CN105085497A - 多取代吡咯类他汀含氟衍生物及其用途 - Google Patents
多取代吡咯类他汀含氟衍生物及其用途 Download PDFInfo
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- CN105085497A CN105085497A CN201510364694.1A CN201510364694A CN105085497A CN 105085497 A CN105085497 A CN 105085497A CN 201510364694 A CN201510364694 A CN 201510364694A CN 105085497 A CN105085497 A CN 105085497A
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- 0 *C[C@](N)OC* Chemical compound *C[C@](N)OC* 0.000 description 2
- MWHKYYUTZDOAQP-UHFFFAOYSA-N CC(C)NC1CCC1 Chemical compound CC(C)NC1CCC1 MWHKYYUTZDOAQP-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (35)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201510364694.1A CN105085497B (zh) | 2015-06-26 | 2015-06-26 | 多取代吡咯类他汀含氟衍生物及其用途 |
Applications Claiming Priority (1)
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CN201510364694.1A CN105085497B (zh) | 2015-06-26 | 2015-06-26 | 多取代吡咯类他汀含氟衍生物及其用途 |
Publications (2)
Publication Number | Publication Date |
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CN105085497A true CN105085497A (zh) | 2015-11-25 |
CN105085497B CN105085497B (zh) | 2017-12-26 |
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CN201510364694.1A Active CN105085497B (zh) | 2015-06-26 | 2015-06-26 | 多取代吡咯类他汀含氟衍生物及其用途 |
Country Status (1)
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CN (1) | CN105085497B (zh) |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1994020492A1 (en) * | 1993-03-03 | 1994-09-15 | Warner-Lambert Company | Novel process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis |
WO1999063994A1 (en) * | 1998-06-08 | 1999-12-16 | Advanced Medicine, Inc. | MULTIBINDING INHIBITORS OF HMG-CoA REDUCTASE |
CN104356118A (zh) * | 2014-10-17 | 2015-02-18 | 上海应用技术学院 | 多取代吡咯类他汀内酯脱水化合物及其用途 |
-
2015
- 2015-06-26 CN CN201510364694.1A patent/CN105085497B/zh active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1994020492A1 (en) * | 1993-03-03 | 1994-09-15 | Warner-Lambert Company | Novel process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis |
WO1999063994A1 (en) * | 1998-06-08 | 1999-12-16 | Advanced Medicine, Inc. | MULTIBINDING INHIBITORS OF HMG-CoA REDUCTASE |
CN104356118A (zh) * | 2014-10-17 | 2015-02-18 | 上海应用技术学院 | 多取代吡咯类他汀内酯脱水化合物及其用途 |
Non-Patent Citations (4)
Title |
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B. D. ROTH,等: "Inhibitors of Cholesterol Biosynthesis. 3.Tetrahydro-4-hydroxy-6-[2-(lH-pyrrol-l-yl)ethyl]-2H-pyran-2-one Inhibitors of HMG-CoA Reductase. 2.Effects of Introducing Substituents at Positions Three and Four of the Pyrrole Nucleus", 《J. MED. CHEM.》 * |
唐伟方,等: "吡咯类HMG-CoA还原酶抑制剂的合成及生物活性", 《中国药科大学学报》 * |
李仁利: "《药物构效关系》", 31 January 2004, 中国医药科技出版社 * |
王晓光,等: "他汀类药物的含氟结构修饰", 《第十一届全国氟化学会议论文集》 * |
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Publication number | Publication date |
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CN105085497B (zh) | 2017-12-26 |
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Address after: No. 100 Hai Quan Road, Fengxian District, Shanghai Patentee after: SHANGHAI INSTITUTE OF TECHNOLOGY Patentee after: SHANGHAI HUALI BIOMEDICAL Co.,Ltd. Address before: 200235 No. 120, Xuhui District, Shanghai, Caobao Road Patentee before: Shanghai Institute of Technology Patentee before: SHANGHAI ECUST BIOMEDICINE Co.,Ltd. |
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Effective date of registration: 20210312 Address after: Room 510, building 3, 245 Jiachuan Road, Xuhui District, Shanghai, 200237 Patentee after: SHANGHAI HUALI BIOMEDICAL Co.,Ltd. Address before: No. 100 Hai Quan Road, Fengxian District, Shanghai Patentee before: SHANGHAI INSTITUTE OF TECHNOLOGY Patentee before: SHANGHAI HUALI BIOMEDICAL Co.,Ltd. |