FI109999B - Kolesterolisynteesin trans-6-(2-(substituoitu pyrrol-1-yyli)alkyyli)pyran-2-oni-inhibiittoreiden uusi valmistusmenetelmä - Google Patents

Kolesterolisynteesin trans-6-(2-(substituoitu pyrrol-1-yyli)alkyyli)pyran-2-oni-inhibiittoreiden uusi valmistusmenetelmä Download PDF

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Publication number
FI109999B
FI109999B FI954073A FI954073A FI109999B FI 109999 B FI109999 B FI 109999B FI 954073 A FI954073 A FI 954073A FI 954073 A FI954073 A FI 954073A FI 109999 B FI109999 B FI 109999B
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FI
Finland
Prior art keywords
formula
compound
phenyl
alkyl
fluorophenyl
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FI954073A
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English (en)
Finnish (fi)
Swedish (sv)
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FI954073A (fi
FI954073A0 (fi
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Donald Eugene Butler
Thomas Norman Nanninga
Tung Van Le
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Warner Lambert Co
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Publication of FI954073A0 publication Critical patent/FI954073A0/fi
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
FI954073A 1993-03-03 1995-08-30 Kolesterolisynteesin trans-6-(2-(substituoitu pyrrol-1-yyli)alkyyli)pyran-2-oni-inhibiittoreiden uusi valmistusmenetelmä FI109999B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US08/025,701 US5298627A (en) 1993-03-03 1993-03-03 Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis
US2570193 1993-03-03
US9402180 1994-02-24
PCT/US1994/002180 WO1994020492A1 (en) 1993-03-03 1994-02-24 Novel process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis

Publications (3)

Publication Number Publication Date
FI954073A FI954073A (fi) 1995-08-30
FI954073A0 FI954073A0 (fi) 1995-08-30
FI109999B true FI109999B (fi) 2002-11-15

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ID=21827596

Family Applications (3)

Application Number Title Priority Date Filing Date
FI954073A FI109999B (fi) 1993-03-03 1995-08-30 Kolesterolisynteesin trans-6-(2-(substituoitu pyrrol-1-yyli)alkyyli)pyran-2-oni-inhibiittoreiden uusi valmistusmenetelmä
FI20021437A FI20021437A (fi) 1993-03-03 2002-08-02 Kolesterolisynteerin trans-6-[2-(substituoitu pyrrol-1-yyli)alkyyli]pyran-2-oni-inhibiittorit
FI20021438A FI20021438A (fi) 1993-03-03 2002-08-02 Kolesterolisynteesin trans-6-[2-(substituoitu pyrrol-1-yyli)alkyyli]pyran-2-oni-inhibiittorit

Family Applications After (2)

Application Number Title Priority Date Filing Date
FI20021437A FI20021437A (fi) 1993-03-03 2002-08-02 Kolesterolisynteerin trans-6-[2-(substituoitu pyrrol-1-yyli)alkyyli]pyran-2-oni-inhibiittorit
FI20021438A FI20021438A (fi) 1993-03-03 2002-08-02 Kolesterolisynteesin trans-6-[2-(substituoitu pyrrol-1-yyli)alkyyli]pyran-2-oni-inhibiittorit

Country Status (19)

Country Link
US (8) US5298627A (sk)
EP (1) EP0687263B1 (sk)
JP (1) JP3510253B2 (sk)
KR (1) KR100302431B1 (sk)
AT (1) ATE156127T1 (sk)
AU (1) AU677047B2 (sk)
CA (1) CA2155952C (sk)
CZ (4) CZ285555B6 (sk)
DE (1) DE69404632T2 (sk)
DK (1) DK0687263T3 (sk)
ES (1) ES2108435T3 (sk)
FI (3) FI109999B (sk)
GR (1) GR3024784T3 (sk)
HU (1) HU222177B1 (sk)
NO (3) NO308529B1 (sk)
NZ (1) NZ262830A (sk)
RU (1) RU2138497C1 (sk)
SK (4) SK281984B6 (sk)
WO (1) WO1994020492A1 (sk)

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