IS6724A - Process for the preparation of N-aryl-anthranilic acids and their derivatives - Google Patents
Process for the preparation of N-aryl-anthranilic acids and their derivativesInfo
- Publication number
- IS6724A IS6724A IS6724A IS6724A IS6724A IS 6724 A IS6724 A IS 6724A IS 6724 A IS6724 A IS 6724A IS 6724 A IS6724 A IS 6724A IS 6724 A IS6724 A IS 6724A
- Authority
- IS
- Iceland
- Prior art keywords
- aryl
- derivatives
- preparation
- anthranilic acids
- anthranilic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/10—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C221/00—Preparation of compounds containing amino groups and doubly-bound oxygen atoms bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/04—Formation of amino groups in compounds containing carboxyl groups
- C07C227/06—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid
- C07C227/08—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid by reaction of ammonia or amines with acids containing functional groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22820600P | 2000-08-25 | 2000-08-25 | |
| PCT/US2001/022948 WO2002018319A1 (en) | 2000-08-25 | 2001-07-20 | Process for making n-aryl-anthranilic acids and their derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IS6724A true IS6724A (en) | 2003-02-20 |
Family
ID=22856235
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IS6724A IS6724A (en) | 2000-08-25 | 2003-02-20 | Process for the preparation of N-aryl-anthranilic acids and their derivatives |
Country Status (31)
| Country | Link |
|---|---|
| EP (1) | EP1313694A1 (en) |
| JP (1) | JP2004507518A (en) |
| KR (1) | KR20030059115A (en) |
| CN (1) | CN1458921A (en) |
| AP (1) | AP2001002249A0 (en) |
| AR (1) | AR032175A1 (en) |
| AU (1) | AU2001277044A1 (en) |
| BG (1) | BG107635A (en) |
| BR (1) | BR0113520A (en) |
| CA (1) | CA2420003A1 (en) |
| CZ (1) | CZ2003477A3 (en) |
| DO (1) | DOP2001000238A (en) |
| EA (1) | EA200300187A1 (en) |
| GT (1) | GT200100174A (en) |
| HN (1) | HN2001000216A (en) |
| HU (1) | HUP0300828A2 (en) |
| IL (1) | IL154507A0 (en) |
| IS (1) | IS6724A (en) |
| MA (1) | MA26949A1 (en) |
| MX (1) | MXPA03001654A (en) |
| NO (1) | NO20030844L (en) |
| PA (1) | PA8526501A1 (en) |
| PE (1) | PE20020393A1 (en) |
| PL (1) | PL360699A1 (en) |
| SK (1) | SK2072003A3 (en) |
| SV (1) | SV2002000601A (en) |
| TN (1) | TNSN01127A1 (en) |
| UY (1) | UY26908A1 (en) |
| WO (1) | WO2002018319A1 (en) |
| YU (1) | YU14303A (en) |
| ZA (1) | ZA200301182B (en) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7235537B2 (en) | 2002-03-13 | 2007-06-26 | Array Biopharma, Inc. | N3 alkylated benzimidazole derivatives as MEK inhibitors |
| KR100984573B1 (en) | 2002-03-13 | 2010-09-30 | 어레이 바이오파마 인크. | N3 Alkylated Benzimidazole Derivatives as MEK Inhibitors |
| US7144907B2 (en) | 2003-09-03 | 2006-12-05 | Array Biopharma Inc. | Heterocyclic inhibitors of MEK and methods of use thereof |
| US7538120B2 (en) | 2003-09-03 | 2009-05-26 | Array Biopharma Inc. | Method of treating inflammatory diseases |
| KR101013932B1 (en) | 2003-10-21 | 2011-02-14 | 워너-램버트 캄파니 엘엘씨 | Polymorphic form of n-[r-2,3-dihydroxy-propoxy]-3,4-difluoro-2-2-fluoro-4-iodophenylamino-benzamide |
| US7732616B2 (en) | 2003-11-19 | 2010-06-08 | Array Biopharma Inc. | Dihydropyridine and dihydropyridazine derivatives as inhibitors of MEK and methods of use thereof |
| AU2004293017B2 (en) | 2003-11-19 | 2010-08-19 | Array Biopharma Inc. | Bicyclic inhibitors of MEK and methods of use thereof |
| US7517994B2 (en) | 2003-11-19 | 2009-04-14 | Array Biopharma Inc. | Heterocyclic inhibitors of MEK and methods of use thereof |
| KR101223914B1 (en) | 2003-11-21 | 2013-01-18 | 어레이 바이오파마 인크. | Akt protein kinase inhibitors |
| UA89035C2 (en) | 2003-12-03 | 2009-12-25 | Лео Фарма А/С | Hydroxamic acid esters and pharmaceutical use thereof |
| PL1877379T3 (en) | 2005-04-13 | 2013-06-28 | Astex Therapeutics Ltd | Hydroxybenzamide derivatives and their use as inhibitors of hsp90 |
| ES2378760T3 (en) | 2005-05-18 | 2012-04-17 | Array Biopharma, Inc. | MEK heterocyclic inhibitors and methods of use thereof |
| US7754725B2 (en) | 2006-03-01 | 2010-07-13 | Astex Therapeutics Ltd. | Dihydroxyphenyl isoindolymethanones |
| EP2054418B1 (en) | 2006-07-06 | 2011-11-09 | Array Biopharma Inc. | Dihydrothieno pyrimidines as akt protein kinase inhibitors |
| US8063050B2 (en) | 2006-07-06 | 2011-11-22 | Array Biopharma Inc. | Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors |
| RU2481336C2 (en) | 2006-07-06 | 2013-05-10 | Эррэй Биофарма Инк. | Cyclopenta(d)pyrimidines as protein kinase akt inhibitors |
| CA2656566C (en) | 2006-07-06 | 2014-06-17 | Array Biopharma Inc. | Dihydrofuro pyrimidines as akt protein kinase inhibitors |
| WO2008044041A1 (en) | 2006-10-12 | 2008-04-17 | Astex Therapeutics Limited | Pharmaceutical combinations |
| US9730912B2 (en) | 2006-10-12 | 2017-08-15 | Astex Therapeutics Limited | Pharmaceutical compounds |
| EP2081891A2 (en) | 2006-10-12 | 2009-07-29 | Astex Therapeutics Limited | Pharmaceutical compounds having hsp90 inhibitory or modulating activity |
| GB0620259D0 (en) | 2006-10-12 | 2006-11-22 | Astex Therapeutics Ltd | Pharmaceutical compounds |
| JP5528807B2 (en) | 2006-10-12 | 2014-06-25 | アステックス、セラピューティックス、リミテッド | Compound drug |
| WO2008044029A1 (en) | 2006-10-12 | 2008-04-17 | Astex Therapeutics Limited | Pharmaceutical combinations |
| US9409886B2 (en) | 2007-07-05 | 2016-08-09 | Array Biopharma Inc. | Pyrimidyl cyclopentanes as AKT protein kinase inhibitors |
| US8846683B2 (en) | 2007-07-05 | 2014-09-30 | Array Biopharma, Inc. | Pyrimidyl cyclopentanes as Akt protein kinase inhibitors |
| KR101624361B1 (en) | 2007-07-05 | 2016-05-25 | 어레이 바이오파마 인크. | Pyrimidyl cyclopentanes as akt protein kinase inhibitors |
| NZ582692A (en) | 2007-07-05 | 2012-05-25 | Array Biopharma Inc | Pyrimidyl cyclopentanes as akt protein kinase inhibitors |
| NZ586720A (en) | 2008-01-09 | 2012-11-30 | Array Biopharma Inc | Hydroxylated pyrimidyl cyclopentane as akt protein kinase inhibitor |
| ES2422733T3 (en) | 2008-01-09 | 2013-09-13 | Array Biopharma Inc | Hydroxylated pyrimidylcyclopentanes as AKT protein kinase inhibitors |
| GB0806527D0 (en) | 2008-04-11 | 2008-05-14 | Astex Therapeutics Ltd | Pharmaceutical compounds |
| CN101985428B (en) * | 2009-07-29 | 2014-02-12 | 杭州民生药业有限公司 | O-anilino benzoic acid derivatives or pharmaceutically acceptable salts thereof as well as preparation method and application thereof |
| CN102958892A (en) * | 2010-02-19 | 2013-03-06 | 国家科学研究中心 | Method for preparing chemical compounds of interest by aromatic nucleophilic substitution |
| CN102985399A (en) * | 2010-02-19 | 2013-03-20 | 国家科学研究中心 | Method for preparing chemical compounds of interest by nucleophilic aromatic substitution of aromatic carboxylic acid derivatives supporting at least one electro-attractive group |
| CN110433165A (en) | 2011-04-01 | 2019-11-12 | 基因泰克公司 | The combination and its application method of AKT and mek inhibitor compound |
| BR112013025353A8 (en) | 2011-04-01 | 2018-01-02 | Genentech Inc | combination of a) a compound of formula ia, compound of formula ia or a pharmaceutically acceptable salt thereof, method for treating a hyperproliferative disorder in a mammal, use of a compound of formula ia or a pharmaceutically acceptable salt thereof, kit and product |
| NZ706723A (en) * | 2012-10-12 | 2018-07-27 | Exelixis Inc | Novel process for making compounds for use in the treatment of cancer |
| CN112745237B (en) * | 2019-10-29 | 2023-06-20 | 中国科学院上海药物研究所 | 2-arylamine compound and preparation method and application thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3138636A (en) * | 1960-06-23 | 1964-06-23 | Parke Davis & Co | Anthranilic acid derivatives |
| AU5610398A (en) * | 1997-02-28 | 1998-09-18 | Warner-Lambert Company | Method of treating or preventing septic shock by administering a mek inhibitor |
| ATE344791T1 (en) * | 1997-07-01 | 2006-11-15 | Warner Lambert Co | 2-(4-BROMINE OR 4-IODINE PHENYLAMINO)BENZOIC ACID DERIVATIVES AND THEIR USE AS MEK INHIBITORS |
| ES2229515T3 (en) * | 1997-07-01 | 2005-04-16 | Warner-Lambert Company Llc | 4-BROMO OR 4-IODINE DERIVATIVES OF BENZHYDROXAMIC PHENYLAMINE ACID AND ITS USE AS INHIBITORS OF THE MEK. |
| CA2348236A1 (en) * | 1999-01-13 | 2000-07-20 | Stephen Douglas Barrett | 4-arylamino, 4-aryloxy, and 4-arylthio diarylamines and derivatives thereof as selective mek inhibitors |
| SK14732001A3 (en) * | 1999-04-21 | 2002-05-09 | Warner-Lambert Company | Method for making 2-(n-phenylamino)benzoic acids |
-
2001
- 2001-07-20 JP JP2002523437A patent/JP2004507518A/en active Pending
- 2001-07-20 SK SK207-2003A patent/SK2072003A3/en unknown
- 2001-07-20 EA EA200300187A patent/EA200300187A1/en unknown
- 2001-07-20 CA CA002420003A patent/CA2420003A1/en not_active Abandoned
- 2001-07-20 AU AU2001277044A patent/AU2001277044A1/en not_active Abandoned
- 2001-07-20 KR KR10-2003-7002675A patent/KR20030059115A/en not_active Application Discontinuation
- 2001-07-20 CZ CZ2003477A patent/CZ2003477A3/en unknown
- 2001-07-20 CN CN01815869A patent/CN1458921A/en active Pending
- 2001-07-20 EP EP01954824A patent/EP1313694A1/en not_active Withdrawn
- 2001-07-20 WO PCT/US2001/022948 patent/WO2002018319A1/en not_active Application Discontinuation
- 2001-07-20 YU YU14303A patent/YU14303A/en unknown
- 2001-07-20 MX MXPA03001654A patent/MXPA03001654A/en unknown
- 2001-07-20 HU HU0300828A patent/HUP0300828A2/en unknown
- 2001-07-20 BR BR0113520-1A patent/BR0113520A/en not_active Application Discontinuation
- 2001-07-20 PL PL36069901A patent/PL360699A1/en unknown
- 2001-07-20 IL IL15450701A patent/IL154507A0/en unknown
- 2001-07-20 AP APAP/P/2001/002249A patent/AP2001002249A0/en unknown
- 2001-08-15 SV SV2001000601A patent/SV2002000601A/en not_active Application Discontinuation
- 2001-08-22 TN TNTNSN01127A patent/TNSN01127A1/en unknown
- 2001-08-23 PA PA20018526501A patent/PA8526501A1/en unknown
- 2001-08-24 DO DO2001000238A patent/DOP2001000238A/en unknown
- 2001-08-24 PE PE2001000853A patent/PE20020393A1/en not_active Application Discontinuation
- 2001-08-24 UY UY26908A patent/UY26908A1/en not_active Application Discontinuation
- 2001-08-24 AR ARP010104047A patent/AR032175A1/en unknown
- 2001-08-24 GT GT200100174A patent/GT200100174A/en unknown
- 2001-09-26 HN HN2001000216A patent/HN2001000216A/en unknown
-
2003
- 2003-02-12 ZA ZA200301182A patent/ZA200301182B/en unknown
- 2003-02-20 IS IS6724A patent/IS6724A/en unknown
- 2003-02-24 NO NO20030844A patent/NO20030844L/en not_active Application Discontinuation
- 2003-03-13 BG BG107635A patent/BG107635A/en unknown
- 2003-03-14 MA MA27069A patent/MA26949A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EA200300187A1 (en) | 2003-08-28 |
| IL154507A0 (en) | 2003-09-17 |
| DOP2001000238A (en) | 2003-01-31 |
| HUP0300828A2 (en) | 2003-09-29 |
| CN1458921A (en) | 2003-11-26 |
| UY26908A1 (en) | 2001-11-30 |
| SV2002000601A (en) | 2002-04-03 |
| EP1313694A1 (en) | 2003-05-28 |
| PA8526501A1 (en) | 2002-07-30 |
| TNSN01127A1 (en) | 2005-11-10 |
| HN2001000216A (en) | 2002-05-22 |
| AU2001277044A1 (en) | 2002-03-13 |
| ZA200301182B (en) | 2004-05-12 |
| SK2072003A3 (en) | 2004-01-08 |
| GT200100174A (en) | 2002-07-18 |
| YU14303A (en) | 2006-08-17 |
| NO20030844L (en) | 2003-02-25 |
| MA26949A1 (en) | 2004-12-20 |
| CZ2003477A3 (en) | 2003-10-15 |
| WO2002018319A1 (en) | 2002-03-07 |
| MXPA03001654A (en) | 2004-09-10 |
| NO20030844D0 (en) | 2003-02-24 |
| JP2004507518A (en) | 2004-03-11 |
| BR0113520A (en) | 2003-06-24 |
| AR032175A1 (en) | 2003-10-29 |
| AP2001002249A0 (en) | 2001-09-30 |
| BG107635A (en) | 2004-09-30 |
| PL360699A1 (en) | 2004-09-20 |
| KR20030059115A (en) | 2003-07-07 |
| PE20020393A1 (en) | 2002-05-09 |
| CA2420003A1 (en) | 2002-03-07 |
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