ES2112597T3 - Nuevos derivados de 17-(3-imino-2-alquil-propenil)-5beta,14beta-androstano activos sobre el sistema cardiovascular, procesos para su preparacion y composiciones farmaceuticas que contienen los mismos. - Google Patents
Nuevos derivados de 17-(3-imino-2-alquil-propenil)-5beta,14beta-androstano activos sobre el sistema cardiovascular, procesos para su preparacion y composiciones farmaceuticas que contienen los mismos.Info
- Publication number
- ES2112597T3 ES2112597T3 ES95117347T ES95117347T ES2112597T3 ES 2112597 T3 ES2112597 T3 ES 2112597T3 ES 95117347 T ES95117347 T ES 95117347T ES 95117347 T ES95117347 T ES 95117347T ES 2112597 T3 ES2112597 T3 ES 2112597T3
- Authority
- ES
- Spain
- Prior art keywords
- imino
- pharmaceutical compositions
- propenil
- androstano
- 14beta
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Abstract
LA INVENCION SE REFIERE A NUEVOS DERIVADOS DEL 17-(3-IMINO-2-ALQUILPROPENIL)-14{BE}-HIDROXIDO-5-BETA-ANDROSTANO DE LA FORMULA GENERAL (I) EN DONDE EL SIMBOLO WWW SIGNIFICA UNA CONFIGURACION ALFA O BETA; LOS ENLACES DOBLES ESTAN EN LA CONFIGURACION E; EN LA QUE R1-R10 TIENEN LOS SIGNIFICADOS DEFINIDOS EN LA DESCRIPCION, LA INVENCION TAMBIEN SE REFIERE A UN PROCESO PARA SU MANUFACTURA Y A LAS COMPOSICIONES FARMACEUTICAS QUE CONTIENEN LOS MISMOS. ESTOS COMPUESTOS SON UTILES EN EL TRATAMIENTO DE ENFERMEDADES CARDIOVASCULARES.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4442486A DE4442486A1 (de) | 1994-11-29 | 1994-11-29 | Neue 17-(3-Imino-2-alkylpropylen)-5ß,14ß-androstan-Derivate, die auf das kardiovaskuläre System wirken, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Zusammensetzungen |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2112597T3 true ES2112597T3 (es) | 1998-04-01 |
Family
ID=6534459
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES95117347T Expired - Lifetime ES2112597T3 (es) | 1994-11-29 | 1995-11-03 | Nuevos derivados de 17-(3-imino-2-alquil-propenil)-5beta,14beta-androstano activos sobre el sistema cardiovascular, procesos para su preparacion y composiciones farmaceuticas que contienen los mismos. |
Country Status (9)
Country | Link |
---|---|
US (1) | US5705662A (es) |
EP (1) | EP0714908B1 (es) |
JP (1) | JP3899136B2 (es) |
AT (1) | ATE163424T1 (es) |
CA (1) | CA2163935C (es) |
DE (2) | DE4442486A1 (es) |
DK (1) | DK0714908T3 (es) |
ES (1) | ES2112597T3 (es) |
HK (1) | HK1009334A1 (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030083231A1 (en) * | 1998-11-24 | 2003-05-01 | Ahlem Clarence N. | Blood cell deficiency treatment method |
US6764817B1 (en) * | 1999-04-20 | 2004-07-20 | Target Discovery, Inc. | Methods for conducting metabolic analyses |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4222404C1 (de) * | 1992-07-08 | 1993-12-02 | Sigma Tau Ind Farmaceuti | Verwendung von Iminoderivaten von Etianaldehyd zur Behandlung von Hypertonie |
DE4227605C2 (de) * | 1992-08-20 | 1995-02-16 | Sigma Tau Ind Farmaceuti | 17-Hydroxyiminomethyl-14beta-hydroxy-5ß-androstan-Derivate, Verfahren zu deren Herstellung und pharmazeutische Zusammensetzungen, die dieselben enthalten |
DE4344236A1 (de) * | 1993-12-23 | 1995-06-29 | Sigma Tau Ind Farmaceuti | Neue 17-Iminomethylalkenyl-5beta,14beta-androstan- und 17-Iminoalkyl-5beta,14beta-androstan-Derivate , die auf das kardiovaskuläre System wirken, Verfahren zu ihrer Herstellung und pharmazeutische Zusammensetzungen, die sie enthalten |
DE4420501A1 (de) * | 1994-06-13 | 1995-12-14 | Sigma Tau Ind Farmaceuti | Neue Hydrazino- und Hydroxyamino-14beta-hydroxyandrostanderivate mit Aktivität für das cardiovaskuläre System, Verfahren zu deren Herstellung und pharmazeutische Zusammensetzungen, die diese enthalten |
-
1994
- 1994-11-29 DE DE4442486A patent/DE4442486A1/de not_active Ceased
-
1995
- 1995-11-03 DK DK95117347T patent/DK0714908T3/da active
- 1995-11-03 EP EP95117347A patent/EP0714908B1/en not_active Expired - Lifetime
- 1995-11-03 AT AT95117347T patent/ATE163424T1/de not_active IP Right Cessation
- 1995-11-03 ES ES95117347T patent/ES2112597T3/es not_active Expired - Lifetime
- 1995-11-03 DE DE69501660T patent/DE69501660T2/de not_active Expired - Fee Related
- 1995-11-15 US US08/559,291 patent/US5705662A/en not_active Expired - Fee Related
- 1995-11-28 CA CA002163935A patent/CA2163935C/en not_active Expired - Fee Related
- 1995-11-29 JP JP31066995A patent/JP3899136B2/ja not_active Expired - Fee Related
-
1998
- 1998-08-15 HK HK98109958A patent/HK1009334A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
DE4442486A1 (de) | 1996-05-30 |
DE69501660D1 (de) | 1998-04-02 |
DK0714908T3 (da) | 1998-09-28 |
ATE163424T1 (de) | 1998-03-15 |
JPH08225591A (ja) | 1996-09-03 |
CA2163935A1 (en) | 1996-05-30 |
EP0714908B1 (en) | 1998-02-25 |
EP0714908A3 (es) | 1996-06-19 |
JP3899136B2 (ja) | 2007-03-28 |
US5705662A (en) | 1998-01-06 |
DE69501660T2 (de) | 1998-07-09 |
EP0714908A2 (en) | 1996-06-05 |
HK1009334A1 (en) | 1999-05-28 |
CA2163935C (en) | 2007-03-06 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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