PL3257564T5 - Chromatografia elucyjna z przeładowaniem - Google Patents

Chromatografia elucyjna z przeładowaniem

Info

Publication number
PL3257564T5
PL3257564T5 PL17157670.5T PL17157670T PL3257564T5 PL 3257564 T5 PL3257564 T5 PL 3257564T5 PL 17157670 T PL17157670 T PL 17157670T PL 3257564 T5 PL3257564 T5 PL 3257564T5
Authority
PL
Poland
Prior art keywords
overload
elute chromatography
elute
chromatography
Prior art date
Application number
PL17157670.5T
Other languages
English (en)
Polish (pl)
Other versions
PL3257564T3 (pl
Inventor
Deepa NADARAJAH
Amit Mehta
Original Assignee
F. Hoffmann-La Roche Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48192803&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL3257564(T5) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by F. Hoffmann-La Roche Ag filed Critical F. Hoffmann-La Roche Ag
Publication of PL3257564T3 publication Critical patent/PL3257564T3/pl
Publication of PL3257564T5 publication Critical patent/PL3257564T5/pl

Links

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D15/00Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08Selective adsorption, e.g. chromatography
    • B01D15/10Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/14Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the introduction of the feed to the apparatus
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D15/00Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08Selective adsorption, e.g. chromatography
    • B01D15/42Selective adsorption, e.g. chromatography characterised by the development mode, e.g. by displacement or by elution
    • B01D15/424Elution mode
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14Extraction; Separation; Purification
    • C07K1/16Extraction; Separation; Purification by chromatography
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14Extraction; Separation; Purification
    • C07K1/16Extraction; Separation; Purification by chromatography
    • C07K1/20Partition-, reverse-phase or hydrophobic interaction chromatography
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14Extraction; Separation; Purification
    • C07K1/16Extraction; Separation; Purification by chromatography
    • C07K1/22Affinity chromatography or related techniques based upon selective absorption processes
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D15/00Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08Selective adsorption, e.g. chromatography
    • B01D15/26Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/32Bonded phase chromatography
    • B01D15/325Reversed phase
    • B01D15/327Reversed phase with hydrophobic interaction
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D15/00Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08Selective adsorption, e.g. chromatography
    • B01D15/26Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
    • B01D15/361Ion-exchange
    • B01D15/363Anion-exchange
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D15/00Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08Selective adsorption, e.g. chromatography
    • B01D15/26Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
    • B01D15/3804Affinity chromatography
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D15/00Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08Selective adsorption, e.g. chromatography
    • B01D15/26Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
    • B01D15/3847Multimodal interactions
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14Extraction; Separation; Purification
    • C07K1/16Extraction; Separation; Purification by chromatography
    • C07K1/165Extraction; Separation; Purification by chromatography mixed-mode chromatography
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14Extraction; Separation; Purification
    • C07K1/16Extraction; Separation; Purification by chromatography
    • C07K1/18Ion-exchange chromatography

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
PL17157670.5T 2011-11-02 2012-11-02 Chromatografia elucyjna z przeładowaniem PL3257564T5 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201161554898P 2011-11-02 2011-11-02
EP17157670.5A EP3257564B2 (en) 2011-11-02 2012-11-02 Overload and elute chromatography
EP12845437.8A EP2773438B2 (en) 2011-11-02 2012-11-02 Overload and elute chromatography
PCT/US2012/063242 WO2013067301A1 (en) 2011-11-02 2012-11-02 Overload and elute chromatography

Publications (2)

Publication Number Publication Date
PL3257564T3 PL3257564T3 (pl) 2019-06-28
PL3257564T5 true PL3257564T5 (pl) 2024-10-07

Family

ID=48192803

Family Applications (2)

Application Number Title Priority Date Filing Date
PL12845437T PL2773438T5 (pl) 2011-11-02 2012-11-02 Chromatografia przeciążenia i elucji
PL17157670.5T PL3257564T5 (pl) 2011-11-02 2012-11-02 Chromatografia elucyjna z przeładowaniem

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PL12845437T PL2773438T5 (pl) 2011-11-02 2012-11-02 Chromatografia przeciążenia i elucji

Country Status (25)

Country Link
US (3) US20140301977A1 (enExample)
EP (3) EP3527274B1 (enExample)
JP (4) JP6356607B2 (enExample)
KR (1) KR20140091721A (enExample)
CN (2) CN107163101B (enExample)
AU (1) AU2012323995B2 (enExample)
BR (1) BR112014010406A2 (enExample)
CA (1) CA2854330A1 (enExample)
DK (2) DK2773438T4 (enExample)
ES (2) ES2717536T5 (enExample)
FI (1) FI3257564T4 (enExample)
HR (1) HRP20190485T4 (enExample)
HU (2) HUE043755T2 (enExample)
IL (1) IL232146A0 (enExample)
LT (1) LT3257564T (enExample)
MX (1) MX2014005330A (enExample)
PL (2) PL2773438T5 (enExample)
PT (1) PT3257564T (enExample)
RS (1) RS58472B2 (enExample)
RU (1) RU2014121884A (enExample)
SG (1) SG11201402019TA (enExample)
SI (2) SI2773438T2 (enExample)
TR (1) TR201903707T4 (enExample)
WO (1) WO2013067301A1 (enExample)
ZA (1) ZA201402932B (enExample)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG10201803960SA (en) 2010-07-30 2018-07-30 Emd Millipore Corp Chromatography media and method
US9062106B2 (en) 2011-04-27 2015-06-23 Abbvie Inc. Methods for controlling the galactosylation profile of recombinantly-expressed proteins
SI2773438T2 (sl) 2011-11-02 2022-05-31 F.Hoffmann-La Roche Ag Izpiralna kromatografija s preobremenitvijo
US9150645B2 (en) 2012-04-20 2015-10-06 Abbvie, Inc. Cell culture methods to reduce acidic species
US9505833B2 (en) 2012-04-20 2016-11-29 Abbvie Inc. Human antibodies that bind human TNF-alpha and methods of preparing the same
US9067990B2 (en) 2013-03-14 2015-06-30 Abbvie, Inc. Protein purification using displacement chromatography
US9181572B2 (en) 2012-04-20 2015-11-10 Abbvie, Inc. Methods to modulate lysine variant distribution
US9249182B2 (en) * 2012-05-24 2016-02-02 Abbvie, Inc. Purification of antibodies using hydrophobic interaction chromatography
US9512214B2 (en) 2012-09-02 2016-12-06 Abbvie, Inc. Methods to control protein heterogeneity
WO2014066471A1 (en) * 2012-10-24 2014-05-01 Genzyme Corporation Elution of biomolecules from multi-modal resins using mes and mops as mobile phase modifiers
US10023608B1 (en) 2013-03-13 2018-07-17 Amgen Inc. Protein purification methods to remove impurities
US9499614B2 (en) 2013-03-14 2016-11-22 Abbvie Inc. Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosaccharides
US9017687B1 (en) 2013-10-18 2015-04-28 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same using displacement chromatography
EP3052640A2 (en) 2013-10-04 2016-08-10 AbbVie Inc. Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins
US9085618B2 (en) 2013-10-18 2015-07-21 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same
US9181337B2 (en) 2013-10-18 2015-11-10 Abbvie, Inc. Modulated lysine variant species compositions and methods for producing and using the same
US20150139988A1 (en) 2013-11-15 2015-05-21 Abbvie, Inc. Glycoengineered binding protein compositions
WO2015088677A1 (en) 2013-12-12 2015-06-18 Emd Millipore Corporation Protein separations using an acrylamide containing filter
ES2869309T3 (es) * 2013-12-13 2021-10-25 Novo Nordisk Healthcare Ag Método para la conjugación de proteínas con tioéter
KR20150083689A (ko) * 2014-01-10 2015-07-20 삼성전자주식회사 항 c-Met 항체 정제 방법
HUE048782T2 (hu) 2014-03-10 2020-08-28 Richter Gedeon Nyrt Immunoglobulin tisztítása elõtisztítási lépések alkalmazásával
EP3124618B1 (en) * 2014-03-24 2019-05-15 Nitto Boseki Co., Ltd. Method for separating and concentrating target substance using novel cationic graft polymer
US10280195B2 (en) * 2014-05-28 2019-05-07 Agency For Science, Technology And Research Virus reduction method
SG11201610431WA (en) * 2014-06-25 2017-01-27 Jhl Biotech Inc Methods and reagents for purification of proteins
CN104208719B (zh) * 2014-09-24 2017-05-03 北京天广实生物技术股份有限公司 一种抗体偶联药物的阳离子交换层析纯化方法
CN107001410A (zh) 2014-12-08 2017-08-01 Emd密理博公司 混合床离子交换吸附剂
ES2761726T3 (es) * 2015-03-06 2020-05-20 Hoffmann La Roche DsbA y DsbC ultrapurificadas y procedimientos de preparación y uso de las mismas
CN106290591B (zh) * 2015-05-14 2019-07-26 上海医药工业研究院 一种庆大霉素C1a的检测方法
GB2539420B (en) * 2015-06-16 2021-01-13 Cytiva Sweden Ab Determination of chromatography conditions
CN107849122B (zh) * 2015-08-21 2022-01-25 豪夫迈·罗氏有限公司 用低电导率洗涤缓冲液进行亲和层析纯化
AU2016312909B2 (en) 2015-08-21 2022-12-08 F. Hoffmann-La Roche Ag Method for the reduction of host cell proteins in affinity chromatography
SG11201901228QA (en) * 2016-08-15 2019-03-28 Genentech Inc Chromatography method for quantifying a non-ionic surfactant in a composition comprising the non-ionic surfactant and a polypeptide
GB201702856D0 (en) * 2017-02-22 2017-04-05 Ge Healthcare Bio Sciences Ab Method in continuous chromatography
US11339377B2 (en) * 2017-11-08 2022-05-24 Bluesky Immunotherapies Gmbh SO3 chromatography for use in a method for virus purification
WO2020007715A1 (en) * 2018-07-04 2020-01-09 Probiogen Ag Method for purifying an enveloped virus
EP3899526B1 (en) * 2018-12-21 2024-05-01 Solventum Intellectual Properties Company Method for testing a chromatography device used for ion exchange
WO2020172658A1 (en) 2019-02-24 2020-08-27 Bristol-Myers Squibb Company Methods of isolating a protein
TWI870412B (zh) * 2019-06-05 2025-01-21 美商建南德克公司 過載層析管柱之再生方法
CN111351876A (zh) * 2020-04-01 2020-06-30 上海中科新生命生物科技有限公司 一种抗体药中宿主细胞蛋白半绝对定量检测方法
US11379651B1 (en) * 2020-07-06 2022-07-05 Turtl Surf & Immerse Limited Methods and systems for interactive content creation
US12486525B2 (en) 2020-09-22 2025-12-02 Bristol-Myers Squibb Company Methods for increasing productivity of therapeutic proteins
JP7620456B2 (ja) * 2021-03-15 2025-01-23 株式会社カネカ κ鎖を含む抗体の製造方法
EP4408856A4 (en) * 2021-09-28 2025-11-12 Kashiv Biosciences Llc IMPROVED PROCESS FOR PROTEIN PURIFICATION
JP2024537490A (ja) * 2021-10-27 2024-10-10 プラズマ テクノロジーズ エルエルシー タンパク質を単離するための構成及び方法

Family Cites Families (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2413974A1 (fr) 1978-01-06 1979-08-03 David Bernard Sechoir pour feuilles imprimees par serigraphie
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4676980A (en) 1985-09-23 1987-06-30 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Target specific cross-linked heteroantibodies
US5567610A (en) 1986-09-04 1996-10-22 Bioinvent International Ab Method of producing human monoclonal antibodies and kit therefor
IL85035A0 (en) 1987-01-08 1988-06-30 Int Genetic Eng Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same
GB8823869D0 (en) 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
US5175384A (en) 1988-12-05 1992-12-29 Genpharm International Transgenic mice depleted in mature t-cells and methods for making transgenic mice
EP0402226A1 (en) 1989-06-06 1990-12-12 Institut National De La Recherche Agronomique Transformation vectors for yeast yarrowia
DE3920358A1 (de) 1989-06-22 1991-01-17 Behringwerke Ag Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
AU641673B2 (en) 1989-06-29 1993-09-30 Medarex, Inc. Bispecific reagents for aids therapy
US5208020A (en) 1989-10-25 1993-05-04 Immunogen Inc. Cytotoxic agents comprising maytansinoids and their therapeutic use
US5229275A (en) 1990-04-26 1993-07-20 Akzo N.V. In-vitro method for producing antigen-specific human monoclonal antibodies
AU8295491A (en) 1990-06-29 1992-01-23 Biosource Technologies Incorporated Melanin production by transformed microorganisms
US5571894A (en) 1991-02-05 1996-11-05 Ciba-Geigy Corporation Recombinant antibodies specific for a growth factor receptor
JPH06507398A (ja) 1991-05-14 1994-08-25 リプリジェン コーポレーション Hiv感染治療のための異種複合抗体
DE122004000008I1 (de) 1991-06-14 2005-06-09 Genentech Inc Humanisierter Heregulin Antikörper.
IE922437A1 (en) 1991-07-25 1993-01-27 Idec Pharma Corp Recombinant antibodies for human therapy
US5565332A (en) 1991-09-23 1996-10-15 Medical Research Council Production of chimeric antibodies - a combinatorial approach
FI941572A7 (fi) 1991-10-07 1994-05-27 Oncologix Inc Anti-erbB-2-monoklonaalisten vasta-aineiden yhdistelmä ja käyttömenete lmä
WO1993008829A1 (en) 1991-11-04 1993-05-13 The Regents Of The University Of California Compositions that mediate killing of hiv-infected cells
EP1136556B1 (en) 1991-11-25 2005-06-08 Enzon, Inc. Method of producing multivalent antigen-binding proteins
JPH08500962A (ja) 1992-02-06 1996-02-06 クリエイティブ バイオモレキュルズ,インコーポレイテッド 癌マーカー用生物合成結合蛋白質
EP0626012B1 (en) 1992-02-11 2003-07-09 Cell Genesys, Inc. Homogenotization of gene-targeting events
US5573905A (en) 1992-03-30 1996-11-12 The Scripps Research Institute Encoded combinatorial chemical libraries
ATE149570T1 (de) 1992-08-17 1997-03-15 Genentech Inc Bispezifische immunoadhesine
EP1005870B1 (en) 1992-11-13 2009-01-21 Biogen Idec Inc. Therapeutic application of chimeric antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma
CA2106612C (en) * 1993-09-21 2001-02-06 Diana Pliura Displacement chromatography process
US5534615A (en) 1994-04-25 1996-07-09 Genentech, Inc. Cardiac hypertrophy factor and uses therefor
US5731168A (en) 1995-03-01 1998-03-24 Genentech, Inc. Method for making heteromultimeric polypeptides
US5641870A (en) 1995-04-20 1997-06-24 Genentech, Inc. Low pH hydrophobic interaction chromatography for antibody purification
US5712374A (en) 1995-06-07 1998-01-27 American Cyanamid Company Method for the preparation of substantiallly monomeric calicheamicin derivative/carrier conjugates
DK2374876T3 (en) * 1996-09-13 2016-05-30 Shire Human Genetic Therapies A process for the purification of alpha-galactosidase A
DK0950067T3 (da) * 1996-11-27 2007-12-27 Genentech Inc Affinitetsoprensning af polypeptid på protein A-matrix
US6489447B1 (en) * 1998-05-06 2002-12-03 Genentech, Inc. Protein purification
IL127127A0 (en) 1998-11-18 1999-09-22 Peptor Ltd Small functional units of antibody heavy chain variable regions
US8372954B2 (en) 2000-12-22 2013-02-12 National Research Council Of Canada Phage display libraries of human VH fragments
UA100967C2 (ru) * 2001-02-01 2013-02-25 Байоджен Айдек Ма Інк. Конъюгаты нейбластина с полимерами и способы их применения
JP2005289809A (ja) 2001-10-24 2005-10-20 Vlaams Interuniversitair Inst Voor Biotechnologie Vzw (Vib Vzw) 突然変異重鎖抗体
US20070261962A1 (en) * 2002-04-02 2007-11-15 Ryszard Gajek Separation Systems with Charge Mosaic Membrane
KR100668573B1 (ko) * 2002-10-18 2007-01-16 아사히 카세이 메디칼 가부시키가이샤 친수성 미다공막
DK1639011T3 (da) 2003-06-30 2009-02-16 Domantis Ltd Pegylerede enkelt-domæne antistoffer (dAb)
ZA200701715B (en) 2004-08-19 2008-07-30 Genentech Inc Polypeptide variants with altered effector function
TR201808537T4 (tr) 2004-09-23 2018-07-23 Genentech Inc Sistein değiştirilmiş antikorlar ve konjugatlar.
RU2457214C2 (ru) 2005-03-11 2012-07-27 Вайет Способ хроматографии в режиме слабого распределения
WO2006116064A2 (en) 2005-04-22 2006-11-02 Waters Investments Limited Apparatus and methods for mass-spectrometric directed purification of biopolymers
ZA200900837B (en) * 2006-08-28 2010-05-26 Ares Trading Sa Process for the purification of FC-containing proteins
CN101541825B (zh) * 2006-08-28 2013-08-14 阿雷斯贸易股份有限公司 Fc融合蛋白的纯化方法
KR101226353B1 (ko) 2007-06-01 2013-01-24 에프. 호프만-라 로슈 아게 면역글로불린 정제
DE102009005479A1 (de) * 2009-01-21 2010-07-22 Sartorius Stedim Biotech Gmbh Vorrichtung und Verfahren für die Stofftrennung
JP5614936B2 (ja) * 2009-02-19 2014-10-29 旭化成ケミカルズ株式会社 アニオン交換基が固定された多孔膜を用いた核酸の精製方法
SG177577A1 (en) * 2009-08-07 2012-03-29 Emd Millipore Corp Methods for purifying a target protein from one or more impurities in a sample
WO2011035282A1 (en) * 2009-09-21 2011-03-24 Ge Healthcare Bio-Sciences Ab Dual capture separation
CN102094034A (zh) * 2009-12-09 2011-06-15 泰州新生源生物医药有限公司 一种重组人Fc融合长效干扰素的纯化工艺
WO2012030512A1 (en) * 2010-09-03 2012-03-08 Percivia Llc. Flow-through protein purification process
WO2012068134A1 (en) 2010-11-15 2012-05-24 Biogen Idec Inc. Enrichment and concentration of select product isoforms by overloaded bind and elute chromatography
SI2773438T2 (sl) 2011-11-02 2022-05-31 F.Hoffmann-La Roche Ag Izpiralna kromatografija s preobremenitvijo

Also Published As

Publication number Publication date
JP2018184405A (ja) 2018-11-22
ZA201402932B (en) 2016-08-31
EP3527274A1 (en) 2019-08-21
SI3257564T2 (sl) 2024-10-30
BR112014010406A2 (pt) 2017-04-25
EP2773438A4 (en) 2015-06-03
LT3257564T (lt) 2019-04-10
CN104023804A (zh) 2014-09-03
EP2773438B1 (en) 2017-06-14
EP2773438B2 (en) 2021-10-20
FI3257564T4 (fi) 2024-08-30
MX2014005330A (es) 2014-09-08
ES2717536T3 (es) 2019-06-21
EP3527274B1 (en) 2025-12-24
SG11201402019TA (en) 2014-09-26
EP3257564B1 (en) 2019-01-23
EP2773438A1 (en) 2014-09-10
CA2854330A1 (en) 2013-05-10
DK3257564T3 (en) 2019-04-15
DK2773438T4 (da) 2022-01-03
PL2773438T5 (pl) 2022-01-17
SI2773438T2 (sl) 2022-05-31
RU2014121884A (ru) 2015-12-10
JP6979442B2 (ja) 2021-12-15
HUE043755T2 (hu) 2019-09-30
EP3257564A1 (en) 2017-12-20
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RS58472B2 (sr) 2024-10-31
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CN104023804B (zh) 2017-05-24
SI2773438T1 (sl) 2017-10-30
RS58472B1 (sr) 2019-04-30
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HK1201489A1 (zh) 2015-09-04
SI3257564T1 (sl) 2019-04-30
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PL2773438T3 (pl) 2017-11-30
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DK2773438T3 (en) 2017-08-21
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