ES2151698T3 - Nuevos derivados de 6-hidroxi y 6-oxo-androstan activos sobre el sistema cardiovascular y composiciones farmaceuticas que los contienen. - Google Patents

Nuevos derivados de 6-hidroxi y 6-oxo-androstan activos sobre el sistema cardiovascular y composiciones farmaceuticas que los contienen.

Info

Publication number
ES2151698T3
ES2151698T3 ES97111651T ES97111651T ES2151698T3 ES 2151698 T3 ES2151698 T3 ES 2151698T3 ES 97111651 T ES97111651 T ES 97111651T ES 97111651 T ES97111651 T ES 97111651T ES 2151698 T3 ES2151698 T3 ES 2151698T3
Authority
ES
Spain
Prior art keywords
oxo
hydroxy
androstan
assets
pharmaceutical compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97111651T
Other languages
English (en)
Inventor
Munari Sergio De
Elena Folpini
Marco Frigerio
Piero Melloni
Fulvio Serra
Simona Sputore
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sigma Tau Industrie Farmaceutiche Riunite SpA
Original Assignee
Sigma Tau Industrie Farmaceutiche Riunite SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Industrie Farmaceutiche Riunite SpA filed Critical Sigma Tau Industrie Farmaceutiche Riunite SpA
Application granted granted Critical
Publication of ES2151698T3 publication Critical patent/ES2151698T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0038—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 with an androstane skeleton, including 18- or 19-substituted derivatives, 18-nor derivatives and also derivatives where position 17-beta is substituted by a carbon atom not directly bonded to a further carbon atom and not being part of an amide group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C07J41/0016—Oximes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

SE DESCRIBEN DERIVADOS DE 6 QUE POSEEN LA FORMULA GENERAL (I): EN LA CUAL EL SIMBOLO REPRESENTA UN ENLACE SENCILLO O DOBLE, Y A, R SUP,1} Y R SUP,2} POSEEN LOS SIGNIFICADOS DADOS EN LA MEMORIA DESCRIPTIVA; UNA COMPOSICION FARMACEUTICA QUE INCLUYEN LOS MISMOS Y SU USO PARA LA PREPARACION DE UN MEDICAMENTO QUE RESULTA UTIL PARA EL TRATAMIENTO DE TRASTORNOS CARDIOVASCULARES, TALES COMO LA INFUCIENCIA CARDIACA Y LA HIPERTENSION.
ES97111651T 1996-08-19 1997-07-09 Nuevos derivados de 6-hidroxi y 6-oxo-androstan activos sobre el sistema cardiovascular y composiciones farmaceuticas que los contienen. Expired - Lifetime ES2151698T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19633349A DE19633349A1 (de) 1996-08-19 1996-08-19 Neue 6-Hydroxy- und 6-Oxo-androstan-Derivate, die auf das kardiovaskuläre System wirken und pharmazeutische Zusammensetzungen, die diese enthalten

Publications (1)

Publication Number Publication Date
ES2151698T3 true ES2151698T3 (es) 2001-01-01

Family

ID=7802998

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97111651T Expired - Lifetime ES2151698T3 (es) 1996-08-19 1997-07-09 Nuevos derivados de 6-hidroxi y 6-oxo-androstan activos sobre el sistema cardiovascular y composiciones farmaceuticas que los contienen.

Country Status (10)

Country Link
US (1) US5914324A (es)
EP (1) EP0825197B1 (es)
JP (1) JP4297994B2 (es)
AT (1) ATE196768T1 (es)
DE (2) DE19633349A1 (es)
DK (1) DK0825197T3 (es)
ES (1) ES2151698T3 (es)
GR (1) GR3034821T3 (es)
HK (1) HK1009139A1 (es)
PT (1) PT825197E (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1317031B1 (it) * 2000-05-17 2003-05-26 Sigma Tau Ind Farmaceuti Procedimento migliorato per la preparazione di (e,z)3-(2-amminoetossimmino)-androstano-6, 17-dione e di suoi analoghi.
US10174070B2 (en) * 2005-09-30 2019-01-08 Endece Llc 6-substituted estradiol derivatives and methods of use
US8168621B2 (en) 2005-09-30 2012-05-01 Endece, Llc 6-substituted estradiol derivatives and methods of use
US20080119447A1 (en) * 2005-09-30 2008-05-22 James Yarger 6-alkoxyalkyl estradiol derivatives and methods of use
TWI392682B (zh) * 2006-04-13 2013-04-11 Sigma Tau Ind Farmaceuti 作為心血管疾病的治療藥物之雄甾烷和雄甾烯的胺基衍生物
TWI389917B (zh) * 2006-04-13 2013-03-21 Sigma Tau Ind Farmaceuti 作為心血管疾病治療藥物的雄甾烷與雄甾烯之氮雜環烷基衍生物
TWI372762B (en) * 2006-06-23 2012-09-21 Sigma Tau Ind Farmaceuti Amino derivatives of b-homoandrostanes and b-heteroandrostanes
KR101499266B1 (ko) 2006-11-30 2015-03-05 엔디씨, 엘엘씨 6-알콕시알킬 에스트라디올 유도체 및 사용법
WO2009047101A1 (en) * 2007-10-12 2009-04-16 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Aminooxime derivatives of 2- and/or 4-substituted androstanes and androstenes as medicaments for cardiovascular disorders
WO2010149666A1 (en) 2009-06-22 2010-12-29 Medexis S.A. Methods for treating neoplasia
AU2011284606A1 (en) * 2010-07-30 2013-03-14 Pharmacellion Ltd Compounds and methods for treating neoplasia
DK2616477T3 (en) 2010-09-14 2017-02-20 Endece Llc 6-substituted demethyl estradiol derivatives as agonists of the type ER-BETA
CN103315968B (zh) * 2013-06-26 2015-04-01 中国生命药物治疗有限公司 一种注射用粉针剂及其制备方法
CN103360457B (zh) * 2013-07-31 2015-10-07 中国生命药物治疗有限公司 一种雄甾烷二酮衍生物晶型及其制备方法
DK3599243T3 (da) 2018-07-26 2023-07-10 Cvie Therapeutics Ltd 17beta-heterocyklyl-digitalis-lignende forbindelser til behandlingen af hjertesvigt
KR20210136048A (ko) 2019-03-05 2021-11-16 윈드트리 세라퓨틱스, 인크. 급성 심부전 (ahf)의 치료를 위한 이스타록심-함유 정맥내 제형
PL3805243T3 (pl) 2019-10-09 2024-03-18 Windtree Therapeutics, Inc. Pochodne androstanowe posiadające aktywność jako czyste lub w przeważającym stopniu czyste stymulatory SERCA2A do leczenia niewydolności serca

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2863885A (en) * 1958-02-10 1958-12-09 Upjohn Co 17-isonitrosoandrostanes
GB1175219A (en) * 1967-06-22 1969-12-23 Ici Ltd 3-Aminoalkoxycarbonylmethylene Steroid Derivatives
CH504427A (de) * 1967-12-06 1971-03-15 Ciba Geigy Ag Verfahren zur Herstellung neuer 4-Imino-19-nor-A-homosteroid-triene
US5144017A (en) * 1988-07-13 1992-09-01 University Of Manitoba Compounds that bind to digitalis receptor
GB9201224D0 (en) * 1992-01-21 1992-03-11 Erba Carlo Spa Difluoromethylenandrostenone derivatives and process for their preparation
DE4227605C2 (de) * 1992-08-20 1995-02-16 Sigma Tau Ind Farmaceuti 17-Hydroxyiminomethyl-14beta-hydroxy-5ß-androstan-Derivate, Verfahren zu deren Herstellung und pharmazeutische Zusammensetzungen, die dieselben enthalten
DE4232656C2 (de) * 1992-09-29 1995-01-12 Sigma Tau Ind Farmaceuti Cyclopentanperhydrophenanthren-17-furyl-3ß-derivate, Verfahren zu deren Herstellung und diese enthaltende pharmazeutischen Zusammensetzungen
DE4344236A1 (de) * 1993-12-23 1995-06-29 Sigma Tau Ind Farmaceuti Neue 17-Iminomethylalkenyl-5beta,14beta-androstan- und 17-Iminoalkyl-5beta,14beta-androstan-Derivate , die auf das kardiovaskuläre System wirken, Verfahren zu ihrer Herstellung und pharmazeutische Zusammensetzungen, die sie enthalten

Also Published As

Publication number Publication date
DE19633349A1 (de) 1998-02-26
DE69703228T2 (de) 2001-02-22
ATE196768T1 (de) 2000-10-15
JP4297994B2 (ja) 2009-07-15
JPH1077292A (ja) 1998-03-24
EP0825197A2 (en) 1998-02-25
US5914324A (en) 1999-06-22
EP0825197B1 (en) 2000-10-04
EP0825197A3 (en) 1999-04-14
DK0825197T3 (da) 2000-10-30
DE69703228D1 (de) 2000-11-09
GR3034821T3 (en) 2001-02-28
PT825197E (pt) 2001-01-31
HK1009139A1 (en) 1999-05-28

Similar Documents

Publication Publication Date Title
ES2151698T3 (es) Nuevos derivados de 6-hidroxi y 6-oxo-androstan activos sobre el sistema cardiovascular y composiciones farmaceuticas que los contienen.
DE69413274T2 (de) Chinoloncarbonsäurederivate, ihre Herstellung und ihre Verwendung als Zelladhäsion Inhibitoren
DK0889876T3 (da) Meta-substituerede phenylensulfonamidderivater
IL109526A0 (en) Benzofuranyl- and thiophenyl-alkanecarboxylic acid derivatives, their preparation and pharmaceutical compositions containing them
NO972482L (no) Nytt amidinonafthylderivat eller salt derav
BR9811818A (pt) Uso de um composto, composto, e, composição farmacêutica
IL94484A0 (en) Diarylstyrylquinoline diacids and pharmaceutical compositions containing them
FI913556A0 (fi) Nya piperidyletrar och -tioetrar som inhibitorer av kolesterolbiosyntes.
ES2111871T3 (es) Nuevos derivados de aminoacidos, su procedimiento de preparacion y composiciones farmaceuticas que los contienen.
ES2110030T3 (es) Nuevos derivados de 17-hidroxiiminometil-5beta,14beta-androstano activos sobre el sistema cardiovascular, procesos para su preparacion y composiciones farmaceuticas que contienen los mismos.
BR9707962A (pt) Compostos e composição farmacêutica
BR9814188A (pt) "agonistas de 5-ht1f"
DE69813263T2 (de) Hydrazono-benzazulen-derivate, pharmazeutische zusammensetzungen und zwischenprodukte
DE69602886D1 (de) Im kardiovaskulären System aktive seco-D-Steroide und diese enthaltende pharmazeutische Zubereitungen
BR0012329A (pt) Derivados de benzofurano
ES2105815T3 (es) Nuevos derivados de hidrazino- e hidroxiamino-14beta-hidroxiandrostano activos sobre el sistema cardiovascular, procesos para su preparacion y composiciones farmaceuticas que contienen los mismos.
ES2145541T3 (es) Nuevos seco-d-esteroides activos sobre el sistema cardiovascular, procedimientos para su preparacion y composiciones farmaceuticas que los contienen.
ZA937085B (en) e derivatives active on the cardiovascular system 17-Aryl and 17-heterocyclyl-5Beta-14Beta androstanprocesses for their preparation and pharmaceutical compositions containing same
DE69403110D1 (de) Zyklische Angiopeptin Derivate, deren Herstellung und pharmazeutische Zusammensetzungen
DE69511449T2 (de) Octahydro-2-Naphthalincarbonsäure-Derivate, ihre Herstellung und Verwendung
DE69701381D1 (de) Peptid-aldehydderivate als antikoagulierende mittel
FI873145A0 (fi) Nya tetracykliska indolderivat.
ES2112597T3 (es) Nuevos derivados de 17-(3-imino-2-alquil-propenil)-5beta,14beta-androstano activos sobre el sistema cardiovascular, procesos para su preparacion y composiciones farmaceuticas que contienen los mismos.
DE69506671D1 (de) Auf das cardiovaskuläre System wirksame 1,5-disubstituierte 7a-methylperhydroinden-3a-ol-Derivate, Verfahren zu deren Herstellung und sie enthaltende pharmazeutische Zusammensetzungen
PT777471E (pt) Metodo de inibicao da biosintese de leucotrieno

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 825197

Country of ref document: ES