DE69703228D1 - Neue 6-Hydroxy und 6-Oxo-Androstan Verbindungen mit Kardioaktivität und pharmazeutische Präparate davon - Google Patents

Neue 6-Hydroxy und 6-Oxo-Androstan Verbindungen mit Kardioaktivität und pharmazeutische Präparate davon

Info

Publication number
DE69703228D1
DE69703228D1 DE69703228T DE69703228T DE69703228D1 DE 69703228 D1 DE69703228 D1 DE 69703228D1 DE 69703228 T DE69703228 T DE 69703228T DE 69703228 T DE69703228 T DE 69703228T DE 69703228 D1 DE69703228 D1 DE 69703228D1
Authority
DE
Germany
Prior art keywords
oxo
hydroxy
cardioactivity
new
pharmaceutical preparations
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69703228T
Other languages
English (en)
Other versions
DE69703228T2 (de
Inventor
Munari Sergio De
Elena Folpini
Marco Frigerio
Piero Melloni
Fulvio Serra
Simona Sputore
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sigma Tau Industrie Farmaceutiche Riunite SpA
Original Assignee
Sigma Tau Industrie Farmaceutiche Riunite SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Industrie Farmaceutiche Riunite SpA filed Critical Sigma Tau Industrie Farmaceutiche Riunite SpA
Priority to DE69703228T priority Critical patent/DE69703228T2/de
Application granted granted Critical
Publication of DE69703228D1 publication Critical patent/DE69703228D1/de
Publication of DE69703228T2 publication Critical patent/DE69703228T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0038—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 with an androstane skeleton, including 18- or 19-substituted derivatives, 18-nor derivatives and also derivatives where position 17-beta is substituted by a carbon atom not directly bonded to a further carbon atom and not being part of an amide group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C07J41/0016—Oximes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE69703228T 1996-08-19 1997-07-09 Neue 6-Hydroxy und 6-Oxo-Androstan Verbindungen mit Kardioaktivität und pharmazeutische Präparate davon Expired - Lifetime DE69703228T2 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE69703228T DE69703228T2 (de) 1996-08-19 1997-07-09 Neue 6-Hydroxy und 6-Oxo-Androstan Verbindungen mit Kardioaktivität und pharmazeutische Präparate davon

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19633349A DE19633349A1 (de) 1996-08-19 1996-08-19 Neue 6-Hydroxy- und 6-Oxo-androstan-Derivate, die auf das kardiovaskuläre System wirken und pharmazeutische Zusammensetzungen, die diese enthalten
DE69703228T DE69703228T2 (de) 1996-08-19 1997-07-09 Neue 6-Hydroxy und 6-Oxo-Androstan Verbindungen mit Kardioaktivität und pharmazeutische Präparate davon

Publications (2)

Publication Number Publication Date
DE69703228D1 true DE69703228D1 (de) 2000-11-09
DE69703228T2 DE69703228T2 (de) 2001-02-22

Family

ID=7802998

Family Applications (2)

Application Number Title Priority Date Filing Date
DE19633349A Withdrawn DE19633349A1 (de) 1996-08-19 1996-08-19 Neue 6-Hydroxy- und 6-Oxo-androstan-Derivate, die auf das kardiovaskuläre System wirken und pharmazeutische Zusammensetzungen, die diese enthalten
DE69703228T Expired - Lifetime DE69703228T2 (de) 1996-08-19 1997-07-09 Neue 6-Hydroxy und 6-Oxo-Androstan Verbindungen mit Kardioaktivität und pharmazeutische Präparate davon

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE19633349A Withdrawn DE19633349A1 (de) 1996-08-19 1996-08-19 Neue 6-Hydroxy- und 6-Oxo-androstan-Derivate, die auf das kardiovaskuläre System wirken und pharmazeutische Zusammensetzungen, die diese enthalten

Country Status (10)

Country Link
US (1) US5914324A (de)
EP (1) EP0825197B1 (de)
JP (1) JP4297994B2 (de)
AT (1) ATE196768T1 (de)
DE (2) DE19633349A1 (de)
DK (1) DK0825197T3 (de)
ES (1) ES2151698T3 (de)
GR (1) GR3034821T3 (de)
HK (1) HK1009139A1 (de)
PT (1) PT825197E (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1317031B1 (it) * 2000-05-17 2003-05-26 Sigma Tau Ind Farmaceuti Procedimento migliorato per la preparazione di (e,z)3-(2-amminoetossimmino)-androstano-6, 17-dione e di suoi analoghi.
US10174070B2 (en) * 2005-09-30 2019-01-08 Endece Llc 6-substituted estradiol derivatives and methods of use
US8168621B2 (en) 2005-09-30 2012-05-01 Endece, Llc 6-substituted estradiol derivatives and methods of use
US20080119447A1 (en) * 2005-09-30 2008-05-22 James Yarger 6-alkoxyalkyl estradiol derivatives and methods of use
TWI392682B (zh) * 2006-04-13 2013-04-11 Sigma Tau Ind Farmaceuti 作為心血管疾病的治療藥物之雄甾烷和雄甾烯的胺基衍生物
TWI389917B (zh) * 2006-04-13 2013-03-21 Sigma Tau Ind Farmaceuti 作為心血管疾病治療藥物的雄甾烷與雄甾烯之氮雜環烷基衍生物
TWI372762B (en) * 2006-06-23 2012-09-21 Sigma Tau Ind Farmaceuti Amino derivatives of b-homoandrostanes and b-heteroandrostanes
KR101499266B1 (ko) 2006-11-30 2015-03-05 엔디씨, 엘엘씨 6-알콕시알킬 에스트라디올 유도체 및 사용법
WO2009047101A1 (en) * 2007-10-12 2009-04-16 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Aminooxime derivatives of 2- and/or 4-substituted androstanes and androstenes as medicaments for cardiovascular disorders
WO2010149666A1 (en) 2009-06-22 2010-12-29 Medexis S.A. Methods for treating neoplasia
AU2011284606A1 (en) * 2010-07-30 2013-03-14 Pharmacellion Ltd Compounds and methods for treating neoplasia
DK2616477T3 (en) 2010-09-14 2017-02-20 Endece Llc 6-substituted demethyl estradiol derivatives as agonists of the type ER-BETA
CN103315968B (zh) * 2013-06-26 2015-04-01 中国生命药物治疗有限公司 一种注射用粉针剂及其制备方法
CN103360457B (zh) * 2013-07-31 2015-10-07 中国生命药物治疗有限公司 一种雄甾烷二酮衍生物晶型及其制备方法
DK3599243T3 (da) 2018-07-26 2023-07-10 Cvie Therapeutics Ltd 17beta-heterocyklyl-digitalis-lignende forbindelser til behandlingen af hjertesvigt
KR20210136048A (ko) 2019-03-05 2021-11-16 윈드트리 세라퓨틱스, 인크. 급성 심부전 (ahf)의 치료를 위한 이스타록심-함유 정맥내 제형
PL3805243T3 (pl) 2019-10-09 2024-03-18 Windtree Therapeutics, Inc. Pochodne androstanowe posiadające aktywność jako czyste lub w przeważającym stopniu czyste stymulatory SERCA2A do leczenia niewydolności serca

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2863885A (en) * 1958-02-10 1958-12-09 Upjohn Co 17-isonitrosoandrostanes
GB1175219A (en) * 1967-06-22 1969-12-23 Ici Ltd 3-Aminoalkoxycarbonylmethylene Steroid Derivatives
CH504427A (de) * 1967-12-06 1971-03-15 Ciba Geigy Ag Verfahren zur Herstellung neuer 4-Imino-19-nor-A-homosteroid-triene
US5144017A (en) * 1988-07-13 1992-09-01 University Of Manitoba Compounds that bind to digitalis receptor
GB9201224D0 (en) * 1992-01-21 1992-03-11 Erba Carlo Spa Difluoromethylenandrostenone derivatives and process for their preparation
DE4227605C2 (de) * 1992-08-20 1995-02-16 Sigma Tau Ind Farmaceuti 17-Hydroxyiminomethyl-14beta-hydroxy-5ß-androstan-Derivate, Verfahren zu deren Herstellung und pharmazeutische Zusammensetzungen, die dieselben enthalten
DE4232656C2 (de) * 1992-09-29 1995-01-12 Sigma Tau Ind Farmaceuti Cyclopentanperhydrophenanthren-17-furyl-3ß-derivate, Verfahren zu deren Herstellung und diese enthaltende pharmazeutischen Zusammensetzungen
DE4344236A1 (de) * 1993-12-23 1995-06-29 Sigma Tau Ind Farmaceuti Neue 17-Iminomethylalkenyl-5beta,14beta-androstan- und 17-Iminoalkyl-5beta,14beta-androstan-Derivate , die auf das kardiovaskuläre System wirken, Verfahren zu ihrer Herstellung und pharmazeutische Zusammensetzungen, die sie enthalten

Also Published As

Publication number Publication date
DE19633349A1 (de) 1998-02-26
DE69703228T2 (de) 2001-02-22
ATE196768T1 (de) 2000-10-15
JP4297994B2 (ja) 2009-07-15
JPH1077292A (ja) 1998-03-24
EP0825197A2 (de) 1998-02-25
US5914324A (en) 1999-06-22
EP0825197B1 (de) 2000-10-04
ES2151698T3 (es) 2001-01-01
EP0825197A3 (de) 1999-04-14
DK0825197T3 (da) 2000-10-30
GR3034821T3 (en) 2001-02-28
PT825197E (pt) 2001-01-31
HK1009139A1 (en) 1999-05-28

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