SV1998000153A - Proceso para la sintesis de 1,3-dioles - Google Patents

Proceso para la sintesis de 1,3-dioles

Info

Publication number
SV1998000153A
SV1998000153A SV1998000153A SV1998000153A SV1998000153A SV 1998000153 A SV1998000153 A SV 1998000153A SV 1998000153 A SV1998000153 A SV 1998000153A SV 1998000153 A SV1998000153 A SV 1998000153A SV 1998000153 A SV1998000153 A SV 1998000153A
Authority
SV
El Salvador
Prior art keywords
dioles
synthesis
cis
beta
trialquilboran
Prior art date
Application number
SV1998000153A
Other languages
English (en)
Inventor
Cabe Richard Joseph Mc
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of SV1998000153A publication Critical patent/SV1998000153A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/40—2,5-Pyrrolidine-diones
    • C07D207/416—2,5-Pyrrolidine-diones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B41/00—Formation or introduction of functional groups containing oxygen
    • C07B41/02—Formation or introduction of functional groups containing oxygen of hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/19—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton
    • C07C255/20—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/19—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton
    • C07C255/21—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton the carbon skeleton being further substituted by doubly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Pyrrole Compounds (AREA)

Abstract

LA INVENCION SE RELACIONA CON UN PROCESO MEJORADO PARA LA PREPARACION DE CIS-1,3-DIOLES DONDE UNA BETA-HIDROXICETONA ES TRATADA CON UN TRIALQUILBORANO O UNA MEZCLA DE UN TRAILQUILBORANO Y UN DIALQUILALCOXIBORANO, SEGUIDO DE RECUPERACION Y REUTILIZACION DE LAS ESPECIES ALQUILBORANO PARA CONVERTIR LA BETA-HIDROXICETONA ADICIONAL EN EL CIS-1,3-DIOL
SV1998000153A 1997-12-19 1998-12-18 Proceso para la sintesis de 1,3-dioles SV1998000153A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US6819397P 1997-12-19 1997-12-19

Publications (1)

Publication Number Publication Date
SV1998000153A true SV1998000153A (es) 1999-09-30

Family

ID=22081016

Family Applications (1)

Application Number Title Priority Date Filing Date
SV1998000153A SV1998000153A (es) 1997-12-19 1998-12-18 Proceso para la sintesis de 1,3-dioles

Country Status (31)

Country Link
US (4) US6433213B1 (es)
EP (1) EP1054860B1 (es)
JP (1) JP2001526256A (es)
KR (2) KR100668575B1 (es)
AR (1) AR014943A1 (es)
AT (1) ATE360608T1 (es)
AU (1) AU755543B2 (es)
BR (1) BR9813760A (es)
CA (1) CA2305618C (es)
CO (1) CO4990941A1 (es)
CU (1) CU22939A3 (es)
CY (1) CY1106612T1 (es)
DE (1) DE69837681T2 (es)
DK (1) DK1054860T3 (es)
ES (1) ES2284219T3 (es)
GT (2) GT199800197AA (es)
HN (1) HN1998000187A (es)
HU (1) HUP0100252A3 (es)
IL (1) IL135562A (es)
IS (1) IS5447A (es)
MY (1) MY118726A (es)
NO (1) NO20003139L (es)
NZ (1) NZ504346A (es)
PA (1) PA8464901A1 (es)
PE (1) PE20000136A1 (es)
PL (1) PL193678B1 (es)
PT (1) PT1054860E (es)
SV (1) SV1998000153A (es)
TW (1) TW444000B (es)
WO (1) WO1999032434A1 (es)
ZA (1) ZA9811586B (es)

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US7521216B2 (en) * 1999-12-29 2009-04-21 Verenium Corporation Nitrilases and methods for making and using them
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US7608445B1 (en) 1999-12-29 2009-10-27 Verenium Corporation Nitrilases, nucleic acids encoding them and methods for making and using them
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AU2002328835A1 (en) 2001-07-06 2003-01-21 Teva Pharmaceutical Industries Ltd Process for the preparation of 7-amino syn 3,5-dihydroxy heptanoic acid derivatives, intermediates thereof and methods for their preparation
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AU2003251523A1 (en) * 2002-06-13 2003-12-31 Diversa Corporation Processes for making (r)-ethyl 4-cyano-3-hydroxybutyric acid
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SG148180A1 (en) * 2003-08-11 2008-12-31 Codexis Inc Improved halohydrin dehalogenases and related polynucleotides
US7588928B2 (en) * 2003-08-11 2009-09-15 Codexis, Inc. Halohydrin dehalogenases and related polynucleotides
WO2005017135A1 (en) * 2003-08-11 2005-02-24 Codexis, Inc. Improved ketoreductase polypeptides and related polynucleotides
EP1663969A1 (en) * 2003-09-17 2006-06-07 Warner-Lambert Company LLC Crystalline forms of [r-(r*,r*)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid
US7557238B2 (en) * 2003-09-18 2009-07-07 Biocon Limited Process for the preparation of tert-butyl 6-cyano-5-hydroxy-3-oxohexanoate
US7851624B2 (en) * 2003-12-24 2010-12-14 Teva Pharamaceutical Industries Ltd. Triol form of rosuvastatin and synthesis of rosuvastatin
US20050159615A1 (en) * 2003-12-24 2005-07-21 Entire Interest. Process for preparation of statins with high syn to anti ratio
WO2005100313A1 (en) * 2004-04-16 2005-10-27 Pfizer Products Inc. Process for forming amorphous atorvastatin calcium
CA2649054A1 (en) 2004-05-05 2005-11-10 Pfizer Products Inc. Salt forms of [r-(r*,r*)]-2-(4-fluorophenyl)-.beta., .delta.-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid
EP1771455B1 (en) * 2004-07-16 2016-05-11 LEK Pharmaceuticals d.d. Oxidative degradation products of atorvastatin calcium
MX2007000765A (es) 2004-07-20 2007-03-28 Warner Lambert Co Formas cristalinas de sal de calcio del acido (r-(r*, r*))-2- (4-fluorofenil)- beta,gama- dihidroxi-5- (1-metiletil)-3 -fenil-4-((fenilamino) (carbonil)-1ih -pirrol-1- heptanoico (2:1).
NZ554541A (en) 2004-10-28 2011-01-28 Warner Lambert Co Process for forming amorphous atorvastatin
WO2006059224A1 (en) * 2004-12-02 2006-06-08 Warner-Lambert Company Llc Pharmaceutical compositions of amorphous atorvastatin and process for preparing same
CA2621506A1 (en) * 2005-09-09 2007-03-15 Pfizer Science And Technology Ireland Limited Preparation of an atorvastatin intermediate
WO2007029217A1 (en) * 2005-09-09 2007-03-15 Pfizer Science And Technology Ireland Limited Preparation of an atorvastatin intermediate
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Also Published As

Publication number Publication date
US20040006231A1 (en) 2004-01-08
NO20003139D0 (no) 2000-06-16
CA2305618C (en) 2004-08-17
DE69837681T2 (de) 2008-01-10
US6596879B2 (en) 2003-07-22
CA2305618A1 (en) 1999-07-01
ZA9811586B (en) 1999-06-17
AU1707499A (en) 1999-07-12
ATE360608T1 (de) 2007-05-15
DE69837681D1 (de) 2007-06-06
US20020161021A1 (en) 2002-10-31
NO20003139L (no) 2000-06-16
GT199800197A (es) 2000-06-06
CO4990941A1 (es) 2000-12-26
CU22939A3 (es) 2004-04-13
US7232915B2 (en) 2007-06-19
CY1106612T1 (el) 2012-01-25
TW444000B (en) 2001-07-01
MY118726A (en) 2005-01-31
US20050197500A1 (en) 2005-09-08
ES2284219T3 (es) 2007-11-01
JP2001526256A (ja) 2001-12-18
IL135562A0 (en) 2001-05-20
US6433213B1 (en) 2002-08-13
KR100668575B1 (ko) 2007-01-17
EP1054860B1 (en) 2007-04-25
HN1998000187A (es) 1999-10-22
DK1054860T3 (da) 2007-07-02
PA8464901A1 (es) 2000-05-24
AR014943A1 (es) 2001-04-11
BR9813760A (pt) 2000-10-03
PL341294A1 (en) 2001-04-09
NZ504346A (en) 2001-11-30
PE20000136A1 (es) 2000-03-11
IS5447A (is) 2000-04-14
KR100681366B1 (ko) 2007-02-12
EP1054860A1 (en) 2000-11-29
WO1999032434A1 (en) 1999-07-01
KR20010033315A (ko) 2001-04-25
AU755543B2 (en) 2002-12-12
GT199800197AA (es) 2000-06-06
HUP0100252A3 (en) 2002-12-28
PL193678B1 (pl) 2007-03-30
HUP0100252A1 (hu) 2001-07-30
US6962994B2 (en) 2005-11-08
PT1054860E (pt) 2007-06-22
IL135562A (en) 2005-08-31
KR20060080941A (ko) 2006-07-11

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