HRP20171095T4 - Postupci pročišćavanja polipeptida - Google Patents
Postupci pročišćavanja polipeptida Download PDFInfo
- Publication number
- HRP20171095T4 HRP20171095T4 HRP20171095TT HRP20171095T HRP20171095T4 HR P20171095 T4 HRP20171095 T4 HR P20171095T4 HR P20171095T T HRP20171095T T HR P20171095TT HR P20171095 T HRP20171095 T HR P20171095T HR P20171095 T4 HRP20171095 T4 HR P20171095T4
- Authority
- HR
- Croatia
- Prior art keywords
- buffer
- antibody
- cation exchange
- exchange material
- mixed sample
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims 27
- 229920001184 polypeptide Polymers 0.000 title claims 4
- 102000004196 processed proteins & peptides Human genes 0.000 title claims 4
- 108090000765 processed proteins & peptides Proteins 0.000 title claims 4
- 239000000463 material Substances 0.000 claims 12
- 238000005341 cation exchange Methods 0.000 claims 9
- 239000006167 equilibration buffer Substances 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 6
- 239000000523 sample Substances 0.000 claims 6
- 239000000872 buffer Substances 0.000 claims 5
- 239000011534 wash buffer Substances 0.000 claims 5
- 239000012634 fragment Substances 0.000 claims 4
- 150000001768 cations Chemical class 0.000 claims 3
- 239000000356 contaminant Substances 0.000 claims 3
- 102000004169 proteins and genes Human genes 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- -1 sulfopropyl Chemical group 0.000 claims 3
- 239000000427 antigen Substances 0.000 claims 2
- 102000036639 antigens Human genes 0.000 claims 2
- 108091007433 antigens Proteins 0.000 claims 2
- 125000000524 functional group Chemical group 0.000 claims 2
- 241000699802 Cricetulus griseus Species 0.000 claims 1
- CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 claims 1
- 229930182566 Gentamicin Natural products 0.000 claims 1
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims 1
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims 1
- 238000005349 anion exchange Methods 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 125000002843 carboxylic acid group Chemical group 0.000 claims 1
- 239000012534 cell culture medium component Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 229960002518 gentamicin Drugs 0.000 claims 1
- 230000002209 hydrophobic effect Effects 0.000 claims 1
- 230000003993 interaction Effects 0.000 claims 1
- 239000012160 loading buffer Substances 0.000 claims 1
- 210000001672 ovary Anatomy 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 238000000746 purification Methods 0.000 claims 1
- 238000011084 recovery Methods 0.000 claims 1
- 239000011347 resin Substances 0.000 claims 1
- 229920005989 resin Polymers 0.000 claims 1
- 125000000542 sulfonic acid group Chemical group 0.000 claims 1
- 230000003612 virological effect Effects 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/18—Ion-exchange chromatography
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
- B01D15/361—Ion-exchange
- B01D15/362—Cation-exchange
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
- B01D15/3847—Multimodal interactions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/165—Extraction; Separation; Purification by chromatography mixed-mode chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
- G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
- G01N2030/8813—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials
- G01N2030/8831—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials involving peptides or proteins
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Analytical Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34814310P | 2010-05-25 | 2010-05-25 | |
| PCT/US2011/037977 WO2011150110A1 (en) | 2010-05-25 | 2011-05-25 | Methods of purifying polypeptides |
| EP11787363.8A EP2575847B2 (en) | 2010-05-25 | 2011-05-25 | Methods of purifying polypeptides |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HRP20171095T1 HRP20171095T1 (hr) | 2017-10-06 |
| HRP20171095T4 true HRP20171095T4 (hr) | 2022-07-22 |
Family
ID=45004368
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20171095TT HRP20171095T4 (hr) | 2010-05-25 | 2011-05-25 | Postupci pročišćavanja polipeptida |
| HRP20241463TT HRP20241463T1 (hr) | 2010-05-25 | 2011-05-25 | Metode pročišćavanja polipeptida |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20241463TT HRP20241463T1 (hr) | 2010-05-25 | 2011-05-25 | Metode pročišćavanja polipeptida |
Country Status (21)
| Country | Link |
|---|---|
| US (5) | US20130079272A1 (enExample) |
| EP (3) | EP4492053A3 (enExample) |
| JP (3) | JP5934190B2 (enExample) |
| KR (1) | KR101976853B1 (enExample) |
| CN (2) | CN102905718A (enExample) |
| AU (1) | AU2011258254B2 (enExample) |
| CA (2) | CA2799915C (enExample) |
| ES (2) | ES2637613T5 (enExample) |
| HK (1) | HK1246328A1 (enExample) |
| HR (2) | HRP20171095T4 (enExample) |
| HU (1) | HUE068857T2 (enExample) |
| IL (2) | IL223029A0 (enExample) |
| MX (2) | MX370828B (enExample) |
| MY (1) | MY161534A (enExample) |
| NZ (1) | NZ603648A (enExample) |
| PL (2) | PL2575847T5 (enExample) |
| RU (1) | RU2594163C2 (enExample) |
| SG (2) | SG10201710439UA (enExample) |
| SI (1) | SI2575847T2 (enExample) |
| WO (1) | WO2011150110A1 (enExample) |
| ZA (1) | ZA201208673B (enExample) |
Families Citing this family (38)
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|---|---|---|---|---|
| HRP20171095T4 (hr) | 2010-05-25 | 2022-07-22 | F. Hoffmann - La Roche Ag | Postupci pročišćavanja polipeptida |
| ES2767135T3 (es) * | 2011-10-19 | 2020-06-16 | Novimmune Sa | Métodos para purificar anticuerpos |
| PL2794635T3 (pl) * | 2011-12-22 | 2019-02-28 | F.Hoffmann-La Roche Ag | Membranowa chromatografia jonowymienna |
| CN102911250B (zh) * | 2012-09-29 | 2014-04-16 | 浙江海正药业股份有限公司 | 酸性重组蛋白药物的纯化方法 |
| CN103880947B (zh) * | 2012-12-21 | 2016-01-13 | 武汉禾元生物科技股份有限公司 | 一种分离纯化高纯度重组人血清白蛋白的层析方法 |
| WO2014118685A2 (en) * | 2013-01-29 | 2014-08-07 | Dr. Reddy's Laboratories Limited | Method of altering the acidic variant content of antibody |
| EP2971087B1 (en) * | 2013-03-14 | 2017-11-01 | Qiagen Sciences, LLC | Assessing dna quality using real-time pcr and ct values |
| CN104236983A (zh) * | 2013-06-14 | 2014-12-24 | 中国科学院大连化学物理研究所 | 溶液样品中含长烷基链的离子液体的去除方法 |
| EP3041593B1 (en) | 2013-09-05 | 2025-01-29 | F. Hoffmann-La Roche AG | Method of cleaning a chromatography material for its reuse |
| PL3044323T3 (pl) | 2013-09-13 | 2022-06-27 | F.Hoffmann-La Roche Ag | Sposoby wykrywania i ilościowego oznaczania białka komórki gospodarza w liniach komórkowych |
| SG11201601823TA (en) | 2013-09-13 | 2016-04-28 | Genentech Inc | Methods and compositions comprising purified recombinant polypeptides |
| AU2014337263B2 (en) | 2013-10-16 | 2019-12-12 | Outlook Therapeutics, Inc. | Buffer formulations for enhanced antibody stability |
| US8859252B1 (en) | 2014-01-02 | 2014-10-14 | Aerial Biopharma, Llc | Prostatic acid phosphatase, compositions comprising the same, and methods for producing and/or purifying the same |
| EP3092002B1 (en) * | 2014-01-09 | 2019-09-25 | Kentucky Bioprocessing, Inc. | Method of purifying monoclonal antibodies |
| EP3116891B1 (en) | 2014-03-10 | 2020-02-12 | Richter Gedeon Nyrt. | Immunoglobulin purification using pre-cleaning steps |
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| WO2015198320A1 (en) * | 2014-06-24 | 2015-12-30 | Insight Biopharmaceuticals Ltd. | Methods of purifying antibodies |
| GB201411802D0 (en) | 2014-07-02 | 2014-08-13 | Univ Bradford | Effervescent compositions |
| EP3247718B1 (en) * | 2015-01-21 | 2021-09-01 | Outlook Therapeutics, Inc. | Modulation of charge variants in a monoclonal antibody composition |
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| CA3026518A1 (en) | 2016-06-17 | 2017-12-21 | Genentech, Inc. | Purification of multispecific antibodies |
| CN115598231B (zh) * | 2016-08-15 | 2025-11-18 | 豪夫迈·罗氏有限公司 | 定量包含非离子表面活性剂和多肽的组合物中非离子表面活性剂的层析方法 |
| JP6564539B1 (ja) | 2018-09-14 | 2019-08-21 | 長瀬産業株式会社 | スルホン酸化合物によるペプチド精製方法 |
| JP7458404B2 (ja) * | 2018-12-20 | 2024-03-29 | アーマジェン・インコーポレイテッド | イズロン酸－２－スルファターゼ免疫グロブリン融合タンパク質の精製 |
| CN109765307B (zh) * | 2018-12-24 | 2021-06-29 | 山东省科学院海洋仪器仪表研究所 | 一种水体中六氯环己烷的测量方法 |
| CN111366547A (zh) * | 2018-12-26 | 2020-07-03 | 贵州中烟工业有限责任公司 | 一种用连续流动法测定烟草或烟草制品中α-氨基氮的检测方法 |
| WO2020153390A1 (ja) | 2019-01-23 | 2020-07-30 | 第一三共株式会社 | 活性炭材料を使用する工程を含む抗体精製方法 |
| AU2020268896B2 (en) | 2019-05-03 | 2024-11-28 | F. Hoffmann-La Roche Ag | Methods of reducing the enzymatic hydrolysis activity rate in a composition obtained from a purification platform |
| AR119264A1 (es) * | 2019-06-05 | 2021-12-09 | Genentech Inc | Método para reutilización de cromatografía |
| CN114599971A (zh) * | 2019-10-14 | 2022-06-07 | 皮尔斯生物科技有限公司 | 肽纯化配制物和方法 |
| AU2021208515A1 (en) | 2020-01-15 | 2022-08-04 | F. Hoffmann-La Roche Ag | Methods to decrease impurities from recombinant protein manufacturing processes |
| AU2021262609A1 (en) | 2020-05-01 | 2022-12-22 | Kashiv Biosciences, Llc | An improved process of purification of protein |
| AU2021281152A1 (en) * | 2020-05-28 | 2022-12-22 | Kashiv Biosciences, Llc | An improved process of storing and preparing the protein |
| US20230251269A1 (en) * | 2020-07-15 | 2023-08-10 | The Johns Hopkins University | Comprehensive analysis of anti-allergen antibodies using phage display |
| IL302333A (en) * | 2020-10-30 | 2023-06-01 | Genentech Inc | Purification platforms for obtaining pharmaceutical preparations with a reduced hydrolytic enzyme activity rate |
| CN112852876B (zh) * | 2021-03-04 | 2022-11-29 | 西南大学 | 一种表达人表皮生长因子的家蚕丝腺重组表达载体及其制备方法和应用 |
| AU2022249605A1 (en) | 2021-03-31 | 2023-09-14 | F. Hoffmann-La Roche Ag | Purification of antibodies by mixed mode chromatography |
| WO2026105035A1 (en) * | 2024-11-14 | 2026-05-21 | H. Lundbeck A/S | Antibody purification by a multi chromatography process |
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