ES2500068T3 - Inhibidores heterocíclicos de MEK y métodos de uso de los mismos - Google Patents

Inhibidores heterocíclicos de MEK y métodos de uso de los mismos Download PDF

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Publication number
ES2500068T3
ES2500068T3 ES11003826.2T ES11003826T ES2500068T3 ES 2500068 T3 ES2500068 T3 ES 2500068T3 ES 11003826 T ES11003826 T ES 11003826T ES 2500068 T3 ES2500068 T3 ES 2500068T3
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Prior art keywords
mek
methods
hoch2ch20
cyclopropyl
ethyl
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Inventor
Richard Anthony Storey
Rebecca Jane Booth
John David Pittam
Allison L. Marlow
Eli Wallace
Jeongbeob Seo
Joseph P. Lyssikatos
Hong Woon Yang
Jim Blake
John Leonard
Mark Richard Fielding
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AstraZeneca AB
Array Biopharma Inc
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AstraZeneca AB
Array Biopharma Inc
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    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Abstract

Composicion farmaceutica que comprende un compuesto que tiene la formula IV:**Fórmula** o una sal farmaceuticamente aceptable del mismo, en la que: R1 es Cl o F; R3 es H, Me, Et, OH, Me0-, Et0-, HOCH2CH20-, HOCH2C(Me)20-, (S)-MeCH(OH)CH20-, (R)- HOCH2CH(OH)CH20-, ciclopropil-CH20-, HOCH2CH2-, R7 es metilo o etilo, en el que dicho nnetilo y etilo estan opcionalmente sustituidos con uno o mas F; R8 es Br, I o SMe; y R9 es H, alquilo C1-C4, Cl o CN, en el que dicho alquilo esta opcionalmente sustituido con uno o mas grupos seleccionados independientemente de F o CN, siempre que cuando a) R1 es F, R8 es Br, R9 es H y R7 es o bien Me o bien Et, entonces R3 no puede ser HOCH2CH20; b) R1 es F, R8 es I, R9 es H y R3 es Me0, entonces R7 no puede ser Me; y c) R1 es F, R8 es Me, R9 es H y R3 es ciclopropil-CH20, entonces R7 no puede ser Me; en combinación con un agente antitumoral o un inhibidor de la transducción de senates

Description

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Claims (1)

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ES11003826.2T 2005-05-18 2006-05-17 Inhibidores heterocíclicos de MEK y métodos de uso de los mismos Active ES2500068T3 (es)

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ES08004958T Active ES2333182T3 (es) 2005-05-18 2006-05-17 Derivados de 4-(fenilamino)-6-oxo-1,6-dihidropiridazina-3-carboxamida como inhibidores de mek para el tratamiento de enfermedades hiperproliferativas.
ES11003826.2T Active ES2500068T3 (es) 2005-05-18 2006-05-17 Inhibidores heterocíclicos de MEK y métodos de uso de los mismos
ES06836069T Active ES2378760T3 (es) 2005-05-18 2006-05-17 Inhibidores heterocíclicos de MEK y métodos de uso de los mismos
ES11003827T Active ES2405785T3 (es) 2005-05-18 2006-05-17 Inhibidores heterocíclicos de MEK y métodos de uso de los mismos

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ES06836069T Active ES2378760T3 (es) 2005-05-18 2006-05-17 Inhibidores heterocíclicos de MEK y métodos de uso de los mismos
ES11003827T Active ES2405785T3 (es) 2005-05-18 2006-05-17 Inhibidores heterocíclicos de MEK y métodos de uso de los mismos

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