PT3257564T - Cromatografia de eluição e sobrecarga - Google Patents
Cromatografia de eluição e sobrecargaInfo
- Publication number
- PT3257564T PT3257564T PT17157670T PT17157670T PT3257564T PT 3257564 T PT3257564 T PT 3257564T PT 17157670 T PT17157670 T PT 17157670T PT 17157670 T PT17157670 T PT 17157670T PT 3257564 T PT3257564 T PT 3257564T
- Authority
- PT
- Portugal
- Prior art keywords
- elution
- overload
- chromatography
- overload chromatography
- Prior art date
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
- B01D15/14—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the introduction of the feed to the apparatus
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/42—Selective adsorption, e.g. chromatography characterised by the development mode, e.g. by displacement or by elution
- B01D15/424—Elution mode
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/20—Partition-, reverse-phase or hydrophobic interaction chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/32—Bonded phase chromatography
- B01D15/325—Reversed phase
- B01D15/327—Reversed phase with hydrophobic interaction
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
- B01D15/361—Ion-exchange
- B01D15/363—Anion-exchange
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
- B01D15/3804—Affinity chromatography
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
- B01D15/3847—Multimodal interactions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/165—Extraction; Separation; Purification by chromatography mixed-mode chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/18—Ion-exchange chromatography
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161554898P | 2011-11-02 | 2011-11-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT3257564T true PT3257564T (pt) | 2019-03-22 |
Family
ID=48192803
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT17157670T PT3257564T (pt) | 2011-11-02 | 2012-11-02 | Cromatografia de eluição e sobrecarga |
Country Status (25)
| Country | Link |
|---|---|
| US (3) | US20140301977A1 (enExample) |
| EP (3) | EP3527274B1 (enExample) |
| JP (4) | JP6356607B2 (enExample) |
| KR (1) | KR20140091721A (enExample) |
| CN (2) | CN107163101B (enExample) |
| AU (1) | AU2012323995B2 (enExample) |
| BR (1) | BR112014010406A2 (enExample) |
| CA (1) | CA2854330A1 (enExample) |
| DK (2) | DK3257564T4 (enExample) |
| ES (2) | ES2637423T5 (enExample) |
| FI (1) | FI3257564T4 (enExample) |
| HR (1) | HRP20190485T4 (enExample) |
| HU (2) | HUE035685T2 (enExample) |
| IL (1) | IL232146A0 (enExample) |
| LT (1) | LT3257564T (enExample) |
| MX (1) | MX2014005330A (enExample) |
| PL (2) | PL3257564T5 (enExample) |
| PT (1) | PT3257564T (enExample) |
| RS (1) | RS58472B2 (enExample) |
| RU (1) | RU2014121884A (enExample) |
| SG (1) | SG11201402019TA (enExample) |
| SI (2) | SI3257564T2 (enExample) |
| TR (1) | TR201903707T4 (enExample) |
| WO (1) | WO2013067301A1 (enExample) |
| ZA (1) | ZA201402932B (enExample) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104722101A (zh) | 2010-07-30 | 2015-06-24 | Emd密理博公司 | 层析介质和方法 |
| WO2012149197A2 (en) | 2011-04-27 | 2012-11-01 | Abbott Laboratories | Methods for controlling the galactosylation profile of recombinantly-expressed proteins |
| ES2637423T5 (es) | 2011-11-02 | 2022-03-17 | Hoffmann La Roche | Cromatografía de sobrecarga y elución |
| US9150645B2 (en) | 2012-04-20 | 2015-10-06 | Abbvie, Inc. | Cell culture methods to reduce acidic species |
| US9181572B2 (en) | 2012-04-20 | 2015-11-10 | Abbvie, Inc. | Methods to modulate lysine variant distribution |
| US9067990B2 (en) | 2013-03-14 | 2015-06-30 | Abbvie, Inc. | Protein purification using displacement chromatography |
| US9249182B2 (en) * | 2012-05-24 | 2016-02-02 | Abbvie, Inc. | Purification of antibodies using hydrophobic interaction chromatography |
| US9512214B2 (en) | 2012-09-02 | 2016-12-06 | Abbvie, Inc. | Methods to control protein heterogeneity |
| WO2014066471A1 (en) | 2012-10-24 | 2014-05-01 | Genzyme Corporation | Elution of biomolecules from multi-modal resins using mes and mops as mobile phase modifiers |
| SG11201507230PA (en) | 2013-03-12 | 2015-10-29 | Abbvie Inc | Human antibodies that bind human tnf-alpha and methods of preparing the same |
| US10023608B1 (en) | 2013-03-13 | 2018-07-17 | Amgen Inc. | Protein purification methods to remove impurities |
| US9499614B2 (en) | 2013-03-14 | 2016-11-22 | Abbvie Inc. | Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosaccharides |
| US9017687B1 (en) | 2013-10-18 | 2015-04-28 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same using displacement chromatography |
| WO2015051293A2 (en) | 2013-10-04 | 2015-04-09 | Abbvie, Inc. | Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins |
| US9181337B2 (en) | 2013-10-18 | 2015-11-10 | Abbvie, Inc. | Modulated lysine variant species compositions and methods for producing and using the same |
| US9085618B2 (en) | 2013-10-18 | 2015-07-21 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same |
| US20150139988A1 (en) | 2013-11-15 | 2015-05-21 | Abbvie, Inc. | Glycoengineered binding protein compositions |
| ES2810232T3 (es) | 2013-12-12 | 2021-03-08 | Emd Millipore Corp | Método de separación de proteína monomérica de agregados de proteínas con una membrana porosa que comprende un copolímero de acrilamida de bencilo y acrilamida |
| EP3079722B1 (en) * | 2013-12-13 | 2021-03-24 | Novo Nordisk Health Care AG | Method for thioether conjugation of proteins |
| KR20150083689A (ko) * | 2014-01-10 | 2015-07-20 | 삼성전자주식회사 | 항 c-Met 항체 정제 방법 |
| ES2784749T3 (es) | 2014-03-10 | 2020-09-30 | Richter Gedeon Nyrt | Purificación de inmunoglobulina con el uso de etapas de limpieza previa |
| KR102354533B1 (ko) * | 2014-03-24 | 2022-01-21 | 니토 보세키 가부시기가이샤 | 신규 양이온성 그래프트 중합체를 사용하는 표적 물질의 분리 및 농축 방법 |
| SG11201609908VA (en) * | 2014-05-28 | 2016-12-29 | Agency Science Tech & Res | Virus reduction method |
| KR20170026521A (ko) | 2014-06-25 | 2017-03-08 | 제이에이치엘 바이오테크 인코포레이티드 | 단백질의 정제를 위한 방법 및 시약 |
| CN104208719B (zh) * | 2014-09-24 | 2017-05-03 | 北京天广实生物技术股份有限公司 | 一种抗体偶联药物的阳离子交换层析纯化方法 |
| US20170298091A1 (en) * | 2014-12-08 | 2017-10-19 | Emd Millipore Corporation | Mixed Bed Ion Exchange Adsorber |
| EP3265557B1 (en) * | 2015-03-06 | 2019-10-16 | F. Hoffmann-La Roche AG | Ultrapurified dsba and dsbc and methods of making and using the same |
| CN106290591B (zh) * | 2015-05-14 | 2019-07-26 | 上海医药工业研究院 | 一种庆大霉素C1a的检测方法 |
| GB2539420B (en) * | 2015-06-16 | 2021-01-13 | Cytiva Sweden Ab | Determination of chromatography conditions |
| WO2017032686A1 (en) | 2015-08-21 | 2017-03-02 | F. Hoffmann-La Roche Ag | Method for the reduction of host cell proteins in affinity chromatography |
| JP7084301B2 (ja) * | 2015-08-21 | 2022-06-14 | エフ．ホフマン－ラ ロシュ アーゲー | 低伝導率洗浄緩衝液を用いたアフィニティークロマトグラフィー精製方法 |
| KR102617148B1 (ko) * | 2016-08-15 | 2023-12-26 | 제넨테크, 인크. | 비이온성 계면활성제 및 폴리펩티드를 포함하는 조성물에서 비이온성 계면활성제를 정량화하기 위한 크로마토그래피 방법 |
| GB201702856D0 (en) * | 2017-02-22 | 2017-04-05 | Ge Healthcare Bio Sciences Ab | Method in continuous chromatography |
| CN111527202B (zh) * | 2017-11-08 | 2024-03-29 | 蓝天免疫疗法有限责任公司 | So3色谱在病毒纯化方法中的应用 |
| JP2021528999A (ja) * | 2018-07-04 | 2021-10-28 | プロバイオジェン アーゲー | エンベロープウイルスの精製方法 |
| WO2020128797A1 (en) * | 2018-12-21 | 2020-06-25 | 3M Innovative Properties Company | Method for testing a chromatography device used for ion exchange |
| WO2020172658A1 (en) | 2019-02-24 | 2020-08-27 | Bristol-Myers Squibb Company | Methods of isolating a protein |
| TWI870412B (zh) | 2019-06-05 | 2025-01-21 | 美商建南德克公司 | 過載層析管柱之再生方法 |
| CN111351876A (zh) * | 2020-04-01 | 2020-06-30 | 上海中科新生命生物科技有限公司 | 一种抗体药中宿主细胞蛋白半绝对定量检测方法 |
| US11379651B1 (en) * | 2020-07-06 | 2022-07-05 | Turtl Surf & Immerse Limited | Methods and systems for interactive content creation |
| WO2022066595A1 (en) * | 2020-09-22 | 2022-03-31 | Bristol-Myers Squibb Company | Methods for producing therapeutic proteins |
| JP7620456B2 (ja) * | 2021-03-15 | 2025-01-23 | 株式会社カネカ | κ鎖を含む抗体の製造方法 |
| CA3233419A1 (en) * | 2021-09-28 | 2023-04-06 | Kashiv Biosciences, Llc | An improved process for purification of protein |
| WO2023075812A1 (en) * | 2021-10-27 | 2023-05-04 | Plasma Technologies, Llc | Compositions and methods for isolating proteins |
Family Cites Families (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2413974A1 (fr) | 1978-01-06 | 1979-08-03 | David Bernard | Sechoir pour feuilles imprimees par serigraphie |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4676980A (en) | 1985-09-23 | 1987-06-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Target specific cross-linked heteroantibodies |
| US5567610A (en) | 1986-09-04 | 1996-10-22 | Bioinvent International Ab | Method of producing human monoclonal antibodies and kit therefor |
| IL85035A0 (en) | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| US5175384A (en) | 1988-12-05 | 1992-12-29 | Genpharm International | Transgenic mice depleted in mature t-cells and methods for making transgenic mice |
| EP0402226A1 (en) | 1989-06-06 | 1990-12-12 | Institut National De La Recherche Agronomique | Transformation vectors for yeast yarrowia |
| DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
| DE69029036T2 (de) | 1989-06-29 | 1997-05-22 | Medarex Inc | Bispezifische reagenzien für die aids-therapie |
| US5208020A (en) | 1989-10-25 | 1993-05-04 | Immunogen Inc. | Cytotoxic agents comprising maytansinoids and their therapeutic use |
| US5229275A (en) | 1990-04-26 | 1993-07-20 | Akzo N.V. | In-vitro method for producing antigen-specific human monoclonal antibodies |
| KR0149181B1 (ko) | 1990-06-29 | 1998-08-17 | 데이비드 알, 맥지 | 형질전환된 미생물에 의한 멜라닌의 제조방법 |
| US5571894A (en) | 1991-02-05 | 1996-11-05 | Ciba-Geigy Corporation | Recombinant antibodies specific for a growth factor receptor |
| WO1992020373A1 (en) | 1991-05-14 | 1992-11-26 | Repligen Corporation | Heteroconjugate antibodies for treatment of hiv infection |
| AU675916B2 (en) | 1991-06-14 | 1997-02-27 | Genentech Inc. | Method for making humanized antibodies |
| MX9204374A (es) | 1991-07-25 | 1993-03-01 | Idec Pharma Corp | Anticuerpo recombinante y metodo para su produccion. |
| US5565332A (en) | 1991-09-23 | 1996-10-15 | Medical Research Council | Production of chimeric antibodies - a combinatorial approach |
| FI941572L (fi) | 1991-10-07 | 1994-05-27 | Oncologix Inc | Anti-erbB-2-monoklonaalisten vasta-aineiden yhdistelmä ja käyttömenetelmä |
| WO1993008829A1 (en) | 1991-11-04 | 1993-05-13 | The Regents Of The University Of California | Compositions that mediate killing of hiv-infected cells |
| EP0617706B1 (en) | 1991-11-25 | 2001-10-17 | Enzon, Inc. | Multivalent antigen-binding proteins |
| ATE419355T1 (de) | 1992-02-06 | 2009-01-15 | Novartis Vaccines & Diagnostic | Marker für krebs und biosynthetisches bindeprotein dafür |
| CA2128862C (en) | 1992-02-11 | 2008-05-20 | Jonathan G. Seidman | Homogenotization of gene-targeting events |
| US5573905A (en) | 1992-03-30 | 1996-11-12 | The Scripps Research Institute | Encoded combinatorial chemical libraries |
| JPH08500017A (ja) | 1992-08-17 | 1996-01-09 | ジェネンテク，インコーポレイテッド | 二特異的免疫アドヘジン |
| WO1994011026A2 (en) | 1992-11-13 | 1994-05-26 | Idec Pharmaceuticals Corporation | Therapeutic application of chimeric and radiolabeled antibodies to human b lymphocyte restricted differentiation antigen for treatment of b cell lymphoma |
| CA2106612C (en) * | 1993-09-21 | 2001-02-06 | Diana Pliura | Displacement chromatography process |
| US5534615A (en) | 1994-04-25 | 1996-07-09 | Genentech, Inc. | Cardiac hypertrophy factor and uses therefor |
| US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| US5641870A (en) | 1995-04-20 | 1997-06-24 | Genentech, Inc. | Low pH hydrophobic interaction chromatography for antibody purification |
| US5712374A (en) | 1995-06-07 | 1998-01-27 | American Cyanamid Company | Method for the preparation of substantiallly monomeric calicheamicin derivative/carrier conjugates |
| DE69732129T2 (de) * | 1996-09-13 | 2005-12-08 | Transkaryotic Therapies, Inc., Cambridge | THERAPIE FÜR alpha GALACTOSIDASE A INSUFFIZIENZ |
| ES2335365T3 (es) * | 1996-11-27 | 2010-03-25 | Genentech, Inc. | Purificacion por afinidad de polipeptido en una matriz de proteina a. |
| AU760048B2 (en) * | 1998-05-06 | 2003-05-08 | Genentech Inc. | Protein purification by ion exchange chromatography |
| IL127127A0 (en) | 1998-11-18 | 1999-09-22 | Peptor Ltd | Small functional units of antibody heavy chain variable regions |
| ES2376454T3 (es) | 2000-12-22 | 2012-03-14 | Grad, Carole, Legal Representative Of Howard, Kaplan | Librer�?as de expresión en fago de fragmentos vh humanos. |
| KR100960063B1 (ko) * | 2001-02-01 | 2010-05-31 | 바이오겐 아이덱 엠에이 인코포레이티드 | 누블라스틴의 중합체 컨쥬게이트 및 이의 사용 방법 |
| JP2005289809A (ja) | 2001-10-24 | 2005-10-20 | Vlaams Interuniversitair Inst Voor Biotechnologie Vzw (Vib Vzw) | 突然変異重鎖抗体 |
| US20070261962A1 (en) * | 2002-04-02 | 2007-11-15 | Ryszard Gajek | Separation Systems with Charge Mosaic Membrane |
| EP1552878A4 (en) * | 2002-10-18 | 2006-03-22 | Asahi Kasei Pharma Corp | MICROPOR SE HYDROPHILIC MEMBRANE |
| ES2315664T3 (es) | 2003-06-30 | 2009-04-01 | Domantis Limited | Anticuerpos de dominio unico (dab) pegilados. |
| JP2008510466A (ja) | 2004-08-19 | 2008-04-10 | ジェネンテック・インコーポレーテッド | エフェクター機能が変更しているポリペプチド変異体 |
| ES2579805T3 (es) | 2004-09-23 | 2016-08-16 | Genentech, Inc. | Anticuerpos y conjugados modificados por ingeniería genética con cisteína |
| WO2006099308A2 (en) | 2005-03-11 | 2006-09-21 | Wyeth | A method of weak partitioning chromatography |
| JP2008537153A (ja) | 2005-04-22 | 2008-09-11 | ウオーターズ・インベストメンツ・リミテツド | 生体高分子の質量分析管理された精製のための装置および方法 |
| EA017733B1 (ru) * | 2006-08-28 | 2013-02-28 | Арес Трейдинг С.А. | СПОСОБ ОЧИСТКИ Fc-СЛИТЫХ БЕЛКОВ |
| CN101535335B (zh) * | 2006-08-28 | 2013-10-02 | 阿雷斯贸易股份有限公司 | 含Fc-蛋白的纯化方法 |
| ES2449148T5 (es) | 2007-06-01 | 2023-06-14 | Hoffmann La Roche | Purificación de inmunoglobulinas |
| DE102009005479A1 (de) * | 2009-01-21 | 2010-07-22 | Sartorius Stedim Biotech Gmbh | Vorrichtung und Verfahren für die Stofftrennung |
| JP5614936B2 (ja) * | 2009-02-19 | 2014-10-29 | 旭化成ケミカルズ株式会社 | アニオン交換基が固定された多孔膜を用いた核酸の精製方法 |
| US8536316B2 (en) * | 2009-08-07 | 2013-09-17 | Emd Millipore Corporation | Methods for purifying a target protein from one or more impurities in a sample |
| WO2011035282A1 (en) | 2009-09-21 | 2011-03-24 | Ge Healthcare Bio-Sciences Ab | Dual capture separation |
| CN102094034A (zh) * | 2009-12-09 | 2011-06-15 | 泰州新生源生物医药有限公司 | 一种重组人Fc融合长效干扰素的纯化工艺 |
| WO2012030512A1 (en) * | 2010-09-03 | 2012-03-08 | Percivia Llc. | Flow-through protein purification process |
| JP2014503495A (ja) * | 2010-11-15 | 2014-02-13 | バイオジェン アイデック インコーポレイテッド | 過負荷結合および溶出クロマトグラフィによる選択生成物アイソフォームの富化および濃縮 |
| ES2637423T5 (es) | 2011-11-02 | 2022-03-17 | Hoffmann La Roche | Cromatografía de sobrecarga y elución |
-
2012
- 2012-11-02 ES ES12845437T patent/ES2637423T5/es active Active
- 2012-11-02 CA CA2854330A patent/CA2854330A1/en not_active Abandoned
- 2012-11-02 AU AU2012323995A patent/AU2012323995B2/en active Active
- 2012-11-02 BR BR112014010406A patent/BR112014010406A2/pt not_active Application Discontinuation
- 2012-11-02 PL PL17157670.5T patent/PL3257564T5/pl unknown
- 2012-11-02 KR KR1020147014357A patent/KR20140091721A/ko not_active Withdrawn
- 2012-11-02 CN CN201710173196.8A patent/CN107163101B/zh active Active
- 2012-11-02 MX MX2014005330A patent/MX2014005330A/es unknown
- 2012-11-02 RS RS20190358A patent/RS58472B2/sr unknown
- 2012-11-02 SI SI201231562T patent/SI3257564T2/sl unknown
- 2012-11-02 EP EP18206718.1A patent/EP3527274B1/en active Active
- 2012-11-02 PL PL12845437T patent/PL2773438T5/pl unknown
- 2012-11-02 PT PT17157670T patent/PT3257564T/pt unknown
- 2012-11-02 DK DK17157670.5T patent/DK3257564T4/da active
- 2012-11-02 LT LTEP17157670.5T patent/LT3257564T/lt unknown
- 2012-11-02 JP JP2014540118A patent/JP6356607B2/ja active Active
- 2012-11-02 SG SG11201402019TA patent/SG11201402019TA/en unknown
- 2012-11-02 RU RU2014121884/10A patent/RU2014121884A/ru not_active Application Discontinuation
- 2012-11-02 SI SI201231031T patent/SI2773438T2/sl unknown
- 2012-11-02 HU HUE12845437A patent/HUE035685T2/en unknown
- 2012-11-02 EP EP12845437.8A patent/EP2773438B2/en active Active
- 2012-11-02 WO PCT/US2012/063242 patent/WO2013067301A1/en not_active Ceased
- 2012-11-02 HU HUE17157670A patent/HUE043755T2/hu unknown
- 2012-11-02 US US14/355,818 patent/US20140301977A1/en not_active Abandoned
- 2012-11-02 CN CN201280065729.6A patent/CN104023804B/zh active Active
- 2012-11-02 DK DK12845437.8T patent/DK2773438T4/da active
- 2012-11-02 HR HRP20190485TT patent/HRP20190485T4/hr unknown
- 2012-11-02 ES ES17157670T patent/ES2717536T5/es active Active
- 2012-11-02 FI FIEP17157670.5T patent/FI3257564T4/fi active
- 2012-11-02 TR TR2019/03707T patent/TR201903707T4/tr unknown
- 2012-11-02 EP EP17157670.5A patent/EP3257564B2/en active Active
-
2014
- 2014-04-22 IL IL232146A patent/IL232146A0/en unknown
- 2014-04-23 ZA ZA2014/02932A patent/ZA201402932B/en unknown
-
2018
- 2018-04-18 US US15/956,635 patent/US20190023768A1/en not_active Abandoned
- 2018-06-14 JP JP2018113263A patent/JP2018184405A/ja active Pending
-
2019
- 2019-11-20 JP JP2019209674A patent/JP6979442B2/ja active Active
-
2020
- 2020-10-20 US US17/075,238 patent/US20210206836A1/en active Pending
-
2021
- 2021-11-15 JP JP2021185350A patent/JP7203928B2/ja active Active
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PT3257564T (pt) | Cromatografia de eluição e sobrecarga | |
| BR112014031820A2 (pt) | aduto de politioéter e composição | |
| HRP20150926T4 (hr) | Pripravci u krutom stanju | |
| IL226307A0 (en) | Compounds and methods for treating pain | |
| BR302012002270S1 (pt) | Configuracao aplicada em motoneta | |
| EP2780789A4 (en) | CHROMATOGRAPHIC CONFIGURATION INTERFACE | |
| DE112010000691A5 (de) | Chromatographievorrichtung | |
| EP2590722A4 (en) | TIMING PROCEDURE | |
| BR112014028441A2 (pt) | composição de proteína | |
| HRP20190470T1 (hr) | Formulacija lijeka s odgođenim otpuštanjem | |
| EP2749168A4 (en) | PLASTERIC COMPOSITION AND ITS USE | |
| EP2801995A4 (en) | CIRCUIT BREAKER | |
| BR302012004412S1 (pt) | Configuração aplicada em chaise | |
| BR302012006511S1 (pt) | Configuração aplicada em estojo | |
| BRDI7106227S (pt) | Configuração aplicada em extensão | |
| IL226378A0 (en) | Pharmaceutical compositions | |
| BR302012005523S1 (pt) | Configuracao aplicada em espaçador | |
| BR302012005759S1 (pt) | Configuração aplicada em arandela | |
| BR302012005732S1 (pt) | Configuração aplicada em tamanco | |
| BR302012005615S1 (pt) | Configuração aplicada em arandela | |
| BR302012005617S1 (pt) | Configuração aplicada em arandela | |
| BR302012005616S1 (pt) | Configuração aplicada em arandela | |
| BR302012003816S1 (pt) | Configuração aplicada em tamanco | |
| BR302012003815S1 (pt) | Configuração aplicada em tamanco | |
| BR302012002500S1 (pt) | Configuração aplicada em tamanco |