ES2905479T3 - Acidos grasos y su uso en la conjugación con biomoléculas - Google Patents

Acidos grasos y su uso en la conjugación con biomoléculas Download PDF

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Publication number
ES2905479T3
ES2905479T3 ES15732508T ES15732508T ES2905479T3 ES 2905479 T3 ES2905479 T3 ES 2905479T3 ES 15732508 T ES15732508 T ES 15732508T ES 15732508 T ES15732508 T ES 15732508T ES 2905479 T3 ES2905479 T3 ES 2905479T3
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Spain
Prior art keywords
hgdf15
ester
pharmaceutically acceptable
amide
salt
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ES15732508T
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English (en)
Spanish (es)
Inventor
David Weninger Barnes
Ken Yamada
Chikwendu Ibebunjo
Alokesh Duttaroy
Louise Clare Kirman
Alexandra Marshall Bruce
Aimee Richardson Usera
Frederic Zecri
Jun Yuan
Changgang Lou
Aaron Kanter
Avirup Bose
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Novartis AG
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Novartis AG
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C—CHEMISTRY; METALLURGY
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
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    • C07C59/285—Polyhydroxy dicarboxylic acids having five or more carbon atoms, e.g. saccharic acids
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate

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  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Diabetes (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
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  • Hospice & Palliative Care (AREA)
ES15732508T 2014-06-23 2015-06-18 Acidos grasos y su uso en la conjugación con biomoléculas Active ES2905479T3 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201462015862P 2014-06-23 2014-06-23
US201462082327P 2014-11-20 2014-11-20
US201562107016P 2015-01-23 2015-01-23
PCT/US2015/036328 WO2015200078A1 (en) 2014-06-23 2015-06-18 Fatty acids and their use in conjugation to biomolecules

Publications (1)

Publication Number Publication Date
ES2905479T3 true ES2905479T3 (es) 2022-04-08

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ES15732508T Active ES2905479T3 (es) 2014-06-23 2015-06-18 Acidos grasos y su uso en la conjugación con biomoléculas

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EP (2) EP3988170A1 (cg-RX-API-DMAC7.html)
JP (5) JP6636959B2 (cg-RX-API-DMAC7.html)
KR (2) KR102559975B1 (cg-RX-API-DMAC7.html)
CN (3) CN114099693A (cg-RX-API-DMAC7.html)
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CA (1) CA2953480A1 (cg-RX-API-DMAC7.html)
CL (1) CL2016003281A1 (cg-RX-API-DMAC7.html)
CR (1) CR20160596A (cg-RX-API-DMAC7.html)
CU (1) CU24455B1 (cg-RX-API-DMAC7.html)
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EA (1) EA039074B1 (cg-RX-API-DMAC7.html)
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ES (1) ES2905479T3 (cg-RX-API-DMAC7.html)
GT (1) GT201600263A (cg-RX-API-DMAC7.html)
HR (1) HRP20220152T1 (cg-RX-API-DMAC7.html)
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Families Citing this family (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8420088B2 (en) 2008-01-28 2013-04-16 Novartis Ag Methods and compositions using FGF23 fusion polypeptides
TW200936156A (en) 2008-01-28 2009-09-01 Novartis Ag Methods and compositions using Klotho-FGF fusion polypeptides
CN103533951B (zh) 2011-04-08 2017-04-19 安姆根有限公司 使用生长分化因子15(gdf‑15)治疗或改善代谢障碍的方法
EA037355B1 (ru) 2013-07-31 2021-03-17 Эмджен Инк. Конструкции на основе фактора дифференцировки и роста 15 (gdf-15)
US10588980B2 (en) 2014-06-23 2020-03-17 Novartis Ag Fatty acids and their use in conjugation to biomolecules
CN107810201A (zh) 2014-12-04 2018-03-16 诺华股份有限公司 使用klotho变体多肽的方法和组合物
CA2972871A1 (en) 2015-01-23 2016-07-28 Novartis Ag Synthetic apelin fatty acid conjugates with improved half-life
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