ES8705415A1 - Procedimiento para la preparacion de nuevos acetales opticamente activos - Google Patents
Procedimiento para la preparacion de nuevos acetales opticamente activosInfo
- Publication number
- ES8705415A1 ES8705415A1 ES551476A ES551476A ES8705415A1 ES 8705415 A1 ES8705415 A1 ES 8705415A1 ES 551476 A ES551476 A ES 551476A ES 551476 A ES551476 A ES 551476A ES 8705415 A1 ES8705415 A1 ES 8705415A1
- Authority
- ES
- Spain
- Prior art keywords
- alpha
- formula
- arylalkanoic acids
- yes
- optically active
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C63/00—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/32—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
- C07C45/46—Friedel-Crafts reactions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
- C07C49/80—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
- C07C49/807—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen all halogen atoms bound to the ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/475—Preparation of carboxylic acid esters by splitting of carbon-to-carbon bonds and redistribution, e.g. disproportionation or migration of groups between different molecules
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/734—Ethers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Pain & Pain Management (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Rheumatology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Steroid Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE ACETALES OPTICAMENTE ACTIVOS, DE FORMULA (I). COMPRENDE LA REACCION DE ACIDO L(B) O D(C) TARTARICO O UNO DE SUS DERIVADOS DE FORMULA (II) CON UN CETAL DE FORMULA (III), PARA FORMAR UN COMPUESTO DE FORMULA (I), EN LAS QUE AR REPRESENTA ARILO, R ES ALQUILO C1-4 Y X, R1, R2, R8 Y R9 PUEDEN SER VARIOS TIPOS DE RADICALES. LA REACCION SE EFECTUA EN CONDICIONES ANHIDRAS, EN PRESENCIA DE UN CATALIZADOR ACIDO, A UNA TEMPERATURA COMPRENDIDA ENTRE 20JC Y 100JC. ESTOS COMPUESTOS TIENEN APLICACIONES COMO INTERMEDIOS EN LA PREPARACION DE ACIDOS ALFA-ARILALCANOICOS, EMPLEADOS COMO ANTIINFLAMATORIOS Y ANALGESICOS.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT8407204A IT1214809B (it) | 1984-04-06 | 1984-04-06 | Intermedi utili per la sintesi di acidi carbossilici. |
IT07206/84A IT1199447B (it) | 1984-08-06 | 1984-08-06 | Intermedi utili per la sintesi di acidi carbossilici |
IT8407207A IT1207420B (it) | 1984-08-06 | 1984-08-06 | Acidi carbossilici. procedimento per la preparazione di |
Publications (2)
Publication Number | Publication Date |
---|---|
ES551476A0 ES551476A0 (es) | 1987-05-01 |
ES8705415A1 true ES8705415A1 (es) | 1987-05-01 |
Family
ID=27272674
Family Applications (5)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES542641A Expired ES8701748A1 (es) | 1984-04-06 | 1985-04-03 | Procedimiento para la preparacion de nuevos acetales opticamente activos. |
ES542640A Expired ES8802295A1 (es) | 1984-04-06 | 1985-04-03 | Procedimiento enantioselectivo para la preparacion de acidosalfa-aril alcanoicos opticamente activos |
ES551476A Expired ES8705415A1 (es) | 1984-04-06 | 1986-01-31 | Procedimiento para la preparacion de nuevos acetales opticamente activos |
ES554936A Expired ES8706661A1 (es) | 1984-04-06 | 1986-05-14 | Procedimiento enantioselectivo para la preparacion de acidos alfa-arilalcanoicos opticamente activos |
ES557037A Expired ES8707490A1 (es) | 1984-04-06 | 1986-08-01 | Procedimiento para la preparacion de acidos alfa-arilalcanoicos. |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES542641A Expired ES8701748A1 (es) | 1984-04-06 | 1985-04-03 | Procedimiento para la preparacion de nuevos acetales opticamente activos. |
ES542640A Expired ES8802295A1 (es) | 1984-04-06 | 1985-04-03 | Procedimiento enantioselectivo para la preparacion de acidosalfa-aril alcanoicos opticamente activos |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES554936A Expired ES8706661A1 (es) | 1984-04-06 | 1986-05-14 | Procedimiento enantioselectivo para la preparacion de acidos alfa-arilalcanoicos opticamente activos |
ES557037A Expired ES8707490A1 (es) | 1984-04-06 | 1986-08-01 | Procedimiento para la preparacion de acidos alfa-arilalcanoicos. |
Country Status (18)
Country | Link |
---|---|
US (4) | US4697036A (es) |
EP (2) | EP0158255B1 (es) |
JP (7) | JPH0784457B2 (es) |
KR (2) | KR920007223B1 (es) |
AT (2) | ATE39691T1 (es) |
AU (2) | AU575927B2 (es) |
CA (3) | CA1282410C (es) |
DE (2) | DE3567209D1 (es) |
DK (2) | DK166272C (es) |
ES (5) | ES8701748A1 (es) |
FI (2) | FI91393C (es) |
GR (2) | GR850847B (es) |
HU (2) | HU197711B (es) |
IE (2) | IE58032B1 (es) |
MX (1) | MX169453B (es) |
NO (2) | NO169385C (es) |
PT (2) | PT80243B (es) |
YU (2) | YU43942B (es) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE39691T1 (de) * | 1984-04-06 | 1989-01-15 | Zambon Spa | Optisch wirksame ketale, verfahren zu deren herstellung und deren verwendung in der synthese von alpha-arylalkansaeuren. |
IT1201443B (it) * | 1985-07-31 | 1989-02-02 | Zambon Spa | Intermedi per la sintesi di acidi carbossilici |
IT1190399B (it) * | 1985-10-04 | 1988-02-16 | Zambon Spa | Processo per la preparazione di composti carbonilici otticamente attivi |
IT1190398B (it) * | 1985-10-04 | 1988-02-16 | Zambon Spa | Processo per la preparazione di alfa aloalchil-aril-chetoni otticamente attivi |
IT1190436B (it) * | 1985-12-13 | 1988-02-16 | Zambon Spa | Processo stereoselettivo per la preparazione di composti carbonilici alfa,beta-disostituiti otticamente attivi |
IT1197800B (it) * | 1986-08-01 | 1988-12-06 | Zambon Spa | Processo per la sintesi di acidi carbossilici |
IT1198234B (it) * | 1986-12-23 | 1988-12-21 | Zambon Spa | Processo stereoconvergente per la preparazione di acidi carbossilici otticamente attivi |
US4912248A (en) * | 1987-05-18 | 1990-03-27 | The Procter & Gamble Company | Novel anti-inflammatory agents, pharmaceutical compositions and methods for reducing inflammation |
IT1227537B (it) * | 1987-07-28 | 1991-04-12 | Zambon Spa | Processo per la preparazione dell'acido s(+)-2-(6-metossi-2-naftil)- propionico |
CN1053010A (zh) * | 1989-05-16 | 1991-07-17 | 梅迪斯化学药物工厂普特两合股份公司 | 药物制剂 |
US5266723A (en) * | 1989-05-16 | 1993-11-30 | Medice, Ltd., Chem.-Pharm. Fabrik Putter Gmbh & Co. Kg | Process for the preparation of optically active 2-aryl-alkanoic acids, especially 2-aryl-propionic acids |
FI94339C (fi) | 1989-07-21 | 1995-08-25 | Warner Lambert Co | Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi |
US6194140B1 (en) | 1990-04-04 | 2001-02-27 | Chiron Corporation | HCV NS3 protein fragments having helicase activity and improved solubility |
IT1251958B (it) * | 1991-10-18 | 1995-05-27 | Zambon Spa | Processo per la dealogenazione di derivati del naftalene |
US5434302A (en) * | 1994-02-18 | 1995-07-18 | Paradies; H. Henrich | Method for the preparation of optically active 2-aryl alkyl aldehydes and formation of 2-aryl-alkanoic acids therefrom |
US5756851A (en) * | 1996-10-21 | 1998-05-26 | Albemarle Corporation | Production of nabumetone or precursors thereof |
US5792886A (en) * | 1997-01-08 | 1998-08-11 | Albemarle Corporation | Production of racemic 2-(6-methoxy-2-naphthyl) propionic acid of precursors thereof |
US6096920A (en) * | 1997-01-08 | 2000-08-01 | Albemarle Corporation | Preparation of carboxylic compounds and their derivatives |
US6080888A (en) * | 1997-01-08 | 2000-06-27 | Albemarle Corporation | Preparation of olefinic compounds and carboxylic derivatives thereof |
US5942527A (en) * | 1997-08-27 | 1999-08-24 | K & K Biosciences, Inc. | Hydrazones, hydrazines, semicarbazones and thiosemicarbazones derived from pyridyl ketones as anticonvulsant drugs and excitatory amino acid antagonists |
WO2000075365A2 (en) | 1999-06-08 | 2000-12-14 | University Of Iowa Research Foundation | Compounds and methods to enhance raav transduction |
IT1315212B1 (it) * | 1999-07-26 | 2003-02-03 | Consiglio Nazionale Ricerche | Impiego di ortoesteri per la sintesi di acidi chirali in processi diesterificazione irreversibili biocatalizzati. |
US20050095225A1 (en) | 2003-03-31 | 2005-05-05 | Engelhardt John F. | Compounds and methods for pharmico-gene therapy of epithelial sodium channel associated disorders |
JP4511809B2 (ja) * | 2003-06-19 | 2010-07-28 | 川口薬品株式会社 | ムスコンのアセタール付加体、その調製方法、並びに(±)−ムスコンの光学分割方法 |
GB0501237D0 (en) * | 2005-01-21 | 2005-03-02 | Givaudan Sa | Organic compounds |
DE102010063609A1 (de) | 2010-12-20 | 2012-06-21 | Awd.Pharma Gmbh & Co. Kg | Neue Multikomponentenkristalle aus ([2-Amino-6-(4-fluoro-benzylamino)-pyridin-3yl)-carbamidsäureethylester und einer Arylpropionsäure |
US11702672B2 (en) | 2016-02-08 | 2023-07-18 | University Of Iowa Research Foundation | Methods to produce chimeric adeno-associated virus/bocavirus parvovirus |
MA43735A (fr) | 2016-03-07 | 2018-11-28 | Univ Iowa Res Found | Expression médiée par aav utilisant un promoteur et un activateur synthétiques |
US11142775B2 (en) | 2017-01-13 | 2021-10-12 | University Of Iowa Research Foundation | Bocaparvovirus small noncoding RNA and uses thereof |
CN110229069A (zh) * | 2019-07-16 | 2019-09-13 | 重庆医药高等专科学校 | 三甲基苯基三溴化铵的制备方法及萘普生生产中三甲基苯基三溴化铵的回收利用方法 |
CN114644554A (zh) * | 2020-12-21 | 2022-06-21 | 上海医药工业研究院 | (s)-氟比洛芬的制备方法及其中间体 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2249519A (en) * | 1940-10-09 | 1941-07-15 | Eastman Kodak Co | Yarn conditioning process and compositions therefor |
US3247240A (en) * | 1962-01-05 | 1966-04-19 | Geigy Ag J R | Process for the preparation of carbonyl compounds containing a hindered phenol group |
SE367181B (es) * | 1969-05-14 | 1974-05-20 | Takeda Chemical Industries Ltd | |
US4107439A (en) * | 1976-06-16 | 1978-08-15 | The Upjohn Company | Process for preparing arylalkanoic acid derivatives |
EP0034781B1 (de) * | 1980-02-21 | 1984-02-01 | BASF Aktiengesellschaft | Verfahren zur Herstellung von duktilen Verbundwerkstoffen |
IE50898B1 (en) * | 1980-02-26 | 1986-08-06 | Blaschim Spa | Process for preparing esters of 2-(6'-methoxy-2'-naphthyl)-propionic acid via rearrangement of new ketals of 2-halo-1-(6'-methoxy-2'-naphthyl)-propan-1-one |
JPS5810525A (ja) * | 1981-06-15 | 1983-01-21 | Sagami Chem Res Center | 光学活性な1−芳香族基置換−1−アルカノン類の製造方法 |
IT1190741B (it) * | 1982-03-22 | 1988-02-24 | Blaschim Spa | Procedimento per preparare esteri dell'acido 2-(6'-metossi-2'-naftil)-propionico |
US4623736A (en) * | 1982-07-09 | 1986-11-18 | The Upjohn Company | Arylalkanoic acid process improvement |
DE3362024D1 (en) * | 1982-08-06 | 1986-03-13 | Zambon Spa | Process for preparing alpha arylalkanoic acids |
JPS6071271A (ja) * | 1983-09-29 | 1985-04-23 | Fuji Xerox Co Ltd | 感熱記録装置 |
ATE39691T1 (de) * | 1984-04-06 | 1989-01-15 | Zambon Spa | Optisch wirksame ketale, verfahren zu deren herstellung und deren verwendung in der synthese von alpha-arylalkansaeuren. |
JPH0585102A (ja) * | 1991-09-24 | 1993-04-06 | Nissan Motor Co Ltd | トルクチユーブ装置 |
-
1985
- 1985-04-01 AT AT85103907T patent/ATE39691T1/de active
- 1985-04-01 EP EP85103907A patent/EP0158255B1/en not_active Expired
- 1985-04-01 AT AT85103906T patent/ATE35810T1/de not_active IP Right Cessation
- 1985-04-01 EP EP85103906A patent/EP0158913B1/en not_active Expired
- 1985-04-01 DE DE8585103907T patent/DE3567209D1/de not_active Expired
- 1985-04-01 DE DE8585103906T patent/DE3563848D1/de not_active Expired
- 1985-04-02 NO NO851349A patent/NO169385C/no not_active IP Right Cessation
- 1985-04-02 DK DK149885A patent/DK166272C/da not_active Application Discontinuation
- 1985-04-02 FI FI851317A patent/FI91393C/fi not_active IP Right Cessation
- 1985-04-02 NO NO851350A patent/NO170685C/no unknown
- 1985-04-02 FI FI851318A patent/FI91528C/fi not_active IP Right Cessation
- 1985-04-02 DK DK149785A patent/DK166876B1/da not_active IP Right Cessation
- 1985-04-03 ES ES542641A patent/ES8701748A1/es not_active Expired
- 1985-04-03 HU HU851282A patent/HU197711B/hu unknown
- 1985-04-03 HU HU851281A patent/HU198439B/hu not_active IP Right Cessation
- 1985-04-03 ES ES542640A patent/ES8802295A1/es not_active Expired
- 1985-04-04 IE IE87985A patent/IE58032B1/en not_active IP Right Cessation
- 1985-04-04 GR GR850847A patent/GR850847B/el unknown
- 1985-04-04 IE IE88085A patent/IE58258B1/en not_active IP Right Cessation
- 1985-04-04 CA CA000478585A patent/CA1282410C/en not_active Expired - Fee Related
- 1985-04-04 PT PT80243A patent/PT80243B/pt not_active IP Right Cessation
- 1985-04-04 PT PT80244A patent/PT80244B/pt not_active IP Right Cessation
- 1985-04-04 AU AU40842/85A patent/AU575927B2/en not_active Ceased
- 1985-04-04 AU AU40840/85A patent/AU577362B2/en not_active Ceased
- 1985-04-04 GR GR850846A patent/GR850846B/el unknown
- 1985-04-04 CA CA000478586A patent/CA1281029C/en not_active Expired - Fee Related
- 1985-04-05 JP JP60071271A patent/JPH0784457B2/ja not_active Expired - Lifetime
- 1985-04-05 US US06/720,380 patent/US4697036A/en not_active Expired - Lifetime
- 1985-04-05 YU YU570/85A patent/YU43942B/xx unknown
- 1985-04-05 US US06/720,379 patent/US4734507A/en not_active Expired - Lifetime
- 1985-04-06 KR KR1019850002311A patent/KR920007223B1/ko not_active IP Right Cessation
- 1985-04-06 KR KR1019850002312A patent/KR920010927B1/ko not_active IP Right Cessation
- 1985-04-06 JP JP60073388A patent/JPH0791214B2/ja not_active Expired - Lifetime
- 1985-04-08 YU YU579/85A patent/YU43686B/xx unknown
- 1985-04-08 MX MX005727A patent/MX169453B/es unknown
-
1986
- 1986-01-31 ES ES551476A patent/ES8705415A1/es not_active Expired
- 1986-05-14 ES ES554936A patent/ES8706661A1/es not_active Expired
- 1986-08-01 ES ES557037A patent/ES8707490A1/es not_active Expired
-
1987
- 1987-08-05 US US07/082,196 patent/US4888433A/en not_active Expired - Lifetime
- 1987-12-17 US US07/134,197 patent/US4855464A/en not_active Expired - Lifetime
-
1989
- 1989-05-02 CA CA000598530A patent/CA1320495C/en not_active Expired - Fee Related
-
1993
- 1993-03-22 JP JP5085104A patent/JPH07107018B2/ja not_active Expired - Fee Related
- 1993-03-22 JP JP5085103A patent/JPH06100498A/ja active Pending
- 1993-03-22 JP JP5085102A patent/JPH0776193B2/ja not_active Expired - Lifetime
-
1995
- 1995-03-06 JP JP7045381A patent/JP2700024B2/ja not_active Expired - Lifetime
- 1995-03-06 JP JP7045380A patent/JP2700023B2/ja not_active Expired - Fee Related
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