FI972326A - Nytt amidinonaftylderivat eller dess salt - Google Patents

Nytt amidinonaftylderivat eller dess salt Download PDF

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Publication number
FI972326A
FI972326A FI972326A FI972326A FI972326A FI 972326 A FI972326 A FI 972326A FI 972326 A FI972326 A FI 972326A FI 972326 A FI972326 A FI 972326A FI 972326 A FI972326 A FI 972326A
Authority
FI
Finland
Prior art keywords
group
formula
represented
chem
hydrogen atom
Prior art date
Application number
FI972326A
Other languages
English (en)
Finnish (fi)
Other versions
FI115051B (sv
FI972326A0 (sv
Inventor
Fukushi Hirayama
Hiroyuki Koshio
Yuzo Matsumoto
Tomihisa Kawasaki
Seiji Kaku
Isao Yanagisawa
Original Assignee
Yamanouchi Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamanouchi Pharma Co Ltd filed Critical Yamanouchi Pharma Co Ltd
Publication of FI972326A publication Critical patent/FI972326A/sv
Publication of FI972326A0 publication Critical patent/FI972326A0/sv
Application granted granted Critical
Publication of FI115051B publication Critical patent/FI115051B/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
FI972326A 1994-12-02 1997-06-02 Nytt amidinonaftylderivat eller dess salt FI115051B (sv)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
JP29996394 1994-12-02
JP29996394 1994-12-02
JP10520595 1995-04-28
JP10520595 1995-04-28
JP19881695 1995-08-03
JP19881695 1995-08-03
JP9502458 1995-12-01
PCT/JP1995/002458 WO1996016940A1 (fr) 1994-12-02 1995-12-01 Nouveau derive d'amidinonaphtyle ou sel de celui-ci

Publications (3)

Publication Number Publication Date
FI972326A true FI972326A (sv) 1997-06-02
FI972326A0 FI972326A0 (sv) 1997-06-02
FI115051B FI115051B (sv) 2005-02-28

Family

ID=27310425

Family Applications (1)

Application Number Title Priority Date Filing Date
FI972326A FI115051B (sv) 1994-12-02 1997-06-02 Nytt amidinonaftylderivat eller dess salt

Country Status (20)

Country Link
US (1) US5869501A (sv)
EP (1) EP0798295B1 (sv)
JP (1) JP3004362B2 (sv)
KR (1) KR100383161B1 (sv)
CN (1) CN1087736C (sv)
AT (1) ATE233240T1 (sv)
AU (1) AU688628B2 (sv)
CA (1) CA2206532C (sv)
DE (1) DE69529770T2 (sv)
ES (1) ES2193202T3 (sv)
FI (1) FI115051B (sv)
HU (1) HUT77313A (sv)
MX (1) MX9704059A (sv)
NO (1) NO309566B1 (sv)
NZ (1) NZ296210A (sv)
PL (1) PL184824B1 (sv)
PT (1) PT798295E (sv)
RU (1) RU2154633C2 (sv)
TW (1) TW300888B (sv)
WO (1) WO1996016940A1 (sv)

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EP0842941A1 (de) 1996-11-16 1998-05-20 Roche Diagnostics GmbH Neue Phosphonate, Verfahren zu ihrer Herstellung und Arzneimittel
AU7808198A (en) 1997-06-03 1998-12-21 Biocryst Pharmaceuticals, Inc. Novel compounds useful in the complement, coagulat and kallikrein pathways and method for their preparation
US6060491A (en) * 1997-06-19 2000-05-09 Dupont Pharmaceuticals 6-membered aromatics as factor Xa inhibitors
EP0993448A1 (en) * 1997-06-19 2000-04-19 The Du Pont Merck Pharmaceutical Company (AMIDINO)6-MEMBERED AROMATICS AS FACTOR Xa INHIBITORS
ZA986594B (en) * 1997-07-25 1999-01-27 Abbott Lab Urokinase inhibitors
US6258822B1 (en) 1997-08-06 2001-07-10 Abbott Laboratories Urokinase inhibitors
AU8886698A (en) * 1997-09-01 1999-03-22 Yamanouchi Pharmaceutical Co., Ltd. Novel naphthamide derivatives or salts thereof
US6686364B2 (en) 1997-12-08 2004-02-03 Berlex Laboratories, Inc. Benzamidine derivatives and their use as anti-coagulants
DE19754490A1 (de) * 1997-12-09 1999-06-10 Boehringer Ingelheim Pharma Durch einen Aminocarbonylrest substituierte Bicyclen, ihre Herstellung und ihre Verwendung als Arzneimittel
CA2318351A1 (en) * 1997-12-26 1999-07-08 Hidemitsu Nishida Aromatic compounds having cyclic amino or salts thereof
WO1999037643A1 (fr) * 1998-01-26 1999-07-29 Yamanouchi Pharmaceutical Co., Ltd. Nouveaux derives heterocycliques a fusion benzenique ou sels de ceux-ci
EP0937723A1 (de) * 1998-02-18 1999-08-25 Roche Diagnostics GmbH Neue Sulfonamide, Verfahren zu ihrer Herstellung sowie diese enthaltende Arzneimittel
EP1066272A4 (en) * 1998-03-27 2002-03-13 Biocryst Pharm Inc NEW CONNECTIONS USEFUL IN THE COMPLEMENT, COAGULATE AND KALLIKREIN REACTION WAY AND METHOD FOR THEIR PRODUCTION
AR015269A1 (es) 1998-04-10 2001-04-18 Japan Tobacco Inc Compuesto amidinico y composicion farmaceutica, inhibidor de la coagulacion sanguinea e inhibidor del factor xa que lo comprenden
US6504031B1 (en) 1998-08-06 2003-01-07 Milan Bruncko Naphthamidine urokinase inhibitors
US6284796B1 (en) 1998-08-06 2001-09-04 Abbott Laboratories Ukokinase inhibitors
US6262088B1 (en) 1998-11-19 2001-07-17 Berlex Laboratories, Inc. Polyhydroxylated monocyclic N-heterocyclic derivatives as anti-coagulants
WO2000039102A1 (en) 1998-12-23 2000-07-06 Du Pont Pharmaceuticals Company THROMBIN OR FACTOR Xa INHIBITORS
CN100488947C (zh) 1999-01-13 2009-05-20 杰南技术公司 丝氨酸蛋白酶抑制剂
WO2000043041A1 (fr) * 1999-01-22 2000-07-27 Yamanouchi Pharmaceutical Co., Ltd. Compositions medicamenteuses presentant une meilleure absorption orale
WO2000051998A1 (en) 1999-03-02 2000-09-08 Boehringer Ingelheim Pharmaceuticals, Inc. Compounds useful as reversible inhibitors of cathepsin s
FR2793247B1 (fr) * 1999-05-04 2001-06-22 Synthelabo Derives de 6-[[(aryl et heteroaryl)oxy]methyl]naphtalene-2- carboximidamide, leur preparation et leur application en therapeutique
US6858599B2 (en) 1999-06-30 2005-02-22 Mochida Pharmaceutical Co., Ltd. Tricyclic compound having spiro union
AU5570900A (en) * 1999-07-01 2001-01-22 Sankyo Company Limited Indoline or tetrahydroquinoline derivatives
US6350761B1 (en) 1999-07-30 2002-02-26 Berlex Laboratories, Inc. Benzenamine derivatives as anti-coagulants
US6420364B1 (en) 1999-09-13 2002-07-16 Boehringer Ingelheim Pharmaceuticals, Inc. Compound useful as reversible inhibitors of cysteine proteases
PL354619A1 (en) 1999-10-28 2004-02-09 Sankyo Company, Limited Benzamidine derivatives
EP1095933A1 (en) * 1999-10-30 2001-05-02 Aventis Pharma Deutschland GmbH Novel N-guanidinoalkylamides, their preparation, their use, and pharmaceutical preparations comprising them
WO2001056989A2 (en) * 2000-02-01 2001-08-09 Cor Therapeutics, Inc. Inhibitors of factor xa
DK1259485T3 (da) 2000-02-29 2006-04-10 Millennium Pharm Inc Benzamider og beslægtede inhibitorer for faktor Xa
WO2001072708A2 (en) * 2000-03-24 2001-10-04 Cor Therapeutics, Inc. OXINDOLE INHIBITORS OF FACTOR Xa
AU776053B2 (en) 2000-03-31 2004-08-26 Astellas Pharma Inc. Diazepan derivatives or salts thereof
US6495562B1 (en) 2000-04-25 2002-12-17 Abbott Laboratories Naphthamidine urokinase inhibitors
CA2421548C (en) 2000-09-11 2007-10-30 Genentech, Inc. Amidine inhibitors of serine proteases
AU2002224064B2 (en) 2000-11-22 2005-12-08 Astellas Pharma Inc. Substituted benzene derivatives or salts thereof
US6710061B2 (en) 2001-03-09 2004-03-23 Ortho-Mcneil Pharamceutical, Inc. Aminopyrrolidine sulfonamides as serine protease inhibitors
WO2002076945A1 (en) 2001-03-09 2002-10-03 Ortho-Mcneil Pharmaceutical, Inc. Aminopyrrolidine sulfonamides as serine protease inhibitors
US7312235B2 (en) 2001-03-30 2007-12-25 Millennium Pharmaceuticals, Inc. Benzamide inhibitors of factor Xa
CN1610666A (zh) 2001-04-05 2005-04-27 三共株式会社 苄脒衍生物
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TWI396686B (zh) 2004-05-21 2013-05-21 Takeda Pharmaceutical 環狀醯胺衍生物、以及其製品和用法
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WO2006055951A2 (en) 2004-11-19 2006-05-26 Portola Pharmaceuticals, Inc. Tetrahydroisoquinolines as factor xa inhibitors
WO2006063113A2 (en) 2004-12-07 2006-06-15 Portola Pharmaceuticals, Inc. Ureas as factor xa inhibitors
WO2006063293A2 (en) * 2004-12-07 2006-06-15 Portola Pharmaceuticals, Inc. THIOUREAS AS FACTOR Xa INHIBITORS
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NZ567992A (en) 2005-11-08 2011-05-27 Millennium Pharm Inc Pharmaceutical salts and polymorphs of N-(5-chloro-2-pyridinyl)-2-[[4-[(dimethylamino)iminomethyl]benzoyl]amino]-5-methoxy-benzamide, a factor Xa inhibitor
US20100261758A1 (en) * 2006-03-28 2010-10-14 Novartis Ag Heterocyclic amides for use as pharmaceuticals
US7884234B2 (en) 2006-10-12 2011-02-08 Institute Of Medicinal Molecular Design, Inc. N-phenyloxamide derivatives
PT2077995E (pt) 2006-11-02 2012-05-10 Millennium Pharm Inc Métodos de sintetizar sais farmacêuticos de um inibidor de fator xa
WO2008066102A1 (fr) 2006-11-30 2008-06-05 Takeda Pharmaceutical Company Limited Préparation à libération prolongée
US8633245B2 (en) * 2008-04-11 2014-01-21 Institute Of Medicinal Molecular Design, Inc. PAI-1 inhibitor
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US11679093B2 (en) 2018-06-11 2023-06-20 The Regents Of The University Of Colorado, A Body Corporate 2-naphthimidamides, analogues thereof, and methods of treatment using same
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Also Published As

Publication number Publication date
CA2206532C (en) 2006-07-11
PL320486A1 (en) 1997-09-29
US5869501A (en) 1999-02-09
CA2206532A1 (en) 1996-06-06
ATE233240T1 (de) 2003-03-15
WO1996016940A1 (fr) 1996-06-06
PL184824B1 (pl) 2002-12-31
FI115051B (sv) 2005-02-28
FI972326A0 (sv) 1997-06-02
AU3994295A (en) 1996-06-19
DE69529770D1 (de) 2003-04-03
EP0798295B1 (en) 2003-02-26
RU2154633C2 (ru) 2000-08-20
NO309566B1 (no) 2001-02-19
MX9704059A (es) 1997-08-30
EP0798295A1 (en) 1997-10-01
NO972482L (no) 1997-08-01
HUT77313A (hu) 1998-03-30
PT798295E (pt) 2003-07-31
EP0798295A4 (en) 1998-03-04
TW300888B (sv) 1997-03-21
KR100383161B1 (ko) 2003-12-24
CN1167484A (zh) 1997-12-10
CN1087736C (zh) 2002-07-17
AU688628B2 (en) 1998-03-12
NZ296210A (en) 1998-05-27
ES2193202T3 (es) 2003-11-01
JP3004362B2 (ja) 2000-01-31
NO972482D0 (no) 1997-05-30
DE69529770T2 (de) 2003-12-24

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