DK1631533T3 - Hidtil ukendt fremgangsmåde til stereoselektiv reduktion af beta-ketoestre - Google Patents
Hidtil ukendt fremgangsmåde til stereoselektiv reduktion af beta-ketoestreInfo
- Publication number
- DK1631533T3 DK1631533T3 DK03816679T DK03816679T DK1631533T3 DK 1631533 T3 DK1631533 T3 DK 1631533T3 DK 03816679 T DK03816679 T DK 03816679T DK 03816679 T DK03816679 T DK 03816679T DK 1631533 T3 DK1631533 T3 DK 1631533T3
- Authority
- DK
- Denmark
- Prior art keywords
- sub
- beta
- hitherto unknown
- aryl
- alkyl
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 238000011916 stereoselective reduction Methods 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000003118 aryl group Chemical group 0.000 abstract 4
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 229910052751 metal Inorganic materials 0.000 abstract 2
- 239000002184 metal Substances 0.000 abstract 2
- 125000006239 protecting group Chemical group 0.000 abstract 2
- 239000003638 chemical reducing agent Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000003253 isopropoxy group Chemical group [H]C([H])([H])C([H])(O*)C([H])([H])[H] 0.000 abstract 1
- 239000012279 sodium borohydride Substances 0.000 abstract 1
- 229910000033 sodium borohydride Inorganic materials 0.000 abstract 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
- C07F7/1872—Preparation; Treatments not provided for in C07F7/20
- C07F7/1892—Preparation; Treatments not provided for in C07F7/20 by reactions not provided for in C07F7/1876 - C07F7/1888
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
- C07C67/31—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by introduction of functional groups containing oxygen only in singly bound form
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/IN2003/000166 WO2004094343A1 (en) | 2003-04-22 | 2003-04-22 | NOVEL PROCESS FOR STEREOSELECTIVE REDUCTION OF ß-KETOESTERS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1631533T3 true DK1631533T3 (da) | 2009-06-02 |
Family
ID=33307096
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK03816679T DK1631533T3 (da) | 2003-04-22 | 2003-04-22 | Hidtil ukendt fremgangsmåde til stereoselektiv reduktion af beta-ketoestre |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7232920B2 (da) |
| EP (1) | EP1631533B1 (da) |
| AT (1) | ATE425132T1 (da) |
| AU (1) | AU2003231926A1 (da) |
| DE (1) | DE60326654D1 (da) |
| DK (1) | DK1631533T3 (da) |
| ES (1) | ES2323366T3 (da) |
| PT (1) | PT1631533E (da) |
| SI (1) | SI1631533T1 (da) |
| WO (1) | WO2004094343A1 (da) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070179166A1 (en) * | 2003-12-24 | 2007-08-02 | Valerie Niddam-Hildesheim | Process for preparation of statins with high syn to anti ratio |
| US7851624B2 (en) | 2003-12-24 | 2010-12-14 | Teva Pharamaceutical Industries Ltd. | Triol form of rosuvastatin and synthesis of rosuvastatin |
| CN102827030B (zh) * | 2012-09-24 | 2014-05-07 | 复旦大学 | 一种 (3r, 5r)-3, 5-二羟基-6-氰基己酸酯的制备方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4645854A (en) * | 1985-04-25 | 1987-02-24 | Merck & Co., Inc. | Process for preparing HMG-CoA reductase inhibitors with a 3,5-dihydroxypentanoate subunit |
| DE3638761A1 (de) * | 1986-11-13 | 1988-05-26 | Schering Ag | Verbesserte ketoreduktion von carbacyclinzwischenprodukten |
| CA2028538A1 (en) | 1989-10-27 | 1991-04-28 | Hideaki Natsugari | 4-substituted isoquinolone derivatives, their production and use |
| FR2670206B1 (fr) * | 1990-12-11 | 1993-01-22 | Rhone Poulenc Sante | Procede de preparation de derives de l'acide dihydroxy-3,5 pentanouique. |
| HRP960312B1 (en) | 1995-07-17 | 2001-10-31 | Warner Lambert Co | NOVEL PROCESS FOR THE PRODUCTION OF AMORPHOUS /R-(R*, R*)/-2-(4-FLUOROPHENYL)-"beta", "delta"-DIHYDROXY-5-PHENYL-4-/(PHENYLAMINO)CARBONYL/-1H-PYRROLE -1-HEPTANOIC ACID CALCIUM SALT (2 : 1) |
| US5998633A (en) * | 1996-07-29 | 1999-12-07 | Warner-Lambert Company | Process for the synthesis of protected esters of (S)-3,4-dihydroxybutyric acid |
| DK1054860T3 (da) * | 1997-12-19 | 2007-07-02 | Pfizer Ireland Pharmaceuticals | Proces for syntesen af 1,3-dioler |
| EP1341785B1 (en) | 2000-11-16 | 2008-10-08 | Teva Pharmaceutical Industries Ltd. | Hydrolysis of r(r*,r*)-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4- [(phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid esters with calcium hydroxide |
| CZ2004158A3 (cs) | 2001-07-06 | 2005-01-12 | Teva Pharmaceutical Industries Ltd. | Syntéza a meziprodukty derivátů 3,5-dihydroxyheptanové kyseliny |
| KR20040017278A (ko) | 2001-07-06 | 2004-02-26 | 테바 파마슈티컬 인더스트리즈 리미티드 | 7-아미노 신 3,5-디히드록시 헵탄산 유도체의 제조 방법,그 중간체 및 상기 중간체의 제조 방법 |
| EP1406860A1 (en) | 2001-07-06 | 2004-04-14 | Teva Pharmaceutical Industries Limited | Process for the preparation of 7-amino syn 3,5-dihydroxy heptanoic acid derivatives via 6-cyano syn 3,5-dihydroxy hexanoic acid derivatives |
| CN100430405C (zh) | 2001-08-16 | 2008-11-05 | 特瓦制药工业有限公司 | 制备他汀类的钙盐形式的方法 |
| KR20040026705A (ko) | 2001-08-16 | 2004-03-31 | 테바 파마슈티컬 인더스트리즈 리미티드 | 스타틴의 칼슘 염 형태의 제조 방법 |
| JP2005522444A (ja) | 2002-02-14 | 2005-07-28 | ランバクシー ラボラトリーズ リミテッド | アルカリ金属の添加により安定化させたアトーバスタチン製剤 |
-
2003
- 2003-04-22 WO PCT/IN2003/000166 patent/WO2004094343A1/en not_active Application Discontinuation
- 2003-04-22 US US10/483,479 patent/US7232920B2/en not_active Expired - Fee Related
- 2003-04-22 PT PT03816679T patent/PT1631533E/pt unknown
- 2003-04-22 ES ES03816679T patent/ES2323366T3/es not_active Expired - Lifetime
- 2003-04-22 EP EP03816679A patent/EP1631533B1/en not_active Expired - Lifetime
- 2003-04-22 SI SI200331564T patent/SI1631533T1/sl unknown
- 2003-04-22 AT AT03816679T patent/ATE425132T1/de not_active IP Right Cessation
- 2003-04-22 AU AU2003231926A patent/AU2003231926A1/en not_active Abandoned
- 2003-04-22 DK DK03816679T patent/DK1631533T3/da active
- 2003-04-22 DE DE60326654T patent/DE60326654D1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| AU2003231926A1 (en) | 2004-11-19 |
| US20040259946A1 (en) | 2004-12-23 |
| ATE425132T1 (de) | 2009-03-15 |
| DE60326654D1 (de) | 2009-04-23 |
| PT1631533E (pt) | 2009-06-04 |
| SI1631533T1 (sl) | 2009-08-31 |
| EP1631533B1 (en) | 2009-03-11 |
| EP1631533A1 (en) | 2006-03-08 |
| WO2004094343A1 (en) | 2004-11-04 |
| US7232920B2 (en) | 2007-06-19 |
| ES2323366T3 (es) | 2009-07-14 |
| EP1631533A4 (en) | 2007-04-25 |
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