESTABILIZAR LIOFILISATO DE GONADOTROPINES RECOMBINANTES.
ES93901557T 1991-12-18 1992-12-17 Composiciones farmaceuticas que contienen gonadotropina, con estabilizador de sacarosa. Expired - Lifetime ES2142860T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITRM910952A IT1250075B (it) 1991-12-18 1991-12-18 Composizioni farmaceutiche contenenti gonadotropine.

Publications (1)

Publication Number Publication Date
ES2142860T3 true ES2142860T3 (es) 2000-05-01

Family

ID=11400511

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93901557T Expired - Lifetime ES2142860T3 (es) 1991-12-18 1992-12-17 Composiciones farmaceuticas que contienen gonadotropina, con estabilizador de sacarosa.

Country Status (13)

Country Link
US (1) US5650390A (es)
EP (1) EP0618808B1 (es)
JP (1) JP3702313B2 (es)
AT (1) ATE189608T1 (es)
AU (1) AU677773B2 (es)
CA (1) CA2124801C (es)
DE (1) DE69230672T2 (es)
DK (1) DK0618808T3 (es)
ES (1) ES2142860T3 (es)
GR (1) GR3033276T3 (es)
IT (1) IT1250075B (es)
PT (1) PT618808E (es)
WO (1) WO1993011788A1 (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5828979A (en) * 1994-09-01 1998-10-27 Harris Corporation Automatic train control system and method
AU707796B2 (en) * 1995-03-21 1999-07-22 Merck Serono Sa HCG liquid formulations
US6319504B1 (en) 1996-06-24 2001-11-20 University Of Maryland Biotechnology Institute Treatment and prevention of HIV infection by administration of derivatives of human chorionic gonadotropin
IT1284876B1 (it) * 1996-08-07 1998-05-22 Applied Research Systems Hcg come inibitore della collagenasi
TW518235B (en) * 1997-01-15 2003-01-21 Akzo Nobel Nv A gonadotropin-containing pharmaceutical composition with improved stability on prolong storage
IL140984A0 (en) * 1998-07-23 2002-02-10 Lilly Co Eli Fsh and fsh variant formulations, products and methods
US20030166525A1 (en) 1998-07-23 2003-09-04 Hoffmann James Arthur FSH Formulation
EP1169053A1 (en) 1999-04-13 2002-01-09 Inhale Therapeutic Systems, Inc. Pulmonary administration of dry powder formulations for treating infertility
AU783320B2 (en) * 2000-02-22 2005-10-13 Merck Serono Sa Process of purification of hCG and recombinant hCG purified by that method
UA78676C2 (en) * 2000-02-22 2007-04-25 Applied Research Systems Purified lh
GB0121709D0 (en) * 2001-09-07 2001-10-31 Imp College Innovations Ltd Food inhibition agent
AU2002331939B2 (en) * 2001-09-12 2007-10-25 Merck Serono Sa Use of LH in controlled ovarian hyperstimulation
CA2474698C (en) * 2002-02-08 2009-07-21 Alkermes Controlled Therapeutics, Inc. Polymer-based compositions for sustained release
CA2518903C (en) 2003-04-02 2013-02-05 Ares Trading S.A. Liquid pharmaceutical formulations of fsh and lh together with a non-ionic surfactant
ES2414705T3 (es) 2003-06-20 2013-07-22 Ares Trading S.A. Formulaciones liofilizadas de FSH/LH
KR101105871B1 (ko) * 2005-09-27 2012-01-16 주식회사 엘지생명과학 인 난포자극호르몬의 안정한 용액 제형
PL2219607T3 (pl) * 2007-11-01 2012-12-31 Merck Serono Sa Ciekłe formulacje LH
CN101269215B (zh) * 2008-05-15 2011-03-23 上海天伟生物制药有限公司 一种糖蛋白激素组合物
CN102309747B (zh) * 2008-09-17 2013-04-17 上海天伟生物制药有限公司 高纯度绝经期促性腺素冻干针剂
WO2011076117A1 (zh) * 2009-12-22 2011-06-30 上海天伟生物制药有限公司 绝经期促性腺素组合物
JP6426410B2 (ja) * 2013-09-11 2018-11-21 第一三共株式会社 室温保存用凍結乾燥製剤

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3637640A (en) * 1970-05-04 1972-01-25 Diagnostic Data Inc Orgotein stabilized with saccharide process and products
US3816617A (en) * 1972-07-25 1974-06-11 American Home Prod Method for inducing menses
DD141996A1 (de) * 1979-02-21 1980-06-04 Ingrid Wolf Verfahren zur herstellung von lyophilisierten lhrh-praeparationen
JPS59109862A (ja) * 1982-12-15 1984-06-25 Takeda Chem Ind Ltd 凍結乾燥感作血球の製造法
EP0957167A1 (en) * 1983-11-02 1999-11-17 Applied Research Systems ARS Holding N.V. Production of heterodimeric human fertility hormones
JPS60258125A (ja) * 1984-06-06 1985-12-20 Hayashibara Biochem Lab Inc 蛋白性生理活性物質を含有する水溶性乾燥物
IT1206302B (it) * 1987-06-26 1989-04-14 Serono Cesare Ist Ricerca Ormone follicolo-stimolante urinario
US5215743A (en) * 1988-04-13 1993-06-01 Maninder Singh Tumor necrosis factor formulations
AU629549B2 (en) * 1988-04-29 1992-10-08 Genetics Institute Inc. Homogeneous dimeric m-csf and storage stable formulations thereof
JPH02121933A (ja) * 1988-10-28 1990-05-09 Kagaku Shiryo Kenkyusho:Kk 動物用油性ホルモン顆粒剤
US5087615A (en) * 1989-03-17 1992-02-11 Applied Research Systems Ars Holding N.V. Novel method of ovulation induction in humans
IE64738B1 (en) * 1990-03-20 1995-09-06 Akzo Nv Stabilized gonadotropin containing preparations

Also Published As

Publication number Publication date
ITRM910952A1 (it) 1993-06-18
AU677773B2 (en) 1997-05-08
ITRM910952A0 (it) 1991-12-18
JPH07507047A (ja) 1995-08-03
EP0618808B1 (en) 2000-02-09
ATE189608T1 (de) 2000-02-15
GR3033276T3 (en) 2000-09-29
CA2124801C (en) 2007-08-07
AU3266293A (en) 1993-07-19
WO1993011788A1 (en) 1993-06-24
DK0618808T3 (da) 2000-05-15
CA2124801A1 (en) 1993-06-24
IT1250075B (it) 1995-03-30
JP3702313B2 (ja) 2005-10-05
US5650390A (en) 1997-07-22
EP0618808A1 (en) 1994-10-12
DE69230672T2 (de) 2000-09-21
PT618808E (pt) 2000-07-31
DE69230672D1 (de) 2000-03-16

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