ATE360608T1 - Verfahren zur herstellung von 1,3-diolen - Google Patents

Verfahren zur herstellung von 1,3-diolen

Info

Publication number
ATE360608T1
ATE360608T1 AT98961855T AT98961855T ATE360608T1 AT E360608 T1 ATE360608 T1 AT E360608T1 AT 98961855 T AT98961855 T AT 98961855T AT 98961855 T AT98961855 T AT 98961855T AT E360608 T1 ATE360608 T1 AT E360608T1
Authority
AT
Austria
Prior art keywords
diols
producing
Prior art date
Application number
AT98961855T
Other languages
English (en)
Inventor
Richard Joseph Mccabe
Thomas Norman Nanninga
Robert Lee Bosch
Robert Joseph Stahl
Original Assignee
Pfizer Ireland Pharmaceuticals
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Ireland Pharmaceuticals filed Critical Pfizer Ireland Pharmaceuticals
Application granted granted Critical
Publication of ATE360608T1 publication Critical patent/ATE360608T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/19—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton
    • C07C255/20—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/40—2,5-Pyrrolidine-diones
    • C07D207/416—2,5-Pyrrolidine-diones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B41/00—Formation or introduction of functional groups containing oxygen
    • C07B41/02—Formation or introduction of functional groups containing oxygen of hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/19—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton
    • C07C255/21—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton the carbon skeleton being further substituted by doubly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Pyrrole Compounds (AREA)
AT98961855T 1997-12-19 1998-12-02 Verfahren zur herstellung von 1,3-diolen ATE360608T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US6819397P 1997-12-19 1997-12-19

Publications (1)

Publication Number Publication Date
ATE360608T1 true ATE360608T1 (de) 2007-05-15

Family

ID=22081016

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98961855T ATE360608T1 (de) 1997-12-19 1998-12-02 Verfahren zur herstellung von 1,3-diolen

Country Status (31)

Country Link
US (4) US6433213B1 (de)
EP (1) EP1054860B1 (de)
JP (1) JP2001526256A (de)
KR (2) KR100681366B1 (de)
AR (1) AR014943A1 (de)
AT (1) ATE360608T1 (de)
AU (1) AU755543B2 (de)
BR (1) BR9813760A (de)
CA (1) CA2305618C (de)
CO (1) CO4990941A1 (de)
CU (1) CU22939A3 (de)
CY (1) CY1106612T1 (de)
DE (1) DE69837681T2 (de)
DK (1) DK1054860T3 (de)
ES (1) ES2284219T3 (de)
GT (2) GT199800197A (de)
HN (1) HN1998000187A (de)
HU (1) HUP0100252A3 (de)
IL (1) IL135562A (de)
IS (1) IS5447A (de)
MY (1) MY118726A (de)
NO (1) NO20003139L (de)
NZ (1) NZ504346A (de)
PA (1) PA8464901A1 (de)
PE (1) PE20000136A1 (de)
PL (1) PL193678B1 (de)
PT (1) PT1054860E (de)
SV (1) SV1998000153A (de)
TW (1) TW444000B (de)
WO (1) WO1999032434A1 (de)
ZA (1) ZA9811586B (de)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA02004082A (es) 1999-12-17 2002-10-11 Warner Lambert Res & Dev Un proceso para producir calcio de atorvastatin cristalino.
WO2001044180A1 (en) 1999-12-17 2001-06-21 Warner Lambert Research And Development Ireland Limited A factory scale process for producing crystalline atorvastatin trihydrate hemi calcium salt
US7608445B1 (en) 1999-12-29 2009-10-27 Verenium Corporation Nitrilases, nucleic acids encoding them and methods for making and using them
US7521216B2 (en) 1999-12-29 2009-04-21 Verenium Corporation Nitrilases and methods for making and using them
US20040014195A1 (en) * 1999-12-29 2004-01-22 Diversa Corporation Nitrilases, nucleic acids encoding them and methods for making and using them
US7300775B2 (en) 1999-12-29 2007-11-27 Verenium Corporation Methods for producing α-substituted carboxylic acids using nitrilases and strecker reagents
CA2442713C (en) 2001-04-05 2010-05-18 Nissan Chemical Industries, Ltd. Method for preparing 7-quinolinyl-3,5-dihydroxyhept-6-enoate
DE60235365D1 (de) 2001-07-06 2010-04-01 Basf Se Verfahren zur herstellung von 7-amino-syn-3,5-dihydroxyheptansäurederivaten und zwischenverbindungen diesesverfahrens und deren herestellung
PL366610A1 (en) 2001-07-06 2005-02-07 Teva Pharmaceutical Industries Ltd. Process for the preparation of 7-amino syn 3,5-dihydroxy heptanoic acid derivatives via 6-cyano syn 3,5-dihydroxy hexanoic acid derivatives
GB0211715D0 (en) 2002-05-22 2002-07-03 Phoenix Chemicals Ltd Process
US7932064B2 (en) * 2002-06-13 2011-04-26 Verenium Corporation Processes for making (R)-ethyl 4-cyano-3-hydroxybutyric acid
DE60336324D1 (de) * 2002-08-09 2011-04-21 Codexis Inc Enzymatische verfahren zur herstellung 4-substituierter 3-hydroxybuttersäure-derivate
PT1631533E (pt) * 2003-04-22 2009-06-04 Biocon Ltd Novo processo para a redução estereosselectiva de betacetoésteres
US7790197B2 (en) * 2003-06-09 2010-09-07 Warner-Lambert Company Llc Pharmaceutical compositions of atorvastatin
US20040253305A1 (en) * 2003-06-12 2004-12-16 Luner Paul E. Pharmaceutical compositions of atorvastatin
US7655692B2 (en) * 2003-06-12 2010-02-02 Pfizer Inc. Process for forming amorphous atorvastatin
US20050271717A1 (en) * 2003-06-12 2005-12-08 Alfred Berchielli Pharmaceutical compositions of atorvastatin
JP2007502124A (ja) * 2003-08-11 2007-02-08 コデクシス， インコーポレイテッド 改良ケトレダクターゼポリペプチドおよび関連ポリヌクレオチド
US7824898B2 (en) * 2003-08-11 2010-11-02 Codexis, Inc. Halohydrin dehalogenases and related polynucleotides
US7541171B2 (en) * 2003-08-11 2009-06-02 Codexis, Inc. Halohydrin dehalogenases and related polynucleotides
US7588928B2 (en) * 2003-08-11 2009-09-15 Codexis, Inc. Halohydrin dehalogenases and related polynucleotides
AU2004288134B2 (en) * 2003-08-11 2009-12-17 Codexis, Inc. Improved glucose dehydrogenase polypeptides and related polynucleotides
KR20060071397A (ko) * 2003-08-11 2006-06-26 코덱시스, 인코포레이티드 4-치환된 3-히드록시부티르산 유도체 및 이웃자리 시아노,히드록시 치환된 카르복실산 에스테르의 효소적 제조 방법
BRPI0414457A (pt) * 2003-09-17 2006-11-14 Warner Lambert Co formas cristalinas do ácido [r-(r*,r*)]-2-(4-fluorofenil)-beta, delta-dihidróxi-5-(1-metiletil)-3-fenil-4-[(fenilamino)-c arbonil]-1h-pirrol-1-heptanóico
US7557238B2 (en) * 2003-09-18 2009-07-07 Biocon Limited Process for the preparation of tert-butyl 6-cyano-5-hydroxy-3-oxohexanoate
US7851624B2 (en) * 2003-12-24 2010-12-14 Teva Pharamaceutical Industries Ltd. Triol form of rosuvastatin and synthesis of rosuvastatin
EP1697338A2 (de) * 2003-12-24 2006-09-06 Teva Pharmaceutical Industries Ltd. Verfahren zur herstellung von statinen mit hohem syn-zu-anti-verhältnis
KR100829268B1 (ko) * 2004-04-16 2008-05-13 화이자 프로덕츠 인코포레이티드 비정질 아토바스타틴 칼슘의 제조 방법
BRPI0510713A (pt) 2004-05-05 2007-11-20 Pfizer Prod Inc formas de sal de ácido [r-(r*,r*)]-2-(4-fluorofenil)-beta, delta-diidróxi-5-(1-metiletil)-3-fenil-4-[(fenilamino)ca rbonil]-1h-pirrol-1- heptanóico
ES2586561T3 (es) * 2004-07-16 2016-10-17 Lek Pharmaceuticals D.D. Productos de degradación oxidativa de atorvastatina calcio
CA2754932C (en) 2004-07-20 2014-04-01 Warner-Lambert Company Llc Novel forms of [r-(r*,r*)]-2-(4-fluorophenyl)-.beta.,.delta.-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid calcium salt (2:1)
EP1807055A1 (de) * 2004-10-28 2007-07-18 Warner-Lambert Company LLC Verfahren zur herstellung von amorphem atorvastatin
EP1819681B1 (de) 2004-11-23 2009-08-12 Warner-Lambert Company LLC 7-(2h-pyrazol-3-yl)-3,5-dihydroxy-heptansäure-derivate als hmg-co-a-reductase-inhibitoren zur behandlung von lipidemia
WO2006059224A1 (en) * 2004-12-02 2006-06-08 Warner-Lambert Company Llc Pharmaceutical compositions of amorphous atorvastatin and process for preparing same
WO2007029217A1 (en) * 2005-09-09 2007-03-15 Pfizer Science And Technology Ireland Limited Preparation of an atorvastatin intermediate
JP2009507821A (ja) * 2005-09-09 2009-02-26 ファイザー・サイエンス・アンド・テクノロジー・アイルランド・リミテッド アトルバスタチン中間体の調製
CA2547216A1 (en) 2005-09-21 2007-03-21 Renuka D. Reddy Process for annealing amorphous atorvastatin
DK1957452T3 (da) * 2005-11-21 2010-07-26 Warner Lambert Co Nye former af [R-(R*,R*)]-2-(4-fluorphenyl)-B,B-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-heptansyre- magnesium
CN101528917B (zh) 2006-10-02 2015-07-29 科德克希思公司 用于制备立体异构纯的他汀类及其合成中间体的组合物和方法
EP2115153B1 (de) 2007-03-01 2013-06-05 BP Corporation North America Inc. Nitrilasen, dafür kodierende nukleinsäuren sowie verfahren zu ihrer herstellung und verwendung
WO2009137691A2 (en) * 2008-05-09 2009-11-12 The Scripps Research Institute 1,3-diol synthesis via controlled, radical-mediated c-h functionalization
EP2379713A4 (de) * 2008-12-18 2013-07-10 Codexis Inc Rekombinante halohydrin-dehalogenase-polypeptide
EP2373609B1 (de) 2008-12-19 2013-10-16 KRKA, D.D., Novo Mesto Verwendung amphiphiler verbindungen zur kontrollierten kristallisation von statinen und statinzwischenprodukten
EP2327682A1 (de) 2009-10-29 2011-06-01 KRKA, D.D., Novo Mesto Verwendung von amphiphilen Verbindungen zur gesteuerten Kristallisation von Statinen und Statin Zwischenprodukte.
WO2012158833A2 (en) * 2011-05-16 2012-11-22 The Regents Of The University Of California Methods for production of hydrocarbons and oxygen-containing hydrocarbons
US20140335179A1 (en) 2011-07-01 2014-11-13 Dsm Sinochem Pharmaceuticals Netherlands B.V. Micronized crystals of atorvastatin hemicalcium
CN108033899B (zh) * 2017-12-06 2020-04-10 浙江科技学院 一种(r)-6-氰基-5-羟基-3-羰基己酸叔丁酯的制备方法
CN111978286A (zh) * 2020-08-21 2020-11-24 江苏万年长药业有限公司 一种制备ats-8的方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR64043B (en) 1977-10-01 1980-01-19 Expansia Sa Borane complexes
DE2912708A1 (de) 1979-03-30 1980-10-09 Basf Ag Datenspeichersystem und magnetscheiben dafuer
US5169857A (en) * 1988-01-20 1992-12-08 Bayer Aktiengesellschaft 7-(polysubstituted pyridyl)-hept-6-endates useful for treating hyperproteinaemia, lipoproteinaemia or arteriosclerosis
US5354772A (en) 1982-11-22 1994-10-11 Sandoz Pharm. Corp. Indole analogs of mevalonolactone and derivatives thereof
US4645854A (en) * 1985-04-25 1987-02-24 Merck & Co., Inc. Process for preparing HMG-CoA reductase inhibitors with a 3,5-dihydroxypentanoate subunit
US4897490A (en) * 1987-02-25 1990-01-30 Bristol-Meyers Company Antihypercholesterolemic tetrazole compounds
US4898949A (en) * 1987-02-25 1990-02-06 Bristol-Myers Company Intermediates for the preparation of antihypercholesterolemic tetrazole compounds
DE3741509A1 (de) 1987-12-08 1989-06-22 Hoechst Ag Verfahren zur herstellung optisch aktiver 3-desmethylmevalonsaeurederivate sowie zwischenprodukte
US5001144A (en) * 1987-12-21 1991-03-19 Rhone-Poulenc Rorer Pharmaceuticals Inc. Substituted cyclohexene derivatives as HMG-CoA reductase inhibitors
US5003080A (en) * 1988-02-22 1991-03-26 Warner-Lambert Company Process for trans-6-(2-(substituted-pyrrol-1-yl)alkyl)pryan-2-one inhibitors of cholesterol synthesis
FR2642065B1 (fr) * 1989-01-24 1991-05-24 Lipha Derives d'acides benzocycloalcenyl dihydroxy alcanoiques, procede de preparation et medicaments les contenant
FI94339C (fi) * 1989-07-21 1995-08-25 Warner Lambert Co Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi
DE3929507A1 (de) * 1989-09-06 1991-03-07 Bayer Ag Substituierte amino-pyridine
US5039802A (en) 1990-04-18 1991-08-13 Merck & Co., Inc. Arylation process for preparation of chiral catalysts for ketone reduction
JP3528186B2 (ja) 1991-06-24 2004-05-17 日産化学工業株式会社 光学活性キノリンメバロン酸のジアステレオマー塩
US5155251A (en) 1991-10-11 1992-10-13 Warner-Lambert Company Process for the synthesis of (5R)-1,1-dimethylethyl-6-cyano-5-hydroxy-3-oxo-hexanoate
US5218138A (en) * 1992-09-02 1993-06-08 Rhone-Poulenc Rorer Pharmaceuticals Inc. Stereoselective reduction of 3-hydroxyket-1-ones to 1,3-syn-dihydroxylated compounds
US5298627A (en) * 1993-03-03 1994-03-29 Warner-Lambert Company Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis

Also Published As

Publication number Publication date
JP2001526256A (ja) 2001-12-18
EP1054860B1 (de) 2007-04-25
WO1999032434A1 (en) 1999-07-01
DE69837681D1 (de) 2007-06-06
US7232915B2 (en) 2007-06-19
HUP0100252A1 (hu) 2001-07-30
HN1998000187A (es) 1999-10-22
PL193678B1 (pl) 2007-03-30
IL135562A (en) 2005-08-31
PE20000136A1 (es) 2000-03-11
AR014943A1 (es) 2001-04-11
CA2305618A1 (en) 1999-07-01
HUP0100252A3 (en) 2002-12-28
PT1054860E (pt) 2007-06-22
DE69837681T2 (de) 2008-01-10
AU755543B2 (en) 2002-12-12
IS5447A (is) 2000-04-14
CO4990941A1 (es) 2000-12-26
US20040006231A1 (en) 2004-01-08
TW444000B (en) 2001-07-01
CU22939A3 (es) 2004-04-13
MY118726A (en) 2005-01-31
US20020161021A1 (en) 2002-10-31
KR20010033315A (ko) 2001-04-25
NZ504346A (en) 2001-11-30
BR9813760A (pt) 2000-10-03
SV1998000153A (es) 1999-09-30
NO20003139D0 (no) 2000-06-16
EP1054860A1 (de) 2000-11-29
ES2284219T3 (es) 2007-11-01
CY1106612T1 (el) 2012-01-25
IL135562A0 (en) 2001-05-20
US20050197500A1 (en) 2005-09-08
PL341294A1 (en) 2001-04-09
PA8464901A1 (es) 2000-05-24
DK1054860T3 (da) 2007-07-02
KR100668575B1 (ko) 2007-01-17
US6433213B1 (en) 2002-08-13
AU1707499A (en) 1999-07-12
NO20003139L (no) 2000-06-16
GT199800197A (es) 2000-06-06
CA2305618C (en) 2004-08-17
GT199800197AA (es) 2000-06-06
KR20060080941A (ko) 2006-07-11
US6962994B2 (en) 2005-11-08
KR100681366B1 (ko) 2007-02-12
ZA9811586B (en) 1999-06-17
US6596879B2 (en) 2003-07-22

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