IL135562A - Process for the synthesis of cis-1,3-diols and a synergistic combination of trialkylborane and dialkylalkoxyborane for such synthesis - Google Patents

Process for the synthesis of cis-1,3-diols and a synergistic combination of trialkylborane and dialkylalkoxyborane for such synthesis

Info

Publication number
IL135562A
IL135562A IL13556298A IL13556298A IL135562A IL 135562 A IL135562 A IL 135562A IL 13556298 A IL13556298 A IL 13556298A IL 13556298 A IL13556298 A IL 13556298A IL 135562 A IL135562 A IL 135562A
Authority
IL
Israel
Prior art keywords
synthesis
dialkylalkoxyborane
trialkylborane
diols
cis
Prior art date
Application number
IL13556298A
Other languages
English (en)
Other versions
IL135562A0 (en
Original Assignee
Warner Lambert Exp Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Exp Ltd filed Critical Warner Lambert Exp Ltd
Publication of IL135562A0 publication Critical patent/IL135562A0/xx
Publication of IL135562A publication Critical patent/IL135562A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/40—2,5-Pyrrolidine-diones
    • C07D207/416—2,5-Pyrrolidine-diones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B41/00—Formation or introduction of functional groups containing oxygen
    • C07B41/02—Formation or introduction of functional groups containing oxygen of hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/19—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton
    • C07C255/20—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/19—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton
    • C07C255/21—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton the carbon skeleton being further substituted by doubly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Pyrrole Compounds (AREA)
IL13556298A 1997-12-19 1998-12-02 Process for the synthesis of cis-1,3-diols and a synergistic combination of trialkylborane and dialkylalkoxyborane for such synthesis IL135562A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6819397P 1997-12-19 1997-12-19
PCT/US1998/025493 WO1999032434A1 (en) 1997-12-19 1998-12-02 Process for the synthesis of 1,3-diols

Publications (2)

Publication Number Publication Date
IL135562A0 IL135562A0 (en) 2001-05-20
IL135562A true IL135562A (en) 2005-08-31

Family

ID=22081016

Family Applications (1)

Application Number Title Priority Date Filing Date
IL13556298A IL135562A (en) 1997-12-19 1998-12-02 Process for the synthesis of cis-1,3-diols and a synergistic combination of trialkylborane and dialkylalkoxyborane for such synthesis

Country Status (31)

Country Link
US (4) US6433213B1 (es)
EP (1) EP1054860B1 (es)
JP (1) JP2001526256A (es)
KR (2) KR100681366B1 (es)
AR (1) AR014943A1 (es)
AT (1) ATE360608T1 (es)
AU (1) AU755543B2 (es)
BR (1) BR9813760A (es)
CA (1) CA2305618C (es)
CO (1) CO4990941A1 (es)
CU (1) CU22939A3 (es)
CY (1) CY1106612T1 (es)
DE (1) DE69837681T2 (es)
DK (1) DK1054860T3 (es)
ES (1) ES2284219T3 (es)
GT (2) GT199800197AA (es)
HN (1) HN1998000187A (es)
HU (1) HUP0100252A3 (es)
IL (1) IL135562A (es)
IS (1) IS5447A (es)
MY (1) MY118726A (es)
NO (1) NO20003139D0 (es)
NZ (1) NZ504346A (es)
PA (1) PA8464901A1 (es)
PE (1) PE20000136A1 (es)
PL (1) PL193678B1 (es)
PT (1) PT1054860E (es)
SV (1) SV1998000153A (es)
TW (1) TW444000B (es)
WO (1) WO1999032434A1 (es)
ZA (1) ZA9811586B (es)

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RU2330840C1 (ru) * 2004-04-16 2008-08-10 Пфайзер Продактс Инк. Способ получения аморфного кальций аторвастатина
ES2739493T3 (es) 2004-05-05 2020-01-31 Pfizer Prod Inc Formas de sal de de atorvastatina con benetamina
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CN101528917B (zh) 2006-10-02 2015-07-29 科德克希思公司 用于制备立体异构纯的他汀类及其合成中间体的组合物和方法
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Also Published As

Publication number Publication date
KR100668575B1 (ko) 2007-01-17
MY118726A (en) 2005-01-31
PT1054860E (pt) 2007-06-22
AU1707499A (en) 1999-07-12
DK1054860T3 (da) 2007-07-02
AU755543B2 (en) 2002-12-12
HUP0100252A3 (en) 2002-12-28
CY1106612T1 (el) 2012-01-25
US20050197500A1 (en) 2005-09-08
US6962994B2 (en) 2005-11-08
HN1998000187A (es) 1999-10-22
BR9813760A (pt) 2000-10-03
NO20003139L (no) 2000-06-16
CA2305618C (en) 2004-08-17
PL341294A1 (en) 2001-04-09
CA2305618A1 (en) 1999-07-01
ZA9811586B (en) 1999-06-17
CO4990941A1 (es) 2000-12-26
KR20010033315A (ko) 2001-04-25
EP1054860A1 (en) 2000-11-29
SV1998000153A (es) 1999-09-30
GT199800197AA (es) 2000-06-06
PE20000136A1 (es) 2000-03-11
DE69837681D1 (de) 2007-06-06
PL193678B1 (pl) 2007-03-30
WO1999032434A1 (en) 1999-07-01
NZ504346A (en) 2001-11-30
TW444000B (en) 2001-07-01
NO20003139D0 (no) 2000-06-16
ES2284219T3 (es) 2007-11-01
IS5447A (is) 2000-04-14
DE69837681T2 (de) 2008-01-10
JP2001526256A (ja) 2001-12-18
ATE360608T1 (de) 2007-05-15
US7232915B2 (en) 2007-06-19
GT199800197A (es) 2000-06-06
US6596879B2 (en) 2003-07-22
AR014943A1 (es) 2001-04-11
HUP0100252A1 (hu) 2001-07-30
CU22939A3 (es) 2004-04-13
EP1054860B1 (en) 2007-04-25
US20020161021A1 (en) 2002-10-31
IL135562A0 (en) 2001-05-20
US6433213B1 (en) 2002-08-13
PA8464901A1 (es) 2000-05-24
KR100681366B1 (ko) 2007-02-12
US20040006231A1 (en) 2004-01-08
KR20060080941A (ko) 2006-07-11

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