MY161534A - Methods of purifying polypeptides - Google Patents

Methods of purifying polypeptides

Info

Publication number
MY161534A
MY161534A MYPI2012005025A MYPI2012005025A MY161534A MY 161534 A MY161534 A MY 161534A MY PI2012005025 A MYPI2012005025 A MY PI2012005025A MY PI2012005025 A MYPI2012005025 A MY PI2012005025A MY 161534 A MY161534 A MY 161534A
Authority
MY
Malaysia
Prior art keywords
methods
polypeptide
purifying
purifying polypeptides
polypeptides
Prior art date
Application number
MYPI2012005025A
Other languages
English (en)
Inventor
Hui F Liu
Brian David Kelley
Deanna E Myers
Beth Mccooey
Krista Marie Petty
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45004368&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MY161534(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of MY161534A publication Critical patent/MY161534A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
    • B01D15/361—Ion-exchange
    • B01D15/362—Cation-exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
    • B01D15/3847—Multimodal interactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/165—Extraction; Separation; Purification by chromatography mixed-mode chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
    • G01N2030/8813—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials
    • G01N2030/8831—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials involving peptides or proteins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
MYPI2012005025A 2010-05-25 2011-05-25 Methods of purifying polypeptides MY161534A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US34814310P 2010-05-25 2010-05-25

Publications (1)

Publication Number Publication Date
MY161534A true MY161534A (en) 2017-04-28

Family

ID=45004368

Family Applications (1)

Application Number Title Priority Date Filing Date
MYPI2012005025A MY161534A (en) 2010-05-25 2011-05-25 Methods of purifying polypeptides

Country Status (21)

Country Link
US (5) US20130079272A1 (enExample)
EP (3) EP3299380B1 (enExample)
JP (3) JP5934190B2 (enExample)
KR (1) KR101976853B1 (enExample)
CN (2) CN107365346A (enExample)
AU (1) AU2011258254B2 (enExample)
CA (2) CA2799915C (enExample)
ES (2) ES2991883T3 (enExample)
HK (1) HK1246328A1 (enExample)
HR (2) HRP20171095T4 (enExample)
HU (1) HUE068857T2 (enExample)
IL (2) IL223029A0 (enExample)
MX (2) MX344248B (enExample)
MY (1) MY161534A (enExample)
NZ (1) NZ603648A (enExample)
PL (2) PL3299380T3 (enExample)
RU (1) RU2594163C2 (enExample)
SG (2) SG185737A1 (enExample)
SI (1) SI2575847T2 (enExample)
WO (1) WO2011150110A1 (enExample)
ZA (1) ZA201208673B (enExample)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY161534A (en) 2010-05-25 2017-04-28 Genentech Inc Methods of purifying polypeptides
AU2012351751B2 (en) * 2011-10-19 2017-09-07 Novimmune S.A. Methods of purifying antibodies
IL267585B (en) * 2011-12-22 2022-09-01 Genentech Inc Ion exchange membrane chromatography
CN102911250B (zh) * 2012-09-29 2014-04-16 浙江海正药业股份有限公司 酸性重组蛋白药物的纯化方法
CN103880947B (zh) * 2012-12-21 2016-01-13 武汉禾元生物科技股份有限公司 一种分离纯化高纯度重组人血清白蛋白的层析方法
WO2014118685A2 (en) * 2013-01-29 2014-08-07 Dr. Reddy's Laboratories Limited Method of altering the acidic variant content of antibody
EP2971087B1 (en) 2013-03-14 2017-11-01 Qiagen Sciences, LLC Assessing dna quality using real-time pcr and ct values
CN104236983A (zh) * 2013-06-14 2014-12-24 中国科学院大连化学物理研究所 溶液样品中含长烷基链的离子液体的去除方法
EP3041593B1 (en) * 2013-09-05 2025-01-29 F. Hoffmann-La Roche AG Method of cleaning a chromatography material for its reuse
CN105722532A (zh) 2013-09-13 2016-06-29 豪夫迈·罗氏有限公司 包含纯化的重组多肽的方法和组合物
BR112016004437A2 (pt) 2013-09-13 2017-10-17 Genentech Inc métodos de imunoteste e de seleção de linhagem de células, anticorpos e kit
US10376582B2 (en) 2013-10-16 2019-08-13 Outlook Therapeutics, Inc. Buffer formulations for enhanced antibody stability
US8859252B1 (en) 2014-01-02 2014-10-14 Aerial Biopharma, Llc Prostatic acid phosphatase, compositions comprising the same, and methods for producing and/or purifying the same
WO2015105551A1 (en) * 2014-01-09 2015-07-16 Kentucky Bioprocessing, Inc. Method of purifying monoclonal antibodies
PT3116891T (pt) 2014-03-10 2020-05-18 Richter Gedeon Nyrt Purificação de imunoglobulina utilizando passos de pré-limpeza
EP3145950B1 (en) * 2014-05-23 2019-01-09 Instituto Massone S.A. A process for obtaining hmg-up (human menopausal gonadotropin with ultra-purity grade) and a composition free of contaminants
US20170183376A1 (en) * 2014-06-24 2017-06-29 Insight Biopharmaceuticals Ltd. Methods of purifying antibodies
GB201411802D0 (en) 2014-07-02 2014-08-13 Univ Bradford Effervescent compositions
WO2016118707A1 (en) * 2015-01-21 2016-07-28 Oncobiologics, Inc. Modulation of charge variants in a monoclonal antibody composition
AU2017213775A1 (en) 2016-02-03 2018-08-16 Outlook Therapeutics, Inc. Buffer formulations for enhanced antibody stability
EP3472177B1 (en) 2016-06-17 2024-08-14 F. Hoffmann-La Roche AG Purification of multispecific antibodies
CN109716127B (zh) 2016-08-15 2022-06-14 豪夫迈·罗氏有限公司 定量包含非离子表面活性剂和多肽的组合物中非离子表面活性剂的层析方法
JP6564539B1 (ja) 2018-09-14 2019-08-21 長瀬産業株式会社 スルホン酸化合物によるペプチド精製方法
US20220002688A1 (en) * 2018-12-20 2022-01-06 Armagen, Inc. Purification of iduronate-2-sulfatase immunoglobulin fusion protein
CN109765307B (zh) * 2018-12-24 2021-06-29 山东省科学院海洋仪器仪表研究所 一种水体中六氯环己烷的测量方法
CN111366547A (zh) * 2018-12-26 2020-07-03 贵州中烟工业有限责任公司 一种用连续流动法测定烟草或烟草制品中α-氨基氮的检测方法
TW202045527A (zh) 2019-01-23 2020-12-16 日商第一三共股份有限公司 包含使用活性碳材料之步驟之抗體純化方法
EP3962924A1 (en) 2019-05-03 2022-03-09 Genentech, Inc. Methods of reducing the enzymatic hydrolysis activity rate in a composition obtained from a purification platform
AR119264A1 (es) * 2019-06-05 2021-12-09 Genentech Inc Método para reutilización de cromatografía
KR20220079844A (ko) * 2019-10-14 2022-06-14 피어스 바이오테크놀로지, 인크 펩티드 정제 제제 및 방법
CA3182940A1 (en) * 2020-05-28 2021-12-02 Kashiv Biosciences, Llc An improved process of storing and preparing the protein formulation
US20230251269A1 (en) * 2020-07-15 2023-08-10 The Johns Hopkins University Comprehensive analysis of anti-allergen antibodies using phage display
EP4237116A1 (en) * 2020-10-30 2023-09-06 Genentech, Inc. Purification platforms for obtaining pharmaceutical compositions having a reduced hydrolytic enzyme activity rate
CN112852876B (zh) * 2021-03-04 2022-11-29 西南大学 一种表达人表皮生长因子的家蚕丝腺重组表达载体及其制备方法和应用
EP4314009A1 (en) 2021-03-31 2024-02-07 F. Hoffmann-La Roche AG Purification of antibodies by mixed mode chromatography

Family Cites Families (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4704362A (en) 1977-11-08 1987-11-03 Genentech, Inc. Recombinant cloning vehicle microbial polypeptide expression
FR2413974A1 (fr) 1978-01-06 1979-08-03 David Bernard Sechoir pour feuilles imprimees par serigraphie
US4399216A (en) 1980-02-25 1983-08-16 The Trustees Of Columbia University Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4419446A (en) 1980-12-31 1983-12-06 The United States Of America As Represented By The Department Of Health And Human Services Recombinant DNA process utilizing a papilloma virus DNA as a vector
NZ201705A (en) 1981-08-31 1986-03-14 Genentech Inc Recombinant dna method for production of hepatitis b surface antigen in yeast
US4601978A (en) 1982-11-24 1986-07-22 The Regents Of The University Of California Mammalian metallothionein promoter system
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4965199A (en) 1984-04-20 1990-10-23 Genentech, Inc. Preparation of functional human factor VIII in mammalian cells using methotrexate based selection
US4676980A (en) 1985-09-23 1987-06-30 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Target specific cross-linked heteroantibodies
US5567610A (en) 1986-09-04 1996-10-22 Bioinvent International Ab Method of producing human monoclonal antibodies and kit therefor
IL85035A0 (en) 1987-01-08 1988-06-30 Int Genetic Eng Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same
DE3850542T2 (de) 1987-09-23 1994-11-24 Bristol Myers Squibb Co Antikörper-Heterokonjugate zur Töting von HIV-infizierten Zellen.
JPH04501201A (ja) 1987-12-21 1992-03-05 ジ・アップジョン・カンパニー 発芽植物種子類のアグロバクテリウム媒介形質転換
GB8823869D0 (en) 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
US5175384A (en) 1988-12-05 1992-12-29 Genpharm International Transgenic mice depleted in mature t-cells and methods for making transgenic mice
FR2646437B1 (fr) 1989-04-28 1991-08-30 Transgene Sa Nouvelles sequences d'adn, leur application en tant que sequence codant pour un peptide signal pour la secretion de proteines matures par des levures recombinantes, cassettes d'expression, levures transformees et procede de preparation de proteines correspondant
EP0402226A1 (en) 1989-06-06 1990-12-12 Institut National De La Recherche Agronomique Transformation vectors for yeast yarrowia
DE3920358A1 (de) 1989-06-22 1991-01-17 Behringwerke Ag Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
ATE144793T1 (de) 1989-06-29 1996-11-15 Medarex Inc Bispezifische reagenzien für die aids-therapie
US5208020A (en) 1989-10-25 1993-05-04 Immunogen Inc. Cytotoxic agents comprising maytansinoids and their therapeutic use
US5229275A (en) 1990-04-26 1993-07-20 Akzo N.V. In-vitro method for producing antigen-specific human monoclonal antibodies
US5571894A (en) 1991-02-05 1996-11-05 Ciba-Geigy Corporation Recombinant antibodies specific for a growth factor receptor
WO1992020373A1 (en) 1991-05-14 1992-11-26 Repligen Corporation Heteroconjugate antibodies for treatment of hiv infection
EP0590058B1 (en) 1991-06-14 2003-11-26 Genentech, Inc. HUMANIZED Heregulin ANTIBODy
MX9204374A (es) 1991-07-25 1993-03-01 Idec Pharma Corp Anticuerpo recombinante y metodo para su produccion.
US5565332A (en) 1991-09-23 1996-10-15 Medical Research Council Production of chimeric antibodies - a combinatorial approach
FI941572L (fi) 1991-10-07 1994-05-27 Oncologix Inc Anti-erbB-2-monoklonaalisten vasta-aineiden yhdistelmä ja käyttömenetelmä
WO1993008829A1 (en) 1991-11-04 1993-05-13 The Regents Of The University Of California Compositions that mediate killing of hiv-infected cells
AU3178993A (en) 1991-11-25 1993-06-28 Enzon, Inc. Multivalent antigen-binding proteins
ATE419355T1 (de) 1992-02-06 2009-01-15 Novartis Vaccines & Diagnostic Marker für krebs und biosynthetisches bindeprotein dafür
EP0626012B1 (en) 1992-02-11 2003-07-09 Cell Genesys, Inc. Homogenotization of gene-targeting events
US5573905A (en) 1992-03-30 1996-11-12 The Scripps Research Institute Encoded combinatorial chemical libraries
ATE149570T1 (de) 1992-08-17 1997-03-15 Genentech Inc Bispezifische immunoadhesine
US5736137A (en) 1992-11-13 1998-04-07 Idec Pharmaceuticals Corporation Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma
ES2091684T3 (es) 1992-11-13 1996-11-01 Idec Pharma Corp Aplicacion terapeutica de anticuerpos quimericos y radiomarcados contra el antigeno de diferenciacion restringida de los linfocitos b humanos para el tratamiento del linfoma de las celulas b.
CA2106612C (en) 1993-09-21 2001-02-06 Diana Pliura Displacement chromatography process
US5545328A (en) * 1993-09-21 1996-08-13 Hemosol Inc. Purification of hemoglobin by displacement chromatography
US5534615A (en) 1994-04-25 1996-07-09 Genentech, Inc. Cardiac hypertrophy factor and uses therefor
US5731168A (en) 1995-03-01 1998-03-24 Genentech, Inc. Method for making heteromultimeric polypeptides
US5840523A (en) 1995-03-01 1998-11-24 Genetech, Inc. Methods and compositions for secretion of heterologous polypeptides
US5641870A (en) 1995-04-20 1997-06-24 Genentech, Inc. Low pH hydrophobic interaction chromatography for antibody purification
US5712374A (en) 1995-06-07 1998-01-27 American Cyanamid Company Method for the preparation of substantiallly monomeric calicheamicin derivative/carrier conjugates
US6592905B1 (en) * 1996-01-31 2003-07-15 Massey University Production of an immunoglobulin enriched fraction from whey protein solutions
US6037454A (en) 1996-11-27 2000-03-14 Genentech, Inc. Humanized anti-CD11a antibodies
US20020032315A1 (en) 1997-08-06 2002-03-14 Manuel Baca Anti-vegf antibodies
ATE321066T1 (de) 1998-05-06 2006-04-15 Genentech Inc Anti-her2 antikörperzusammensetzung
JP4319979B2 (ja) 2002-04-26 2009-08-26 ジェネンテック・インコーポレーテッド タンパク質の非アフィニティ精製
SE526227C2 (sv) 2002-05-15 2005-08-02 North China Pharmaceutical Group Metod för rening av rekombinant humant serumalbumin
EP1753455A2 (en) 2004-06-04 2007-02-21 Genentech, Inc. Method for treating multiple sclerosis
WO2006031370A2 (en) 2004-08-19 2006-03-23 Genentech, Inc. Polypeptide variants with altered effector function
ES2579805T3 (es) 2004-09-23 2016-08-16 Genentech, Inc. Anticuerpos y conjugados modificados por ingeniería genética con cisteína
WO2006043895A1 (en) 2004-10-21 2006-04-27 Ge Healthcare Bio-Sciences Ab A method of antibody purification
KR101482791B1 (ko) 2005-03-11 2015-01-21 와이어쓰 엘엘씨 약한 분배성 크로마토그래피법
JP2008535913A (ja) * 2005-04-11 2008-09-04 メダレックス インコーポレーティッド タンパク質精製方法
DE112006001012B4 (de) 2005-04-22 2017-05-18 Waters Technologies Corp. (N.D.Ges.D. Staates Delaware) Verfahren für eine auf Massenspektrometrie gerichtete Aufbereitung von Biopolymeren
US7691980B2 (en) 2007-01-09 2010-04-06 Bio-Rad Laboratories, Inc. Enhanced capacity and purification of antibodies by mixed mode chromatography in the presence of aqueous-soluble nonionic organic polymers
JP5361738B2 (ja) 2007-01-22 2013-12-04 ジェネンテック， インコーポレイテッド 多価電解質沈殿物及びタンパク質の精製
MX2009012786A (es) 2007-06-01 2009-12-10 Hoffmann La Roche Purificacion de inmunoglobulina.
US9433922B2 (en) * 2007-08-14 2016-09-06 Emd Millipore Corporation Media for membrane ion exchange chromatography based on polymeric primary amines, sorption device containing that media, and chromatography scheme and purification method using the same
CL2008003218A1 (es) * 2007-10-30 2009-03-06 Genentech Inc Método para la purificación de un anticuerpo a partir de una composición que comprende el anticuerpo y al menos un contaminante.
US8188242B2 (en) 2008-04-08 2012-05-29 Bio-Rad Laboratories, Inc. Chromatography purification of antibodies
US20110105725A1 (en) 2008-05-15 2011-05-05 Novo Nordisk A/S Antibody purification process
KR101843915B1 (ko) 2008-08-14 2018-04-02 제넨테크, 인크. 고유 단백질 대체 이온 교환 막 크로마토그래피를 이용한 오염물의 제거 방법
EP2360183B1 (en) 2008-12-19 2016-07-27 Takeda Pharmaceutical Company Limited Antibody purification method by mixed mode chromatography utilizing an arginine-containing loading solution
RU2011140486A (ru) * 2009-03-06 2013-04-20 МЕДИММЬЮН, ЭлЭлСи Композиции, содержащие гуманизированные антитела к cd19
CN102574911B (zh) 2009-08-07 2017-06-06 Emd密理博公司 从样品的一或多种杂质中纯化靶蛋白的方法
WO2011035282A1 (en) 2009-09-21 2011-03-24 Ge Healthcare Bio-Sciences Ab Dual capture separation
WO2011037983A1 (en) * 2009-09-23 2011-03-31 Medarex, Inc. Cation exchange chromatography
MY161534A (en) 2010-05-25 2017-04-28 Genentech Inc Methods of purifying polypeptides
WO2012068134A1 (en) 2010-11-15 2012-05-24 Biogen Idec Inc. Enrichment and concentration of select product isoforms by overloaded bind and elute chromatography

Also Published As

Publication number Publication date
US20250034204A1 (en) 2025-01-30
HRP20171095T4 (hr) 2022-07-22
HUE068857T2 (hu) 2025-02-28
NZ603648A (en) 2014-12-24
ES2991883T3 (es) 2024-12-05
SI2575847T1 (sl) 2017-09-29
US20190300566A1 (en) 2019-10-03
EP2575847B2 (en) 2022-04-27
MX344248B (es) 2016-12-09
EP3299380C0 (en) 2024-08-28
JP2018087192A (ja) 2018-06-07
KR20130086544A (ko) 2013-08-02
PL3299380T3 (pl) 2024-12-16
US12152054B2 (en) 2024-11-26
CA2799915C (en) 2023-09-26
HK1246328A1 (zh) 2018-09-07
US20130079272A1 (en) 2013-03-28
CA2799915A1 (en) 2011-12-01
JP5934190B2 (ja) 2016-06-15
EP4492053A2 (en) 2025-01-15
JP2016190851A (ja) 2016-11-10
MX370828B (es) 2020-01-08
PL2575847T3 (pl) 2017-10-31
US20200399307A1 (en) 2020-12-24
BR112012029904A2 (pt) 2017-08-08
CN107365346A (zh) 2017-11-21
AU2011258254A1 (en) 2013-01-10
ES2637613T5 (es) 2022-07-20
EP2575847A1 (en) 2013-04-10
HRP20241463T1 (hr) 2025-01-03
CN102905718A (zh) 2013-01-30
IL223029A0 (en) 2013-02-03
EP2575847A4 (en) 2014-10-08
EP3299380B1 (en) 2024-08-28
KR101976853B1 (ko) 2019-05-09
IL261147A (en) 2018-10-31
CA3209878A1 (en) 2011-12-01
JP6272941B2 (ja) 2018-01-31
RU2012156271A (ru) 2014-06-27
ES2637613T3 (es) 2017-10-13
WO2011150110A1 (en) 2011-12-01
JP2013530156A (ja) 2013-07-25
HRP20171095T1 (hr) 2017-10-06
AU2011258254B2 (en) 2016-01-07
US20220064209A1 (en) 2022-03-03
EP3299380A1 (en) 2018-03-28
SG10201710439UA (en) 2018-01-30
RU2594163C2 (ru) 2016-08-10
EP2575847B1 (en) 2017-06-14
MX2012013575A (es) 2013-03-21
ZA201208673B (en) 2016-02-24
PL2575847T5 (pl) 2022-07-18
SG185737A1 (en) 2013-01-30
SI2575847T2 (sl) 2022-08-31
EP4492053A3 (en) 2025-03-19

Similar Documents

Publication Publication Date Title
MY161534A (en) Methods of purifying polypeptides
WO2010034032A3 (en) Methods for preparing purified polypeptide compositions
PH12017502300A1 (en) Pesticidal compositions and processes related thereto
PH12017501298A1 (en) Pesticidal compositions and processes related thereto
HUE046909T2 (hu) Eljárás rekombináns ADAMTS13 és más proteinek és készítményeik tisztítására
MX2010003685A (es) Analogos de quinolona y metodos relacionados con los mismos.
MX2010006576A (es) Composiciones y metodos para producir isopreno.
IL194120A0 (en) Stabilized polypeptide compositions
PH12013502686A1 (en) Pesticidal compositions and processes related thereto
MX336807B (es) Composiciones y metodos para producir una composicion.
MX355431B (es) Composiciones plaguicidas y procesos relacionados con dichas composiciones.
PH12014500910A1 (en) Pesticidal compositions and processes related thereto
WO2012068105A3 (en) Compositions and uses thereof in converting contaminants
UA97502C2 (ru) Кристаллическая твердая основа разагилина
MX342920B (es) Metodo para purificar polipeptidos o inmunoconjugados activos.
CA2705357C (en) Formulations for taci-immunoglobulin fusion proteins
ZA200709239B (en) Compositions for administering RNAIII-inhibiting peptides
MX2007005221A (es) Formas cristalinas de ascomicina y preparacion de ellas.
IL187460A0 (en) Versatile high load concentrate compositions comprising metaflumizone for control of ecto- parasites
IN2015MN00027A (enExample)
ZA201202491B (en) Process for the purification of recombinant human erythropoietin (epo), epo thus purified and pharmaceutical compositions comprising same
ZA200807964B (en) Stabilized polypeptide compositions
MX339461B (es) Polipeptidos y composiciones inmunizantes que contienen polipeptidos grampositivos y metodos de uso.
PL2004149T3 (pl) Preparaty farmaceutyczne zawierające leflunomid
TW200638932A (en) CCI-779 polymorph and use thereof