JP2013530156A5 - - Google Patents
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- Publication number
- JP2013530156A5 JP2013530156A5 JP2013512218A JP2013512218A JP2013530156A5 JP 2013530156 A5 JP2013530156 A5 JP 2013530156A5 JP 2013512218 A JP2013512218 A JP 2013512218A JP 2013512218 A JP2013512218 A JP 2013512218A JP 2013530156 A5 JP2013530156 A5 JP 2013530156A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- cation exchange
- loading
- exchange material
- buffer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims description 58
- 239000000463 material Substances 0.000 claims description 49
- 238000005341 cation exchange Methods 0.000 claims description 30
- 239000000203 mixture Substances 0.000 claims description 26
- 239000000356 contaminant Substances 0.000 claims description 6
- 239000011347 resin Substances 0.000 claims description 6
- 229920005989 resin Polymers 0.000 claims description 6
- 238000000746 purification Methods 0.000 claims description 4
- 239000006167 equilibration buffer Substances 0.000 claims 6
- 239000012160 loading buffer Substances 0.000 claims 6
- 239000011534 wash buffer Substances 0.000 claims 6
- 229920002684 Sepharose Polymers 0.000 claims 4
- 239000012634 fragment Substances 0.000 claims 4
- 102000004169 proteins and genes Human genes 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- -1 sulfopropyl Chemical group 0.000 claims 3
- 239000000427 antigen Substances 0.000 claims 2
- 102000036639 antigens Human genes 0.000 claims 2
- 108091007433 antigens Proteins 0.000 claims 2
- 125000000524 functional group Chemical group 0.000 claims 2
- 241000699802 Cricetulus griseus Species 0.000 claims 1
- CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 claims 1
- 229930182566 Gentamicin Natural products 0.000 claims 1
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims 1
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims 1
- 238000005349 anion exchange Methods 0.000 claims 1
- 239000013018 capto adhere resin Substances 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 125000002843 carboxylic acid group Chemical group 0.000 claims 1
- 239000006143 cell culture medium Substances 0.000 claims 1
- 239000000919 ceramic Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 229960002518 gentamicin Drugs 0.000 claims 1
- 230000002209 hydrophobic effect Effects 0.000 claims 1
- 230000003993 interaction Effects 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- 238000002156 mixing Methods 0.000 claims 1
- 210000001672 ovary Anatomy 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 125000000542 sulfonic acid group Chemical group 0.000 claims 1
- 230000003612 virological effect Effects 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 description 6
- 102000004196 processed proteins & peptides Human genes 0.000 description 6
- 108090000765 processed proteins & peptides Proteins 0.000 description 6
- 239000013019 capto adhere Substances 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34814310P | 2010-05-25 | 2010-05-25 | |
| US61/348,143 | 2010-05-25 | ||
| PCT/US2011/037977 WO2011150110A1 (en) | 2010-05-25 | 2011-05-25 | Methods of purifying polypeptides |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016093347A Division JP6272941B2 (ja) | 2010-05-25 | 2016-05-06 | ポリペプチドの精製方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013530156A JP2013530156A (ja) | 2013-07-25 |
| JP2013530156A5 true JP2013530156A5 (enExample) | 2016-02-25 |
| JP5934190B2 JP5934190B2 (ja) | 2016-06-15 |
Family
ID=45004368
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013512218A Active JP5934190B2 (ja) | 2010-05-25 | 2011-05-25 | ポリペプチドの精製方法 |
| JP2016093347A Active JP6272941B2 (ja) | 2010-05-25 | 2016-05-06 | ポリペプチドの精製方法 |
| JP2018000140A Pending JP2018087192A (ja) | 2010-05-25 | 2018-01-04 | ポリペプチドの精製方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016093347A Active JP6272941B2 (ja) | 2010-05-25 | 2016-05-06 | ポリペプチドの精製方法 |
| JP2018000140A Pending JP2018087192A (ja) | 2010-05-25 | 2018-01-04 | ポリペプチドの精製方法 |
Country Status (21)
| Country | Link |
|---|---|
| US (5) | US20130079272A1 (enExample) |
| EP (3) | EP4492053A3 (enExample) |
| JP (3) | JP5934190B2 (enExample) |
| KR (1) | KR101976853B1 (enExample) |
| CN (2) | CN102905718A (enExample) |
| AU (1) | AU2011258254B2 (enExample) |
| CA (2) | CA2799915C (enExample) |
| ES (2) | ES2637613T5 (enExample) |
| HK (1) | HK1246328A1 (enExample) |
| HR (2) | HRP20171095T4 (enExample) |
| HU (1) | HUE068857T2 (enExample) |
| IL (2) | IL223029A0 (enExample) |
| MX (2) | MX370828B (enExample) |
| MY (1) | MY161534A (enExample) |
| NZ (1) | NZ603648A (enExample) |
| PL (2) | PL2575847T5 (enExample) |
| RU (1) | RU2594163C2 (enExample) |
| SG (2) | SG10201710439UA (enExample) |
| SI (1) | SI2575847T2 (enExample) |
| WO (1) | WO2011150110A1 (enExample) |
| ZA (1) | ZA201208673B (enExample) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HRP20171095T4 (hr) | 2010-05-25 | 2022-07-22 | F. Hoffmann - La Roche Ag | Postupci pročišćavanja polipeptida |
| ES2767135T3 (es) * | 2011-10-19 | 2020-06-16 | Novimmune Sa | Métodos para purificar anticuerpos |
| PL2794635T3 (pl) * | 2011-12-22 | 2019-02-28 | F.Hoffmann-La Roche Ag | Membranowa chromatografia jonowymienna |
| CN102911250B (zh) * | 2012-09-29 | 2014-04-16 | 浙江海正药业股份有限公司 | 酸性重组蛋白药物的纯化方法 |
| CN103880947B (zh) * | 2012-12-21 | 2016-01-13 | 武汉禾元生物科技股份有限公司 | 一种分离纯化高纯度重组人血清白蛋白的层析方法 |
| WO2014118685A2 (en) * | 2013-01-29 | 2014-08-07 | Dr. Reddy's Laboratories Limited | Method of altering the acidic variant content of antibody |
| EP2971087B1 (en) * | 2013-03-14 | 2017-11-01 | Qiagen Sciences, LLC | Assessing dna quality using real-time pcr and ct values |
| CN104236983A (zh) * | 2013-06-14 | 2014-12-24 | 中国科学院大连化学物理研究所 | 溶液样品中含长烷基链的离子液体的去除方法 |
| EP3041593B1 (en) | 2013-09-05 | 2025-01-29 | F. Hoffmann-La Roche AG | Method of cleaning a chromatography material for its reuse |
| PL3044323T3 (pl) | 2013-09-13 | 2022-06-27 | F.Hoffmann-La Roche Ag | Sposoby wykrywania i ilościowego oznaczania białka komórki gospodarza w liniach komórkowych |
| SG11201601823TA (en) | 2013-09-13 | 2016-04-28 | Genentech Inc | Methods and compositions comprising purified recombinant polypeptides |
| AU2014337263B2 (en) | 2013-10-16 | 2019-12-12 | Outlook Therapeutics, Inc. | Buffer formulations for enhanced antibody stability |
| US8859252B1 (en) | 2014-01-02 | 2014-10-14 | Aerial Biopharma, Llc | Prostatic acid phosphatase, compositions comprising the same, and methods for producing and/or purifying the same |
| EP3092002B1 (en) * | 2014-01-09 | 2019-09-25 | Kentucky Bioprocessing, Inc. | Method of purifying monoclonal antibodies |
| EP3116891B1 (en) | 2014-03-10 | 2020-02-12 | Richter Gedeon Nyrt. | Immunoglobulin purification using pre-cleaning steps |
| WO2015177751A1 (en) * | 2014-05-23 | 2015-11-26 | Instituto Massone S.A. | A process for obtaining hmg-up (human menopausal gonadotropin with ultra-purity grade) and a composition free of contaminants |
| WO2015198320A1 (en) * | 2014-06-24 | 2015-12-30 | Insight Biopharmaceuticals Ltd. | Methods of purifying antibodies |
| GB201411802D0 (en) | 2014-07-02 | 2014-08-13 | Univ Bradford | Effervescent compositions |
| EP3247718B1 (en) * | 2015-01-21 | 2021-09-01 | Outlook Therapeutics, Inc. | Modulation of charge variants in a monoclonal antibody composition |
| EP3411401A1 (en) | 2016-02-03 | 2018-12-12 | Oncobiologics, Inc. | Buffer formulations for enhanced antibody stability |
| CA3026518A1 (en) | 2016-06-17 | 2017-12-21 | Genentech, Inc. | Purification of multispecific antibodies |
| CN115598231B (zh) * | 2016-08-15 | 2025-11-18 | 豪夫迈·罗氏有限公司 | 定量包含非离子表面活性剂和多肽的组合物中非离子表面活性剂的层析方法 |
| JP6564539B1 (ja) | 2018-09-14 | 2019-08-21 | 長瀬産業株式会社 | スルホン酸化合物によるペプチド精製方法 |
| JP7458404B2 (ja) * | 2018-12-20 | 2024-03-29 | アーマジェン・インコーポレイテッド | イズロン酸－２－スルファターゼ免疫グロブリン融合タンパク質の精製 |
| CN109765307B (zh) * | 2018-12-24 | 2021-06-29 | 山东省科学院海洋仪器仪表研究所 | 一种水体中六氯环己烷的测量方法 |
| CN111366547A (zh) * | 2018-12-26 | 2020-07-03 | 贵州中烟工业有限责任公司 | 一种用连续流动法测定烟草或烟草制品中α-氨基氮的检测方法 |
| WO2020153390A1 (ja) | 2019-01-23 | 2020-07-30 | 第一三共株式会社 | 活性炭材料を使用する工程を含む抗体精製方法 |
| AU2020268896B2 (en) | 2019-05-03 | 2024-11-28 | F. Hoffmann-La Roche Ag | Methods of reducing the enzymatic hydrolysis activity rate in a composition obtained from a purification platform |
| AR119264A1 (es) * | 2019-06-05 | 2021-12-09 | Genentech Inc | Método para reutilización de cromatografía |
| CN114599971A (zh) * | 2019-10-14 | 2022-06-07 | 皮尔斯生物科技有限公司 | 肽纯化配制物和方法 |
| AU2021208515A1 (en) | 2020-01-15 | 2022-08-04 | F. Hoffmann-La Roche Ag | Methods to decrease impurities from recombinant protein manufacturing processes |
| AU2021262609A1 (en) | 2020-05-01 | 2022-12-22 | Kashiv Biosciences, Llc | An improved process of purification of protein |
| AU2021281152A1 (en) * | 2020-05-28 | 2022-12-22 | Kashiv Biosciences, Llc | An improved process of storing and preparing the protein |
| US20230251269A1 (en) * | 2020-07-15 | 2023-08-10 | The Johns Hopkins University | Comprehensive analysis of anti-allergen antibodies using phage display |
| IL302333A (en) * | 2020-10-30 | 2023-06-01 | Genentech Inc | Purification platforms for obtaining pharmaceutical preparations with a reduced hydrolytic enzyme activity rate |
| CN112852876B (zh) * | 2021-03-04 | 2022-11-29 | 西南大学 | 一种表达人表皮生长因子的家蚕丝腺重组表达载体及其制备方法和应用 |
| AU2022249605A1 (en) | 2021-03-31 | 2023-09-14 | F. Hoffmann-La Roche Ag | Purification of antibodies by mixed mode chromatography |
| WO2026105035A1 (en) * | 2024-11-14 | 2026-05-21 | H. Lundbeck A/S | Antibody purification by a multi chromatography process |
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-
2011
- 2011-05-25 HR HRP20171095TT patent/HRP20171095T4/hr unknown
- 2011-05-25 SI SI201131267T patent/SI2575847T2/sl unknown
- 2011-05-25 PL PL11787363.8T patent/PL2575847T5/pl unknown
- 2011-05-25 HU HUE17167800A patent/HUE068857T2/hu unknown
- 2011-05-25 CN CN2011800254040A patent/CN102905718A/zh active Pending
- 2011-05-25 WO PCT/US2011/037977 patent/WO2011150110A1/en not_active Ceased
- 2011-05-25 SG SG10201710439UA patent/SG10201710439UA/en unknown
- 2011-05-25 AU AU2011258254A patent/AU2011258254B2/en active Active
- 2011-05-25 HR HRP20241463TT patent/HRP20241463T1/hr unknown
- 2011-05-25 MY MYPI2012005025A patent/MY161534A/en unknown
- 2011-05-25 KR KR1020127033600A patent/KR101976853B1/ko active Active
- 2011-05-25 MX MX2016016228A patent/MX370828B/es unknown
- 2011-05-25 EP EP24189611.7A patent/EP4492053A3/en active Pending
- 2011-05-25 CN CN201710269454.2A patent/CN107365346A/zh active Pending
- 2011-05-25 NZ NZ603648A patent/NZ603648A/en unknown
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2016
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2020
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