FI67214C - Foerfarande foer framstaellning av nya terapeutiskt vaerdefulla taurinderivat - Google Patents
Foerfarande foer framstaellning av nya terapeutiskt vaerdefulla taurinderivat Download PDFInfo
- Publication number
- FI67214C FI67214C FI821650A FI821650A FI67214C FI 67214 C FI67214 C FI 67214C FI 821650 A FI821650 A FI 821650A FI 821650 A FI821650 A FI 821650A FI 67214 C FI67214 C FI 67214C
- Authority
- FI
- Finland
- Prior art keywords
- therapeutic
- compounds
- effect
- taurine
- added
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Saccharide Compounds (AREA)
Claims (2)
1. Förfarande för framställning av nya terapeutiskt värdefulla taurinderivat enligt formel I | Nsn-ch2ch2so2nr1 ^ I där är H R2 är en metyl-, etyl-, n-propyl-, isopropyl e Her n-butylgrupp eller där /""i NR.^ ar N kännetecknat därav, att ftalimidoetansulfonyl-klorid enligt formel II I n-ch2ch2so2ci ii omsättes med en primär- eller sekundär amin med allmänna fontein NR^H, där , R2 och NR.^ har saimta betydelse som o van, i ett inert or-ganiskt lösningsmedel vid 0-50°C i närvaro av en bas, t.ex. i ett överskott av den ifrägavarande aminen enligt reaktionen III ,5 6721 4 | NN-CH„CH„S0„C1 III I / 2 2 2 CO + HNR1R2 I | N-CajCHjSOjNS,^ co7 eller därav, att ftalimidoetansulfonamid enligt forme1 IV !^V®\ I N-CH2CH2S02NH2 IV tillates att reagera med alkyleringsmedel sasorn alkylhalogenider eller dlalkylsulfat i ett inert organiskt lösningsmedel genom att lata blandningen koka under aterlopp i närvaro av en bas, företrädesvis i närvaro av kaiiumkarbonat enligt reaktionen V N-CHoCHoS0oNHo V I j 2 2 2 2 N^^co' v + =¾ r^V°\ . II -N-C^CHjSO^Rj där X är en halogenid är väte R2 är en metyl-, etyl-, n-ptopy1-, isopropyl- eller n-butylgrupp 16 6 721 4 Patenttivaatimus
1. Menetelmä uusien terapeuttisesti arvokkaiden kaavan I mukaisten tauriinijohdannaisten valmistamiseksi ^CH2S02NRiR2 I jossa R on H Rj on metyyli-, etyyli-, n-propyyli-, isopropyyli-tai n-butyyliryhma tai jossa —> NR^R2 o*"1 tunnettu siitä, että kaavan II mukaisen ftaali-imidoetaanisulfonyylikloridin r^V^N I N-CH2CH2S0,C1 II annetaan reagoida primääri- tai sekundääriamiinin kanssa, jonka yleinen kaava on OTL,R^ missä , Rj ja NR^Rj merkitsevät samaa kuin yllä, inertisessä liuottimessa 0-50°C:ssa emäksen läsnäollessa esim. kyseessä olevan amiinin ylimäärässä reaktiokaavan III mukaan
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE8004261 | 1980-06-06 | ||
| SE8004261A SE434638B (sv) | 1980-06-06 | 1980-06-06 | Nya terapeutiska verdefulla taurinderivat och deras framstellning |
| FI8100037 | 1981-05-22 | ||
| PCT/FI1981/000037 WO1981003492A1 (en) | 1980-06-06 | 1981-05-22 | Chemical compounds,their production,and their use in drugs |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| FI821650A0 FI821650A0 (fi) | 1982-05-11 |
| FI821650L FI821650L (fi) | 1982-05-11 |
| FI67214B FI67214B (fi) | 1984-10-31 |
| FI67214C true FI67214C (fi) | 1985-02-11 |
Family
ID=20341162
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI821650A FI67214C (fi) | 1980-06-06 | 1982-05-11 | Foerfarande foer framstaellning av nya terapeutiskt vaerdefulla taurinderivat |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US4556673A (fi) |
| JP (1) | JPS57500877A (fi) |
| AT (1) | AT376206B (fi) |
| BE (1) | BE889100A (fi) |
| CA (1) | CA1165322A (fi) |
| CH (1) | CH647505A5 (fi) |
| CS (2) | CS235088B2 (fi) |
| DD (1) | DD159427A5 (fi) |
| DE (1) | DE3152071C2 (fi) |
| DK (1) | DK155521B (fi) |
| ES (1) | ES8203342A1 (fi) |
| FI (1) | FI67214C (fi) |
| FR (1) | FR2486077B1 (fi) |
| GB (1) | GB2093457B (fi) |
| HU (1) | HU184871B (fi) |
| IE (1) | IE51264B1 (fi) |
| IL (1) | IL62824A (fi) |
| IT (1) | IT8122151A0 (fi) |
| NL (1) | NL8120217A (fi) |
| NO (1) | NO155840C (fi) |
| PL (2) | PL128574B1 (fi) |
| PT (1) | PT73061B (fi) |
| SE (1) | SE434638B (fi) |
| SU (1) | SU1097198A3 (fi) |
| WO (1) | WO1981003492A1 (fi) |
| ZA (1) | ZA813387B (fi) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE458606B (sv) * | 1987-04-10 | 1989-04-17 | Huhtamaeki Oy | 2-ftalimidoetansulfon-n-arylamider och foerfarande foer framstaellning av dessa |
| US5801195A (en) | 1994-12-30 | 1998-09-01 | Celgene Corporation | Immunotherapeutic aryl amides |
| AR016384A1 (es) * | 1997-07-30 | 2001-07-04 | Smithkline Beecham Corp | Inhibidores de caspasas, composiciones farmaceuticas que comprenden dichos inhibidores de caspasas y uso de los inhibidores de caspasas para prepararun medicamento util para el tratamiento de apoptosis y desordenes asociados con excesiva actividad de la convertosa il-1 beta. |
| US6020358A (en) * | 1998-10-30 | 2000-02-01 | Celgene Corporation | Substituted phenethylsulfones and method of reducing TNFα levels |
| AU2006200033B8 (en) * | 1998-10-30 | 2008-09-11 | Celgene Corporation | Substituted phenethylsulfones and methods of reducing TNF-alpha levels |
| US6667316B1 (en) | 1999-11-12 | 2003-12-23 | Celgene Corporation | Pharmaceutically active isoindoline derivatives |
| US6326388B1 (en) | 1999-12-21 | 2001-12-04 | Celgene Corporation | Substituted 1,3,4-oxadiazoles and a method of reducing TNF-alpha level |
| US6699899B1 (en) | 1999-12-21 | 2004-03-02 | Celgene Corporation | Substituted acylhydroxamic acids and method of reducing TNFα levels |
| US8030343B2 (en) * | 2000-06-08 | 2011-10-04 | Celgene Corporation | Pharmaceutically active isoindoline derivatives |
| US7491634B2 (en) * | 2006-04-28 | 2009-02-17 | Asm International N.V. | Methods for forming roughened surfaces and applications thereof |
| WO2003000654A1 (en) * | 2001-06-26 | 2003-01-03 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Valproyltaurinamide derivatives as anticonvulsant and cns active agents |
| US7244759B2 (en) * | 2004-07-28 | 2007-07-17 | Celgene Corporation | Isoindoline compounds and methods of making and using the same |
| CN114539106B (zh) * | 2022-03-15 | 2023-05-02 | 梯尔希（南京）药物研发有限公司 | 一种稳定同位素标记的牛磺酰胺盐酸盐的合成方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2184279A (en) * | 1937-11-27 | 1939-12-26 | Squibb & Sons Inc | Amino-aliphatic sulphonamides and process for preparing them |
| AT219039B (de) * | 1959-05-27 | 1962-01-10 | Geigy Ag J R | Verfahren zur Herstellung von neuen Isoindolinderivaten |
| GB1254414A (en) * | 1969-05-08 | 1971-11-24 | Shun-Ichi Naito | Novel aminoethanesulfonylamino derivatives and their production |
| US4093723A (en) * | 1976-05-19 | 1978-06-06 | Smithkline Corporation | 7-Acyl-3-(sulfonic acid and sulfamoyl substituted tetrazolyl thiomethyl) cephalosporins |
| ZA76757B (en) * | 1975-03-18 | 1977-01-26 | Smithkline Corp | New cephalosporin compounds |
| US4048311A (en) * | 1976-01-08 | 1977-09-13 | Smithkline Corporation | 7-Acyl-3-(sulfonic acid and sulfamoyl substituted tetrazolyl thiomethyl)cephalosporins |
| US4066762A (en) * | 1976-07-12 | 1978-01-03 | Smithkline Corporation | Derivatives of 7-(2-substituted-2-hydroxyiminoacetamido)-3-(1-substituted tetrazol-5-ylthiomethyl-3-cephem-4-carboxylic acid |
-
1980
- 1980-06-06 SE SE8004261A patent/SE434638B/sv not_active IP Right Cessation
-
1981
- 1981-05-08 IL IL62824A patent/IL62824A/xx unknown
- 1981-05-11 IE IE1037/81A patent/IE51264B1/en unknown
- 1981-05-20 ZA ZA00813387A patent/ZA813387B/xx unknown
- 1981-05-20 PT PT73061A patent/PT73061B/pt unknown
- 1981-05-22 HU HU812299A patent/HU184871B/hu unknown
- 1981-05-22 US US06/342,018 patent/US4556673A/en not_active Expired - Fee Related
- 1981-05-22 GB GB8212499A patent/GB2093457B/en not_active Expired
- 1981-05-22 JP JP56502071A patent/JPS57500877A/ja active Pending
- 1981-05-22 AT AT0907681A patent/AT376206B/de not_active IP Right Cessation
- 1981-05-22 CH CH725/82A patent/CH647505A5/de not_active IP Right Cessation
- 1981-05-22 WO PCT/FI1981/000037 patent/WO1981003492A1/en active IP Right Grant
- 1981-05-22 DE DE19813152071 patent/DE3152071C2/de not_active Expired
- 1981-05-22 NL NL8120217A patent/NL8120217A/nl unknown
- 1981-05-27 FR FR8110527A patent/FR2486077B1/fr not_active Expired
- 1981-05-28 CS CS813955A patent/CS235088B2/cs unknown
- 1981-06-04 ES ES502761A patent/ES8203342A1/es not_active Expired
- 1981-06-04 DD DD81230575A patent/DD159427A5/de unknown
- 1981-06-04 BE BE0/205004A patent/BE889100A/fr not_active IP Right Cessation
- 1981-06-05 PL PL1981235510A patent/PL128574B1/pl unknown
- 1981-06-05 PL PL1981231531A patent/PL128321B1/pl unknown
- 1981-06-05 IT IT8122151A patent/IT8122151A0/it unknown
- 1981-06-05 CA CA000379126A patent/CA1165322A/en not_active Expired
-
1982
- 1982-01-25 DK DK030082A patent/DK155521B/da not_active Application Discontinuation
- 1982-01-25 NO NO82820213A patent/NO155840C/no unknown
- 1982-02-11 CS CS82940A patent/CS235091B2/cs unknown
- 1982-05-11 FI FI821650A patent/FI67214C/fi not_active IP Right Cessation
- 1982-07-05 SU SU823461553A patent/SU1097198A3/ru active
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM | Patent lapsed |
Owner name: LAEKEMEDELSFABRIKEN-MEDICA AB |