ES8101603A1 - Un procedimiento para la preparacion de derivados de penici-lina o de cefalosporina - Google Patents

Un procedimiento para la preparacion de derivados de penici-lina o de cefalosporina

Info

Publication number
ES8101603A1
ES8101603A1 ES80488231A ES488231A ES8101603A1 ES 8101603 A1 ES8101603 A1 ES 8101603A1 ES 80488231 A ES80488231 A ES 80488231A ES 488231 A ES488231 A ES 488231A ES 8101603 A1 ES8101603 A1 ES 8101603A1
Authority
ES
Spain
Prior art keywords
halogenation
hydroxy
cephalosporin
beta
processes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES80488231A
Other languages
English (en)
Other versions
ES488231A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27358615&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES8101603(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US06/008,647 external-priority patent/US4226986A/en
Priority claimed from US06/008,470 external-priority patent/US4211702A/en
Priority claimed from US06/008,645 external-priority patent/US4223133A/en
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of ES8101603A1 publication Critical patent/ES8101603A1/es
Publication of ES488231A0 publication Critical patent/ES488231A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/04—Preparation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/02—Preparation
    • C07D501/04—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D505/00—Heterocyclic compounds containing 5-oxa-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Catalysts (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

PROCEDIMIENTO DE OBTENCION DE DERIVADOS DE PENICILINA O DE CEFALOSPORINA. CONSISTE EN HACER REACCIONAR UNA C-C-ACILAMINOPENICILINA O UNA C.7-ACILAMINO-CEFALOSPORINA CON 1,0 A 2,0, EQUIVALENTES DE UN COMPLEJO HALOGENO-FOSFITO DE TRIARILO. CUANDO LA PENICILINA O LA CEFALOSPORINA ESTAN SUSTITUIDAS POR GRUPOS HIDROXI, AMINO O CARBOXI, ESTOS SE PROTEGEN CON GRUPOS HIDROXI, AMINO O CARBOXI CONVENCIONALES. SE EMPLEA UN COMPUESTO DE HALOGENACION DE CONTROL CINETICO, PARA CUYA PREPARACION SE EMPLEA UN DISOLVENTE ORGANICO INERTE APROTICO Y EN GRAN MEDIDA ANHIDRO.
ES488231A 1979-02-01 1980-02-01 Un procedimiento para la preparacion de derivados de penici-lina o de cefalosporina Granted ES488231A0 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US06/008,647 US4226986A (en) 1979-02-01 1979-02-01 Process for halogenation of β-lactam compounds
US06/008,470 US4211702A (en) 1979-02-01 1979-02-01 Process for preparation of penicillin and cephalosporin imino halides
US06/008,645 US4223133A (en) 1979-02-01 1979-02-01 Cephalosporin reduction process

Publications (2)

Publication Number Publication Date
ES8101603A1 true ES8101603A1 (es) 1980-12-16
ES488231A0 ES488231A0 (es) 1980-12-16

Family

ID=27358615

Family Applications (1)

Application Number Title Priority Date Filing Date
ES488231A Granted ES488231A0 (es) 1979-02-01 1980-02-01 Un procedimiento para la preparacion de derivados de penici-lina o de cefalosporina

Country Status (32)

Country Link
EP (1) EP0014567B1 (es)
JP (12) JPS55113789A (es)
KR (1) KR830001901B1 (es)
AT (1) AT372684B (es)
AU (1) AU538175B2 (es)
BE (1) BE881425A (es)
BG (1) BG35899A3 (es)
CA (1) CA1133468A (es)
CH (3) CH652405A5 (es)
DD (1) DD153374A5 (es)
DE (1) DE3066119D1 (es)
DK (2) DK163513C (es)
ES (1) ES488231A0 (es)
FI (1) FI74968C (es)
FR (1) FR2447924A1 (es)
GB (1) GB2044256B (es)
GR (1) GR72278B (es)
IE (1) IE49377B1 (es)
IL (1) IL59269A (es)
IT (1) IT1193908B (es)
LU (1) LU82120A1 (es)
MA (1) MA18715A1 (es)
MW (1) MW880A1 (es)
MY (1) MY8500598A (es)
NL (1) NL191791C (es)
NO (1) NO160660C (es)
NZ (1) NZ192749A (es)
OA (1) OA06451A (es)
PH (1) PH15158A (es)
PL (4) PL129604B1 (es)
PT (1) PT70744A (es)
YU (4) YU22580A (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0348124B1 (en) * 1988-06-22 1994-04-27 Eli Lilly And Company Intermediate for 1-carba(dethia)cephalosporin
EP1961636B1 (en) 2007-02-20 2013-04-24 Yamaha Hatsudoki Kabushiki Kaisha Hydraulic master cylinder and vehicle provided with the same
JP5319035B1 (ja) 2012-03-09 2013-10-16 真一郎 谷 トレーニングラダー
US9741942B2 (en) 2012-10-11 2017-08-22 Merck Patent Gmbh Materials for organic electroluminescent devices
JP6202969B2 (ja) * 2013-10-01 2017-09-27 富士電機株式会社 情報処理装置、暗号化方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK118506B (da) * 1963-02-18 1970-08-31 Ciba Geigy Fremgangsmåde til fremstilling af 7-aminocephalosporansyre eller estere deraf.
US3641014A (en) * 1968-10-03 1972-02-08 Lilly Co Eli Reduction of delta**3-cephalosporin sulfoxides
US3925372A (en) * 1973-02-23 1975-12-09 Lilly Co Eli Alpha-aminoacyl-3-halo cephalosporins

Also Published As

Publication number Publication date
IT1193908B (it) 1988-08-31
DK41480A (da) 1980-08-02
JPH0372633B2 (es) 1991-11-19
IL59269A0 (en) 1980-05-30
DK179991A (da) 1991-10-30
IT8019609A0 (it) 1980-01-31
MY8500598A (en) 1985-12-31
JPH0372631B2 (es) 1991-11-19
GR72278B (es) 1983-10-11
EP0014567A1 (en) 1980-08-20
DE3066119D1 (en) 1984-02-23
FR2447924B1 (es) 1983-10-21
PL128595B1 (en) 1984-02-29
MA18715A1 (fr) 1980-10-01
PH15158A (en) 1982-08-24
YU22580A (en) 1983-06-30
JPH0649706B2 (ja) 1994-06-29
EP0014567B1 (en) 1984-01-18
JPH0371435B2 (es) 1991-11-13
JPH0649705B2 (ja) 1994-06-29
IE800190L (en) 1980-08-01
JPH0372634B2 (es) 1991-11-19
PL126947B1 (en) 1983-09-30
JPH04356490A (ja) 1992-12-10
IE49377B1 (en) 1985-10-02
YU16483A (en) 1984-02-29
MW880A1 (en) 1981-09-09
BG35899A3 (en) 1984-07-16
AT372684B (de) 1983-11-10
LU82120A1 (fr) 1980-04-23
PL129604B1 (en) 1984-05-31
JPH0334982A (ja) 1991-02-14
JPH0565513B2 (es) 1993-09-17
FR2447924A1 (fr) 1980-08-29
CH652405A5 (fr) 1985-11-15
CH656385A5 (fr) 1986-06-30
NL191791C (nl) 1996-08-02
DK163513B (da) 1992-03-09
YU18283A (en) 1984-02-29
JPH07121950B2 (ja) 1995-12-25
YU16383A (en) 1984-02-29
JPS55113789A (en) 1980-09-02
JPH04364187A (ja) 1992-12-16
ATA50280A (de) 1983-03-15
DK179991D0 (da) 1991-10-30
AU538175B2 (en) 1984-08-02
NO160660C (no) 1989-05-16
PT70744A (en) 1980-02-01
JPH0517483A (ja) 1993-01-26
JPH089629B2 (ja) 1996-01-31
GB2044256B (en) 1983-05-05
YU44734B (en) 1991-02-28
BE881425A (fr) 1980-07-30
JPH0334981A (ja) 1991-02-14
DD153374A5 (de) 1982-01-06
ES488231A0 (es) 1980-12-16
JPH0565514B2 (es) 1993-09-17
JPH0334984A (ja) 1991-02-14
OA06451A (fr) 1981-07-31
JPH0372632B2 (es) 1991-11-19
NL8000545A (nl) 1980-08-05
IL59269A (en) 1984-04-30
JPH0532669A (ja) 1993-02-09
NO160660B (no) 1989-02-06
JPH0334985A (ja) 1991-02-14
GB2044256A (en) 1980-10-15
DK163667B (da) 1992-03-23
NO800251L (no) 1980-08-04
KR830001943A (ko) 1983-05-19
FI74968C (fi) 1988-04-11
JPH054991A (ja) 1993-01-14
FI800303A (fi) 1980-08-02
DK163667C (da) 1992-08-17
PL221744A1 (es) 1980-12-01
DK163513C (da) 1992-07-27
NZ192749A (en) 1983-06-17
JPH054990A (ja) 1993-01-14
CH648318A5 (fr) 1985-03-15
NL191791B (nl) 1996-04-01
FI74968B (fi) 1987-12-31
AU5502980A (en) 1980-08-07
JPH0334983A (ja) 1991-02-14
JPH0372231B2 (es) 1991-11-18
CA1133468A (en) 1982-10-12
PL129399B1 (en) 1984-05-31
KR830001901B1 (ko) 1983-09-19

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