ES8802295A1 - Procedimiento enantioselectivo para la preparacion de acidosalfa-aril alcanoicos opticamente activos - Google Patents

Procedimiento enantioselectivo para la preparacion de acidosalfa-aril alcanoicos opticamente activos

Info

Publication number
ES8802295A1
ES8802295A1 ES542640A ES542640A ES8802295A1 ES 8802295 A1 ES8802295 A1 ES 8802295A1 ES 542640 A ES542640 A ES 542640A ES 542640 A ES542640 A ES 542640A ES 8802295 A1 ES8802295 A1 ES 8802295A1
Authority
ES
Spain
Prior art keywords
alpha
formula
arylalkanoic acids
yes
optically active
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES542640A
Other languages
English (en)
Other versions
ES542640A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zambon SpA
Original Assignee
Zambon SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IT8407204A external-priority patent/IT1214809B/it
Priority claimed from IT07206/84A external-priority patent/IT1199447B/it
Priority claimed from IT8407207A external-priority patent/IT1207420B/it
Application filed by Zambon SpA filed Critical Zambon SpA
Publication of ES542640A0 publication Critical patent/ES542640A0/es
Publication of ES8802295A1 publication Critical patent/ES8802295A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C63/00—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/32—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/80—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
    • C07C49/807—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen all halogen atoms bound to the ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/475—Preparation of carboxylic acid esters by splitting of carbon-to-carbon bonds and redistribution, e.g. disproportionation or migration of groups between different molecules
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/734—Ethers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pain & Pain Management (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

SE OBTIENE UN UNICO ENANTIOMERO DE LOS ACIDOS ALFA-ARILALCANOICOS (I), OPTICAMENTE ACTIVO,DONDE AR ES ARILO Y R ALQUILO C1-4, POR HALOGENACION, EN LA POSICION ALFA RESPECTO DEL CETALICO, DE UN ARILALQUILCETAL (II), DONDE R1 Y R2 SON OH, CICLOALQUILO C1-6 Y OTROS, MEDIANTE SISTEMA AQUIRAL HALOGENANTE, TAL COMO BROMO, PERHALUROS DE AMONIO CUATERNARIOS, CLORURO DE SULFURILO Y OTROS, EN DISOLVENTE ORGANICO INERTE, ENTRE C40 Y 20JC PARA OBTENER UNA MEZCLA EPIMERICA DE ALFAHALO-CETALES (III) CONSTITUIDA ESENCIALMENTE POR UN ENANTIOMERO, REORDENANDOSE ESTA MEZCLA EN UN MEDIO ACUOSO A UN PH 4-6 Y ENTRE 20 Y 100Y, POR TRATAMIENTO EN DOS ETAPAS CON UN MEDIO ORGANICO LIBRE DE ALCOHOLES Y GLICOLES CON SEPARACION DE UN COMPUESTO (IV). PRESENTAN PROPIEDADES ANTIPIRETICAS Y ANTIINFLAMATORIAS.
ES542640A 1984-04-06 1985-04-03 Procedimiento enantioselectivo para la preparacion de acidosalfa-aril alcanoicos opticamente activos Expired ES8802295A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT8407204A IT1214809B (it) 1984-04-06 1984-04-06 Intermedi utili per la sintesi di acidi carbossilici.
IT07206/84A IT1199447B (it) 1984-08-06 1984-08-06 Intermedi utili per la sintesi di acidi carbossilici
IT8407207A IT1207420B (it) 1984-08-06 1984-08-06 Acidi carbossilici. procedimento per la preparazione di

Publications (2)

Publication Number Publication Date
ES542640A0 ES542640A0 (es) 1988-05-01
ES8802295A1 true ES8802295A1 (es) 1988-05-01

Family

ID=27272674

Family Applications (5)

Application Number Title Priority Date Filing Date
ES542641A Expired ES8701748A1 (es) 1984-04-06 1985-04-03 Procedimiento para la preparacion de nuevos acetales opticamente activos.
ES542640A Expired ES8802295A1 (es) 1984-04-06 1985-04-03 Procedimiento enantioselectivo para la preparacion de acidosalfa-aril alcanoicos opticamente activos
ES551476A Expired ES8705415A1 (es) 1984-04-06 1986-01-31 Procedimiento para la preparacion de nuevos acetales opticamente activos
ES554936A Expired ES8706661A1 (es) 1984-04-06 1986-05-14 Procedimiento enantioselectivo para la preparacion de acidos alfa-arilalcanoicos opticamente activos
ES557037A Expired ES8707490A1 (es) 1984-04-06 1986-08-01 Procedimiento para la preparacion de acidos alfa-arilalcanoicos.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES542641A Expired ES8701748A1 (es) 1984-04-06 1985-04-03 Procedimiento para la preparacion de nuevos acetales opticamente activos.

Family Applications After (3)

Application Number Title Priority Date Filing Date
ES551476A Expired ES8705415A1 (es) 1984-04-06 1986-01-31 Procedimiento para la preparacion de nuevos acetales opticamente activos
ES554936A Expired ES8706661A1 (es) 1984-04-06 1986-05-14 Procedimiento enantioselectivo para la preparacion de acidos alfa-arilalcanoicos opticamente activos
ES557037A Expired ES8707490A1 (es) 1984-04-06 1986-08-01 Procedimiento para la preparacion de acidos alfa-arilalcanoicos.

Country Status (18)

Country Link
US (4) US4697036A (es)
EP (2) EP0158255B1 (es)
JP (7) JPH0784457B2 (es)
KR (2) KR920007223B1 (es)
AT (2) ATE39691T1 (es)
AU (2) AU575927B2 (es)
CA (3) CA1282410C (es)
DE (2) DE3567209D1 (es)
DK (2) DK166272C (es)
ES (5) ES8701748A1 (es)
FI (2) FI91393C (es)
GR (2) GR850847B (es)
HU (2) HU197711B (es)
IE (2) IE58032B1 (es)
MX (1) MX169453B (es)
NO (2) NO169385C (es)
PT (2) PT80243B (es)
YU (2) YU43942B (es)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE39691T1 (de) * 1984-04-06 1989-01-15 Zambon Spa Optisch wirksame ketale, verfahren zu deren herstellung und deren verwendung in der synthese von alpha-arylalkansaeuren.
IT1201443B (it) * 1985-07-31 1989-02-02 Zambon Spa Intermedi per la sintesi di acidi carbossilici
IT1190399B (it) * 1985-10-04 1988-02-16 Zambon Spa Processo per la preparazione di composti carbonilici otticamente attivi
IT1190398B (it) * 1985-10-04 1988-02-16 Zambon Spa Processo per la preparazione di alfa aloalchil-aril-chetoni otticamente attivi
IT1190436B (it) * 1985-12-13 1988-02-16 Zambon Spa Processo stereoselettivo per la preparazione di composti carbonilici alfa,beta-disostituiti otticamente attivi
IT1197800B (it) * 1986-08-01 1988-12-06 Zambon Spa Processo per la sintesi di acidi carbossilici
IT1198234B (it) * 1986-12-23 1988-12-21 Zambon Spa Processo stereoconvergente per la preparazione di acidi carbossilici otticamente attivi
US4912248A (en) * 1987-05-18 1990-03-27 The Procter & Gamble Company Novel anti-inflammatory agents, pharmaceutical compositions and methods for reducing inflammation
IT1227537B (it) * 1987-07-28 1991-04-12 Zambon Spa Processo per la preparazione dell'acido s(+)-2-(6-metossi-2-naftil)- propionico
CN1053010A (zh) * 1989-05-16 1991-07-17 梅迪斯化学药物工厂普特两合股份公司 药物制剂
US5266723A (en) * 1989-05-16 1993-11-30 Medice, Ltd., Chem.-Pharm. Fabrik Putter Gmbh & Co. Kg Process for the preparation of optically active 2-aryl-alkanoic acids, especially 2-aryl-propionic acids
FI94339C (fi) 1989-07-21 1995-08-25 Warner Lambert Co Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi
US6194140B1 (en) 1990-04-04 2001-02-27 Chiron Corporation HCV NS3 protein fragments having helicase activity and improved solubility
IT1251958B (it) * 1991-10-18 1995-05-27 Zambon Spa Processo per la dealogenazione di derivati del naftalene
US5434302A (en) * 1994-02-18 1995-07-18 Paradies; H. Henrich Method for the preparation of optically active 2-aryl alkyl aldehydes and formation of 2-aryl-alkanoic acids therefrom
US5756851A (en) * 1996-10-21 1998-05-26 Albemarle Corporation Production of nabumetone or precursors thereof
US5792886A (en) * 1997-01-08 1998-08-11 Albemarle Corporation Production of racemic 2-(6-methoxy-2-naphthyl) propionic acid of precursors thereof
US6096920A (en) * 1997-01-08 2000-08-01 Albemarle Corporation Preparation of carboxylic compounds and their derivatives
US6080888A (en) * 1997-01-08 2000-06-27 Albemarle Corporation Preparation of olefinic compounds and carboxylic derivatives thereof
US5942527A (en) * 1997-08-27 1999-08-24 K & K Biosciences, Inc. Hydrazones, hydrazines, semicarbazones and thiosemicarbazones derived from pyridyl ketones as anticonvulsant drugs and excitatory amino acid antagonists
WO2000075365A2 (en) 1999-06-08 2000-12-14 University Of Iowa Research Foundation Compounds and methods to enhance raav transduction
IT1315212B1 (it) * 1999-07-26 2003-02-03 Consiglio Nazionale Ricerche Impiego di ortoesteri per la sintesi di acidi chirali in processi diesterificazione irreversibili biocatalizzati.
US20050095225A1 (en) 2003-03-31 2005-05-05 Engelhardt John F. Compounds and methods for pharmico-gene therapy of epithelial sodium channel associated disorders
JP4511809B2 (ja) * 2003-06-19 2010-07-28 川口薬品株式会社 ムスコンのアセタール付加体、その調製方法、並びに（±）−ムスコンの光学分割方法
GB0501237D0 (en) * 2005-01-21 2005-03-02 Givaudan Sa Organic compounds
DE102010063609A1 (de) 2010-12-20 2012-06-21 Awd.Pharma Gmbh & Co. Kg Neue Multikomponentenkristalle aus ([2-Amino-6-(4-fluoro-benzylamino)-pyridin-3yl)-carbamidsäureethylester und einer Arylpropionsäure
US11702672B2 (en) 2016-02-08 2023-07-18 University Of Iowa Research Foundation Methods to produce chimeric adeno-associated virus/bocavirus parvovirus
MA43735A (fr) 2016-03-07 2018-11-28 Univ Iowa Res Found Expression médiée par aav utilisant un promoteur et un activateur synthétiques
US11142775B2 (en) 2017-01-13 2021-10-12 University Of Iowa Research Foundation Bocaparvovirus small noncoding RNA and uses thereof
CN110229069A (zh) * 2019-07-16 2019-09-13 重庆医药高等专科学校 三甲基苯基三溴化铵的制备方法及萘普生生产中三甲基苯基三溴化铵的回收利用方法
CN114644554A (zh) * 2020-12-21 2022-06-21 上海医药工业研究院 (s)-氟比洛芬的制备方法及其中间体

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* Cited by examiner, † Cited by third party
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US2249519A (en) * 1940-10-09 1941-07-15 Eastman Kodak Co Yarn conditioning process and compositions therefor
US3247240A (en) * 1962-01-05 1966-04-19 Geigy Ag J R Process for the preparation of carbonyl compounds containing a hindered phenol group
SE367181B (es) * 1969-05-14 1974-05-20 Takeda Chemical Industries Ltd
US4107439A (en) * 1976-06-16 1978-08-15 The Upjohn Company Process for preparing arylalkanoic acid derivatives
EP0034781B1 (de) * 1980-02-21 1984-02-01 BASF Aktiengesellschaft Verfahren zur Herstellung von duktilen Verbundwerkstoffen
IE50898B1 (en) * 1980-02-26 1986-08-06 Blaschim Spa Process for preparing esters of 2-(6'-methoxy-2'-naphthyl)-propionic acid via rearrangement of new ketals of 2-halo-1-(6'-methoxy-2'-naphthyl)-propan-1-one
JPS5810525A (ja) * 1981-06-15 1983-01-21 Sagami Chem Res Center 光学活性な１−芳香族基置換−１−アルカノン類の製造方法
IT1190741B (it) * 1982-03-22 1988-02-24 Blaschim Spa Procedimento per preparare esteri dell'acido 2-(6'-metossi-2'-naftil)-propionico
US4623736A (en) * 1982-07-09 1986-11-18 The Upjohn Company Arylalkanoic acid process improvement
DE3362024D1 (en) * 1982-08-06 1986-03-13 Zambon Spa Process for preparing alpha arylalkanoic acids
JPS6071271A (ja) * 1983-09-29 1985-04-23 Fuji Xerox Co Ltd 感熱記録装置
ATE39691T1 (de) * 1984-04-06 1989-01-15 Zambon Spa Optisch wirksame ketale, verfahren zu deren herstellung und deren verwendung in der synthese von alpha-arylalkansaeuren.
JPH0585102A (ja) * 1991-09-24 1993-04-06 Nissan Motor Co Ltd トルクチユーブ装置

Also Published As

Publication number Publication date
ES542641A0 (es) 1986-12-16
FI851318A0 (fi) 1985-04-02
JPS60228441A (ja) 1985-11-13
AU4084085A (en) 1985-10-10
EP0158913B1 (en) 1988-07-20
KR920007223B1 (ko) 1992-08-28
EP0158255A2 (en) 1985-10-16
HUT37931A (en) 1986-03-28
US4855464A (en) 1989-08-08
CA1281029C (en) 1991-03-05
JPH0791214B2 (ja) 1995-10-04
DK149885D0 (da) 1985-04-02
KR920010927B1 (ko) 1992-12-24
ES8701748A1 (es) 1986-12-16
HUT40598A (en) 1987-01-28
DE3563848D1 (en) 1988-08-25
FI91528C (fi) 1994-07-11
EP0158255A3 (en) 1986-09-03
NO169385C (no) 1992-06-17
JPH06100498A (ja) 1994-04-12
DK166272B (da) 1993-03-29
ES551476A0 (es) 1987-05-01
PT80243A (en) 1985-05-01
MX169453B (es) 1993-07-06
FI91528B (fi) 1994-03-31
KR850007594A (ko) 1985-12-07
JPH07107018B2 (ja) 1995-11-15
FI91393C (fi) 1994-06-27
CA1282410C (en) 1991-04-02
FI851317A0 (fi) 1985-04-02
DK149885A (da) 1985-10-07
NO170685C (no) 1992-11-18
AU577362B2 (en) 1988-09-22
JPH0784457B2 (ja) 1995-09-13
PT80243B (en) 1987-04-28
ES542640A0 (es) 1988-05-01
ES8706661A1 (es) 1987-07-01
PT80244A (en) 1985-05-01
AU575927B2 (en) 1988-08-11
ES8705415A1 (es) 1987-05-01
PT80244B (en) 1987-04-23
JPH06116201A (ja) 1994-04-26
FI851318L (fi) 1985-10-07
JPH0859552A (ja) 1996-03-05
JPS60228440A (ja) 1985-11-13
ATE39691T1 (de) 1989-01-15
JPH0776193B2 (ja) 1995-08-16
ES554936A0 (es) 1987-07-01
KR850008484A (ko) 1985-12-18
ES8707490A1 (es) 1987-08-01
GR850847B (es) 1985-11-25
YU43686B (en) 1989-10-31
DK149785D0 (da) 1985-04-02
EP0158255B1 (en) 1989-01-04
IE58258B1 (en) 1993-08-25
US4734507A (en) 1988-03-29
JPH0867652A (ja) 1996-03-12
NO851349L (no) 1985-10-07
US4888433A (en) 1989-12-19
FI851317L (fi) 1985-10-07
GR850846B (es) 1985-11-25
YU43942B (en) 1989-12-31
HU197711B (en) 1989-05-29
JP2700024B2 (ja) 1998-01-19
IE58032B1 (en) 1993-06-16
JP2700023B2 (ja) 1998-01-19
DK166272C (da) 1993-10-25
IE850880L (en) 1985-10-06
AU4084285A (en) 1985-10-10
FI91393B (fi) 1994-03-15
CA1320495C (en) 1993-07-20
DK149785A (da) 1985-10-07
JPH06100491A (ja) 1994-04-12
NO851350L (no) 1985-10-07
IE850879L (en) 1985-10-06
DE3567209D1 (en) 1989-02-09
DK166876B1 (da) 1993-07-26
NO169385B (no) 1992-03-09
NO170685B (no) 1992-08-10
US4697036A (en) 1987-09-29
YU57985A (en) 1987-12-31
YU57085A (en) 1987-12-31
EP0158913A2 (en) 1985-10-23
ATE35810T1 (de) 1988-08-15
ES557037A0 (es) 1987-08-01
HU198439B (en) 1989-10-30
EP0158913A3 (en) 1985-12-11

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