CN105085497B - 多取代吡咯类他汀含氟衍生物及其用途 - Google Patents
多取代吡咯类他汀含氟衍生物及其用途 Download PDFInfo
- Publication number
- CN105085497B CN105085497B CN201510364694.1A CN201510364694A CN105085497B CN 105085497 B CN105085497 B CN 105085497B CN 201510364694 A CN201510364694 A CN 201510364694A CN 105085497 B CN105085497 B CN 105085497B
- Authority
- CN
- China
- Prior art keywords
- acid
- compound
- carbon atom
- fluorine
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 0 CC1=C*C=C*1 Chemical compound CC1=C*C=C*1 0.000 description 1
- VFMBWIWKYJYQAR-NBXIYJJMSA-N C[C@]12OCCC[C@H]1OCC2SC Chemical compound C[C@]12OCCC[C@H]1OCC2SC VFMBWIWKYJYQAR-NBXIYJJMSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
Abstract
Description
Claims (4)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201510364694.1A CN105085497B (zh) | 2015-06-26 | 2015-06-26 | 多取代吡咯类他汀含氟衍生物及其用途 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201510364694.1A CN105085497B (zh) | 2015-06-26 | 2015-06-26 | 多取代吡咯类他汀含氟衍生物及其用途 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN105085497A CN105085497A (zh) | 2015-11-25 |
CN105085497B true CN105085497B (zh) | 2017-12-26 |
Family
ID=54566913
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201510364694.1A Active CN105085497B (zh) | 2015-06-26 | 2015-06-26 | 多取代吡咯类他汀含氟衍生物及其用途 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN105085497B (zh) |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1994020492A1 (en) * | 1993-03-03 | 1994-09-15 | Warner-Lambert Company | Novel process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis |
WO1999063994A1 (en) * | 1998-06-08 | 1999-12-16 | Advanced Medicine, Inc. | MULTIBINDING INHIBITORS OF HMG-CoA REDUCTASE |
CN104356118A (zh) * | 2014-10-17 | 2015-02-18 | 上海应用技术学院 | 多取代吡咯类他汀内酯脱水化合物及其用途 |
-
2015
- 2015-06-26 CN CN201510364694.1A patent/CN105085497B/zh active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1994020492A1 (en) * | 1993-03-03 | 1994-09-15 | Warner-Lambert Company | Novel process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis |
WO1999063994A1 (en) * | 1998-06-08 | 1999-12-16 | Advanced Medicine, Inc. | MULTIBINDING INHIBITORS OF HMG-CoA REDUCTASE |
CN104356118A (zh) * | 2014-10-17 | 2015-02-18 | 上海应用技术学院 | 多取代吡咯类他汀内酯脱水化合物及其用途 |
Non-Patent Citations (3)
Title |
---|
Inhibitors of Cholesterol Biosynthesis. 3.Tetrahydro-4-hydroxy-6-[2-(lH-pyrrol-l-yl)ethyl]-2H-pyran-2-one Inhibitors of HMG-CoA Reductase. 2.Effects of Introducing Substituents at Positions Three and Four of the Pyrrole Nucleus;B. D. Roth,等;《J. Med. Chem.》;19911231;第34卷(第1期);第357-366页 * |
他汀类药物的含氟结构修饰;王晓光,等;《第十一届全国氟化学会议论文集》;20101013;第107页 * |
吡咯类HMG-CoA还原酶抑制剂的合成及生物活性;唐伟方,等;《中国药科大学学报》;20081231;第39卷(第5期);第398-405页 * |
Also Published As
Publication number | Publication date |
---|---|
CN105085497A (zh) | 2015-11-25 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN104356118B (zh) | 多取代吡咯类他汀内酯脱水化合物及其用途 | |
CN104356119B (zh) | 多取代嘧啶类他汀内酯脱水化合物及其用途 | |
JP6155395B2 (ja) | 新規dgat2阻害剤 | |
CN1863805B (zh) | 环糖的二硫化物、硫化物、亚砜和砜衍生物及其用途 | |
Liu et al. | Insights into the solubility and structural features of four praziquantel cocrystals | |
EP3480207A1 (en) | Orphan nuclear receptor nur77 ligand and application thereof | |
Haviv et al. | Crystal packing mediates enantioselective ligand recognition at the peripheral site of acetylcholinesterase | |
Chang et al. | Fragment-based discovery of novel pentacyclic triterpenoid derivatives as cholesteryl ester transfer protein inhibitors | |
CN105017231B (zh) | 多取代吲哚类他汀含氟修饰物及其用途 | |
Knapp et al. | New glycomimetics: anomeric sulfonates, sulfenamides, and sulfonamides | |
CN104356120B (zh) | 多取代喹啉类他汀内酯脱水化合物及其用途 | |
CN105175399B (zh) | 多取代嘧啶类他汀含氟衍生物及其用途 | |
CN105017230B (zh) | 多取代喹啉类他汀含氟衍生物及其用途 | |
CN105085497B (zh) | 多取代吡咯类他汀含氟衍生物及其用途 | |
CN103450163B (zh) | 吲唑类化合物、其制备方法及其药物用途 | |
EP3170820A1 (en) | Benzothiazole compound and medicine containing same | |
CN106916143B (zh) | 一种预防和治疗冠心病的药物及其应用 | |
Titz et al. | Probing the carbohydrate recognition domain of E-selectin: The importance of the acid orientation in sLex mimetics | |
Dong et al. | Discovery of core-structurally novel PTP1B inhibitors with specific selectivity containing oxindole-fused spirotetrahydrofurochroman by one-pot reaction | |
CN104327057B (zh) | 多取代吲哚类他汀内酯脱水化合物及其用途 | |
CN113072484A (zh) | 含有琥珀酸酯的磺胺苯甲酰胺类化合物及其制备方法与应用 | |
CN104311517B (zh) | 他汀内酯脱水化合物及其用途 | |
Gobbini et al. | Novel Analogues of Istaroxime, a Potent Inhibitor of Na+, K+-ATPase: Synthesis and Structure− Activity Relationship | |
CN105111173B (zh) | 他汀含氟衍生物及其用途 | |
Shemchuk et al. | Ionic cocrystals of levodopa and its biological precursors L-tyrosine and L-phenylalanine with LiCl |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
GR01 | Patent grant | ||
CP03 | Change of name, title or address |
Address after: No. 100 Hai Quan Road, Fengxian District, Shanghai Patentee after: SHANGHAI INSTITUTE OF TECHNOLOGY Patentee after: SHANGHAI HUALI BIOMEDICAL Co.,Ltd. Address before: 200235 No. 120, Xuhui District, Shanghai, Caobao Road Patentee before: Shanghai Institute of Technology Patentee before: SHANGHAI ECUST BIOMEDICINE Co.,Ltd. |
|
CP03 | Change of name, title or address | ||
TR01 | Transfer of patent right |
Effective date of registration: 20210312 Address after: Room 510, building 3, 245 Jiachuan Road, Xuhui District, Shanghai, 200237 Patentee after: SHANGHAI HUALI BIOMEDICAL Co.,Ltd. Address before: No. 100 Hai Quan Road, Fengxian District, Shanghai Patentee before: SHANGHAI INSTITUTE OF TECHNOLOGY Patentee before: SHANGHAI HUALI BIOMEDICAL Co.,Ltd. |
|
TR01 | Transfer of patent right |