DK1054860T3 - Proces for syntesen af 1,3-dioler - Google Patents

Proces for syntesen af 1,3-dioler

Info

Publication number
DK1054860T3
DK1054860T3 DK98961855T DK98961855T DK1054860T3 DK 1054860 T3 DK1054860 T3 DK 1054860T3 DK 98961855 T DK98961855 T DK 98961855T DK 98961855 T DK98961855 T DK 98961855T DK 1054860 T3 DK1054860 T3 DK 1054860T3
Authority
DK
Denmark
Prior art keywords
diols
synthesis
Prior art date
Application number
DK98961855T
Other languages
Danish (da)
English (en)
Inventor
Richard Joseph Mccabe
Robert Lee Bosch
Robert Joseph Stahl
Thomas Norman Nanninga
Original Assignee
Pfizer Ireland Pharmaceuticals
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Ireland Pharmaceuticals filed Critical Pfizer Ireland Pharmaceuticals
Application granted granted Critical
Publication of DK1054860T3 publication Critical patent/DK1054860T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/40—2,5-Pyrrolidine-diones
    • C07D207/416—2,5-Pyrrolidine-diones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B41/00—Formation or introduction of functional groups containing oxygen
    • C07B41/02—Formation or introduction of functional groups containing oxygen of hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/19—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton
    • C07C255/20—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/19—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton
    • C07C255/21—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton the carbon skeleton being further substituted by doubly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Pyrrole Compounds (AREA)
DK98961855T 1997-12-19 1998-12-02 Proces for syntesen af 1,3-dioler DK1054860T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6819397P 1997-12-19 1997-12-19
PCT/US1998/025493 WO1999032434A1 (en) 1997-12-19 1998-12-02 Process for the synthesis of 1,3-diols

Publications (1)

Publication Number Publication Date
DK1054860T3 true DK1054860T3 (da) 2007-07-02

Family

ID=22081016

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98961855T DK1054860T3 (da) 1997-12-19 1998-12-02 Proces for syntesen af 1,3-dioler

Country Status (31)

Country Link
US (4) US6433213B1 (es)
EP (1) EP1054860B1 (es)
JP (1) JP2001526256A (es)
KR (2) KR100681366B1 (es)
AR (1) AR014943A1 (es)
AT (1) ATE360608T1 (es)
AU (1) AU755543B2 (es)
BR (1) BR9813760A (es)
CA (1) CA2305618C (es)
CO (1) CO4990941A1 (es)
CU (1) CU22939A3 (es)
CY (1) CY1106612T1 (es)
DE (1) DE69837681T2 (es)
DK (1) DK1054860T3 (es)
ES (1) ES2284219T3 (es)
GT (2) GT199800197AA (es)
HN (1) HN1998000187A (es)
HU (1) HUP0100252A3 (es)
IL (1) IL135562A (es)
IS (1) IS5447A (es)
MY (1) MY118726A (es)
NO (1) NO20003139D0 (es)
NZ (1) NZ504346A (es)
PA (1) PA8464901A1 (es)
PE (1) PE20000136A1 (es)
PL (1) PL193678B1 (es)
PT (1) PT1054860E (es)
SV (1) SV1998000153A (es)
TW (1) TW444000B (es)
WO (1) WO1999032434A1 (es)
ZA (1) ZA9811586B (es)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA02004078A (es) 1999-12-17 2002-10-11 Warner Lambert Res & Dev Un proceso a escala industrial para producir sal de hemi calcio de trihidrato de atorvastatin cristalino.
WO2001044181A1 (en) 1999-12-17 2001-06-21 Warner Lambert Research And Development Ireland Limited A process for producing crystalline atorvastatin calcium
US7521216B2 (en) * 1999-12-29 2009-04-21 Verenium Corporation Nitrilases and methods for making and using them
US7608445B1 (en) 1999-12-29 2009-10-27 Verenium Corporation Nitrilases, nucleic acids encoding them and methods for making and using them
US7300775B2 (en) 1999-12-29 2007-11-27 Verenium Corporation Methods for producing α-substituted carboxylic acids using nitrilases and strecker reagents
US20040014195A1 (en) * 1999-12-29 2004-01-22 Diversa Corporation Nitrilases, nucleic acids encoding them and methods for making and using them
RU2260001C2 (ru) * 2001-04-05 2005-09-10 Ниссан Кемикал Индастриз, ЛТД Способ получения 7-хинолинил-3,5-дигидроксигепт-6-еноата
IL159719A0 (en) * 2001-07-06 2004-06-20 Teva Pharma Process for the preparation of 7-amino syn 3,5-dihydroxy heptanoic acid derivatives via 6-cyano syn 3,5-dihydroxy hexanoic acid derivatives
SK792004A3 (sk) * 2001-07-06 2005-03-04 Teva Pharmaceutical Industries Ltd. Syntéza a medziprodukty derivátov 3,5-dihydroxyheptánovej kyseliny
GB0211715D0 (en) * 2002-05-22 2002-07-03 Phoenix Chemicals Ltd Process
US7932064B2 (en) 2002-06-13 2011-04-26 Verenium Corporation Processes for making (R)-ethyl 4-cyano-3-hydroxybutyric acid
DE60336324D1 (de) * 2002-08-09 2011-04-21 Codexis Inc Enzymatische verfahren zur herstellung 4-substituierter 3-hydroxybuttersäure-derivate
EP1631533B1 (en) * 2003-04-22 2009-03-11 Biocon Limited Novel process for stereoselective reduction of beta-ketoesters
US7790197B2 (en) * 2003-06-09 2010-09-07 Warner-Lambert Company Llc Pharmaceutical compositions of atorvastatin
US20050271717A1 (en) * 2003-06-12 2005-12-08 Alfred Berchielli Pharmaceutical compositions of atorvastatin
US7655692B2 (en) * 2003-06-12 2010-02-02 Pfizer Inc. Process for forming amorphous atorvastatin
US20040253305A1 (en) * 2003-06-12 2004-12-16 Luner Paul E. Pharmaceutical compositions of atorvastatin
CA2533838A1 (en) * 2003-08-11 2005-02-24 Codexis, Inc. Improved ketoreductase polypeptides and related polynucleotides
KR20060064620A (ko) * 2003-08-11 2006-06-13 코덱시스, 인코포레이티드 개선된 글루코스 데히드로게나제 폴리펩티드 및 관련폴리뉴클레오티드
KR20060071397A (ko) * 2003-08-11 2006-06-26 코덱시스, 인코포레이티드 4-치환된 3-히드록시부티르산 유도체 및 이웃자리 시아노,히드록시 치환된 카르복실산 에스테르의 효소적 제조 방법
US7541171B2 (en) * 2003-08-11 2009-06-02 Codexis, Inc. Halohydrin dehalogenases and related polynucleotides
US7588928B2 (en) * 2003-08-11 2009-09-15 Codexis, Inc. Halohydrin dehalogenases and related polynucleotides
US7824898B2 (en) 2003-08-11 2010-11-02 Codexis, Inc. Halohydrin dehalogenases and related polynucleotides
CN1852894A (zh) * 2003-09-17 2006-10-25 沃尼尔·朗伯有限责任公司 [R－(R*, R*)]－2－(4－氟苯基) －β,δ－二羟基－5－(1－甲基乙基) －3－苯基－4－[(苯基氨基)羰基] －1 H－吡咯－1－庚酸的结晶形式
AU2003272080A1 (en) * 2003-09-18 2005-04-06 Biocon Limited Novel process for the preparation of tert-butyl 6-cyano-5-hydroxy-3-oxohexanoate
US7851624B2 (en) * 2003-12-24 2010-12-14 Teva Pharamaceutical Industries Ltd. Triol form of rosuvastatin and synthesis of rosuvastatin
WO2005063728A2 (en) * 2003-12-24 2005-07-14 Teva Pharmaceutical Industries Ltd. Process for preparation of statins with high syn to anti ratio
CA2562844A1 (en) * 2004-04-16 2005-10-27 Pfizer Products Inc. Process for forming amorphous atorvastatin calcium
CA2649054A1 (en) 2004-05-05 2005-11-10 Pfizer Products Inc. Salt forms of [r-(r*,r*)]-2-(4-fluorophenyl)-.beta., .delta.-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid
ES2586561T3 (es) * 2004-07-16 2016-10-17 Lek Pharmaceuticals D.D. Productos de degradación oxidativa de atorvastatina calcio
MX2007000765A (es) 2004-07-20 2007-03-28 Warner Lambert Co Formas cristalinas de sal de calcio del acido (r-(r*, r*))-2- (4-fluorofenil)- beta,gama- dihidroxi-5- (1-metiletil)-3 -fenil-4-((fenilamino) (carbonil)-1ih -pirrol-1- heptanoico (2:1).
MX2007004722A (es) * 2004-10-28 2007-06-15 Warner Lambert Co Procedimiento para formar atorvastatina amorfa.
EP1819319A1 (en) * 2004-12-02 2007-08-22 Warner-Lambert Company LLC Pharmaceutical compositions of amorphous atorvastatin and process for preparing same
JP2009507822A (ja) * 2005-09-09 2009-02-26 ファイザー・サイエンス・アンド・テクノロジー・アイルランド・リミテッド アトルバスタチン中間体の調製
JP2009507821A (ja) * 2005-09-09 2009-02-26 ファイザー・サイエンス・アンド・テクノロジー・アイルランド・リミテッド アトルバスタチン中間体の調製
CA2547216A1 (en) 2005-09-21 2007-03-21 Renuka D. Reddy Process for annealing amorphous atorvastatin
PT1957452E (pt) 2005-11-21 2010-05-25 Warner Lambert Co Novas formas de ácido [r-(r*,r*)]-2-(4-fluorofenil)-b,b--di-hidroxi-5-(1-metiletil)-3-fenil-4-[(fenilamino)-carbonil]-1h-pirrole-1-heptanóico magnésico
WO2008042876A2 (en) 2006-10-02 2008-04-10 Codexis, Inc. Compositions and methods for producing stereoisomerically pure statins and synthetic intermediates therefor
DK2115153T3 (da) 2007-03-01 2013-09-08 Bp Corp North America Inc Nitrilaser, nucleinsyrer som koder for dem og fremgangsmåder til at fremstille og anvende disse
WO2009137691A2 (en) * 2008-05-09 2009-11-12 The Scripps Research Institute 1,3-diol synthesis via controlled, radical-mediated c-h functionalization
SG172231A1 (en) 2008-12-18 2011-07-28 Codexis Inc Recombinant halohydrin dehalogenase polypeptides
EP2327682A1 (en) 2009-10-29 2011-06-01 KRKA, D.D., Novo Mesto Use of amphiphilic compounds for controlled crystallization of statins and statin intermediates
EP2373609B1 (en) 2008-12-19 2013-10-16 KRKA, D.D., Novo Mesto Use of amphiphilic compounds for controlled crystallization of statins and statin intermediates
WO2012158833A2 (en) * 2011-05-16 2012-11-22 The Regents Of The University Of California Methods for production of hydrocarbons and oxygen-containing hydrocarbons
CN103702982A (zh) 2011-07-01 2014-04-02 中化帝斯曼制药有限公司荷兰公司 阿托伐他汀半钙的超细晶体
CN108033899B (zh) * 2017-12-06 2020-04-10 浙江科技学院 一种(r)-6-氰基-5-羟基-3-羰基己酸叔丁酯的制备方法
CN111978286A (zh) * 2020-08-21 2020-11-24 江苏万年长药业有限公司 一种制备ats-8的方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR64043B (en) 1977-10-01 1980-01-19 Expansia Sa Borane complexes
DE2912708A1 (de) 1979-03-30 1980-10-09 Basf Ag Datenspeichersystem und magnetscheiben dafuer
US5169857A (en) * 1988-01-20 1992-12-08 Bayer Aktiengesellschaft 7-(polysubstituted pyridyl)-hept-6-endates useful for treating hyperproteinaemia, lipoproteinaemia or arteriosclerosis
US5354772A (en) 1982-11-22 1994-10-11 Sandoz Pharm. Corp. Indole analogs of mevalonolactone and derivatives thereof
US4645854A (en) 1985-04-25 1987-02-24 Merck & Co., Inc. Process for preparing HMG-CoA reductase inhibitors with a 3,5-dihydroxypentanoate subunit
US4898949A (en) * 1987-02-25 1990-02-06 Bristol-Myers Company Intermediates for the preparation of antihypercholesterolemic tetrazole compounds
US4897490A (en) * 1987-02-25 1990-01-30 Bristol-Meyers Company Antihypercholesterolemic tetrazole compounds
DE3741509A1 (de) 1987-12-08 1989-06-22 Hoechst Ag Verfahren zur herstellung optisch aktiver 3-desmethylmevalonsaeurederivate sowie zwischenprodukte
US5001144A (en) * 1987-12-21 1991-03-19 Rhone-Poulenc Rorer Pharmaceuticals Inc. Substituted cyclohexene derivatives as HMG-CoA reductase inhibitors
US5003080A (en) * 1988-02-22 1991-03-26 Warner-Lambert Company Process for trans-6-(2-(substituted-pyrrol-1-yl)alkyl)pryan-2-one inhibitors of cholesterol synthesis
FR2642065B1 (fr) * 1989-01-24 1991-05-24 Lipha Derives d'acides benzocycloalcenyl dihydroxy alcanoiques, procede de preparation et medicaments les contenant
FI94339C (fi) * 1989-07-21 1995-08-25 Warner Lambert Co Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi
DE3929507A1 (de) * 1989-09-06 1991-03-07 Bayer Ag Substituierte amino-pyridine
US5039802A (en) 1990-04-18 1991-08-13 Merck & Co., Inc. Arylation process for preparation of chiral catalysts for ketone reduction
JP3528186B2 (ja) 1991-06-24 2004-05-17 日産化学工業株式会社 光学活性キノリンメバロン酸のジアステレオマー塩
US5155251A (en) 1991-10-11 1992-10-13 Warner-Lambert Company Process for the synthesis of (5R)-1,1-dimethylethyl-6-cyano-5-hydroxy-3-oxo-hexanoate
US5218138A (en) * 1992-09-02 1993-06-08 Rhone-Poulenc Rorer Pharmaceuticals Inc. Stereoselective reduction of 3-hydroxyket-1-ones to 1,3-syn-dihydroxylated compounds
US5298627A (en) * 1993-03-03 1994-03-29 Warner-Lambert Company Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis

Also Published As

Publication number Publication date
IS5447A (is) 2000-04-14
TW444000B (en) 2001-07-01
PL193678B1 (pl) 2007-03-30
IL135562A0 (en) 2001-05-20
PA8464901A1 (es) 2000-05-24
KR20010033315A (ko) 2001-04-25
PE20000136A1 (es) 2000-03-11
ATE360608T1 (de) 2007-05-15
KR100668575B1 (ko) 2007-01-17
KR20060080941A (ko) 2006-07-11
CU22939A3 (es) 2004-04-13
HUP0100252A1 (hu) 2001-07-30
CA2305618C (en) 2004-08-17
NO20003139L (no) 2000-06-16
PL341294A1 (en) 2001-04-09
AU1707499A (en) 1999-07-12
DE69837681D1 (de) 2007-06-06
CA2305618A1 (en) 1999-07-01
AU755543B2 (en) 2002-12-12
GT199800197AA (es) 2000-06-06
CO4990941A1 (es) 2000-12-26
DE69837681T2 (de) 2008-01-10
BR9813760A (pt) 2000-10-03
US6962994B2 (en) 2005-11-08
ES2284219T3 (es) 2007-11-01
SV1998000153A (es) 1999-09-30
HUP0100252A3 (en) 2002-12-28
US20020161021A1 (en) 2002-10-31
ZA9811586B (en) 1999-06-17
US20040006231A1 (en) 2004-01-08
EP1054860A1 (en) 2000-11-29
US20050197500A1 (en) 2005-09-08
HN1998000187A (es) 1999-10-22
PT1054860E (pt) 2007-06-22
US6433213B1 (en) 2002-08-13
WO1999032434A1 (en) 1999-07-01
KR100681366B1 (ko) 2007-02-12
MY118726A (en) 2005-01-31
IL135562A (en) 2005-08-31
JP2001526256A (ja) 2001-12-18
GT199800197A (es) 2000-06-06
US6596879B2 (en) 2003-07-22
CY1106612T1 (el) 2012-01-25
NZ504346A (en) 2001-11-30
NO20003139D0 (no) 2000-06-16
AR014943A1 (es) 2001-04-11
EP1054860B1 (en) 2007-04-25
US7232915B2 (en) 2007-06-19

Similar Documents

Publication Publication Date Title
DK1054860T3 (da) Proces for syntesen af 1,3-dioler
DK0773940T4 (da) Fremgangsmåde til syntese af substituerede sulfoxider
FI19992060A (fi) Prosessikojeen alusta
DK0770615T3 (da) Fremgangsmåde til fremstilling af dihalogenazolopyrimidiner
DK0858440T3 (da) Fremgangsmåde til fremstilling af 1,1,1,3,3-pentafluorpropan
DK0911416T3 (da) Fremgangsmåde til fremstilling af protein
DK0937055T3 (da) Fremgangsmåde til fremstilling af d,I-alfa-tocopherol
DK1027315T3 (da) Fremgangsmåde til fremstilling af n-butanol
DK1028960T3 (da) Fremgangsmåde til fremstilling af thiazolidinedion
DK0970939T3 (da) Fremgangsmåde til fremstilling af methanol
DK0973769T3 (da) Fremgangsmåde til fremstilling af eprosartan
DK0927766T3 (da) Enzymatisk fremgangsmåde til fremstilling af (S)-cyanhydriner
FI971035A (fi) Biokonversioprosessi trans-hydroksisulfonin syntetisoimiseksi
DK0815092T3 (da) Fremgangsmåde til fremstilling af 1,2-benzisothiazolin-3-oner
DK0842930T3 (da) Fremgangsmåde til syntese af benzothiophener
NO963187D0 (no) Fremgangsmåte for syntese av gamma-pyroner
DK0970073T3 (da) Fremgangsmåde til fremstilling af eprosartan
DK1075473T3 (da) Fremgangsmåde til fremstilling af 1,3-disubstituerede-4-oxocykliske urinstoffer
DK0735043T3 (da) Fremgangsmåde til fremstilling af 2-substitueret 3,3-difluorfuran
DK1023292T3 (da) Fremgangsmåde til syntese af chlorpurinintermediater
IS5162A (is) Aðferð við að framleiða efnasambönd úr bensóþíasólóni
FI961827A0 (fi) Menetelmä 1,3-diolien monoesterien valmistamiseksi
DK1012152T3 (da) Fremgangsmåde til fremstilling af oxazaphosphorin-2-aminer
DK0721929T3 (da) Fremgangsmåde til fremstilling af hydroxyalkoxybenzophenoner
DK0863874T3 (da) Fremgangsmåde til fremstilling af dioxoazabicyclohexaner