FI3257564T4 - Ylikuormitus ja eluointikromatografia - Google Patents
Ylikuormitus ja eluointikromatografia Download PDFInfo
- Publication number
- FI3257564T4 FI3257564T4 FIEP17157670.5T FI17157670T FI3257564T4 FI 3257564 T4 FI3257564 T4 FI 3257564T4 FI 17157670 T FI17157670 T FI 17157670T FI 3257564 T4 FI3257564 T4 FI 3257564T4
- Authority
- FI
- Finland
- Prior art keywords
- antibody
- chromatography
- buffer
- approximately
- filling
- Prior art date
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
- B01D15/14—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the introduction of the feed to the apparatus
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/42—Selective adsorption, e.g. chromatography characterised by the development mode, e.g. by displacement or by elution
- B01D15/424—Elution mode
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/20—Partition-, reverse-phase or hydrophobic interaction chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/32—Bonded phase chromatography
- B01D15/325—Reversed phase
- B01D15/327—Reversed phase with hydrophobic interaction
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
- B01D15/361—Ion-exchange
- B01D15/363—Anion-exchange
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
- B01D15/3804—Affinity chromatography
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
- B01D15/3847—Multimodal interactions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/165—Extraction; Separation; Purification by chromatography mixed-mode chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/18—Ion-exchange chromatography
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161554898P | 2011-11-02 | 2011-11-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| FI3257564T4 true FI3257564T4 (fi) | 2024-08-30 |
Family
ID=48192803
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FIEP17157670.5T FI3257564T4 (fi) | 2011-11-02 | 2012-11-02 | Ylikuormitus ja eluointikromatografia |
Country Status (25)
| Country | Link |
|---|---|
| US (3) | US20140301977A1 (enExample) |
| EP (3) | EP3257564B2 (enExample) |
| JP (4) | JP6356607B2 (enExample) |
| KR (1) | KR20140091721A (enExample) |
| CN (2) | CN107163101B (enExample) |
| AU (1) | AU2012323995B2 (enExample) |
| BR (1) | BR112014010406A2 (enExample) |
| CA (1) | CA2854330A1 (enExample) |
| DK (2) | DK2773438T4 (enExample) |
| ES (2) | ES2637423T5 (enExample) |
| FI (1) | FI3257564T4 (enExample) |
| HR (1) | HRP20190485T4 (enExample) |
| HU (2) | HUE043755T2 (enExample) |
| IL (1) | IL232146A0 (enExample) |
| LT (1) | LT3257564T (enExample) |
| MX (1) | MX2014005330A (enExample) |
| PL (2) | PL2773438T5 (enExample) |
| PT (1) | PT3257564T (enExample) |
| RS (1) | RS58472B2 (enExample) |
| RU (1) | RU2014121884A (enExample) |
| SG (1) | SG11201402019TA (enExample) |
| SI (2) | SI2773438T2 (enExample) |
| TR (1) | TR201903707T4 (enExample) |
| WO (1) | WO2013067301A1 (enExample) |
| ZA (1) | ZA201402932B (enExample) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013535683A (ja) | 2010-07-30 | 2013-09-12 | イー・エム・デイー・ミリポア・コーポレイシヨン | クロマトグラフィー媒体及び方法 |
| WO2012149197A2 (en) | 2011-04-27 | 2012-11-01 | Abbott Laboratories | Methods for controlling the galactosylation profile of recombinantly-expressed proteins |
| EP3257564B2 (en) | 2011-11-02 | 2024-05-29 | F. Hoffmann-La Roche AG | Overload and elute chromatography |
| US9181572B2 (en) | 2012-04-20 | 2015-11-10 | Abbvie, Inc. | Methods to modulate lysine variant distribution |
| US9150645B2 (en) | 2012-04-20 | 2015-10-06 | Abbvie, Inc. | Cell culture methods to reduce acidic species |
| US9067990B2 (en) | 2013-03-14 | 2015-06-30 | Abbvie, Inc. | Protein purification using displacement chromatography |
| US9249182B2 (en) * | 2012-05-24 | 2016-02-02 | Abbvie, Inc. | Purification of antibodies using hydrophobic interaction chromatography |
| US9512214B2 (en) | 2012-09-02 | 2016-12-06 | Abbvie, Inc. | Methods to control protein heterogeneity |
| MX379269B (es) | 2012-10-24 | 2025-03-11 | Genzyme Corp | Elucion de biomoleculas de resinas multimodales utilizando mes y mops como modificadores de fase movil. |
| AU2013381687A1 (en) | 2013-03-12 | 2015-09-24 | Abbvie Inc. | Human antibodies that bind human TNF-alpha and methods of preparing the same |
| US10023608B1 (en) | 2013-03-13 | 2018-07-17 | Amgen Inc. | Protein purification methods to remove impurities |
| US9017687B1 (en) | 2013-10-18 | 2015-04-28 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same using displacement chromatography |
| US9499614B2 (en) | 2013-03-14 | 2016-11-22 | Abbvie Inc. | Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosaccharides |
| US9598667B2 (en) | 2013-10-04 | 2017-03-21 | Abbvie Inc. | Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins |
| US9181337B2 (en) | 2013-10-18 | 2015-11-10 | Abbvie, Inc. | Modulated lysine variant species compositions and methods for producing and using the same |
| US9085618B2 (en) | 2013-10-18 | 2015-07-21 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same |
| WO2015073884A2 (en) | 2013-11-15 | 2015-05-21 | Abbvie, Inc. | Glycoengineered binding protein compositions |
| CN105980047B (zh) | 2013-12-12 | 2019-01-04 | Emd密理博公司 | 使用含丙烯酰胺的过滤器分离蛋白 |
| ES2869309T3 (es) * | 2013-12-13 | 2021-10-25 | Novo Nordisk Healthcare Ag | Método para la conjugación de proteínas con tioéter |
| KR20150083689A (ko) * | 2014-01-10 | 2015-07-20 | 삼성전자주식회사 | 항 c-Met 항체 정제 방법 |
| EP3116891B1 (en) | 2014-03-10 | 2020-02-12 | Richter Gedeon Nyrt. | Immunoglobulin purification using pre-cleaning steps |
| EP3124618B1 (en) * | 2014-03-24 | 2019-05-15 | Nitto Boseki Co., Ltd. | Method for separating and concentrating target substance using novel cationic graft polymer |
| CN106459139A (zh) * | 2014-05-28 | 2017-02-22 | 新加坡科技研究局 | 病毒减少方法 |
| RU2017101727A (ru) | 2014-06-25 | 2018-07-25 | ДжейЭйчЭл БИОТЕК, ИНК. | Способы и реагенты для очистки белков |
| CN104208719B (zh) * | 2014-09-24 | 2017-05-03 | 北京天广实生物技术股份有限公司 | 一种抗体偶联药物的阳离子交换层析纯化方法 |
| US20170298091A1 (en) | 2014-12-08 | 2017-10-19 | Emd Millipore Corporation | Mixed Bed Ion Exchange Adsorber |
| HRP20192217T1 (hr) * | 2015-03-06 | 2020-02-21 | F. Hoffmann - La Roche Ag | ULTRA-PROČIŠĆENI DsbA I DsbC TE POSTUPCI NJIHOVE IZRADE I UPORABE |
| CN106290591B (zh) * | 2015-05-14 | 2019-07-26 | 上海医药工业研究院 | 一种庆大霉素C1a的检测方法 |
| GB2539420B (en) * | 2015-06-16 | 2021-01-13 | Cytiva Sweden Ab | Determination of chromatography conditions |
| EP3337818A1 (en) * | 2015-08-21 | 2018-06-27 | H. Hoffnabb-La Roche Ag | Affinity chromatography purification with low conductivity wash buffer |
| PL3337812T3 (pl) | 2015-08-21 | 2021-10-11 | F. Hoffmann-La Roche Ag | Sposób zmniejszenia zawartości białek komórki gospodarza w chromatografii powinowactwa |
| WO2018035025A1 (en) * | 2016-08-15 | 2018-02-22 | Genentech, Inc. | Chromatography method for quantifying a non-ionic surfactant in a composition comprising the non-ionic surfactant and a polypeptide |
| GB201702856D0 (en) * | 2017-02-22 | 2017-04-05 | Ge Healthcare Bio Sciences Ab | Method in continuous chromatography |
| EP3707250A1 (en) * | 2017-11-08 | 2020-09-16 | Blue Sky Vaccines GmbH | So3 chromatography for use in a method for virus purification |
| US11999975B2 (en) * | 2018-07-04 | 2024-06-04 | Probiogen Ag | Method for purifying an enveloped virus |
| WO2020128797A1 (en) * | 2018-12-21 | 2020-06-25 | 3M Innovative Properties Company | Method for testing a chromatography device used for ion exchange |
| WO2020172658A1 (en) | 2019-02-24 | 2020-08-27 | Bristol-Myers Squibb Company | Methods of isolating a protein |
| AR119264A1 (es) * | 2019-06-05 | 2021-12-09 | Genentech Inc | Método para reutilización de cromatografía |
| CN111351876A (zh) * | 2020-04-01 | 2020-06-30 | 上海中科新生命生物科技有限公司 | 一种抗体药中宿主细胞蛋白半绝对定量检测方法 |
| US11379651B1 (en) * | 2020-07-06 | 2022-07-05 | Turtl Surf & Immerse Limited | Methods and systems for interactive content creation |
| EP4217383A1 (en) * | 2020-09-22 | 2023-08-02 | Bristol-Myers Squibb Company | Methods for producing therapeutic proteins |
| CN116802206A (zh) * | 2020-12-28 | 2023-09-22 | 等离子体技术有限责任公司 | 用于生产规模的免疫球蛋白g分离系统和方法 |
| JP7620456B2 (ja) * | 2021-03-15 | 2025-01-23 | 株式会社カネカ | κ鎖を含む抗体の製造方法 |
| WO2023053030A1 (en) * | 2021-09-28 | 2023-04-06 | Kashiv Biosciences, Llc | An improved process for purification of protein |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| FR2413974A1 (fr) | 1978-01-06 | 1979-08-03 | David Bernard | Sechoir pour feuilles imprimees par serigraphie |
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| EP3257564B2 (en) | 2011-11-02 | 2024-05-29 | F. Hoffmann-La Roche AG | Overload and elute chromatography |
-
2012
- 2012-11-02 EP EP17157670.5A patent/EP3257564B2/en active Active
- 2012-11-02 JP JP2014540118A patent/JP6356607B2/ja active Active
- 2012-11-02 ES ES12845437T patent/ES2637423T5/es active Active
- 2012-11-02 SI SI201231031T patent/SI2773438T2/sl unknown
- 2012-11-02 MX MX2014005330A patent/MX2014005330A/es unknown
- 2012-11-02 DK DK12845437.8T patent/DK2773438T4/da active
- 2012-11-02 HU HUE17157670A patent/HUE043755T2/hu unknown
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