FI115051B - Uusi amidinonaftyylijohdannainen tai sen suola - Google Patents

Uusi amidinonaftyylijohdannainen tai sen suola Download PDF

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Publication number
FI115051B
FI115051B FI972326A FI972326A FI115051B FI 115051 B FI115051 B FI 115051B FI 972326 A FI972326 A FI 972326A FI 972326 A FI972326 A FI 972326A FI 115051 B FI115051 B FI 115051B
Authority
FI
Finland
Prior art keywords
group
methyl
oxy
piperidyl
phenyl
Prior art date
Application number
FI972326A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI972326A (fi
FI972326A0 (fi
Inventor
Yuzo Matsumoto
Isao Yanagisawa
Hiroyuki Koshio
Fukushi Hirayama
Tomihisa Kawasaki
Seiji Kaku
Original Assignee
Yamanouchi Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamanouchi Pharma Co Ltd filed Critical Yamanouchi Pharma Co Ltd
Publication of FI972326A publication Critical patent/FI972326A/fi
Publication of FI972326A0 publication Critical patent/FI972326A0/fi
Application granted granted Critical
Publication of FI115051B publication Critical patent/FI115051B/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
FI972326A 1994-12-02 1997-06-02 Uusi amidinonaftyylijohdannainen tai sen suola FI115051B (fi)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
JP29996394 1994-12-02
JP29996394 1994-12-02
JP10520595 1995-04-28
JP10520595 1995-04-28
JP19881695 1995-08-03
JP19881695 1995-08-03
JP9502458 1995-12-01
PCT/JP1995/002458 WO1996016940A1 (fr) 1994-12-02 1995-12-01 Nouveau derive d'amidinonaphtyle ou sel de celui-ci

Publications (3)

Publication Number Publication Date
FI972326A FI972326A (fi) 1997-06-02
FI972326A0 FI972326A0 (fi) 1997-06-02
FI115051B true FI115051B (fi) 2005-02-28

Family

ID=27310425

Family Applications (1)

Application Number Title Priority Date Filing Date
FI972326A FI115051B (fi) 1994-12-02 1997-06-02 Uusi amidinonaftyylijohdannainen tai sen suola

Country Status (20)

Country Link
US (1) US5869501A (hr)
EP (1) EP0798295B1 (hr)
JP (1) JP3004362B2 (hr)
KR (1) KR100383161B1 (hr)
CN (1) CN1087736C (hr)
AT (1) ATE233240T1 (hr)
AU (1) AU688628B2 (hr)
CA (1) CA2206532C (hr)
DE (1) DE69529770T2 (hr)
ES (1) ES2193202T3 (hr)
FI (1) FI115051B (hr)
HU (1) HUT77313A (hr)
MX (1) MX9704059A (hr)
NO (1) NO309566B1 (hr)
NZ (1) NZ296210A (hr)
PL (1) PL184824B1 (hr)
PT (1) PT798295E (hr)
RU (1) RU2154633C2 (hr)
TW (1) TW300888B (hr)
WO (1) WO1996016940A1 (hr)

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AU7808198A (en) 1997-06-03 1998-12-21 Biocryst Pharmaceuticals, Inc. Novel compounds useful in the complement, coagulat and kallikrein pathways and method for their preparation
WO1998057934A1 (en) * 1997-06-19 1998-12-23 The Du Pont Merck Pharmaceutical Company (AMIDINO)6-MEMBERED AROMATICS AS FACTOR Xa INHIBITORS
US6060491A (en) * 1997-06-19 2000-05-09 Dupont Pharmaceuticals 6-membered aromatics as factor Xa inhibitors
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US6258822B1 (en) 1997-08-06 2001-07-10 Abbott Laboratories Urokinase inhibitors
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US6686364B2 (en) 1997-12-08 2004-02-03 Berlex Laboratories, Inc. Benzamidine derivatives and their use as anti-coagulants
DE19754490A1 (de) * 1997-12-09 1999-06-10 Boehringer Ingelheim Pharma Durch einen Aminocarbonylrest substituierte Bicyclen, ihre Herstellung und ihre Verwendung als Arzneimittel
WO1999033805A1 (fr) * 1997-12-26 1999-07-08 Mochida Pharmaceutical Co., Ltd. Composes aromatiques presentant des groupements amino cycliques ou leur sels
WO1999037643A1 (fr) * 1998-01-26 1999-07-29 Yamanouchi Pharmaceutical Co., Ltd. Nouveaux derives heterocycliques a fusion benzenique ou sels de ceux-ci
EP0937723A1 (de) * 1998-02-18 1999-08-25 Roche Diagnostics GmbH Neue Sulfonamide, Verfahren zu ihrer Herstellung sowie diese enthaltende Arzneimittel
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US6262088B1 (en) 1998-11-19 2001-07-17 Berlex Laboratories, Inc. Polyhydroxylated monocyclic N-heterocyclic derivatives as anti-coagulants
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JP4599714B2 (ja) * 1999-01-22 2010-12-15 アステラス製薬株式会社 経口吸収改善医薬用組成物
WO2000051998A1 (en) 1999-03-02 2000-09-08 Boehringer Ingelheim Pharmaceuticals, Inc. Compounds useful as reversible inhibitors of cathepsin s
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US6350761B1 (en) 1999-07-30 2002-02-26 Berlex Laboratories, Inc. Benzenamine derivatives as anti-coagulants
US6420364B1 (en) 1999-09-13 2002-07-16 Boehringer Ingelheim Pharmaceuticals, Inc. Compound useful as reversible inhibitors of cysteine proteases
CZ20021432A3 (cs) 1999-10-28 2002-10-16 Sankyo Company Limited Benzamidové deriváty
EP1095933A1 (en) * 1999-10-30 2001-05-02 Aventis Pharma Deutschland GmbH Novel N-guanidinoalkylamides, their preparation, their use, and pharmaceutical preparations comprising them
AU2001234689A1 (en) * 2000-02-01 2001-08-14 Cor Therapeutics, Inc. Bivalent phenylene inhibitors of factor xa
WO2001064643A2 (en) 2000-02-29 2001-09-07 Cor Therapeutics, Inc. BENZAMIDES AND RELATED INHIBITORS OF FACTOR Xa
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US6495562B1 (en) 2000-04-25 2002-12-17 Abbott Laboratories Naphthamidine urokinase inhibitors
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WO2002076945A1 (en) 2001-03-09 2002-10-03 Ortho-Mcneil Pharmaceutical, Inc. Aminopyrrolidine sulfonamides as serine protease inhibitors
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US7312235B2 (en) 2001-03-30 2007-12-25 Millennium Pharmaceuticals, Inc. Benzamide inhibitors of factor Xa
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US11679093B2 (en) 2018-06-11 2023-06-20 The Regents Of The University Of Colorado, A Body Corporate 2-naphthimidamides, analogues thereof, and methods of treatment using same
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Also Published As

Publication number Publication date
PT798295E (pt) 2003-07-31
NZ296210A (en) 1998-05-27
JP3004362B2 (ja) 2000-01-31
AU688628B2 (en) 1998-03-12
EP0798295A1 (en) 1997-10-01
NO972482D0 (no) 1997-05-30
NO309566B1 (no) 2001-02-19
AU3994295A (en) 1996-06-19
ES2193202T3 (es) 2003-11-01
DE69529770D1 (de) 2003-04-03
US5869501A (en) 1999-02-09
HUT77313A (hu) 1998-03-30
FI972326A (fi) 1997-06-02
CA2206532A1 (en) 1996-06-06
KR100383161B1 (ko) 2003-12-24
NO972482L (no) 1997-08-01
EP0798295A4 (en) 1998-03-04
CA2206532C (en) 2006-07-11
TW300888B (hr) 1997-03-21
WO1996016940A1 (fr) 1996-06-06
RU2154633C2 (ru) 2000-08-20
CN1087736C (zh) 2002-07-17
MX9704059A (es) 1997-08-30
PL320486A1 (en) 1997-09-29
CN1167484A (zh) 1997-12-10
ATE233240T1 (de) 2003-03-15
PL184824B1 (pl) 2002-12-31
EP0798295B1 (en) 2003-02-26
DE69529770T2 (de) 2003-12-24
FI972326A0 (fi) 1997-06-02

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