FI972326A - Uusi amidinonaftyylijohdannainen tai sen suola - Google Patents

Uusi amidinonaftyylijohdannainen tai sen suola Download PDF

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Publication number
FI972326A
FI972326A FI972326A FI972326A FI972326A FI 972326 A FI972326 A FI 972326A FI 972326 A FI972326 A FI 972326A FI 972326 A FI972326 A FI 972326A FI 972326 A FI972326 A FI 972326A
Authority
FI
Finland
Prior art keywords
group
formula
represented
chem
hydrogen atom
Prior art date
Application number
FI972326A
Other languages
English (en)
Swedish (sv)
Other versions
FI115051B (fi
FI972326A0 (fi
Inventor
Fukushi Hirayama
Hiroyuki Koshio
Yuzo Matsumoto
Tomihisa Kawasaki
Seiji Kaku
Isao Yanagisawa
Original Assignee
Yamanouchi Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamanouchi Pharma Co Ltd filed Critical Yamanouchi Pharma Co Ltd
Publication of FI972326A publication Critical patent/FI972326A/fi
Publication of FI972326A0 publication Critical patent/FI972326A0/fi
Application granted granted Critical
Publication of FI115051B publication Critical patent/FI115051B/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
FI972326A 1994-12-02 1997-06-02 Uusi amidinonaftyylijohdannainen tai sen suola FI115051B (fi)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
JP29996394 1994-12-02
JP29996394 1994-12-02
JP10520595 1995-04-28
JP10520595 1995-04-28
JP19881695 1995-08-03
JP19881695 1995-08-03
PCT/JP1995/002458 WO1996016940A1 (fr) 1994-12-02 1995-12-01 Nouveau derive d'amidinonaphtyle ou sel de celui-ci
JP9502458 1995-12-01

Publications (3)

Publication Number Publication Date
FI972326A true FI972326A (fi) 1997-06-02
FI972326A0 FI972326A0 (fi) 1997-06-02
FI115051B FI115051B (fi) 2005-02-28

Family

ID=27310425

Family Applications (1)

Application Number Title Priority Date Filing Date
FI972326A FI115051B (fi) 1994-12-02 1997-06-02 Uusi amidinonaftyylijohdannainen tai sen suola

Country Status (20)

Country Link
US (1) US5869501A (fi)
EP (1) EP0798295B1 (fi)
JP (1) JP3004362B2 (fi)
KR (1) KR100383161B1 (fi)
CN (1) CN1087736C (fi)
AT (1) ATE233240T1 (fi)
AU (1) AU688628B2 (fi)
CA (1) CA2206532C (fi)
DE (1) DE69529770T2 (fi)
ES (1) ES2193202T3 (fi)
FI (1) FI115051B (fi)
HU (1) HUT77313A (fi)
MX (1) MX9704059A (fi)
NO (1) NO309566B1 (fi)
NZ (1) NZ296210A (fi)
PL (1) PL184824B1 (fi)
PT (1) PT798295E (fi)
RU (1) RU2154633C2 (fi)
TW (1) TW300888B (fi)
WO (1) WO1996016940A1 (fi)

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AU7808198A (en) 1997-06-03 1998-12-21 Biocryst Pharmaceuticals, Inc. Novel compounds useful in the complement, coagulat and kallikrein pathways and method for their preparation
US6060491A (en) * 1997-06-19 2000-05-09 Dupont Pharmaceuticals 6-membered aromatics as factor Xa inhibitors
CA2293824A1 (en) * 1997-06-19 1998-12-23 Mimi Lifen Quan (amidino)6-membered aromatics as factor xa inhibitors
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US6258822B1 (en) 1997-08-06 2001-07-10 Abbott Laboratories Urokinase inhibitors
AU8886698A (en) * 1997-09-01 1999-03-22 Yamanouchi Pharmaceutical Co., Ltd. Novel naphthamide derivatives or salts thereof
US6686364B2 (en) 1997-12-08 2004-02-03 Berlex Laboratories, Inc. Benzamidine derivatives and their use as anti-coagulants
DE19754490A1 (de) * 1997-12-09 1999-06-10 Boehringer Ingelheim Pharma Durch einen Aminocarbonylrest substituierte Bicyclen, ihre Herstellung und ihre Verwendung als Arzneimittel
WO1999033805A1 (fr) * 1997-12-26 1999-07-08 Mochida Pharmaceutical Co., Ltd. Composes aromatiques presentant des groupements amino cycliques ou leur sels
AU2074699A (en) * 1998-01-26 1999-08-09 Yamanouchi Pharmaceutical Co., Ltd. Novel benzene-fused heterocyclic derivatives or salts thereof
EP0937723A1 (de) * 1998-02-18 1999-08-25 Roche Diagnostics GmbH Neue Sulfonamide, Verfahren zu ihrer Herstellung sowie diese enthaltende Arzneimittel
EP1066272A4 (en) * 1998-03-27 2002-03-13 Biocryst Pharm Inc NEW CONNECTIONS USEFUL IN THE COMPLEMENT, COAGULATE AND KALLIKREIN REACTION WAY AND METHOD FOR THEIR PRODUCTION
PL343424A1 (en) 1998-04-10 2001-08-13 Japan Tobacco Inc Amidine compounds
US6504031B1 (en) 1998-08-06 2003-01-07 Milan Bruncko Naphthamidine urokinase inhibitors
US6284796B1 (en) 1998-08-06 2001-09-04 Abbott Laboratories Ukokinase inhibitors
US6262088B1 (en) 1998-11-19 2001-07-17 Berlex Laboratories, Inc. Polyhydroxylated monocyclic N-heterocyclic derivatives as anti-coagulants
AU3127900A (en) 1998-12-23 2000-07-31 Du Pont Pharmaceuticals Company Thrombin or factor xa inhibitors
AU771776B2 (en) 1999-01-13 2004-04-01 Genentech Inc. Serine protease inhibitors
WO2000043041A1 (fr) * 1999-01-22 2000-07-27 Yamanouchi Pharmaceutical Co., Ltd. Compositions medicamenteuses presentant une meilleure absorption orale
EP1159273A1 (en) 1999-03-02 2001-12-05 Boehringer Ingelheim Pharmaceuticals Inc. Compounds useful as reversible inhibitors of cathepsin s
FR2793247B1 (fr) * 1999-05-04 2001-06-22 Synthelabo Derives de 6-[[(aryl et heteroaryl)oxy]methyl]naphtalene-2- carboximidamide, leur preparation et leur application en therapeutique
US6858599B2 (en) * 1999-06-30 2005-02-22 Mochida Pharmaceutical Co., Ltd. Tricyclic compound having spiro union
WO2001002356A1 (fr) * 1999-07-01 2001-01-11 Sankyo Company, Limited Dérivés d'indoline ou tétrahydroquinoline
US6350761B1 (en) 1999-07-30 2002-02-26 Berlex Laboratories, Inc. Benzenamine derivatives as anti-coagulants
US6420364B1 (en) 1999-09-13 2002-07-16 Boehringer Ingelheim Pharmaceuticals, Inc. Compound useful as reversible inhibitors of cysteine proteases
KR100642953B1 (ko) 1999-10-28 2006-11-10 상꾜 가부시키가이샤 벤즈아미딘 유도체
EP1095933A1 (en) * 1999-10-30 2001-05-02 Aventis Pharma Deutschland GmbH Novel N-guanidinoalkylamides, their preparation, their use, and pharmaceutical preparations comprising them
US20020065303A1 (en) * 2000-02-01 2002-05-30 Bing-Yan Zhu Bivalent phenylene inhibitors of factor Xa
ATE311366T1 (de) 2000-02-29 2005-12-15 Millennium Pharm Inc Benzamide und ähnliche inhibitoren vom faktor xa
AU2001249397A1 (en) * 2000-03-24 2001-10-08 Cor Therapeutics, Inc. Oxindole inhibitors of factor xa
AU776053B2 (en) 2000-03-31 2004-08-26 Astellas Pharma Inc. Diazepan derivatives or salts thereof
US6495562B1 (en) 2000-04-25 2002-12-17 Abbott Laboratories Naphthamidine urokinase inhibitors
US6838479B2 (en) 2000-09-11 2005-01-04 Genentech, Inc. Amidine inhibitors of serine proteases
CA2424522C (en) 2000-11-22 2009-12-29 Yamanouchi Pharmaceutical Co., Ltd. Substituted benzene derivatives or salts thereof
US6538017B2 (en) 2001-03-09 2003-03-25 Ortho-Mcneil Pharmaceutical, Inc. Aminopyrrolidine sulfonamides as serine protease inhibitors
US6710061B2 (en) 2001-03-09 2004-03-23 Ortho-Mcneil Pharamceutical, Inc. Aminopyrrolidine sulfonamides as serine protease inhibitors
US7312235B2 (en) 2001-03-30 2007-12-25 Millennium Pharmaceuticals, Inc. Benzamide inhibitors of factor Xa
SK12082003A3 (sk) 2001-04-05 2004-09-08 Sankyo Company Limited Benzamidínové deriváty
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KR20080098548A (ko) * 2006-03-28 2008-11-10 노파르티스 아게 Ｇ 단백질 관련 질환의 치료를 위한 아미드 유도체 및 그의투여
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EP2090300A4 (en) * 2006-11-30 2010-02-10 Takeda Pharmaceutical PREPARATION WITH EXTENDED RELEASE
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Also Published As

Publication number Publication date
PL184824B1 (pl) 2002-12-31
US5869501A (en) 1999-02-09
NO309566B1 (no) 2001-02-19
KR100383161B1 (ko) 2003-12-24
AU688628B2 (en) 1998-03-12
PT798295E (pt) 2003-07-31
NO972482L (no) 1997-08-01
FI115051B (fi) 2005-02-28
EP0798295B1 (en) 2003-02-26
NZ296210A (en) 1998-05-27
MX9704059A (es) 1997-08-30
CA2206532A1 (en) 1996-06-06
HUT77313A (hu) 1998-03-30
EP0798295A1 (en) 1997-10-01
CN1167484A (zh) 1997-12-10
NO972482D0 (no) 1997-05-30
RU2154633C2 (ru) 2000-08-20
WO1996016940A1 (fr) 1996-06-06
DE69529770T2 (de) 2003-12-24
CN1087736C (zh) 2002-07-17
PL320486A1 (en) 1997-09-29
FI972326A0 (fi) 1997-06-02
TW300888B (fi) 1997-03-21
ES2193202T3 (es) 2003-11-01
JP3004362B2 (ja) 2000-01-31
AU3994295A (en) 1996-06-19
ATE233240T1 (de) 2003-03-15
DE69529770D1 (de) 2003-04-03
EP0798295A4 (en) 1998-03-04
CA2206532C (en) 2006-07-11

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