JP2014532718A5 - - Google Patents
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- JP2014532718A5 JP2014532718A5 JP2014540118A JP2014540118A JP2014532718A5 JP 2014532718 A5 JP2014532718 A5 JP 2014532718A5 JP 2014540118 A JP2014540118 A JP 2014540118A JP 2014540118 A JP2014540118 A JP 2014540118A JP 2014532718 A5 JP2014532718 A5 JP 2014532718A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- conductivity
- elution buffer
- buffer
- antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161554898P | 2011-11-02 | 2011-11-02 | |
| US61/554,898 | 2011-11-02 | ||
| PCT/US2012/063242 WO2013067301A1 (en) | 2011-11-02 | 2012-11-02 | Overload and elute chromatography |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018113263A Division JP2018184405A (ja) | 2011-11-02 | 2018-06-14 | オーバーロード／溶出クロマトグラフィー |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014532718A JP2014532718A (ja) | 2014-12-08 |
| JP2014532718A5 true JP2014532718A5 (enExample) | 2015-12-24 |
| JP6356607B2 JP6356607B2 (ja) | 2018-07-11 |
Family
ID=48192803
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014540118A Active JP6356607B2 (ja) | 2011-11-02 | 2012-11-02 | オーバーロード／溶出クロマトグラフィー |
| JP2018113263A Pending JP2018184405A (ja) | 2011-11-02 | 2018-06-14 | オーバーロード／溶出クロマトグラフィー |
| JP2019209674A Active JP6979442B2 (ja) | 2011-11-02 | 2019-11-20 | オーバーロード／溶出クロマトグラフィー |
| JP2021185350A Active JP7203928B2 (ja) | 2011-11-02 | 2021-11-15 | オーバーロード／溶出クロマトグラフィー |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018113263A Pending JP2018184405A (ja) | 2011-11-02 | 2018-06-14 | オーバーロード／溶出クロマトグラフィー |
| JP2019209674A Active JP6979442B2 (ja) | 2011-11-02 | 2019-11-20 | オーバーロード／溶出クロマトグラフィー |
| JP2021185350A Active JP7203928B2 (ja) | 2011-11-02 | 2021-11-15 | オーバーロード／溶出クロマトグラフィー |
Country Status (25)
| Country | Link |
|---|---|
| US (3) | US20140301977A1 (enExample) |
| EP (3) | EP3527274B1 (enExample) |
| JP (4) | JP6356607B2 (enExample) |
| KR (1) | KR20140091721A (enExample) |
| CN (2) | CN104023804B (enExample) |
| AU (1) | AU2012323995B2 (enExample) |
| BR (1) | BR112014010406A2 (enExample) |
| CA (1) | CA2854330A1 (enExample) |
| DK (2) | DK3257564T4 (enExample) |
| ES (3) | ES3062963T3 (enExample) |
| FI (1) | FI3257564T4 (enExample) |
| HR (2) | HRP20260140T1 (enExample) |
| HU (2) | HUE043755T2 (enExample) |
| IL (1) | IL232146A0 (enExample) |
| LT (1) | LT3257564T (enExample) |
| MX (1) | MX2014005330A (enExample) |
| PL (3) | PL2773438T5 (enExample) |
| PT (1) | PT3257564T (enExample) |
| RS (1) | RS58472B2 (enExample) |
| RU (1) | RU2014121884A (enExample) |
| SG (1) | SG11201402019TA (enExample) |
| SI (2) | SI2773438T2 (enExample) |
| TR (1) | TR201903707T4 (enExample) |
| WO (1) | WO2013067301A1 (enExample) |
| ZA (1) | ZA201402932B (enExample) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9029517B2 (en) | 2010-07-30 | 2015-05-12 | Emd Millipore Corporation | Chromatography media and method |
| US9062106B2 (en) | 2011-04-27 | 2015-06-23 | Abbvie Inc. | Methods for controlling the galactosylation profile of recombinantly-expressed proteins |
| EP3527274B1 (en) | 2011-11-02 | 2025-12-24 | F. Hoffmann-La Roche AG | Overload and elute chromatography |
| WO2013158273A1 (en) | 2012-04-20 | 2013-10-24 | Abbvie Inc. | Methods to modulate c-terminal lysine variant distribution |
| US9067990B2 (en) | 2013-03-14 | 2015-06-30 | Abbvie, Inc. | Protein purification using displacement chromatography |
| WO2013158279A1 (en) | 2012-04-20 | 2013-10-24 | Abbvie Inc. | Protein purification methods to reduce acidic species |
| US9249182B2 (en) * | 2012-05-24 | 2016-02-02 | Abbvie, Inc. | Purification of antibodies using hydrophobic interaction chromatography |
| US9512214B2 (en) | 2012-09-02 | 2016-12-06 | Abbvie, Inc. | Methods to control protein heterogeneity |
| CN104884147A (zh) | 2012-10-24 | 2015-09-02 | 建新公司 | 使用mes和mops作为流动相改性剂从多峰树脂洗脱生物分子 |
| SG11201507230PA (en) | 2013-03-12 | 2015-10-29 | Abbvie Inc | Human antibodies that bind human tnf-alpha and methods of preparing the same |
| US10023608B1 (en) | 2013-03-13 | 2018-07-17 | Amgen Inc. | Protein purification methods to remove impurities |
| US9017687B1 (en) | 2013-10-18 | 2015-04-28 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same using displacement chromatography |
| WO2014151878A2 (en) | 2013-03-14 | 2014-09-25 | Abbvie Inc. | Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosacharides |
| EP3052640A2 (en) | 2013-10-04 | 2016-08-10 | AbbVie Inc. | Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins |
| US9181337B2 (en) | 2013-10-18 | 2015-11-10 | Abbvie, Inc. | Modulated lysine variant species compositions and methods for producing and using the same |
| US9085618B2 (en) | 2013-10-18 | 2015-07-21 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same |
| WO2015073884A2 (en) | 2013-11-15 | 2015-05-21 | Abbvie, Inc. | Glycoengineered binding protein compositions |
| WO2015088677A1 (en) | 2013-12-12 | 2015-06-18 | Emd Millipore Corporation | Protein separations using an acrylamide containing filter |
| CN106068127B (zh) * | 2013-12-13 | 2020-06-19 | 诺和诺德保健股份有限公司 | 蛋白质的硫醚缀合方法 |
| KR20150083689A (ko) * | 2014-01-10 | 2015-07-20 | 삼성전자주식회사 | 항 c-Met 항체 정제 방법 |
| SI3116891T1 (sl) | 2014-03-10 | 2020-07-31 | Richter Gedeon Nyrt. | Čiščenje imunoglobulina z uporabo predčistilnih stopenj |
| US10252258B2 (en) * | 2014-03-24 | 2019-04-09 | Nitto Boseki Co., Ltd. | Method for separating and concentrating target substance using novel cationic graft polymer |
| SG11201609908VA (en) * | 2014-05-28 | 2016-12-29 | Agency Science Tech & Res | Virus reduction method |
| KR20170026521A (ko) * | 2014-06-25 | 2017-03-08 | 제이에이치엘 바이오테크 인코포레이티드 | 단백질의 정제를 위한 방법 및 시약 |
| CN104208719B (zh) * | 2014-09-24 | 2017-05-03 | 北京天广实生物技术股份有限公司 | 一种抗体偶联药物的阳离子交换层析纯化方法 |
| US20170298091A1 (en) | 2014-12-08 | 2017-10-19 | Emd Millipore Corporation | Mixed Bed Ion Exchange Adsorber |
| SG10202005917SA (en) * | 2015-03-06 | 2020-07-29 | Genentech Inc | Ultrapurified dsba and dsbc and methods of making and using the same |
| CN106290591B (zh) * | 2015-05-14 | 2019-07-26 | 上海医药工业研究院 | 一种庆大霉素C1a的检测方法 |
| GB2539420B (en) * | 2015-06-16 | 2021-01-13 | Cytiva Sweden Ab | Determination of chromatography conditions |
| ES2877532T3 (es) | 2015-08-21 | 2021-11-17 | Hoffmann La Roche | Procedimiento para la reducción de proteínas de célula huésped en cromatografía de afinidad |
| WO2017032610A1 (en) * | 2015-08-21 | 2017-03-02 | F. Hoffmann-La Roche Ag | Affinity chromatography purification with low conductivity wash buffer |
| JP7286536B2 (ja) * | 2016-08-15 | 2023-06-05 | ジェネンテック， インコーポレイテッド | 非イオン性サーファクタント及びポリペプチドを含む組成物中の非イオン性サーファクタントを定量するためのクロマトグラフィー法 |
| GB201702856D0 (en) * | 2017-02-22 | 2017-04-05 | Ge Healthcare Bio Sciences Ab | Method in continuous chromatography |
| WO2019092084A1 (en) * | 2017-11-08 | 2019-05-16 | Blue Sky Vaccines Gmbh | So3 chromatography for use in a method for virus purification |
| CA3104392A1 (en) * | 2018-07-04 | 2020-01-09 | Probiogen Ag | Method for purifying an enveloped virus |
| WO2020128797A1 (en) * | 2018-12-21 | 2020-06-25 | 3M Innovative Properties Company | Method for testing a chromatography device used for ion exchange |
| US20220135619A1 (en) | 2019-02-24 | 2022-05-05 | Bristol-Myers Squibb Company | Methods of isolating a protein |
| AR119264A1 (es) | 2019-06-05 | 2021-12-09 | Genentech Inc | Método para reutilización de cromatografía |
| CN111351876A (zh) * | 2020-04-01 | 2020-06-30 | 上海中科新生命生物科技有限公司 | 一种抗体药中宿主细胞蛋白半绝对定量检测方法 |
| US11379651B1 (en) * | 2020-07-06 | 2022-07-05 | Turtl Surf & Immerse Limited | Methods and systems for interactive content creation |
| US12486525B2 (en) | 2020-09-22 | 2025-12-02 | Bristol-Myers Squibb Company | Methods for increasing productivity of therapeutic proteins |
| CN116802206A (zh) * | 2020-12-28 | 2023-09-22 | 等离子体技术有限责任公司 | 用于生产规模的免疫球蛋白g分离系统和方法 |
| JP7620456B2 (ja) * | 2021-03-15 | 2025-01-23 | 株式会社カネカ | κ鎖を含む抗体の製造方法 |
| WO2023053030A1 (en) * | 2021-09-28 | 2023-04-06 | Kashiv Biosciences, Llc | An improved process for purification of protein |
Family Cites Families (56)
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|---|---|---|---|---|
| FR2413974A1 (fr) | 1978-01-06 | 1979-08-03 | David Bernard | Sechoir pour feuilles imprimees par serigraphie |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4676980A (en) | 1985-09-23 | 1987-06-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Target specific cross-linked heteroantibodies |
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| IL85035A0 (en) | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| US5175384A (en) | 1988-12-05 | 1992-12-29 | Genpharm International | Transgenic mice depleted in mature t-cells and methods for making transgenic mice |
| EP0402226A1 (en) | 1989-06-06 | 1990-12-12 | Institut National De La Recherche Agronomique | Transformation vectors for yeast yarrowia |
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| WO2012030512A1 (en) * | 2010-09-03 | 2012-03-08 | Percivia Llc. | Flow-through protein purification process |
| AU2011329053A1 (en) | 2010-11-15 | 2013-06-06 | Biogen Inc. | Enrichment and concentration of select product isoforms by overloaded bind and elute chromatography |
| EP3527274B1 (en) | 2011-11-02 | 2025-12-24 | F. Hoffmann-La Roche AG | Overload and elute chromatography |
-
2012
- 2012-11-02 EP EP18206718.1A patent/EP3527274B1/en active Active
- 2012-11-02 PL PL12845437T patent/PL2773438T5/pl unknown
- 2012-11-02 BR BR112014010406A patent/BR112014010406A2/pt not_active Application Discontinuation
- 2012-11-02 CN CN201280065729.6A patent/CN104023804B/zh active Active
- 2012-11-02 EP EP17157670.5A patent/EP3257564B2/en active Active
- 2012-11-02 PL PL17157670.5T patent/PL3257564T5/pl unknown
- 2012-11-02 ES ES18206718T patent/ES3062963T3/es active Active
- 2012-11-02 PT PT17157670T patent/PT3257564T/pt unknown
- 2012-11-02 HU HUE17157670A patent/HUE043755T2/hu unknown
- 2012-11-02 ES ES12845437T patent/ES2637423T5/es active Active
- 2012-11-02 US US14/355,818 patent/US20140301977A1/en not_active Abandoned
- 2012-11-02 SI SI201231031T patent/SI2773438T2/sl unknown
- 2012-11-02 AU AU2012323995A patent/AU2012323995B2/en active Active
- 2012-11-02 SG SG11201402019TA patent/SG11201402019TA/en unknown
- 2012-11-02 RS RS20190358A patent/RS58472B2/sr unknown
- 2012-11-02 SI SI201231562T patent/SI3257564T2/sl unknown
- 2012-11-02 RU RU2014121884/10A patent/RU2014121884A/ru not_active Application Discontinuation
- 2012-11-02 JP JP2014540118A patent/JP6356607B2/ja active Active
- 2012-11-02 HR HRP20260140TT patent/HRP20260140T1/hr unknown
- 2012-11-02 DK DK17157670.5T patent/DK3257564T4/da active
- 2012-11-02 HU HUE12845437A patent/HUE035685T2/en unknown
- 2012-11-02 DK DK12845437.8T patent/DK2773438T4/da active
- 2012-11-02 ES ES17157670T patent/ES2717536T5/es active Active
- 2012-11-02 CA CA2854330A patent/CA2854330A1/en not_active Abandoned
- 2012-11-02 KR KR1020147014357A patent/KR20140091721A/ko not_active Withdrawn
- 2012-11-02 TR TR2019/03707T patent/TR201903707T4/tr unknown
- 2012-11-02 FI FIEP17157670.5T patent/FI3257564T4/fi active
- 2012-11-02 MX MX2014005330A patent/MX2014005330A/es unknown
- 2012-11-02 EP EP12845437.8A patent/EP2773438B2/en active Active
- 2012-11-02 PL PL18206718.1T patent/PL3527274T3/pl unknown
- 2012-11-02 CN CN201710173196.8A patent/CN107163101B/zh active Active
- 2012-11-02 LT LTEP17157670.5T patent/LT3257564T/lt unknown
- 2012-11-02 HR HRP20190485TT patent/HRP20190485T4/hr unknown
- 2012-11-02 WO PCT/US2012/063242 patent/WO2013067301A1/en not_active Ceased
-
2014
- 2014-04-22 IL IL232146A patent/IL232146A0/en unknown
- 2014-04-23 ZA ZA2014/02932A patent/ZA201402932B/en unknown
-
2018
- 2018-04-18 US US15/956,635 patent/US20190023768A1/en not_active Abandoned
- 2018-06-14 JP JP2018113263A patent/JP2018184405A/ja active Pending
-
2019
- 2019-11-20 JP JP2019209674A patent/JP6979442B2/ja active Active
-
2020
- 2020-10-20 US US17/075,238 patent/US20210206836A1/en active Pending
-
2021
- 2021-11-15 JP JP2021185350A patent/JP7203928B2/ja active Active
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