JP6356607B2 - オーバーロード／溶出クロマトグラフィー - Google Patents

オーバーロード／溶出クロマトグラフィー Download PDF

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Publication number
JP6356607B2
JP6356607B2 JP2014540118A JP2014540118A JP6356607B2 JP 6356607 B2 JP6356607 B2 JP 6356607B2 JP 2014540118 A JP2014540118 A JP 2014540118A JP 2014540118 A JP2014540118 A JP 2014540118A JP 6356607 B2 JP6356607 B2 JP 6356607B2
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antibody
polypeptide
chromatography
buffer
conductivity
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Japanese (ja)
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JP2014532718A (ja
JP2014532718A5 (enExample
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ディーパ ナダラジャ，
ディーパ ナダラジャ，
アミト メータ，
アミト メータ，
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Genentech Inc
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Genentech Inc
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/14—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the introduction of the feed to the apparatus
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/42—Selective adsorption, e.g. chromatography characterised by the development mode, e.g. by displacement or by elution
    • B01D15/424—Elution mode
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/20—Partition-, reverse-phase or hydrophobic interaction chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/32—Bonded phase chromatography
    • B01D15/325—Reversed phase
    • B01D15/327—Reversed phase with hydrophobic interaction
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
    • B01D15/361—Ion-exchange
    • B01D15/363—Anion-exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
    • B01D15/3804—Affinity chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
    • B01D15/3847—Multimodal interactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/165—Extraction; Separation; Purification by chromatography mixed-mode chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2014540118A 2011-11-02 2012-11-02 オーバーロード／溶出クロマトグラフィー Active JP6356607B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161554898P 2011-11-02 2011-11-02
US61/554,898 2011-11-02
PCT/US2012/063242 WO2013067301A1 (en) 2011-11-02 2012-11-02 Overload and elute chromatography

Related Child Applications (1)

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JP2018113263A Division JP2018184405A (ja) 2011-11-02 2018-06-14 オーバーロード／溶出クロマトグラフィー

Publications (3)

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JP2014532718A JP2014532718A (ja) 2014-12-08
JP2014532718A5 JP2014532718A5 (enExample) 2015-12-24
JP6356607B2 true JP6356607B2 (ja) 2018-07-11

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JP2014540118A Active JP6356607B2 (ja) 2011-11-02 2012-11-02 オーバーロード／溶出クロマトグラフィー
JP2018113263A Pending JP2018184405A (ja) 2011-11-02 2018-06-14 オーバーロード／溶出クロマトグラフィー
JP2019209674A Active JP6979442B2 (ja) 2011-11-02 2019-11-20 オーバーロード／溶出クロマトグラフィー
JP2021185350A Active JP7203928B2 (ja) 2011-11-02 2021-11-15 オーバーロード／溶出クロマトグラフィー

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JP2021185350A Active JP7203928B2 (ja) 2011-11-02 2021-11-15 オーバーロード／溶出クロマトグラフィー

Country Status (25)

Country Link
US (3) US20140301977A1 (enExample)
EP (3) EP3527274B1 (enExample)
JP (4) JP6356607B2 (enExample)
KR (1) KR20140091721A (enExample)
CN (2) CN104023804B (enExample)
AU (1) AU2012323995B2 (enExample)
BR (1) BR112014010406A2 (enExample)
CA (1) CA2854330A1 (enExample)
DK (2) DK3257564T4 (enExample)
ES (2) ES2637423T5 (enExample)
FI (1) FI3257564T4 (enExample)
HR (1) HRP20190485T4 (enExample)
HU (2) HUE035685T2 (enExample)
IL (1) IL232146A0 (enExample)
LT (1) LT3257564T (enExample)
MX (1) MX2014005330A (enExample)
PL (2) PL2773438T5 (enExample)
PT (1) PT3257564T (enExample)
RS (1) RS58472B2 (enExample)
RU (1) RU2014121884A (enExample)
SG (1) SG11201402019TA (enExample)
SI (2) SI2773438T2 (enExample)
TR (1) TR201903707T4 (enExample)
WO (1) WO2013067301A1 (enExample)
ZA (1) ZA201402932B (enExample)

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