IL154507A0 - Process for making n-aryl-anthranilic acids and their derivatives - Google Patents
Process for making n-aryl-anthranilic acids and their derivativesInfo
- Publication number
- IL154507A0 IL154507A0 IL15450701A IL15450701A IL154507A0 IL 154507 A0 IL154507 A0 IL 154507A0 IL 15450701 A IL15450701 A IL 15450701A IL 15450701 A IL15450701 A IL 15450701A IL 154507 A0 IL154507 A0 IL 154507A0
- Authority
- IL
- Israel
- Prior art keywords
- aryl
- derivatives
- making
- anthranilic acids
- anthranilic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/04—Formation of amino groups in compounds containing carboxyl groups
- C07C227/06—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid
- C07C227/08—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid by reaction of ammonia or amines with acids containing functional groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/10—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C221/00—Preparation of compounds containing amino groups and doubly-bound oxygen atoms bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22820600P | 2000-08-25 | 2000-08-25 | |
| PCT/US2001/022948 WO2002018319A1 (en) | 2000-08-25 | 2001-07-20 | Process for making n-aryl-anthranilic acids and their derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL154507A0 true IL154507A0 (en) | 2003-09-17 |
Family
ID=22856235
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL15450701A IL154507A0 (en) | 2000-08-25 | 2001-07-20 | Process for making n-aryl-anthranilic acids and their derivatives |
Country Status (31)
| Country | Link |
|---|---|
| EP (1) | EP1313694A1 (en) |
| JP (1) | JP2004507518A (en) |
| KR (1) | KR20030059115A (en) |
| CN (1) | CN1458921A (en) |
| AP (1) | AP2001002249A0 (en) |
| AR (1) | AR032175A1 (en) |
| AU (1) | AU2001277044A1 (en) |
| BG (1) | BG107635A (en) |
| BR (1) | BR0113520A (en) |
| CA (1) | CA2420003A1 (en) |
| CZ (1) | CZ2003477A3 (en) |
| DO (1) | DOP2001000238A (en) |
| EA (1) | EA200300187A1 (en) |
| GT (1) | GT200100174A (en) |
| HN (1) | HN2001000216A (en) |
| HU (1) | HUP0300828A2 (en) |
| IL (1) | IL154507A0 (en) |
| IS (1) | IS6724A (en) |
| MA (1) | MA26949A1 (en) |
| MX (1) | MXPA03001654A (en) |
| NO (1) | NO20030844L (en) |
| PA (1) | PA8526501A1 (en) |
| PE (1) | PE20020393A1 (en) |
| PL (1) | PL360699A1 (en) |
| SK (1) | SK2072003A3 (en) |
| SV (1) | SV2002000601A (en) |
| TN (1) | TNSN01127A1 (en) |
| UY (1) | UY26908A1 (en) |
| WO (1) | WO2002018319A1 (en) |
| YU (1) | YU14303A (en) |
| ZA (1) | ZA200301182B (en) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7235537B2 (en) | 2002-03-13 | 2007-06-26 | Array Biopharma, Inc. | N3 alkylated benzimidazole derivatives as MEK inhibitors |
| IL163995A0 (en) | 2002-03-13 | 2005-12-18 | Array Biopharma Inc | N3 alkylated benzimidazole derivatives as mek inhibitors |
| US7144907B2 (en) | 2003-09-03 | 2006-12-05 | Array Biopharma Inc. | Heterocyclic inhibitors of MEK and methods of use thereof |
| US7538120B2 (en) | 2003-09-03 | 2009-05-26 | Array Biopharma Inc. | Method of treating inflammatory diseases |
| KR101013932B1 (en) | 2003-10-21 | 2011-02-14 | 워너-램버트 캄파니 엘엘씨 | Polymorphic form of n-[r-2,3-dihydroxy-propoxy]-3,4-difluoro-2-2-fluoro-4-iodophenylamino-benzamide |
| US7732616B2 (en) | 2003-11-19 | 2010-06-08 | Array Biopharma Inc. | Dihydropyridine and dihydropyridazine derivatives as inhibitors of MEK and methods of use thereof |
| KR101190912B1 (en) | 2003-11-19 | 2012-10-12 | 어레이 바이오파마 인크. | Heterocyclic inhibitors of mek and methods of use thereof |
| US7517994B2 (en) | 2003-11-19 | 2009-04-14 | Array Biopharma Inc. | Heterocyclic inhibitors of MEK and methods of use thereof |
| KR101223914B1 (en) | 2003-11-21 | 2013-01-18 | 어레이 바이오파마 인크. | Akt protein kinase inhibitors |
| UA89035C2 (en) * | 2003-12-03 | 2009-12-25 | Лео Фарма А/С | Hydroxamic acid esters and pharmaceutical use thereof |
| ME01541B (en) | 2005-04-13 | 2014-04-20 | Astex Therapeutics Ltd | Hydroxybenzamide derivatives and their use as in hibitor of hsp90 |
| WO2007044084A2 (en) | 2005-05-18 | 2007-04-19 | Array Biopharma Inc. | Heterocyclic inhibitors of mek and methods of use thereof |
| US7754725B2 (en) | 2006-03-01 | 2010-07-13 | Astex Therapeutics Ltd. | Dihydroxyphenyl isoindolymethanones |
| CN101511842B (en) | 2006-07-06 | 2012-10-31 | 阵列生物制药公司 | Dihydrofuro pyrimidines as AKT protein kinase inhibitors |
| DK2054418T3 (en) | 2006-07-06 | 2012-02-27 | Array Biopharma Inc | Dihydrothienopyrimidines as AKT protein kinase inhibitors |
| MY147628A (en) | 2006-07-06 | 2012-12-31 | Array Biopharma Inc | Cyclopenta [d] pyrimidines as akt protein kinase inhibitors |
| US8063050B2 (en) | 2006-07-06 | 2011-11-22 | Array Biopharma Inc. | Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors |
| JP5528806B2 (en) | 2006-10-12 | 2014-06-25 | アステックス、セラピューティックス、リミテッド | Compound drug |
| US8779132B2 (en) | 2006-10-12 | 2014-07-15 | Astex Therapeutics Limited | Pharmaceutical compounds |
| JP5518478B2 (en) | 2006-10-12 | 2014-06-11 | アステックス、セラピューティックス、リミテッド | Pharmaceutical compounds |
| GB0620259D0 (en) | 2006-10-12 | 2006-11-22 | Astex Therapeutics Ltd | Pharmaceutical compounds |
| WO2008044045A1 (en) | 2006-10-12 | 2008-04-17 | Astex Therapeutics Limited | Pharmaceutical combinations |
| JP5721949B2 (en) | 2006-10-12 | 2015-05-20 | アステックス、セラピューティックス、リミテッドＡｓｔｅｘ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｌｉｍｉｔｅｄ | Compound drug |
| US8846683B2 (en) | 2007-07-05 | 2014-09-30 | Array Biopharma, Inc. | Pyrimidyl cyclopentanes as Akt protein kinase inhibitors |
| US9409886B2 (en) | 2007-07-05 | 2016-08-09 | Array Biopharma Inc. | Pyrimidyl cyclopentanes as AKT protein kinase inhibitors |
| AR067413A1 (en) | 2007-07-05 | 2009-10-07 | Genentech Inc | HETEROCICLICAL COMPOUNDS CONTAINING CYCLOPENTA [D] PYRIMIDINE INHIBITORS OF AKT PROTEINQUINASES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, METHOD OF PREPARATION AND USE OF THE SAME FOR THE TREATMENT OF HYPER-TROLIFERATIVE TIPERIFERATIVE AS-ISSUES |
| WO2009006569A1 (en) | 2007-07-05 | 2009-01-08 | Array Biopharma Inc. | Pyrimidyl cyclopentanes as akt protein kinase inhibitors |
| AU2009204025B2 (en) | 2008-01-09 | 2014-02-20 | Array Biopharma Inc. | Hydroxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors |
| JP5539225B2 (en) | 2008-01-09 | 2014-07-02 | アレイ バイオファーマ、インコーポレイテッド | Hydroxylated pyrimidylcyclopentane as an AKT protein kinase inhibitor |
| GB0806527D0 (en) | 2008-04-11 | 2008-05-14 | Astex Therapeutics Ltd | Pharmaceutical compounds |
| CN101985428B (en) * | 2009-07-29 | 2014-02-12 | 杭州民生药业有限公司 | O-anilino benzoic acid derivatives or pharmaceutically acceptable salts thereof as well as preparation method and application thereof |
| EP2536683A1 (en) * | 2010-02-19 | 2012-12-26 | Centre National De La Recherche Scientifique | Method for preparing chemical compounds of interest by aromatic nucleophilic substitution |
| EP2536682A1 (en) * | 2010-02-19 | 2012-12-26 | Centre National De La Recherche Scientifique | Method for preparing chemical compounds of interest by nucleophilic aromatic substitution of aromatic carboxylic acid derivatives supporting at least one electro-attractive group |
| MX2013011329A (en) | 2011-04-01 | 2014-03-12 | Genentech Inc | Combinations of akt inhibitor compounds and erlotinib, and methods of use. |
| WO2012135779A1 (en) | 2011-04-01 | 2012-10-04 | Genentech, Inc. | Combinations of akt and mek inhibitor compounds, and methods of use |
| EA030613B1 (en) * | 2012-10-12 | 2018-08-31 | Экселиксис, Инк. | Novel process for making compounds for use in the treatment of cancer |
| CN112745237B (en) * | 2019-10-29 | 2023-06-20 | 中国科学院上海药物研究所 | 2-arylamine compound and preparation method and application thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3138636A (en) * | 1960-06-23 | 1964-06-23 | Parke Davis & Co | Anthranilic acid derivatives |
| AU5610398A (en) * | 1997-02-28 | 1998-09-18 | Warner-Lambert Company | Method of treating or preventing septic shock by administering a mek inhibitor |
| ES2274572T3 (en) * | 1997-07-01 | 2007-05-16 | Warner-Lambert Company Llc | ACID DERIVATIVES 2- (4-BROMO- OR 4-IODO-PHENYLAMINE) BENZOIC AND ITS USE AS A MEK INHIBITOR. |
| IL132840A (en) * | 1997-07-01 | 2004-12-15 | Warner Lambert Co | 4-bromo or 4-iodo phenylamino benzhydroxamic acid derivatives and pharmaceutical compositions comprising them for use as mek inhibitors |
| CA2348236A1 (en) * | 1999-01-13 | 2000-07-20 | Stephen Douglas Barrett | 4-arylamino, 4-aryloxy, and 4-arylthio diarylamines and derivatives thereof as selective mek inhibitors |
| ES2235843T3 (en) * | 1999-04-21 | 2005-07-16 | Warner-Lambert Company Llc | METHOD FOR THE PRODUCTION OF BENZOIC ACIDS 2- (N-PHENYLAMINE). |
-
2001
- 2001-07-20 CN CN01815869A patent/CN1458921A/en active Pending
- 2001-07-20 CA CA002420003A patent/CA2420003A1/en not_active Abandoned
- 2001-07-20 IL IL15450701A patent/IL154507A0/en unknown
- 2001-07-20 WO PCT/US2001/022948 patent/WO2002018319A1/en not_active Application Discontinuation
- 2001-07-20 MX MXPA03001654A patent/MXPA03001654A/en unknown
- 2001-07-20 PL PL36069901A patent/PL360699A1/en unknown
- 2001-07-20 YU YU14303A patent/YU14303A/en unknown
- 2001-07-20 KR KR10-2003-7002675A patent/KR20030059115A/en not_active Application Discontinuation
- 2001-07-20 AU AU2001277044A patent/AU2001277044A1/en not_active Abandoned
- 2001-07-20 CZ CZ2003477A patent/CZ2003477A3/en unknown
- 2001-07-20 EA EA200300187A patent/EA200300187A1/en unknown
- 2001-07-20 SK SK207-2003A patent/SK2072003A3/en unknown
- 2001-07-20 BR BR0113520-1A patent/BR0113520A/en not_active Application Discontinuation
- 2001-07-20 JP JP2002523437A patent/JP2004507518A/en active Pending
- 2001-07-20 HU HU0300828A patent/HUP0300828A2/en unknown
- 2001-07-20 AP APAP/P/2001/002249A patent/AP2001002249A0/en unknown
- 2001-07-20 EP EP01954824A patent/EP1313694A1/en not_active Withdrawn
- 2001-08-15 SV SV2001000601A patent/SV2002000601A/en not_active Application Discontinuation
- 2001-08-22 TN TNTNSN01127A patent/TNSN01127A1/en unknown
- 2001-08-23 PA PA20018526501A patent/PA8526501A1/en unknown
- 2001-08-24 UY UY26908A patent/UY26908A1/en not_active Application Discontinuation
- 2001-08-24 PE PE2001000853A patent/PE20020393A1/en not_active Application Discontinuation
- 2001-08-24 AR ARP010104047A patent/AR032175A1/en unknown
- 2001-08-24 GT GT200100174A patent/GT200100174A/en unknown
- 2001-08-24 DO DO2001000238A patent/DOP2001000238A/en unknown
- 2001-09-26 HN HN2001000216A patent/HN2001000216A/en unknown
-
2003
- 2003-02-12 ZA ZA200301182A patent/ZA200301182B/en unknown
- 2003-02-20 IS IS6724A patent/IS6724A/en unknown
- 2003-02-24 NO NO20030844A patent/NO20030844L/en not_active Application Discontinuation
- 2003-03-13 BG BG107635A patent/BG107635A/en unknown
- 2003-03-14 MA MA27069A patent/MA26949A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1313694A1 (en) | 2003-05-28 |
| JP2004507518A (en) | 2004-03-11 |
| MXPA03001654A (en) | 2004-09-10 |
| ZA200301182B (en) | 2004-05-12 |
| SK2072003A3 (en) | 2004-01-08 |
| HUP0300828A2 (en) | 2003-09-29 |
| EA200300187A1 (en) | 2003-08-28 |
| DOP2001000238A (en) | 2003-01-31 |
| IS6724A (en) | 2003-02-20 |
| CA2420003A1 (en) | 2002-03-07 |
| AU2001277044A1 (en) | 2002-03-13 |
| TNSN01127A1 (en) | 2005-11-10 |
| GT200100174A (en) | 2002-07-18 |
| BR0113520A (en) | 2003-06-24 |
| AP2001002249A0 (en) | 2001-09-30 |
| AR032175A1 (en) | 2003-10-29 |
| CZ2003477A3 (en) | 2003-10-15 |
| HN2001000216A (en) | 2002-05-22 |
| CN1458921A (en) | 2003-11-26 |
| PE20020393A1 (en) | 2002-05-09 |
| NO20030844D0 (en) | 2003-02-24 |
| YU14303A (en) | 2006-08-17 |
| MA26949A1 (en) | 2004-12-20 |
| UY26908A1 (en) | 2001-11-30 |
| NO20030844L (en) | 2003-02-25 |
| BG107635A (en) | 2004-09-30 |
| SV2002000601A (en) | 2002-04-03 |
| WO2002018319A1 (en) | 2002-03-07 |
| PL360699A1 (en) | 2004-09-20 |
| KR20030059115A (en) | 2003-07-07 |
| PA8526501A1 (en) | 2002-07-30 |
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