ES2657750T3 - Combinación de compuesto inhibidor de AKT y vemurafenib para su uso en tratamientos terapéuticos - Google Patents

Combinación de compuesto inhibidor de AKT y vemurafenib para su uso en tratamientos terapéuticos Download PDF

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Publication number
ES2657750T3
ES2657750T3 ES12765234.5T ES12765234T ES2657750T3 ES 2657750 T3 ES2657750 T3 ES 2657750T3 ES 12765234 T ES12765234 T ES 12765234T ES 2657750 T3 ES2657750 T3 ES 2657750T3
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Prior art keywords
compound
vemurafenib
combination
illustrates
acceptable salt
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Spanish (es)
Inventor
Klaus Hoeflich
Mark Merchant
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Genentech Inc
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Genentech Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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ES12765234.5T 2011-04-01 2012-03-30 Combinación de compuesto inhibidor de AKT y vemurafenib para su uso en tratamientos terapéuticos Active ES2657750T3 (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161470803P 2011-04-01 2011-04-01
US201161470624P 2011-04-01 2011-04-01
US201161470803P 2011-04-01
US201161470624P 2011-04-01
PCT/US2012/031665 WO2012135750A1 (en) 2011-04-01 2012-03-30 Combinations of akt inhibitor compounds and vemurafenib, and methods of use

Publications (1)

Publication Number Publication Date
ES2657750T3 true ES2657750T3 (es) 2018-03-06

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Application Number Title Priority Date Filing Date
ES12765234.5T Active ES2657750T3 (es) 2011-04-01 2012-03-30 Combinación de compuesto inhibidor de AKT y vemurafenib para su uso en tratamientos terapéuticos
ES12764184.3T Active ES2620644T3 (es) 2011-04-01 2012-03-30 Combinaciones de compuestos inhibidores de AKT y agentes quimioterapéuticos, y métodos de uso
ES12764765T Active ES2660263T5 (en) 2011-04-01 2012-03-30 Combination of akt inhibitor compound and abiraterone for use in therapeutic treatments

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ES12764184.3T Active ES2620644T3 (es) 2011-04-01 2012-03-30 Combinaciones de compuestos inhibidores de AKT y agentes quimioterapéuticos, y métodos de uso
ES12764765T Active ES2660263T5 (en) 2011-04-01 2012-03-30 Combination of akt inhibitor compound and abiraterone for use in therapeutic treatments

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US (7) US9150549B2 (OSRAM)
EP (4) EP2694485B1 (OSRAM)
JP (4) JP6143739B2 (OSRAM)
KR (4) KR101950044B1 (OSRAM)
CN (8) CN111643504A (OSRAM)
AU (4) AU2012236144B2 (OSRAM)
BR (4) BR112013025386B1 (OSRAM)
CA (4) CA2831937A1 (OSRAM)
DK (1) DK2694072T4 (OSRAM)
ES (3) ES2657750T3 (OSRAM)
FI (1) FI2694072T4 (OSRAM)
HK (1) HK1204575A1 (OSRAM)
HR (1) HRP20180223T4 (OSRAM)
HU (1) HUE036513T2 (OSRAM)
IL (4) IL228637B (OSRAM)
LT (1) LT2694072T (OSRAM)
ME (1) ME02998B (OSRAM)
MX (4) MX2013011329A (OSRAM)
MY (1) MY179607A (OSRAM)
PL (2) PL2694072T5 (OSRAM)
PT (1) PT2694072T (OSRAM)
RS (1) RS56759B2 (OSRAM)
RU (4) RU2013148728A (OSRAM)
SG (5) SG10201504303SA (OSRAM)
SI (1) SI2694072T2 (OSRAM)
SM (1) SMT201800250T1 (OSRAM)
TR (1) TR201802093T4 (OSRAM)
WO (4) WO2012135759A1 (OSRAM)
ZA (4) ZA201308064B (OSRAM)

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DK2240451T3 (da) 2008-01-04 2017-11-20 Intellikine Llc Isoquinolinonderivater substitueret med en purin, der er anvendelig som pi3k-inhibitorer
US8193182B2 (en) 2008-01-04 2012-06-05 Intellikine, Inc. Substituted isoquinolin-1(2H)-ones, and methods of use thereof
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