SI1631533T1 - Nov postopek za stereoselektivno redukcijo beta - ketoestrov - Google Patents
Nov postopek za stereoselektivno redukcijo beta - ketoestrovInfo
- Publication number
- SI1631533T1 SI1631533T1 SI200331564T SI200331564T SI1631533T1 SI 1631533 T1 SI1631533 T1 SI 1631533T1 SI 200331564 T SI200331564 T SI 200331564T SI 200331564 T SI200331564 T SI 200331564T SI 1631533 T1 SI1631533 T1 SI 1631533T1
- Authority
- SI
- Slovenia
- Prior art keywords
- sub
- aryl
- alkyl
- ketoesters
- beta
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 238000011916 stereoselective reduction Methods 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000003118 aryl group Chemical group 0.000 abstract 4
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 229910052751 metal Inorganic materials 0.000 abstract 2
- 239000002184 metal Substances 0.000 abstract 2
- 125000006239 protecting group Chemical group 0.000 abstract 2
- 239000003638 chemical reducing agent Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000003253 isopropoxy group Chemical group [H]C([H])([H])C([H])(O*)C([H])([H])[H] 0.000 abstract 1
- 239000012279 sodium borohydride Substances 0.000 abstract 1
- 229910000033 sodium borohydride Inorganic materials 0.000 abstract 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
- C07F7/1872—Preparation; Treatments not provided for in C07F7/20
- C07F7/1892—Preparation; Treatments not provided for in C07F7/20 by reactions not provided for in C07F7/1876 - C07F7/1888
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
- C07C67/31—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by introduction of functional groups containing oxygen only in singly bound form
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03816679A EP1631533B1 (en) | 2003-04-22 | 2003-04-22 | Novel process for stereoselective reduction of beta-ketoesters |
| PCT/IN2003/000166 WO2004094343A1 (en) | 2003-04-22 | 2003-04-22 | NOVEL PROCESS FOR STEREOSELECTIVE REDUCTION OF ß-KETOESTERS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI1631533T1 true SI1631533T1 (sl) | 2009-08-31 |
Family
ID=33307096
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI200331564T SI1631533T1 (sl) | 2003-04-22 | 2003-04-22 | Nov postopek za stereoselektivno redukcijo beta - ketoestrov |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7232920B2 (sl) |
| EP (1) | EP1631533B1 (sl) |
| AT (1) | ATE425132T1 (sl) |
| AU (1) | AU2003231926A1 (sl) |
| DE (1) | DE60326654D1 (sl) |
| DK (1) | DK1631533T3 (sl) |
| ES (1) | ES2323366T3 (sl) |
| PT (1) | PT1631533E (sl) |
| SI (1) | SI1631533T1 (sl) |
| WO (1) | WO2004094343A1 (sl) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7851624B2 (en) * | 2003-12-24 | 2010-12-14 | Teva Pharamaceutical Industries Ltd. | Triol form of rosuvastatin and synthesis of rosuvastatin |
| US20070179166A1 (en) * | 2003-12-24 | 2007-08-02 | Valerie Niddam-Hildesheim | Process for preparation of statins with high syn to anti ratio |
| CN102827030B (zh) * | 2012-09-24 | 2014-05-07 | 复旦大学 | 一种 (3r, 5r)-3, 5-二羟基-6-氰基己酸酯的制备方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4645854A (en) * | 1985-04-25 | 1987-02-24 | Merck & Co., Inc. | Process for preparing HMG-CoA reductase inhibitors with a 3,5-dihydroxypentanoate subunit |
| DE3638761A1 (de) * | 1986-11-13 | 1988-05-26 | Schering Ag | Verbesserte ketoreduktion von carbacyclinzwischenprodukten |
| EP0424929A1 (en) * | 1989-10-27 | 1991-05-02 | Takeda Chemical Industries, Ltd. | Isoquinolone derivatives, their production and use |
| FR2670206B1 (fr) * | 1990-12-11 | 1993-01-22 | Rhone Poulenc Sante | Procede de preparation de derives de l'acide dihydroxy-3,5 pentanouique. |
| HRP960312B1 (en) * | 1995-07-17 | 2001-10-31 | Warner Lambert Co | NOVEL PROCESS FOR THE PRODUCTION OF AMORPHOUS /R-(R*, R*)/-2-(4-FLUOROPHENYL)-"beta", "delta"-DIHYDROXY-5-PHENYL-4-/(PHENYLAMINO)CARBONYL/-1H-PYRROLE -1-HEPTANOIC ACID CALCIUM SALT (2 : 1) |
| HU226465B1 (en) * | 1996-07-29 | 2008-12-29 | Warner Lambert Co | Improved process for the synthesis of protected esters of (s)-3,4-dihydroxybutyric acid |
| IL135562A (en) * | 1997-12-19 | 2005-08-31 | Warner Lambert Exp Ltd | Process for the synthesis of cis-1,3-diols and a synergistic combination of trialkylborane and dialkylalkoxyborane for such synthesis |
| DE60136095D1 (de) * | 2000-11-16 | 2008-11-20 | Teva Pharma | Hydrolyse von är(r*,r*)ü-2-(4-fluorphenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-ä(phenylamino)carbonylü-1h-pyrrol-heptansäureestern mit calciumhydroxid |
| JP2004533481A (ja) | 2001-07-06 | 2004-11-04 | テバ ファーマシューティカル インダストリーズ リミティド | ７−アミノｓｙｎ３，５−ジヒドロキシヘプタン酸誘導体の製造方法、それらの中間体及び中間体の製造方法 |
| US7199261B2 (en) | 2001-07-06 | 2007-04-03 | Teva Pharmaceutical Industries Ltd | Process for the preparation of 7-amino syn 3,5-dihydroxy heptanoic acid derivatives via 6-cyano syn 3,5-dihydroxy hexanoic acid derivatives |
| CA2448917A1 (en) | 2001-07-06 | 2003-01-16 | Reinhold Ohrlein | Process for the preparation of intermediates useful in the synthesis of statin derivatives especially 7-amino 3,5-dihydroxy heptanoic acid derivatives, and intermediates thereof |
| KR20040026705A (ko) | 2001-08-16 | 2004-03-31 | 테바 파마슈티컬 인더스트리즈 리미티드 | 스타틴의 칼슘 염 형태의 제조 방법 |
| CZ2004337A3 (cs) | 2001-08-16 | 2005-01-12 | Teva Pharmaceutical Industries Ltd. | Způsob přípravy vápenatých solí statinů |
| AU2003245736A1 (en) | 2002-02-14 | 2003-09-04 | Ranbaxy Laboratories Limited | Formulations of atorvastatin stabilized with alkali metal additions |
-
2003
- 2003-04-22 SI SI200331564T patent/SI1631533T1/sl unknown
- 2003-04-22 PT PT03816679T patent/PT1631533E/pt unknown
- 2003-04-22 US US10/483,479 patent/US7232920B2/en not_active Expired - Fee Related
- 2003-04-22 DE DE60326654T patent/DE60326654D1/de not_active Expired - Lifetime
- 2003-04-22 ES ES03816679T patent/ES2323366T3/es not_active Expired - Lifetime
- 2003-04-22 EP EP03816679A patent/EP1631533B1/en not_active Expired - Lifetime
- 2003-04-22 AU AU2003231926A patent/AU2003231926A1/en not_active Abandoned
- 2003-04-22 WO PCT/IN2003/000166 patent/WO2004094343A1/en not_active Application Discontinuation
- 2003-04-22 DK DK03816679T patent/DK1631533T3/da active
- 2003-04-22 AT AT03816679T patent/ATE425132T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1631533A4 (en) | 2007-04-25 |
| AU2003231926A1 (en) | 2004-11-19 |
| US20040259946A1 (en) | 2004-12-23 |
| ES2323366T3 (es) | 2009-07-14 |
| WO2004094343A1 (en) | 2004-11-04 |
| EP1631533B1 (en) | 2009-03-11 |
| DK1631533T3 (da) | 2009-06-02 |
| US7232920B2 (en) | 2007-06-19 |
| PT1631533E (pt) | 2009-06-04 |
| EP1631533A1 (en) | 2006-03-08 |
| DE60326654D1 (de) | 2009-04-23 |
| ATE425132T1 (de) | 2009-03-15 |
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